Src-family tyrosine kinases, phosphoinositide 3-kinase and Gab1 regulate extracellular signal-regulated kinase 1 activation induced by the type A endothelin-1 G-protein-coupled receptor

Biochemical Journal

Volumn 360, Issue 1, 2001, Pages 77-85

  Bisotto, S ^a   Fixman, E D ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Cross talk; Growth regulation; Signal transduction

Indexed keywords

ACTIVATION ANALYSIS; CELLS;

PHOSPHORYLATION;

ENZYMES;

2 MORPHOLINO 8 PHENYLCHROMONE; BINDING PROTEIN; DOCKING PROTEIN; ENDOTHELIN 1; G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN GAB1; PROTEIN P85; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANDROSTADIENES; ANIMALS; BLOTTING, WESTERN; CELL LINE; CHROMONES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; FLAVONOIDS; HUMANS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOLINES; PHOSPHOPROTEINS; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEINS; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN; SRC HOMOLOGY DOMAINS; SRC-FAMILY KINASES; TIME FACTORS; TYROSINE;

EID: 0035890485     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3600077     Document Type: Article

References (52)

1. A novel potent vasoconstrictor peptide produced by vascular endothelial cells
2. Cloning and expression of a cDNA encoding an endothelin receptor
3. Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
4. Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene
5. An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo
6. Extracellular matrix and pulmonary hypertension: Control of vascular smooth muscle cell contractility
7. Nuclear signaling by endothelin-1 requires Src protein-tyrosine kinases
8. Endothelin-1 inhibits apoptosis of vascular smooth muscle cells induced by nitric oxide and serum deprivation via MAP kinase pathway
9. Inhibition of ERK activation attenuates endothelin-stimulated airway smooth muscle cell proliferation
10. Extracellutar signal-regulated kinases are involved in the antiapoptotic effect of endothelin-1
11. The role of endothelin in coronary atherosclerosis
12. Levels of endothelin in the bronchoalveolar lavage fluid of patients with symptomatic asthma and reversible airflow obstruction
13. Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate
14. Mitogen-activated protein kinase cascades and regulation of gene expression
15. Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits
16. cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells
17. Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway
18. Cell growth control by G protein-coupled receptors: From signal transduction to signal integration
19. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
20. Signal characteristics of G protein-transactivated EGF receptor
21. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
22. Gβγ subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation
23. Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases
24. Increasing complexity of Ras signaling
25. Phosphatidylinositol 3-kinase is an early intermediate in the Gβγ-mediated mitogen-activated protein kinase signaling pathway
26. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma
27. A novel mitogenic signaling pathway of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, phosphatidylinositol 3-kinase β, and protein kinase Cε
28. i protein-coupled receptor
29. A Grb2-associated docking protein in EGF- and insulin-receptor signalling
30. Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor
31. The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase
32. The IRS-signalling system during insulin and cytokine action
33. Efficient cellular transformation by the met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1
34. The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor
35. Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356
36. Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase
37. Engagement of gab1 and gab2 in erythropoietin signaling
38. Requirement of SHP2 Binding to Grb2-associated binder-1 for mitogen-activated protein kinase activation in response to lysophosphatidic acid and epidermal growth factor
39. Gab1 mediates neurite outgrowth, DNA synthesis, and survival in PC12 cells
40. A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
41. Absence of endothelin receptors and receptor mRNA in mammalian fibroblasts transformed with SV40 or ras oncogene
42. Molecular mechanisms of endothelin-1-induced cell-cycle progression: Involvement of extracellular signal-regulated kinase, protein kinase C, and phosphatidylinositol 3-kinase at distinct points
43. Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation in intact Swiss 3T3 cells
44. 2+ and protein kinase C in endothelin-stimulated Rat-1 cells
45. Structural basis of G protein specificity of human endothelin receptors. A study with endothelinA/B chimeras
46. Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast
47. A conserved inositol phospholipid binding site within the Gab1 pleckstrin homology domain is required for epithelial morphogenesis
48. Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases
49. Src-family tyrosine kinases in activation of ERK-1 and p85/p110- phosphatidylinositol 3-kinase by G/CCKB receptors
50. Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gβγ subunit-mediated activation of mitogen-activated protein kinases
51. The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase
52. 3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins