Conversion of the Ion Selectivity of the 5-HT3A Receptor from Cationic to Anionic Reveals a Conserved Feature of the Ligand-gated Ion Channel Superfamily

Journal of Biological Chemistry

Volumn 276, Issue 14, 2001, Pages 10977-10983

  Gunthorpe, Martin J ^a,c   Lummis, Sarah C R ^a,b  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b Department of Biochemistry ^*  (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTROPHYSIOLOGY; ION SELECTIVE ELECTRODES; MECHANICAL PERMEABILITY; MUTAGENESIS; NEGATIVE IONS; ORGANIC ACIDS; POSITIVE IONS; SUBSTITUTION REACTIONS;

LIGAND-GATED ION CHANNEL SUPERFAMILY;

BIOCHEMISTRY;

4 AMINOBUTYRIC ACID; ACETYLCHOLINE; ANION; CATION; CHOLINERGIC RECEPTOR; GLUTAMIC ACID; GLYCINE RECEPTOR; ION CHANNEL; LIGAND; PROLINE; SEROTONIN 3 RECEPTOR; SEROTONIN RECEPTOR; CHLORIDE; RECOMBINANT PROTEIN; SODIUM;

ARTICLE; CHANNEL GATING; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; NEUROTRANSMISSION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; CELL LINE; PHYSIOLOGY; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; CHEMISTRY; ELECTROCHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; PATCH CLAMP; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT;

STAPHYLOCOCCUS PHAGE 3A;

ANIONS; CATIONS; CELL LINE; HUMANS; ION CHANNEL GATING; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CHLORIDES; ELECTROCHEMISTRY; LIGANDS; MICE; MOLECULAR SEQUENCE DATA; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SODIUM;

EID: 0035815730     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009575200     Document Type: Article

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