Conference overview: Molecular mechanisms of metal toxicity and carcinogenesis

Molecular and Cellular Biochemistry

Volumn 279, Issue 1-2, 2005, Pages 3-15

  Bower, Jacquelyn J ^a,b   Leonard, Stephen S ^a,b   Shi, Xianglin ^a,b  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Antioxidants; Carcinogenesis; DNA damage; Metals; Reactive oxygen species

Indexed keywords

4 HYDROXYNONENAL; ADENOSINE TRIPHOSPHATASE; ARSENIC; ASCORBIC ACID; BIOLOGICAL MARKER; CADMIUM; CHROMIUM; COPPER; DISULFIDE; DISULFIRAM; DITHIOCARBAMIC ACID DERIVATIVE; FREE RADICAL; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HFE PROTEIN; HISTAMINE; IMMUNOGLOBULIN G; INDIUM; IRON; LEAD; MANGANESE; MERCURY; METAL; REACTIVE OXYGEN METABOLITE; RESVERATROL; RHENIUM; SUPEROXIDE DISMUTASE; TRACE ELEMENT; TRANSCRIPTION FACTOR NFAT; UNINDEXED DRUG;

ALCOHOLISM; AMINO ACID SUBSTITUTION; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARSENIC POISONING; ATOMIC ABSORPTION SPECTROMETRY; BLOOD ANALYSIS; CADMIUM POISONING; CANCER RISK; CANCER SUSCEPTIBILITY; CHEMICAL CARCINOGENESIS; DNA ADDUCT; DNA DAMAGE; DNA MICROARRAY; DNA REPAIR; DNA REPLICATION; DNA STRAND; DOWN REGULATION; ELECTRON SPIN RESONANCE; ENVIRONMENTAL EXPOSURE; GALLBLADDER CARCINOMA; HEMOCHROMATOSIS; HISTAMINE RELEASE; HUMAN; INTOXICATION; IRON OVERLOAD; LEAD POISONING; LIPID PEROXIDATION; LIVER CANCER; LIVER CARCINOGENESIS; MECHANICAL STRESS; MEDICAL RESEARCH; MELANOMA; MERCURIALISM; METAL BINDING; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; REVIEW; RISK ASSESSMENT; RISK FACTOR; SIGNAL TRANSDUCTION; UNITED STATES; UPREGULATION; WILSON DISEASE;

ANIMALS; ANTIOXIDANTS; ARSENIC; BILIARY TRACT NEOPLASMS; CARCINOGENICITY TESTS; CARCINOGENS; CHROMIUM; COPPER; DNA DAMAGE; ENVIRONMENTAL EXPOSURE; HUMANS; METALS; MITOSIS; MODELS, ANIMAL; MOUTH NEOPLASMS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR MARKERS, BIOLOGICAL;

ANIMALIA;

EID: 30344458490     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-005-8210-7     Document Type: Review

References (121)

1. Churg A, Brauer M, Carmen Avila-Casado M, Fortoul TI, Wright JL: Chronic exposure to high levels of particulate air pollution and small airway remodeling. Environ Health Perspect 111: 714-718, 2003 12727599
2. Gambelunghe A, Piccinini R, Ambrogi M, Villarini M, Moretti M, Marchetti C, Abbritti G, Muzi G: Primary DNA damage in chrome-plating workers. Toxicology 188: 187-195, 2003 12767690
3. Hunder G, Javdani J, Elsenhans B, Schumann K: 109Cd accumulation in the calcified parts of rat bones. Toxicology 159: 1-10, 2001 10.1016/ S0300-483X(00)00364-4
4. Tsai SM, Wang TN, Ko YC: Mortality for certain diseases in areas with high levels of arsenic in drinking water. Arch Environ Health 54: 186-193, 1999 10444040
5. Gaetke LM, Chow CK: Copper toxicity, oxidative stress, and antioxidant nutrients. Toxicology 189: 147-163, 2003 10.1016/S0300-483X(03)00159-8
6. Papanikolaou G, Pantopoulos K: Iron metabolism and toxicity. Toxicol Appl Pharmacol 202: 199-211, 2005 15629195
7. Tanzi RE, Petrukhin K, Chernov I, Pellequer JL, Wasco W, Ross B, Romano DM, Parano E, Pavone L, Brzustowicz LM: The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene. Nat Genet 5: 344-350, 1993 10.1038/ng1293-344
8. Parkkila S, Waheed A, Britton RS, Bacon BR, Zhou XY, Tomatsu S, Fleming RE, Sly WS: Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis. Proc Natl Acad Sci USA 94: 13198-13202, 1997 10.1073/pnas.94.24.13198
9. Nair J, Carmichael PL, Fernando RC, Phillips DH, Strain AJ, Bartsch H: Lipid peroxidation-induced etheno-DNA adducts in the liver of patients with the genetic metal storage disorders Wilson's disease and primary hemochromatosis. Cancer Epidemiol Biomarkers Prev 7:435-440, 1998 9610794
10. Feng Z, Hu W, Amin S, Tang MS: Mutational spectrum and genotoxicity of the major lipid peroxidation product, trans-4-hydroxy-2-nonenal, induced DNA adducts in nucleotide excision repair-proficient and -deficient human cells. Biochemistry 42: 7848-7854, 2003 10.1021/bi034431g
11. Benedetti A, Pompella A, Fulceri R, Romani A, Comporti M: 4-Hydroxynonenal and other aldehydes produced in the liver in vivo after bromobenzene intoxication. Toxicol Pathol 14: 457-461, 1986 3809897
12. Bartsch H, Nair J, Velic I: Etheno-DNA base adducts as tools in human cancer aetiology and chemoprevention. Eur J Cancer Prev 6: 529-534, 1997 9496454
13. McCullough ML, Giovannucci EL: Diet and cancer prevention. Oncogene 23: 6349-6364, 2004 10.1038/sj.onc.1207716
14. Rohrmann S, Smit E, Giovannucci E, Platz EA: Association between serum concentrations of micronutrients and lower urinary tract symptoms in older men in the Third National Health and Nutrition Examination Survey. Urology 64: 504-509, 2004 10.1016/j.urology.2004.04.012
15. Karunasinghe N, Ryan J, Tuckey J, Masters J, Jamieson M, Clarke LC, Marshall JR, Ferguson LR: DNA stability and serum selenium levels in a high-risk group for prostate cancer. Cancer Epidemiol Biomarkers Prev 13: 391-397, 2004 15006914
16. Ames BN: DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat Res 475: 7-20, 2001 11295149
17. Goddard JG, Gower JD, Green CJ: A chelator is required for microsomal lipid peroxidation following reductive ferritin-iron mobilisation. Free Radic Res Commun 17: 177-185, 1992 1459490
18. Reif DW, Simmons RD: Nitric oxide mediates iron release from ferritin. Arch Biochem Biophys 283: 537-541, 1990 10.1016/0003-9861(90)90680-W
19. Winston GW, Feierman DE, Cederbaum AI: The role of iron chelates in hydroxyl radical production by rat liver microsomes, NADPH-cytochrome P-450 reductase and xanthine oxidase. Arch Biochem Biophys 232: 378-390, 1984 10.1016/0003-9861(84)90553-8
20. Morgan EH: Studies on the mechanism of iron release from transferrin. Biochim Biophys Acta 580: 312-326, 1979 42443
21. Huang C, Li J, Zhang Q, Huang X: Role of bioavailable iron in coal dust-induced activation of activator protein-1 and nuclear factor of activated T cells: Difference between Pennsylvania and Utah coal dusts. Am J Respir Cell Mol Biol 27: 568-574, 2002 12397016
22. Zhang Q, Dai J, Ali A, Chen L, Huang X: Roles of bioavailable iron and calcium in coal dust-induced oxidative stress: Possible implications in coal workers' lung disease. Free Radic Res 36: 285-294, 2002 10.1080/ 10715760290019309
23. Katzer A, Hockertz S, Buchhorn GH, Loehr JF: In vitro toxicity and mutagenicity of CoCrMo and Ti6Al wear particles. Toxicology 190: 145-154, 2003 10.1016/S0300-483X(03)00147-1
24. Leonard SS, Roberts JR, Antonini JM, Castranova V, Shi X: PbCrO4 mediates cellular responses via reactive oxygen species. Mol Cell Biochem 255: 171-179, 2004 10.1023/B:MCBI.0000007273.23747.67
25. Shi X, Flynn DC, Porter DW, Leonard SS, Vallyathan V, Castranova V: Efficacy of taurine based compounds as hydroxyl radical scavengers in silica induced peroxidation. Ann Clin Lab Sci 27: 365-374, 1997 9303176
26. Wang Y, Fang J, Leonard SS, Rao KM: Cadmium inhibits the electron transfer chain and induces reactive oxygen species. Free Radic Biol Med 36: 1434-1443, 2004 10.1016/j.freeradbiomed.2004.03.010
27. Leonard S, Gannett PM, Rojanasakul Y, Schwegler-Berry D, Castranova V, Vallyathan V, Shi X: Cobalt-mediated generation of reactive oxygen species and its possible mechanism. J Inorg Biochem 70: 239-244, 1998 10.1016/S0162-0134(98)10022-3
28. Hei TK, Filipic M: Role of oxidative damage in the genotoxicity of arsenic. Free Radic Biol Med 37: 574-581, 2004 10.1016/ j.freeradbiomed.2004.02.003
29. Lefebvre Y, Pezerat H: Reactive oxygen species produced from chromate pigments and ascorbate. Environ Health Perspect 102(Suppl 3): 243-245, 1994 7843106
30. Wang S, Leonard SS, Ye J, Ding M, Shi X: The role of hydroxyl radical as a messenger in Cr(VI)-induced p53 activation. Am J Physiol Cell Physiol 279: C868-C875, 2000 10942736
31. Balamurugan K, Rajaram R, Ramasami T, Narayanan S: Chromium(III)-induced apoptosis of lymphocytes: Death decision by ROS and Src-family tyrosine kinases. Free Radic Biol Med 33: 1622-1640, 2002 12488131
32. Petit A, Mwale F, Tkaczyk C, Antoniou J, Zukor DJ, Huk OL: Induction of protein oxidation by cobalt and chromium ions in human U937 macrophages. Biomaterials 26: 4416-4422, 2005 10.1016/j.biomaterials.2004.11.019
33. Chakrabarti SK, Bai C, Subramanian KS: DNA-protein crosslinks induced by nickel compounds in isolated rat lymphocytes: Role of reactive oxygen species and specific amino acids. Toxicol Appl Pharmacol 170: 153-165, 2001 10.1006/taap.2000.9097
34. Kang J, Zhang Y, Chen J, Chen H, Lin C, Wang Q, Ou Y: Nickel-induced histone hypoacetylation: The role of reactive oxygen species. Toxicol Sci 74: 279-286, 2003 10.1093/toxsci/kfg137
35. Lin C, Kang J, Zheng R: Oxidative stress is involved in inhibition of copper on histone acetylation in cells. Chem Biol Interact 151: 167-176, 2005 10.1016/j.cbi.2005.01.003
36. Bagchi D, Bagchi M, Stohs SJ: Chromium (VI)-induced oxidative stress, apoptotic cell death and modulation of p53 tumor suppressor gene. Mol Cell Biochem 222: 149-158, 2001 10.1023/A:1017958028256
37. Wang S, Leonard SS, Ye J, Gao N, Wang L, Shi X: Role of reactive oxygen species and Cr(VI) in Ras-mediated signal transduction. Mol Cell Biochem 255: 119-127, 2004 10.1023/B:MCBI.0000007268.42733.53
38. Newbold RF, Amos J, Connell JR: The cytotoxic, mutagenic and clastogenic effects of chromium-containing compounds on mammalian cells in culture. Mutat Res 67: 55-63, 1979 10.1016/0165-1218(79)90099-5
39. Wise JP, Leonard JC, Patierno SR: Clastogenicity of lead chromate particles in hamster and human cells. Mutat Res 278: 69-79, 1992 10.1016/ 0165-1218(92)90287-A
40. Wise JP, Sr., Wise SS, Little JE: The cytotoxicity and genotoxicity of particulate and soluble hexavalent chromium in human lung cells. Mutat Res 517: 221-229, 2002 12034323
41. Leonard SS, Vallyathan V, Castranova V, Shi X: Generation of reactive oxygen species in the enzymatic reduction of PbCrO4 and related DNA damage. Mol Cell Biochem 234-235: 309-315, 2002 10.1023/A:1015917922980
42. Han JY, Takeshita K, Utsumi H: Noninvasive detection of hydroxyl radical generation in lung by diesel exhaust particles. Free Radic Biol Med 30: 516-525, 2001 10.1016/S0891-5849(00)00501-3
43. Casillas AM, Hiura T, Li N, Nel AE: Enhancement of allergic inflammation by diesel exhaust particles: Permissive role of reactive oxygen species. Ann Allergy Asthma Immunol 83: 624-629, 1999 10619333
44. Tsurudome Y, Hirano T, Yamato H, Tanaka I, Sagai M, Hirano H, Nagata N, Itoh H, Kasai H: Changes in levels of 8-hydroxyguanine in DNA, its repair and OGG1 mRNA in rat lungs after intratracheal administration of diesel exhaust particles. Carcinogenesis 20: 1573-1576, 1999 10.1093/ carcin/20.8.1573
45. Baulig A, Garlatti M, Bonvallot V, Marchand A, Barouki R, Marano F, Baeza-Squiban A: Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 285: L671-L679, 2003 12730081
46. Siegel PD, Saxena RK, Saxena QB, Ma JK, Ma JY, Yin XJ, Castranova V, Al Humadi N, Lewis DM: Effect of diesel exhaust particulate (DEP) on immune responses: Contributions of particulate versus organic soluble components. J Toxicol Environ Health A 67: 221-231, 2004 14681077
47. Schuetzle D: Sampling of vehicle emissions for chemical analysis and biological testing. Environ Health Perspect 47: 65-80, 1983 6186484
48. Ichinose T, Furuyama A, Sagai M: Biological effects of diesel exhaust particles (DEP). II. Acute toxicity of DEP introduced into lung by intratracheal instillation. Toxicology 99: 153-167, 1995 10.1016/ 0300-483X(94)03013-R
49. Rah DK, Han DW, Baek HS, Hyon SH, Park JC: Prevention of reactive oxygen species-induced oxidative stress in human microvascular endothelial cells by green tea polyphenol. Toxicol Lett 155: 269-275, 2005 10.1016/ j.toxlet.2004.10.002
50. Erba D, Riso P, Bordoni A, Foti P, Biagi PL, Testolin G: Effectiveness of moderate green tea consumption on antioxidative status and plasma lipid profile in humans. J Nutr Biochem 16: 144-149, 2005 10.1016/ j.jnutbio.2004.11.006
51. Qanungo S, Das M, Haldar S, Basu A: Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells. Carcinogenesis, 2005
52. Zykova TA, Zhang Y, Zhu F, Bode AM, Dong Z: The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols. Carcinogenesis 26: 331-342, 2005 10.1093/carcin/bgh334
53. Elbling L, Weiss RM, Teufelhofer O, Uhl M, Knasmueller S, Schulte-Hermann R, Berger W, Micksche M: Green tea extract and (-)-epigallocatechin-3-gallate, the major tea catechin, exert oxidant but lack antioxidant activities. FASEB J 2005
54. McCord JM: The evolution of free radicals and oxidative stress. Am J Med 108: 652-659, 2000 10.1016/S0002-9343(00)00412-5
55. Stahl W, Sies H: Antioxidant defense: Vitamins E and C and carotenoids. Diabetes 46(Suppl 2): S14-S18, 1997 9285493
56. Podmore ID, Griffiths HR, Herbert KE, Mistry N, Mistry P, Lunec J: Vitamin C exhibits pro-oxidant properties. Nature 392: 559, 1998
57. Herbert V, Shaw S, Jayatilleke E: Vitamin C-driven free radical generation from iron. J Nutr 126: 1213S-1220S, 1996 8642459
58. Leonard SS, Cutler D, Ding M, Vallyathan V, Castranova V, Shi X: Antioxidant properties of fruit and vegetable juices: More to the story than ascorbic acid. Ann Clin Lab Sci 32: 193-200, 2002 12017203
59. Pirozhkova-Patalah IV, Shtemenko NI: Influence of cis-[Re2GABA2Cl4]Cl2 on the antioxidant defense system parameters of normal human blood. Biochemistry (Mosc) 66: 721-724, 2001 10.1023/A:1010200426222
60. Hrynevych I, Oliinyk SA, Shtemenko NI, Shtemenko OV: Antioxidant properties of rhenium cluster complexes with butyric acid derivatives in blood plasma and erythrocytes. Ukr Biokhim Zh 75: 65-71, 2003 14574740
61. Turner RJ, Weiner JH, Taylor DE: Selenium metabolism in Escherichia coli. Biometals 11: 223-227, 1998 10.1023/A:1009290213301
62. Madesh M, Hajnoczky G: VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. J Cell Biol 155: 1003-1015, 2001 10.1083/ jcb.200105057
63. Yan L, Spallholz JE: Generation of reactive oxygen species from the reaction of selenium compounds with thiols and mammary tumor cells. Biochem Pharmacol 45: 429-437, 1993 8382065
64. ElAttar TM, Virji AS: Modulating effect of resveratrol and quercetin on oral cancer cell growth and proliferation. Anticancer Drugs 10: 187-193, 1999 10211549
65. Bau DT, Wang TS, Chung CH, Wang AS, Wang AS, Jan KY: Oxidative DNA adducts and DNA-protein cross-links are the major DNA lesions induced by arsenite. Environ Health Perspect 110(Suppl 5): 753-756, 2002 12426126
66. Matsui M, Nishigori C, Toyokuni S, Takada J, Akaboshi M, Ishikawa M, Imamura S, Miyachi Y: The role of oxidative DNA damage in human arsenic carcinogenesis: Detection of 8-hydroxy-2′-deoxyguanosine in arsenic-related Bowen's disease. J Invest Dermatol 113: 26-31, 1999 10.1046/j.1523-1747.1999.00630.x
67. Shibutani S, Takeshita M, Grollman AP: Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature 349: 431-434, 1991 10.1038/349431a0
68. Grollman AP, Moriya M: Mutagenesis by 8-oxoguanine: An enemy within. Trends Genet 9: 246-249, 1993 10.1016/0168-9525(93)90089-Z
69. Henderson PT, Delaney JC, Muller JG, Neeley WL, Tannenbaum SR, Burrows CJ, Essigmann JM: The hydantoin lesions formed from oxidation of 7,8-dihydro-8-oxoguanine are potent sources of replication errors in vivo. Biochemistry 42: 9257-9262, 2003 10.1021/bi0347252
70. Leipold MD, Muller JG, Burrows CJ, David SS: Removal of hydantoin products of 8-oxoguanine oxidation by the Escherichia coli DNA repair enzyme, FPG. Biochemistry 39: 14984-14992, 2000 10.1021/bi0017982
71. Henderson PT, Delaney JC, Gu F, Tannenbaum SR, Essigmann JM: Oxidation of 7,8-dihydro-8-oxoguanine affords lesions that are potent sources of replication errors in vivo. Biochemistry 41: 914-921, 2002 10.1021/ bi0156355
72. Muller JG, Duarte V, Hickerson RP, Burrows CJ: Gel electrophoretic detection of 7,8-dihydro-8-oxoguanine and 7,8-dihydro-8-oxoadenine via oxidation by Ir (IV). Nucleic Acids Res 26: 2247-2249, 1998 10.1093/nar/ 26.9.2247
73. Michaels ML, Tchou J, Grollman AP, Miller JH: A repair system for 8-oxo-7,8-dihydrodeoxyguanine. Biochemistry 31: 10964-10968, 1992 10.1021/bi00160a004
74. Michaels ML, Cruz C, Grollman AP, Miller JH: Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA. Proc Natl Acad Sci USA 89: 7022-7025, 1992 1495996
75. Hailer MK, Slade PG, Martin BD, Rosenquist TA, Sugden KD: Recognition of the oxidized lesions spiroiminodihydantoin and guanidinohydantoin in DNA by the mammalian base excision repair glycosylases NEIL1 and NEIL2. DNA Repair (Amst) 4: 41-50, 2005 10.1016/j.dnarep.2004.07.006
76. Ramon O, Sauvaigo S, Gasparutto D, Faure P, Favier A, Cadet J: Effects of 8-oxo-7,8-dihydro-2′-deoxyguanosine on the binding of the transcription factor Sp1 to its cognate target DNA sequence (GC box). Free Radic Res 31: 217-229, 1999 10499779
77. Hailer-Morrison MK, Kotler JM, Martin BD, Sugden KD: Oxidized guanine lesions as modulators of gene transcription. Altered p50 binding affinity and repair shielding by 7,8-dihydro-8-oxo-2′-deoxyguanosine lesions in the NF-kappaB promoter element. Biochemistry 42: 9761-9770, 2003 10.1021/bi034546k
78. Miller BM, Adler ID: Suspect spindle poisons: Analysis of c-mitotic effects in mouse bone marrow cells. Mutagenesis 4: 208-215, 1989 2659939
79. Mateuca R, Aka PV, De Boeck M, Hauspie R, Kirsch-Volders M, Lison D: Influence of hOGG1, XRCC1 and XRCC3 genotypes on biomarkers of genotoxicity in workers exposed to cobalt or hard metal dusts. Toxicol Lett 156: 277-288, 2005 10.1016/j.toxlet.2004.12.002
80. Kim YD, An SC, Oyama T, Kawamoto T, Kim H: Oxidative stress, hogg1 expression and NF-kappaB activity in cells exposed to low level chromium. J Occup Health 45: 271-277, 2003 10.1539/joh.45.271
81. Zharkov DO, Rosenquist TA: Inactivation of mammalian 8-oxoguanine-DNA glycosylase by cadmium(II): Implications for cadmium genotoxicity. DNA Repair (Amst) 1: 661-670, 2002 10.1016/S1568-7864(02)00074-5
82. Palmiter RD: Regulation of metallothionein genes by heavy metals appears to be mediated by a zinc-sensitive inhibitor that interacts with a constitutively active transcription factor, MTF-1. Proc Natl Acad Sci USA 91: 1219-1223, 1994 8108390
83. Saydam N, Adams TK, Steiner F, Schaffner W, Freedman JH: Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: Identification of signal transduction cascades that control metal-inducible transcription. J Biol Chem 277: 20438-20445, 2002 10.1074/jbc.M110631200
84. Rosen BP: Transport and detoxification systems for transition metals, heavy metals and metalloids in eukaryotic and prokaryotic microbes. Comp Biochem Physiol A Mol Integr Physiol 133: 689-693, 2002 10.1016/ S1095-6433(02)00201-5
85. Rosen BP: Biochemistry of arsenic detoxification. FEBS Lett 529: 86-92, 2002 10.1016/S0014-5793(02)03186-1
86. Rosen BP, Hsu CM, Karkaria CE, Owolabi JB, Tisa LS: Molecular analysis of an ATP-dependent anion pump. Philos Trans R Soc Lond B Biol Sci 326: 455-463, 1990 1970649
87. Liu Z, Boles E, Rosen BP: Arsenic trioxide uptake by hexose permeases in Saccharomyces cerevisiae. J Biol Chem 279: 17312-17318, 2004 10.1074/ jbc.M314006200
88. Liu Z, Carbrey JM, Agre P, Rosen BP: Arsenic trioxide uptake by human and rat aquaglyceroporins. Biochem Biophys Res Commun 316: 1178-1185, 2004 10.1016/j.bbrc.2004.03.003
89. Bhattacharjee H, Carbrey J, Rosen BP, Mukhopadhyay R: Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9. Biochem Biophys Res Commun 322: 836-841, 2004 10.1016/j.bbrc.2004.08.002
90. Lee TC, Ho IC: Modulation of cellular antioxidant defense activities by sodium arsenite in human fibroblasts. Arch Toxicol 69: 498-504, 1995 10.1007/s002040050204
91. Seol JG, Park WH, Kim ES, Jung CW, Hyun JM, Kim BK, Lee YY: Effect of arsenic trioxide on cell cycle arrest in head and neck cancer cell line PCI-1. Biochem Biophys Res Commun 265: 400-404, 1999 10.1006/ bbrc.1999.1697
92. Millar JB, Russell P: The cdc25 M-phase inducer: An unconventional protein phosphatase. Cell 68: 407-410, 1992 10.1016/0092-8674(92)90177-E
93. Chou IN: Distinct cytoskeletal injuries induced by As, Cd, Co, Cr, and Ni compounds. Biomed Environ Sci 2: 358-365, 1989 2604903
94. Qian Y, Liu KJ, Chen Y, Flynn DC, Castranova V, Shi X: Cdc42 regulates arsenic-induced NADPH oxidase activation and cell migration through actin filament reorganization. J Biol Chem 280: 3875-3884, 2005 10.1074/ jbc.M403788200
95. Ivanov VN, Hei TK: Arsenite sensitizes human melanomas to apoptosis via tumor necrosis factor alpha-mediated pathway. J Biol Chem 279: 22747-22758, 2004 10.1074/jbc.M314131200
96. Wang S, Shi X: Mechanisms of Cr(VI)-induced p53 activation: The role of phosphorylation, mdm2 and ERK. Carcinogenesis 22: 757-762, 2001 10.1093/ carcin/22.5.757
97. Ha L, Ceryak S, Patierno SR: Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest. J Biol Chem 278: 17885-17894, 2003 12637545
98. Buscemi G, Perego P, Carenini N, Nakanishi M, Chessa L, Chen J, Khanna K, Delia D: Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks. Oncogene 23: 7691-7700, 2004 10.1038/sj.onc.1207986
99. McKinnon PJ: ATM and ataxia telangiectasia. EMBO Rep 5: 772-776, 2004 10.1038/sj.embor.7400210
100. Falck J, Coates J, Jackson SP: Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 434: 605-611, 2005 10.1038/nature03442
101. Lee JH, Paull TT: ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308: 551-554, 2005 10.1126/ science.1108297
102. Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM: DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 273: 5858-5868, 1998 10.1074/jbc.273.10.5858
103. Joseph P, Lei YX, Whong WZ, Ong TM: Molecular cloning and functional analysis of a novel cadmium-responsive proto-oncogene. Cancer Res 62: 703-707, 2002 11830523
104. Joseph P, Lei YX, Whong WZ, Ong TM: Oncogenic potential of mouse translation elongation factor-1 delta, a novel cadmium-responsive proto-oncogene. J Biol Chem 277: 6131-6136, 2002 10.1074/jbc.M109373200
105. Lemarie A, Lagadic-Gossmann D, Morzadec C, Allain N, Fardel O, Vernhet L: Cadmium induces caspase-independent apoptosis in liver Hep3B cells: role for calcium in signaling oxidative stress-related impairment of mitochondria and relocation of endonuclease G and apoptosis-inducing factor. Free Radic Biol Med 36: 1517-1531, 2004 10.1016/ j.freeradbiomed.2004.03.020
106. Moulin JJ, Wild P, Romazini S, Lasfargues G, Peltier A, Bozec C, Deguerry P, Pellet F, Perdrix A: Lung cancer risk in hard-metal workers. Am J Epidemiol 148: 241-248, 1998 9690360
107. Fan LZ, Cherian MG: Potential role of p53 on metallothionein induction in human epithelial breast cancer cells. Br J Cancer 87: 1019-1026, 2002 10.1038/sj.bjc.6600549
108. Ostrakhovitch EA, Cherian MG: Differential regulation of signal transduction pathways in wild type and mutated p53 breast cancer epithelial cells by copper and zinc. Arch Biochem Biophys 423: 351-361, 2004 10.1016/j.abb.2004.01.004
109. Ostrakhovitch EA, Cherian MG: Role of p53 and reactive oxygen species in apoptotic response to copper and zinc in epithelial breast cancer cells. Apoptosis 10: 111-121, 2005 10.1007/s10495-005-6066-7
110. Nickel and Nickel Compounds. IARC Monographs 49: 257-445, 1990
111. Zhao J, Yan Y, Salnikow K, Kluz T, Costa M: Nickel-induced down-regulation of serpin by hypoxic signaling. Toxicol Appl Pharmacol 194: 60-68, 2004 10.1016/j.taap.2003.08.011
112. Bal W, Karantza V, Moudrianakis EN, Kasprzak KS: Interaction of Nickel(II) with histones: In vitro binding of nickel(II) to the core histone tetramer. Arch Biochem Biophys 364: 161-166, 1999 10.1006/ abbi.1999.1137
113. Bal W, Liang R, Lukszo J, Lee SH, Dizdaroglu M, Kasprzak KS: Ni(II) specifically cleaves the C-terminal tail of the major variant of histone H2A and forms an oxidative damage-mediating complex with the cleaved-off octapeptide. Chem Res Toxicol 13: 616-624, 2000 10.1021/tx000044l
114. Davidson T, Salnikow K, Costa M, Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel Mol Pharmacol 64: 1485-1493, 2003 10.1124/mol.64.6.1485
115. Miller AC, Blakely WF, Livengood D, Whittaker T, Xu J, Ejnik JW, Hamilton MM, Parlette E, John TS, Gerstenberg HM, Hsu H: Transformation of human osteoblast cells to the tumorigenic phenotype by depleted uranium-uranyl chloride. Environ Health Perspect 106: 465-471, 1998 9681973
116. Miller AC, Fuciarelli AF, Jackson WE, Ejnik EJ, Emond C, Strocko S, Hogan J, Page N, Pellmar T: Urinary and serum mutagenicity studies with rats implanted with depleted uranium or tantalum pellets. Mutagenesis 13: 643-648, 1998 9862198
117. Yazzie M, Gamble SL, Civitello ER, Stearns DM: Uranyl acetate causes DNA single strand breaks in vitro in the presence of ascorbate (vitamin C). Chem Res Toxicol 16: 524-530, 2003 10.1021/tx025685q
118. Miller AC, Brooks K, Stewart M, Anderson B, Shi L, McClain D, Page N: Genomic instability in human osteoblast cells after exposure to depleted uranium: Delayed lethality and micronuclei formation. J Environ Radioact 64: 247-259, 2003 10.1016/S0265-931X(02)00053-X
119. Stearns DM, Wise JP, Sr., Patierno SR, Wetterhahn KE: Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells. FASEB J 9: 1643-1648, 1995 8529845
120. Bagchi D, Bagchi M, Balmoori J, Ye X, Stohs SJ: Comparative induction of oxidative stress in cultured J774A.1 macrophage cells by chromium picolinate and chromium nicotinate. Res Commun Mol Pathol Pharmacol 97: 335-346, 1997 9387193
121. Stearns DM, Silveira SM, Wolf KK, Luke AM: Chromium(III) tris(picolinate) is mutagenic at the hypoxanthine (guanine) phosphoribosyltransferase locus in Chinese hamster ovary cells. Mutat Res 513: 135-142, 2002 11719098