Cyclooxygenase 2-mediated suppression of macrophage interleukin-12 production after thermal injury

American Journal of Physiology - Cell Physiology

Volumn 282, Issue 2 51-2, 2002, Pages

  Schwacha, Martin G ^a,b,c   Chung, Chun Shiang ^a,b   Ayala, Alfred ^a,b   Bland, Kirby I ^a,b   Chaudry, Irshad H ^a,b  

^a Kentucky   (United States)

^b BROWN UNIVERSITY   (United States)

^c UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

Author keywords

Burns; Immunosuppression; Interleukin 10; Prostaglandin E2; Sepsis

Indexed keywords

CYCLOOXYGENASE 2; INTERLEUKIN 10; INTERLEUKIN 12; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY SURFACE; BURN; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; ENZYME REPRESSION; FEMALE; IMMUNE DEFICIENCY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; THERMAL INJURY;

ANIMALIA;

EID: 0036087125     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00357.2001     Document Type: Article

References (55)

1. Prostaglandin E2 and IL-4 provide naive CD4+ T cells with distinct inhibitory signals for the priming of IFN-gamma production
2. Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10
3. Mechanism of enhanced susceptibility to sepsis following hemorrhage. Interleukin-10 suppression of T-cell response is mediated by eicosanoid-induced interleukin-4 release
4. Evaluation of factors affecting mortality rate after sepsis in murine cecal ligation and puncture model
5. T lymphocytes and immunosuppression in the burned patient: A review
6. Prostaglandin E 2 inhibits production of Th1 lymphokines but not of Th2 lymphokines
7. Interleukin-12
8. Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells
9. Animal models of sepsis and shock: A review and lessons learned
10. Prostaglandin E2 primes naive T cells for the production of anti-inflammatory cytokines
11. The role of interleukin 6 in interferon-γ production in thermally injured mice
12. Blockade of prostaglandin production increases cachectin synthesis and prevents depression of macrophage functions following hemorrhagic shock
13. The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes
14. Injury induces deficient interleukin-12 production, but interleukin-12 therapy after injury restores resistance to infection
15. 2 in immune suppression following injury
16. Human cyclooxygenase-2 cDNA
17. Therapeutic protective effects of IL-12 combined with soluble IL-4 receptor against established infections of herpes simplex virus type 1 in thermally injured mice
18. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
19. Cyclooxygenase isoenzymes and newer therapeutic potential for selective COX-2 inhibitors
20. Sensitivity difference to the suppressive effect of prostaglandin E2 among mouse strains: A possible mechanism to polarize Th2 type response in BALB/c mice
21. 2) in severely burned patients
22. Major injury induces increased production of interleukin-10 by cells of the immune system with a negative impact on resistance to infection
23. Interleukin-12 protects thermally injured mice from herpes simplex virus type 1 infection
24. 2 production in severely injured patients
25. Interferon-gamma (IFN-gamma) and prostaglandin E2 (PGE2) regulate differently IL-12 production in human intestinal lamina propria mononuclear cells (LPMC)
26. Temporal correlation of impaired immune response after thermal injury with susceptibility to infection in a murine model
27. Regulation by interleukin-10 and interleukin-4 of cyclo-oxygenase-2 expression in human neutrophils
28. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues
29. Interleukin-12 treatment restores normal resistance to bacterial challenge after burn injury
30. Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection
31. The production of tumor necrosis factor, interleukin 1, interleukin 6, and prostaglandin E2 by isolated enterocytes and gut macrophages: Effect of lipopolysaccharide and thermal injury
32. A new view of prostaglandin E regulation of the immune response
33. Differential inhibitory mechanism of cyclic AMP on TNF-alpha and IL-12 synthesis by macrophages exposed to microbial stimuli
34. Multiple organ failure in patients with thermal injury
35. Insights into the role of γδ T-lymphocytes in the immunopathogenic response to thermal injury
36. Role of protein kinase C in cyclic AMP-mediated suppression of T-lymphocyte activation following burn injury
37. Does burn wound excision after thermal injury attenuate subsequent macrophage hyperactivity and immunosuppression?
38. 2: Contribution to the enhancement of inducible nitric oxide synthase activity
39. Thermal injury induced immunosuppression in mice: The role of macrophage derived reactive nitrogen intermediates
40. IL-12 as an adjuvant for cell-mediated immunity
41. Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming
42. Cyclooxygenase-2 inhibitor NS-398 improves survival and restores leukocyte counts in burn infection
43. Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes
44. Multiple roles for IL-12 in a model of acute septic peritonitis
45. Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2
46. Blocking prostaglandin E2 after trauma attenuates pro-inflammatory cytokines and improves survival
47. Immunoregulation by interleukin-12
48. Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma
49. A mechanism of interleukin-12 unresponsiveness associated with thermal injury
50. Interleukin (IL)-4 production by human T cells: Differential regulation of IL-4 vs. IL-2 production
51. Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production
52. Prostaglandin endoperoxide synthase: Why two isoforms?
53. Prolonged survival of mice with Pseudomonas aeruginosa-induced sepsis by rIL-12 modulation of IL-10 and interferon-gamma
54. The role of macrophages (Mφ) and PGE-2 in postburn immunosuppression
55. Anti-interleukin-12 therapy protects mice in lethal endotoxemia but impairs bacterial clearance in murine Escherichia coli peritoneal sepsis