Oxidized guanine lesions as modulators of gene transcription. Altered p50 binding affinity and repair shielding by 7,8-dihydro-8-oxo-2′-deoxyguanosine lesions in the NF-κB promoter element

Biochemistry

Volumn 42, Issue 32, 2003, Pages 9761-9770

  Hailer Morrison, M Katie ^a   Kotler, J Michelle ^a   Martin, Brooke D ^a   Sugden, Kent D ^a  

^a UNIVERSITY OF MONTANA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE TRANSCRIPTION;

CELLS; DNA; ENZYMES; ESCHERICHIA COLI; GENETIC ENGINEERING; OXIDATION; SUBSTITUTION REACTIONS;

BIOCHEMISTRY;

7,8 DIHYDRO 8 OXO 2' DEOXYGUANOSINE; DEOXYGUANOSINE DERIVATIVE; DNA GLYCOSYLTRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P50; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DNA DAMAGE; DNA REPAIR; ELECTROPHORETIC MOBILITY; MOLECULAR RECOGNITION; NUCLEIC ACID BASE SUBSTITUTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; TRANSCRIPTION REGULATION;

BASE SEQUENCE; BINDING SITES; CONSENSUS SEQUENCE; DEOXYGUANOSINE; DNA REPAIR; DNA-FORMAMIDOPYRIMIDINE GLYCOSYLASE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ESCHERICHIA COLI PROTEINS; GUANINE; HUMANS; N-GLYCOSYL HYDROLASES; NF-KAPPA B; OXIDATION-REDUCTION; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN SUBUNITS; TIME FACTORS; TRANSCRIPTION, GENETIC;

ESCHERICHIA COLI; ZIZIPHUS MAURITIANA;

EID: 0042026553     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034546k     Document Type: Article

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