Alterations in the distribution and orexigenic effects of dexamethasone in CAR-null mice

Pharmacology Biochemistry and Behavior

Volumn 78, Issue 2, 2004, Pages 285-291

  Qatanani, Mohammed ^a   Wei, Ping ^b   Moore, David D ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b EXELIXIS INC   (United States)

Author keywords

CAR; CO; constitutive androstane receptor; corn oil; CYP; cytochrome P450; Dex; dexamethasone; Drug metabolism; glucocorticoid receptor; GR; neuropeptide Y; neuropeptide Y receptor subtype 1; NPY; NPY R1; NPY R5; Xenobiotic response; Xenosensor function

Indexed keywords

APPETITE STIMULANT; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR; NEUROPEPTIDE Y RECEPTOR 1; PREGNANE X RECEPTOR; RECEPTOR SUBTYPE; STEROID RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APPETITE; ARTICLE; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG METABOLISM; HYPOTHALAMUS; MALE; MOUSE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR UPREGULATION; STOMACH; TISSUE DISTRIBUTION; XENOBIOTIC METABOLISM;

ANIMALS; BODY WEIGHT; DEXAMETHASONE; MALE; MICE; MICE, KNOCKOUT; NEUROPEPTIDE Y; ORGAN SIZE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, NEUROPEPTIDE Y; STOMACH; TRANSCRIPTION FACTORS;

ANIMALIA; ZEA MAYS;

EID: 3042526317     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2004.04.001     Document Type: Article

References (40)

1. Baes M., Gulick T., Choi H.S., Martinoli M.G., Simha D., Moore D.D. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Mol. Cell Biol. 14:1994;1544-1551
2. Cavagnini F., Croci M., Putignano P., Petroni M.L., Invitti C. Glucocorticoids and neuroendocrine function. Int. J. Obes. Relat. Metab. Disord. 24(Suppl 2):2000;S77-S79
3. Choi H.S., Chung M., Tzameli I., Simha D., Lee Y.K., Seol W., et al. Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR. J. Biol. Chem. 272:1997;23565-23571
4. Cholerton S., Daly A.K., Idle J.R. The role of individual human cytochromes P450 in drug metabolism and clinical response. Trends Pharmacol. Sci. 13:1992;434-439
5. Demeule M., Jodoin J., Beaulieu E., Brossard M., Beliveau R. Dexamethasone modulation of multidrug transporters in normal tissues. FEBS Lett. 442:1999;208-214
6. Forman B.M., Tzameli I., Choi H.S., Chen J., Simha D., Seol W., et al. Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. Nature. 395:1998;612-615
7. Fuhr U. Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans. Clin. Pharmacokinet. 38:2000;493-504
8. Goodwin B., Moore L.B., Stoltz C.M., McKee D.D., Kliewer S.A. Regulation of the human CYP2B6 gene by the nuclear pregnane x receptor. Mol. Pharmacol. 60:2001;427-431
9. Goodwin B., Hodgson E., D'Costa D.J., Robertson G.R., Liddle C. Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor. Mol. Pharmacol. 62:2002;359-365
10. Honkakoski P., Negishi M. Regulation of cytochrome P450 (CYP) genes by nuclear receptors. Biochem. J. 347:2000;321-337
11. Huang W., Zhang J., Chua S.S., Qatanani M., Han Y., Granata R., et al. Induction of bilirubin clearance by the constitutive androstane receptor (CAR). Proc. Natl. Acad. Sci. U. S. A. 100:2003;4156-4161
12. Humphreys G.A., Davison J.S., Veale W.L. Hypothalamic neuropeptide Y inhibits gastric acid output in rat: role of the autonomic nervous system. Am. J. Physiol. 263:1992;G726-G732
13. Inui A. Feeding and body-weight regulation by hypothalamic neuropeptides - mediation of the actions of leptin. Trends Neurosci. 22:1999;62-67
14. Jubiz W., Meikle A.W., Levinson R.A., Mizutani S., West C.D., Tyler F.H. Effect of diphenylhydantoin on the metabolism of dexamethasone. N. Engl. J. Med. 283:1970;11-14
15. Kaga T., Fujimiya M., Inui A. Emerging functions of neuropeptide Y Y(2) receptors in the brain. Peptides. 22:2001;501-506
16. Kalra P.S., Dube M.G., Xu B., Farmerie W.G., Kalra S.P. Neuropeptide Y (NPY) Y1 receptor mRNA is upregulated in association with transient hyperphagia and body weight gain: evidence for a hypothalamic site for concurrent development of leptin resistance. J. Neuroendocrinol. 10:1998;43-49
17. Kast H.R., Goodwin B., Tarr P.T., Jones S.A., Anisfeld A.M., Stoltz C.M., et al. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J. Biol. Chem. 277:2002;2908-2915
18. Kawamoto T., Sueyoshi T., Zelko I., Moore R., Washburn K., Negishi M. Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol. Cell Biol. 19:1999;6318-6322
19. Kliewer S.A., Moore J.T., Wade L., Staudinger J.L., Watson M.A., Jones S.A., et al. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell. 92:1998;73-82
20. Lehmann J.M., McKee D.D., Watson M.A., Willson T.M., Moore J.T., Kliewer S.A. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J. Clin. Invest. 102:1998;1016-1023
21. Maglich J.M., Stoltz C.M., Goodwin B., Hawkins-Brown D., Moore J.T., Kliewer S.A. Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol. Pharmacol. 62:2002;638-646
22. Matsuda M., Aono M., Moriga M., Okuma M. Centrally administered neuropeptide Y (NPY) inhibits gastric emptying and intestinal transit in the rat. Dig. Dis. Sci. 38:1993;845-850
23. Misaki N., Higuchi H., Yamagata K., Miki N. Identification of glucocorticoid responsive elements (GREs) at far upstream of rat NPY gene. Neurochem. Int. 21:1992;185-189
24. Moore L.B., Parks D.J., Jones S.A., Bledsoe R.K., Consler T.G., Stimmel J.B., et al. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J. Biol. Chem. 275:2000;15122-15127
25. Pascussi J.M., Gerbal-Chaloin S., Fabre J.M., Maurel P., Vilarem M.J. Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation. Mol. Pharmacol. 58:2000;1441-1450
26. Pascussi J.M., Busson-Le Coniat M., Maurel P., Vilarem M.J. Transcriptional analysis of the orphan nuclear receptor constitutive androstane receptor (NR1I3) gene promoter: identification of a distal glucocorticoid response element. Mol. Endocrinol. 17:2003;42-55
27. Recuenco I., Espinosa E., Garcia B., Carcas A. Effect of dexamethasone on the decrease of serum phenytoin concentrations. Ann. Pharmacother. 29:1995;935
28. Regina A., Romero I.A., Greenwood J., Adamson P., Bourre J.M., Couraud P.O., et al. Dexamethasone regulation of P-glycoprotein activity in an immortalized rat brain endothelial cell line, GPNT. J. Neurochem. 73:1999;1954-1963
29. Schinkel A.H., Wagenaar E., van Deemter L., Mol C.A., Borst P. Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J. Clin. Invest. 96:1995;1698-1705
30. Sueyoshi T., Kawamoto T., Zelko I., Honkakoski P., Negishi M. The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J. Biol. Chem. 274:1999;6043-6046
31. Sugatani J., Kojima H., Ueda A., Kakizaki S., Yoshinari K., Gong Q.H., et al. The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology. 33:2001;1232-1238
32. Tzameli I., Pissios P., Schuetz E.G., Moore D.D. The xenobiotic compound 1, 4-bis[2-(3, 5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol. Cell Biol. 20:2000;2951-2958
33. Wei P., Zhang J., Egan-Hafley M., Liang S., Moore D.D. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature. 407:2000;920-923
34. Wei P., Zhang J., Dohan D., Han Y., Moore D.D. Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response. Pharmacogenomics J. 2:2002;117-126
35. Weng G., Yee F., Michl P., Reis D., Wahlestedt C. Studies on neuropeptide Y receptors in a mouse adrenocortical cell line. Mol. Pharmacol. 48:1995;9-14
36. Xie W., Evans R.M. Orphan nuclear receptors: the exotics of xenobiotics. J. Biol. Chem. 276:2001;37739-37742
37. Xie W., Barwick J.L., Simon C.M., Pierce A.M., Safe S., Blumberg B., et al. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Genes Dev. 14:2000;3014-3023
38. Xiong H., Yoshinari K., Brouwer K.L., Negishi M. Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital. Drug Metab. Dispos. 30:2002;918-923
39. Yokogawa K., Shimada T., Higashi Y., Itoh Y., Masue T., Ishizaki J., et al. Modulation of mdr1a and CYP3A gene expression in the intestine and liver as possible cause of changes in the cyclosporin A disposition kinetics by dexamethasone. Biochem. Pharmacol. 63:2002;777-783
40. Yokosuka M., Dube M.G., Kalra P.S., Kalra S.P. The mPVN mediates blockade of NPY-induced feeding by a Y5 receptor antagonist: a c-fos analysis. Peptides. 22:2001;507-514