Modulation of mdr1a and CYP3A gene expression in the intestine and liver as possible cause of changes in the cyclosporin A disposition kinetics by dexamethasone

Biochemical Pharmacology

Volumn 63, Issue 4, 2002, Pages 777-783

  Yokogawa, Koichi ^a   Shimada, Tsutomu ^a   Higashi, Yasuhiko ^a   Itoh, Yoshie ^a   Masue, Toshiko ^a   Ishizaki, Junko ^a   Asahi, Mariko ^a   Miyamoto, Ken ichi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Cyclosporin A; CYP3A2; Dexamethasone; Expression; mdr1a; P Glycoprotein; Pharmacokinetics

Indexed keywords

CYCLOSPORIN A; CYTOCHROME P450 3A2; DEXAMETHASONE; GLYCOPROTEIN P; PROTEIN; PROTEIN MDR1A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION; INTESTINE; LIVER LEVEL; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE LEVEL;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARYL HYDROCARBON HYDROXYLASES; ATP-BINDING CASSETTE TRANSPORTERS; BLOTTING, WESTERN; CYCLOSPORINE; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; DRUG INTERACTIONS; ENZYME INHIBITORS; GENE EXPRESSION; INTESTINES; KINETICS; LIVER; MALE; OXIDOREDUCTASES, N-DEMETHYLATING; P-GLYCOPROTEINS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS;

EID: 0037085027     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00911-X     Document Type: Article

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