Update on the mechanisms of immune suppression of injury and immune modulation

World Journal of Surgery

Volumn 20, Issue 4, 1996, Pages 454-459

  Faist, E ^a   Schinkel, C ^a   Zimmer, S ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PENTOXIFYLLINE; PROSTAGLANDIN E2; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 13; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ANTIBODY;

CELLULAR IMMUNITY; CLINICAL TRIAL; GENE EXPRESSION; HELPER CELL; HUMAN; IMMUNE DEFICIENCY; IMMUNOMODULATION; INFECTION RISK; INFLAMMATION; INJURY; MONOCYTE; MULTIPLE ORGAN FAILURE; PHAGOCYTOSIS; REVIEW; SEPSIS; T LYMPHOCYTE ACTIVATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; HUMANS; IMMUNE TOLERANCE; IMMUNITY, CELLULAR; INFLAMMATION MEDIATORS; MACROPHAGE ACTIVATION; MULTIPLE ORGAN FAILURE; MULTIPLE TRAUMA; PHAGOCYTOSIS; PROGNOSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 0029872486     PISSN: 03642313     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002689900071     Document Type: Review

References (32)

1. Faist, E., Storck, M., Hueltner, L., et al.: Functional analysis of monocyte (Mφ) activity via synthesis patterns of interleukin 1, 6, 8 (IL-1, IL-6, IL-8) and neopterin in surgical intensive care patients. Surgery 112:562, 1992
2. Faist, E., Baue, A.E., Dittmer, H., Heberer, G.: Multiple organ failure in polytrauma patients. J. Trauma 23:775, 1983
3. 2) dependent suppression of interleukin-2 (IL-2) production in patients with major trauma. J. Trauma 27:837, 1987
4. Phipps, R.P., Stein, S.H., Roper, R.L.: A new view point of prostaglandin E regulation of the immune response. Immunol. Today 12:10, 1991
5. Faist, E., Markewitz, A., Fuchs, D., et al.: Immunomodulatory therapy with thymopentin (TP-5) and indomethacin: successful restoration of interleukin-2 (IL-2) synthesis in patients undergoing major surgery. Ann. Surg. 214:264, 1991
6. Faist, E., Ertel, W., Cohnert, T., et al.: Immune protective effects of cyclooxygenase inhibition in patients with major surgical trauma. Surg. Forum 34:114, 1988
7. Mosmann, T.R., Cherwinsk, H., Bond, M.W., Giedlin, M.A., Coffman, R.L.: Two types of murine helper T-cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2384, 1986
8. 2 subsets: paradigms lost. Immunol. Today 16:374, 1995
9. Mannick, J.A.: Trauma, sepsis and immune defects. In Host Defense Dysfunction in Trauma, Shock and Sepsis: Mechanisms and Therapeutic Approaches, E. Faist, J.L. Meakins, F.W. Schildberg, editors. New York, Springer-Verlag, 1993, pp. 15-21
10. 2 lymphokines. J. Immunol. 146:108, 1991
11. Ayala, A., Lehmann, D.L., Herdon, C.D., Chaudry, I.H.: Mechanisms of enhanced susceptibility to sepsis following hemorrhage: interleu-kin-10 suppression of T-cell response is mediated by eicosanoid-induced interleukin-4 disease. Arch. Surg. 129:1172, 1994
12. + contrasuppressor T-cells improve the resistance of thermally injured mice infected with HSV. J. Leukoc. Biol. 58:159, 1995
13. 2 lymphocyte phenotype and diminished IL-12 production associated with decreased resistance to infection Ann. Surg. 222:482, 1995
14. Faist, E., Mewes, A., Strasser T., et al.: Alteration of monocyte function following major injury. Arch. Surg. 123:287, 1988
15. 2 production in severely injured patients. Arch. Surg. 123:293, 1988
16. O'Riordain, M.G., Mannick, J.A., Rodrick, M.L.: Cytokine response to surgery, trauma and burns. In Clinical Applications of Cytokines: Role of Pathogenesis, Diagnosis and Therapy, J.J. Oppenheim, J.L. Rossio, A.J.W. Gearing, editors. New York, Oxford University Press, 1993, pp. 301-305
17. Moore, F.A., Peterson, V.M., Moore, E.E.: Inadequate granulopoiesis after major torso trauma: a hematopoietic regulatory paradox. Surgery 108:667, 1990
18. Cioffi, W.G., Jr., Burleson, D.G., Jordan, B.S., et al.: Effects of granulocyte-macrophage colony-stimulating factor in burn patients. Arch. Surg. 126:74, 1991
19. Hartung, T., Krieger, G., Volk, H.D., Wendel, A.: Reduced proinflammatory cytokines and increased antagonists in LPS-stimulated blood from G-CSF-treated volunteers. J. Intensive Care Med. 20:142, 1994
20. Schade, F.U., Zabel, P.: Modulating effects of pentoxifylline on cytokine release syndromes. In Sepsis: Current Perspectives in Pathophysiology and Therapy, K. Reinhart, K. Eyrich, C. Sprung, editors. New York, Springer-Verlag, 1994, pp. 371-381
21. Hoffman, H., Reichert, K., Faist, E., Markewitz, A., Jochum, M.: Supplemental treatment with pentoxifylline in patients at risk for sepsis: a pilot study. Presented at the Surgical Infection Society, Fifteenth Annual Meeting, 1995, p. 14
22. Oismüller, C., Mayer, N., Micksche, M., Steltzer, H., Hammerle, A.: In-vivo modulation of human neutrophil function by pentoxifylline in patients with septic syndrome. Shock 4:161, 1995
23. Kim, C., Faist, E., Minty, A., et al.: Interleukin-13 (IL-13) effectively downregulates a monocyte inflammatory potential during traumatic stress. Arch. Surg. (in press)
24. Faist, E., Markewitz, A., Fuchs, D., et al.: Immunomodulatory therapy with thymopentin (TP-5) and indomethacin: successful restoration of interleukin-2 (IL-2) synthesis in patients undergoing major surgery. Ann. Surg. 214:264, 1991
25. Dries, D.J., Polk, H.C. Jr.: Interferon gamma on trauma related sepsis: results of two large multicenter studies. J. Intensive Care Med. 20:123, 1994
26. Hershman, M.J., Sonnenfeld, G., Mays, B.W., et al.: Effects of interferon-gamma treatment on surgically simulated wound infection in mice. Microb. Pathog. 4:165, 1988
27. Gennari, R., Alexander, W., Eaves-Pyles, T.: IFN-γ decreases translocation and improves survival following transfusion and thermal injury. J. Surg Res. 56:530, 1994
28. Ertel, W., Morrison, M.H., Ayala, A., Dean, R.E., Chaudry, I.H.: Interferon-γ attenuates hemorrhage-induced suppression of macrophage and splenocyte functions and decreases susceptibility to sepsis. Surgery 111:177, 1992
29. Silva, A.T., Cohen, J.: Role of interfeion-γ in experimental gramnegative sepsis. J. Infect. Dis. 166:331, 1992
30. Jurkovich, G.J., Mileski, W.J., Maier, R.V., Winn, R.K., Rice, C.L.: Interferon-γ increases sensitivity to endotoxin. J. Surg Res. 51:197, 1991
31. Faist, E., Licht, K., Schinkel, C., et al.: Gamma-interferon (γ-IFN) driven monocytic cytokine release patterns are highly differentiated and depend on inflammation induced states of cellular preactivation. In Abstract Book, no. 32. American Association for the Surgery of Trauma, Fifty-Fifth Annual Meeting, 1995
32. Trinchieri, G., Scott, P.: The role of interleukin-12 in the immune response, disease and therapy. Immunol. Today 15:460, 1994