N-terminal protein acylation confers localization to cholesterol, sphingolipid-enriched membranes but not to lipid rafts/caveolae

Molecular Biology of the Cell

Volumn 12, Issue 11, 2001, Pages 3601-3617

  McCabe, J B ^a   Berthiaume, L G ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CAVEOLIN; CHOLESTEROL; GREEN FLUORESCENT PROTEIN; PROTEIN; SPHINGOLIPID;

ACYLATION; ANIMAL CELL; ARTICLE; CHIMERA; GOLGI COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT;

ANIMALIA;

EID: 0035200238     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.11.3601     Document Type: Article

References (88)

1. Plasma membrane microdomains act as concentration platforms to facilitate intoxication by aerolysin
2. The caveolae membrane system
3. Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme
4. Association of GAP-43 with detergent-resistant membranes requires two palmitoylated cysteine residues
5. yes
6. Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking
7. Oxidized low density lipoprotein displaces endothelial nitric-oxide synthase (eNOS) from plasmalemmal caveolae and impairs eNOS activation
8. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface
9. Functions of lipid rafts in biological membranes
10. Structure and origin of ordered lipid domains in biological membranes
11. oα
12. Progesterone blocks cholesterol translocation from lysosomes
13. Isolation and characterization of Chinese hamster ovary cell mutants defective in intracellular low density lipoprotein-cholesterol trafficking
14. Intracellular distribution of Arf proteins in mammalian cells
15. Endomembrane trafficking of ras: The CAAX motif targets proteins to the ER and Golgi
16. Caveolin cycles between plasma membrane caveolae and the Golgi complex by microtubule-dependent and microtubule-independent steps
17. Synaptic targeting of the postsynaptic density, protein PSD-95 mediated by lipid and protein motifs
18. Static and dynamic lipid asymmetry in cell membranes
19. Phagosomal maturation, acidificatiion, and inhibition of bacterial growth in nonphagocytic cells transfected with FcγRIIA receptors
20. Signaling functions of protein palmitoylation
21. z
22. Synthesis of mitochondrial DNA in permeabilized human culture cells
23. Quantitative analysis of phospholipids in functionally important membrane domains from RBL-2H3 mast cells using tandem high-resolution mass spectrometry
24. i1α is sufficient to target a green fluorescent protein reporter to caveolin-enriched plasma membrane domains
25. Phenotypic behavior of caveolin-3 mutations that cause autosomal dominant limb girdle muscular dystrophy (LGMD-1C): Retention of LGMD-1C caveolin-3 mutants within the Golgi complex
26. Regulation of caveolin and caveolae by cholesterol in MDCK cells
27. Selective accumulation of raft-associated membrane protein LAT in T cell receptor signaling assemblies
28. Lipid domain structure of the plasma membrane revealed by patching of membrane components
29. Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains
30. The biosynthesis of phosphatidylserines by acylation of 1-acyl-sn-glycero-3-phosphoserine in rat liver
31. Detergent-insoluble glycosphingolipid/cholesterol-rich membrane domains, lipid rafts and caveolae
32. Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane
33. Separation of "glycosphingolipid signaling domain" from caveolin-containing membrane fraction in mouse melanoma B16 cells and its role in cell adhesion coupled with signaling
34. Looking at lipid rafts?
35. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor
36. Amphitropic proteins: Regulation by reversible membrane interactions
37. Association of engrailed homeoproteins with vesicles presenting caveolae-like properties
38. Extraction of cholesterol with methyl-β-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles
39. Membrane microdomains and caveolae
40. The 2.0 Å crystal structure of a heterotrimeric G protein
41. Intracellular sorting of neuromodulin (GAP-43) mutants modified in the membrane targeting domain
42. Molecular characterization of caveolin association with the Golgi complex: Identification of a cis-Golgi targeting domain in the caveolin molecule
43. yes controls polymeric IgA transcytosis in vivo
44. Functionally different GPI proteins are organized in different domains on the neuronal surface
45. New insights into the interaction of Ras with the plasma membrane
46. Cholesterol-dependent retention of GPI-anchored proteins in endosomes
47. Functional roles for fatty acylated amino-terminal domains in subcellular localization
48. Palmitoylation of GAP-43 by the ER-Golgi intermediate compartment and Golgi apparatus
49. Characterization of proteins in detergent-resistant membrane complexes from Madin-Darby canine kidney epithelial cells
50. Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts
51. Polarized distribution of endogenous Rac1 and RhoA at the cell surface
52. Relationships bewteen EEA1 binding partners and their role in endosome fusion
53. Lipid-dependent targeting of G proteins into rafts
54. Structural heterogeneity of endocytic membranes in macrophages as revealed by the cholesterol probe, filipin
55. Cholesterol distribution in living cells: Fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog
56. Filipin as a flow microfluorometry probe for cellular cholesterol
57. VIP21/caveolin is a cholesterol-binding protein
58. Rapid cycling of lipid raft markers between the cell surface and Golgi complex
59. Immunoisolation of caveolae with high affinity antibody binding to the oligomeric cage
60. Filipin-dependent inhibition of cholera toxin: Evidence for toxin internalization and activation through caveolae-like domains
61. Isolation and characterization of two distinct low-density, Triton-insoluble, complexes from porcine lung membranes
62. Ultrastructural localization of gangliosides: GM1 is concentrated in caveolae
63. Digging into caveolae
64. GFP in mammalian cells
65. A chimeric transmembrane domain directs endothelial nitric-oxide synthase palmitoylation and targeting to plasmalemmal caveolae
66. Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content
67. Fatty acylation of proteins: New insights into membrane targeting of myristoylated and palmitoylated protiens
68. Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains
69. Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior
70. Cholesterol and sphingolipid enhance the Triton X-100 insolubility of glycosylphosphatidylinositol-anchored proteins by promoting the formation of detergent-insoluble ordered membrane domains
71. Doubly-lipid-modified sequence motifs exhibit long-lived anchorage to lipid bilayer membranes
72. Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcεRI and their association with detergent-resistant membranes
73. Localization and insulin-regulated relocation of phosphoinositide 5-kinase PIKfyve in 3T3-L1 adipocytes
74. Functional rafts in cell membranes
75. Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains
76. Targeting of a G alpha subunit (Gi1 alpha) and c-Src tyrosine kinase to caveolae membranes: Clarifying the role of N-myristoylation
77. Glycosphingolipid domains on cell plasma membrane
78. Clathrin, adaptors, and eps15 in endosomes containing activated epidermal growth factor receptors
79. Polyunsaturated fatty acids inhibit T cell signal transduction by modification of detergent-insoluble membrane domains
80. Acute cholesterol depletion inhibits clathrin-coated pit budding
81. Cellubrevin-targeted fluorescence uncovers heterogeneity in the recycling endosomes
82. Characterization of a cytosolic heat-shock protein-caveolin chaperone complex
83. Ligand-induced internalization of neurotensin in transfected COS-7 cells: Differential intracellular trafficking of ligand and receptor
84. 2-terminal myristoylation and palmitoylation at cysteine-3
85. GPI-anchored proteins are organized in submicron domains at the cell surface
86. Epidermal growth factor receptor activation is localized within low-buoyant density, non-caveolar membrane domains
87. fyn is reversible and sufficient for plasma membrane association
88. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells