Spectroscopic analyses of the binding kinetics of 15d-PGJ2 to the PPARγ ligand-binding domain by multi-wavelength global fitting

Biochemical Journal

Volumn 393, Issue 3, 2006, Pages 749-755

  Shiraki, Takuma ^a   Kodama, Takashi S ^a,c   Shiki, Sayaka ^a   Nakagawa, Tatsuo ^b   Jingami, Hisato ^a  

^a BIOMOL ENG RESEARCH INSTITUTE   (Japan)

^b Japan Science and Technology Agency   (Japan)

^c OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

15 deoxy 12,14 prostaglandin J 2 (15d PGJ2); Covalent binding; Michael addition; Multi wavelength global fitting analysis; Peroxisome proliferator activated receptor (PPAR ); Stopped flow spectroscopy

Indexed keywords

LIPIDS; MATHEMATICAL MODELS; METABOLITES; MUTAGENESIS; OXIDATION; SPECTROSCOPIC ANALYSIS;

15-DEOXY-Δ12,14-PROSTAGLANDIN J2 (15D-PGJ2); COVALENT BINDING; MICHAEL-ADDITION; MULTI-WAVELENGTH GLOBAL FITTING ANALYSIS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR Γ (PPARΓ); STOPPED-FLOW SPECTROSCOPY;

REACTION KINETICS;

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ARTICLE; BINDING KINETICS; COMPLEX FORMATION; ENZYME ACTIVATION; LIGAND BINDING; MICHAEL ADDITION; MULTI WAVELENGTH GLOBAL FITTING ANALYSIS; OXIDATION; PRIORITY JOURNAL; PROTEIN DOMAIN; REACTION ANALYSIS; SPECTROSCOPY; STOPPED FLOW SPECTROSCOPY; WILD TYPE;

ANIMALS; CELL LINE; KINETICS; MUTATION; PPAR GAMMA; PROSTAGLANDIN D2; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SPECTRUM ANALYSIS;

RUMEX;

EID: 31544450241     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20050930     Document Type: Article

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