Terbenzimidazoles: Influence of 2''-, 4-, and 5-substituents on cytotoxicity and relative potency as topoisomerase I poisons

Journal of Medicinal Chemistry

Volumn 40, Issue 18, 1997, Pages 2818-2824

  Kim, Jung Sun ^a   Yu, Chiang ^b   Liu, Angela ^b   Liu, Leroy F ^b   LaVoie, Edmond J ^a  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; CYTOTOXIC AGENT; DNA FRAGMENT; DNA TOPOISOMERASE; METHYL GROUP; NAPHTHALENE DERIVATIVE; NAPHTHYL GROUP; PHENYL GROUP;

ARTICLE; CONTROLLED STUDY; DNA CLEAVAGE; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LYMPHOBLASTOMA; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; CELL SURVIVAL; CLONING, MOLECULAR; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0001106331     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960658g     Document Type: Article

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