Different effects of TrkA expression in neuroblastoma cell lines with or without MYCN amplification

Medical and Pediatric Oncology

Volumn 35, Issue 6, 2000, Pages 623-627

  Eggert, Angelika ^a   Ho, Ruth ^a   Ikegaki, Naohiko ^a   Liu, Xing Ge ^a   Brodeur, Garrett M ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Differentiation; Neuroblastoma; Neurotrophins; Signal transduction; Tyrosine kinase receptors

Indexed keywords

NERVE GROWTH FACTOR; TYROSINE KINASE RECEPTOR;

AUTOPHOSPHORYLATION; CANCER GROWTH; CANCER SURVIVAL; CELL PROLIFERATION; CONFERENCE PAPER; GENE AMPLIFICATION; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMEDIATE EARLY GENE; NERVE CELL DIFFERENTIATION; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

CELL DIVISION; CELL SURVIVAL; GENE AMPLIFICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MYC; HUMANS; NEUROBLASTOMA; PHOSPHORYLATION; RECEPTOR, TRKA; RNA, MESSENGER; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0033646879     PISSN: 00981532     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-911X(20001201)35:6<623::AID-MPO29>3.0.CO;2-H     Document Type: Conference Paper

References (11)

1. Association between high levels of expression of the Trk gene and favorable outcome in human neuroblastomas
2. Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells
3. Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma
4. A relative quantitative RT-PCR protocol for TrkB expression in neuroblastoma using GAPD as an internal control, Biotechniques
5. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
6. Nerve growth factor-induced differentiation of human neuroblastoma and neuroepithelioma cell lines
7. Constitutive N-myc gene expression inhibits trkA mediated neuronal differentiation
8. N-myc proto-oncogene expression during organogenesis in the developing mouse as revealed by in situ hybridization
9. Constitutive c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitment
10. Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma
11. Retinoic acid-induced growth arrest and differentiation of neuroblastoma cells are counteracted by N-myc and enhanced by max overexpressions