Neurotrophins: Novel mediators of angiogenesis

Frontiers in Bioscience

Volumn 8, Issue SUPPL., 2003, Pages

  Kraemer, Rosemary ^a   Hempstead, Barbara L ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b NY USA   (United States)

Author keywords

Angiogenesis; Endothelial cells; Neurotrophins; p75 neurotrophin receptor; Smooth muscle cells; Trk receptors

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GROWTH FACTOR; MATRIX METALLOPROTEINASE; NERVE GROWTH FACTOR; NEUROTROPHIN; NEUROTROPHIN 3; NEUROTROPHIN RECEPTOR; PROTEIN P75; PROTEIN TYROSINE KINASE;

ANGIOGENESIS; APOPTOSIS; BLOOD VESSEL INJURY; CELL DIFFERENTIATION; CELL SURVIVAL; CELL TYPE; CHEMOTAXIS; ENDOTHELIUM CELL; INJURY; ISCHEMIA; MITOGENESIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULARIZATION;

EID: 3142752927     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: None     Document Type: Review

References (54)

1. W Risau: Mechanisms of angiogenesis. Nature 386, 671-674 (1997)
2. P Carmeliet: Mechanisms of angiogenesis and arteriogenesis. Nat Med. 6, 389-395 (2000)
3. E.M. Conway: Molecular mechanisms of blood vessels growth. Cardiovasc Res 49, 507-521 (2001)
4. Carmeliet, P. & R.K. Jain: Angiogenesis in cancer and other diseases. Nature 407, 249-257 (2000)
5. Heissig, B, K Hattori, M Friedrich, S Rafii, & Z Werb: Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases. Current Opinion in Hematology 10, 136-141 (2003)
6. L.M. Goncalves: Angiogenic growth factors: potential new treatment for acute myocardial infarction? Cardiovasc Res 45, 294-302 (2000)
7. Bikfalvi, A. & R Bicknell: Recent advances in angiogenesis, anti-angiogenesis and vascular targeting. Trends Pharmacol.Sci. 23, 576-582 (2002)
8. Luttun, A, M. Tjwa & P. Carmeliet: Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): Novel therapeutic targets for angiogenic disorders. Ann. N.Y. Acad. Sci. 979, 80-93 (2002)
9. Dunn, I.F., O. Heese & P. M. Black: Growth factors in glioma angiogenesis: FGFs, PDGF, EGF and TGFs. J. Neuro-Oncol 50, 121-137 (2000)
10. Gale, N. W. & G. D. Yancolpoulos: Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes and Development 13, 1055-1066 (1999)
11. Sofroniew, M. V., C. L. Howe, & W. C. Mobley: Nerve growth factor signaling, neuroprotection, and neural repair. Ann Rev Neurosci 24, 1217-1281 (2001)
12. Chao, M. V. & B. L. Hempstead: p75 and trk: a two-receptor system. Trends Neurosci 18, 321-326 (1995)
13. Klein, R., D. Conway, L.F. Parada & M. Barbacid: The trk B tyrosine kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell 61, 647-656 (1990)
14. Tsoulfas, P., D. Soppet, E. Escandon, L. Tessarollo, J.-L. Mendoza-Rameriez, A. Rosental, K. Nikolics, & L.F. Parada: The rat trkC locus endodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells. Neuron 10, 975-990 (1993)
15. Eide, F. F., E.R. Vining, B.L. Eide, K.L. Zang, X.Y. Wang & L.F. Reichardt: Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling. J.Neurosci. 16, 3123-3129 (1996)
16. Das, I., J.R. Sparrow, M.I. Lin, E. Shih, T. Mikawa & B.L. Hempstead: Trk C signaling is required for retinal progenitor cell proliferation. J.Neurosci. 20, 2887-2895 (2000)
17. Palko, M. E., V. Coppola & L. Tessarollo Evidence for a role of truncated trk C receptor isoforms in mouse development. J.Neurosci. 19, 775-782 (1999)
18. Tessarollo, L., P. Tsoulfas, M.J. Donovan, M.E. Palko, J. Blair-Flynn, B.L. Hempstead & L.F. Parada: Targeted deletion of all isoforms of the trkC gene suggests the use of alternative receptors by its ligand neurotrophin-3 in neuronal development and implicates trk C in normal cardiogenesis. Proc.Natl.Acad.Sci.U.S.A. 94, 14776-14781 (1997)
19. Greene, L.A. & D.R. Kaplan: Early events in neurotrophin signalling via Trk and p75 receptors. Current Opinion in Neurobiology 5, 579-587 (1995)
20. Friedman, W.J. & L.A. Greene: Neurotrophin signaling via trks and p75. Experimental Cell Research 253, 131-142 (1999)
21. Miller, F.D. & D.R. Kaplan: Neurotrophin signaling pathways regulating neuronal apoptosis. Cell Mol Life Sci 58, 1043-1053 (2001)
22. Hempstead, B.L., D. Martin-Zanca, D.R. Kaplan, L.F. Parada, & M.V. Chao: High affinity NGF binding requires coexpression of the trk proto-oncogene and the low affinity NGF receptor. Nature 350, 678-683 (1991)
23. NTR. EMBO 18, 616-622 (1999)
24. NTR is necessary to inhibit neurotrophin-3 signaling through TrkA. J. Biol. Chem. 276, 11294-11301 (2001)
25. NTR mediates neurotrophin-induced apoptosis of vascular smooth muscle cells. Am.J.Pathol. 157, 1247-1258 (2000)
26. Frade, J. M., A. Rodriguez-Tebar & Y.A. Barde: Induction of cell death by endogenous nerve growth factor through its p75 receptor. Nature 383, 166-168 (1996)
27. Casaccia-Bonnefil, P., L. Aibel & M.V. Chao: Central glial and neuronal populations display differential sensitivity to ceramide-dependent cell death. J.Neurosci.Res. 43, 382-389 (1996)
28. Donovan, M. J., R.C. Miranda, R. Kraemer, T.A. Mccaffrey, L. Tessarollo, D. Mahadeo, S. Sharif, D.R. Kaplan, P. Tsoulfas, L. Parada, D. Toran-Allerand, D.P. Hajjar & Hempstead, B. L.: Neurotrophin and neurotrophin receptors in vascular smooth muscle cells: regulation of expression in response to injury. Am.J.Pathol. 147, 309-324 (1995)
29. Donovan, M. J., M. Lin, P. Wiegn, T. Ringsted, R. Kraemer, R. Hahn, S. Wang, C. Ibanez, S. Rafii & B.L. Hempstead: Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development 127, 4531-4540 (2000)
30. Turrini, P., C. Gaetano, A. Antonelli, M.C. Capogrossi, & L. Aloe: Nerve growth factor induces angiogenic activity in a mouse model of hindlimb ischemia. Neuroscience Letters 323, 102-112 (2002)
31. Cantarella, G., L. Lempereur, M. Presta, D. Ribatti, G. Lombardo, P. Lazarovici, G. Zappala, C. Pafumi & R. Bernardini: Nerve growth factor-endothelial cell interaction leads to angiogenesis in vitro and in vivo. FASEB J 16, 1307-1309 (2002)
32. Calza, L., L. Giardino, A. Giuliani, L. Aloe & R. Levi-Montalcini: Nerve growth factor control of neuronal expression of angiogenic and vasoactive factors. Proc Natl Acad Sci USA 98, 4160-4165 (2001)
33. Emanueli, C., M.B. Salis, A. Pinna, G. Graiani, L. Manni & P. Madeddu: Nerve growth factor promotes angiogenesis and arteriogenesis in ischemic hindlimbs. Circulation 106, 2257-2262 (2002)
34. Kraemer, R., K.L. March & B.L. Hempstead: NGF activates similar intracellular signaling pathways in vascular smooth muscle cells as PDGF-BB but elicits different biological respones. Arteriosclerosis, Thrombosis and Vascular Biology 19, 1041-1050 (1999)
35. Lee, R., P. Kermani, K.K. Teng & B.L. Hempstead: Regulation of cell survival by secreted neurotrophins. Science 294, 1945-1948 (2001)
36. Newby, A. C. & A.B. Zaltsman: Molecular mechanisms in intimal hyperplasia. Journal of Pathology 190, 300-309 (2000)
37. Nagase, H.: Zinc Metalloproteinases in Health and Disease., Taylor and Francis, London (1996)
38. Rundhaug, J. E.: Matrix metalloproteinases, angiogenesis, and cancer. Clinical Cancer Research 9, 551-554 (2003)
39. Machida, C.M., J.D. Scott & G. Ciment: NGF-induction of the metalloproteinase-transin/stromelysin in PC12 cells: involvement of multiple protein kinases. J. Cell. Biol. 114, 1037-1048 (1991)
40. Machida, C.M., K.D. Rodland, L. Matrisian, B.E. Magun & G. Ciment: NGF induction of the gene encoding the protease transin accompanies neuronal differentiation in PC12 cells. Neuron 2, 1587-1596 (1989)
41. K.M.F. Khan, D. J. Falcone and R. Kraemer: NGF activation of Erk-1 and Erk-2 induces MMP-9 expression in vascular smooth muscle cells. J.Biol.Chem. 277, 2353-2359 (2002)
42. Galis, Z. S., C. Johnson, D. Godin, R. Magid, J.M. Shipley, R. M. Senior & E. Ivan: Targeted disruption of the matrix metalloproteinase-9 gene impairs smooth muscle cell migration and geometrical arterial modeling. Circ Res 91, 504-509 (2002)
43. NTR-null mutant mice. Circ.Res. 91, 494-500 (2002)
44. NTR causes defects both in the nervous system and the vascular system. Nature Neurosci. 4, 977-978 (2001)
45. Hiltunen, J.O., A. Laurikainen, A. Vakeva, S. Meri & M. Saarma: Nerve growth factor and brain-derived neurotrophic factor mRNAs are regulated in distinct cell populations of rat heart after ischemia and reperfusion. J. Pathology 194, 247-253 (2001)
46. Patterson, P. An introduction to Molecular Neurobiology: Neuron-Target Interactions., Sinauer Associates, Sunderland, MA (1992)
47. Miknyoszki, S.J., H. Chang, A. Klein-Szanto, C.A. Dionne and B.A. Ruggeri: The Trk tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits significant antitumor efficacy in preclinical xenograft models of human pancreatic ductal adenocarcinoma. Clin. Cancer Res. 5, 2205-2212 (1999)
48. Krygier, S. & D. Djakiew: Neurotrophin receptor p75(NTR) suppresses growth and nerve growth factor-mediated metastasis of human prostate cancer cells. Int. J. Cancer 98, 1-7 (2002)
49. McGregor, L.M., B.K. McCune, J.R. Graff, P.R. McDowell, K.E. Romans, G.D. Yancolpoulos, D.W. Ball, S.B. Baylin & B.D. Nelkin: Roles of trk family neurotrophin receptors in medullary thyroid carcinoma development and progression. Proc Natl Acad Sci USA 96, 4540-4545(1999)
50. Descamps, S., V. Pawlowski, F. Revillion, L. Hornez, M. Hebbar, B. Boilly, H. Hondermarck & J.P. Peyrat: Expression of nerve growth factor receptors and their prognostic value in human breast cancer. Cancer Res 61, 4337-4340 (2001)
51. Eguchi, M., M. Eguchi-Ishimae, A. Tojo, K. Morishita, K. Suzuki, Y. Sato, S. Kudoh, K. Tanaka, M. Setoyama, F. Nagamura, S. Asano & N. Kamada: Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25). Blood 15, 1355-1363 (1999)
52. Donovan, M. J., B. Hempstead, L.J. Huber, D. Kaplan, P. Tsoulfas, M. Chao, L. Parada & D. Scholfield: Identification of the neurotrophin receptors p75 and trk in a series of Wilms' tumors. Am.J.Pathol. 145, 792-801 (1994)
53. Eggert, A., R. Ho, N. Ikegaki, X.G. Liu & G.M. Brodeur: Different effects of Trk A expression in neuroblastoma cell lines with or without MYCN amplification. Med. Pediatr. Oncol. 35, 623-627 (2000)
54. Kishibe, K., Y. Yamada & K. Ogawa: Production of nerve growth factor by mouse hepatocellular carcinoma cells and expression of trk A in tumor associated arteries in mice. Gastroenterology 122, 1978-1986 (2002)