Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin, amino acid- and exercise-induced signalling

Proceedings of the Nutrition Society

Volumn 63, Issue 2, 2004, Pages 351-356

  Bolster, Douglas R ^a   Jefferson, Leonard S ^a   Kimball, Scot R ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Mammalian target of rapamycin; mRNA translation; Phosphatidylinositol 3 kinase; Resistance exercise

Indexed keywords

AMINO ACID; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; RAPAMYCIN;

BIOGENESIS; CELL GROWTH; CONFERENCE PAPER; ENZYME ACTIVATION; EXERCISE; GENE EXPRESSION; MUSCLE HYPERTROPHY; PROTEIN SYNTHESIS; RIBOSOME; RNA TRANSLATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

AMINO ACIDS; EXERCISE; GENE EXPRESSION REGULATION; HUMANS; HYPERTROPHY; INSULIN; MUSCLE PROTEINS; MUSCLE, SKELETAL; PROTEIN BIOSYNTHESIS; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 2942733632     PISSN: 00296651     EISSN: None     Source Type: Journal    
DOI: 10.1079/PNS2004355     Document Type: Conference Paper

References (38)

1. Alessi DR & Downes CP (1998) The role of PI 3-kinase in insulin action. Biochimica et Biophysica Acta 1436, 151-164.
2. S6k correlates with increased skeletal muscle mass following resistance exercise. American Journal of Physiology 276, C120-C127.
3. Biolo G, Fleming R & Wolfe R (1995a) Physiologic hyper-insulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle. Journal of Clinical Investigation 95, 811-819.
4. Biolo G, Maggi S, Williams B, Tipton K & Wolfe R (1995b) Increased rates of muscle protein turnover and amino acid transport following resistance exercise in humans. American Journal of Physiology 268, E514-E520.
5. Biolo G, Tipton KD, Klein S & Wolfe RR (1997) An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. American Journal of Physiology 273, E122-E129.
6. Biolo G, Williams BD, Fleming RY & Wolfe RR (1999) Insulin action on muscle protein kinetics and amino acid transport during recovery after resistance exercise. Diabetes 48, 949-957.
7. Bodine SC, Stitt TN, Gonzalez M, Kline WO, Stover GL, Bauerlein R, Zlotchenko E, Scrimgeour A, Lawrence JC, Glass DJ & Yancopoulous GD (2001) Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nature Cell Biology 3, 1014-1019.
8. Bolster DR, Kimball SR & Jefferson LS (2003) Translational control mechanisms modulate skeletal muscle gene expression during hypertrophy. Exercise and Sport Sciences Reviews 31, 111-116.
9. Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296, 1655-1657.
10. Coffer PJ, Jin J & Woodgett JR (1998) Protein kinase B (c-Akt): a multifactorial mediator of phosphatidylinositol 3-kinase activation. Biochemical Journal 335, 1-13.
11. Farrell PA, Fedele MJ, Vary TC, Kimball SR, Lang CH & Jefferson LS (1999) Regulation of protein synthesis after acute resistance exercise in diabetic rats. American Journal of Physiology 276, E721-E727.
12. Fedele MJ, Hernandez JM, Lang CH, Vary TC, Kimball SR, Jefferson LS & Farrell PA (2000) Severe diabetes prohibits elevations in muscle protein synthesis after acute resistance exercise in rats. Journal of Applied Physiology 88, 102-108.
13. Fingar DC, Salama S, Tsou C, Harlow E & Blenis J (2002) Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes and Development 16, 1472-1487.
14. Fluckey JD, Kraemer WJ & Farrell PA (1995) Pancreatic islet insulin secretion is increased after resistance exercise in rats. Journal of Applied Physiology 79, 1100-1105.
15. Gao X, Zhang Y, Arrazola P, Hino O, Kobayashi T, Yeung RS, Ru B & Pan D (2002) Tsc tumour suppressor proteins antagonize amino acid-mTOR signaling. Nature Cell Biology 4, 699-704.
16. Garami A, Zwartkruis FJT, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL & Thomas G (2003) Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP1 signaling, is inhibited by TSC1 and 2. Molecular Cell 11, 1457-1466.
17. Gingras A-C, Raught B & Sonenberg N (2001) Regulation of translation initiation by FRAP/mTOR. Genes and Development 15, 807-826.
18. Hara K, Yonezawa K, Weng Q-P, Kozlowski MT, Belham C & Avruch J (1998) Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. Journal of Biological Chemistry 273, 14484-14494.
19. Hernandez JM, Fedele MJ & Farrell PA (2000) Time course evaluation of protein synthesis and glucose uptake after acute resistance exercise in rats. Journal of Applied Physiology 88, 1142-1149.
20. Hershey JWB & Merrick WC (2000) The pathway and mechanism of initiation of protein synthesis. In Translational Control of Gene Expression, pp. 33-88. [N Sonenberg, JWB Hershey and MB Mathews, editors]. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
21. Kim D-H, Sarbassov DD, Ali SM, Latek RR, Guntur KVP, Erdjument-Bromage H, Tempst P & Sabatini D (2003) GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Molecular Cell 11, 895-904.
22. Kimball SR, Farrell PA & Jefferson LS (2002) Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise. Journal of Applied Physiology 93, 1168-1180.
23. Kostyak JC, Kimball SR, Jefferson LS & Farrell PA (2001) Severe diabetes inhibits resistance exercise-induced increase in eukaryotic initiation factor 2B activity. Journal of Applied Physiology 91, 79-84.
24. Kraemer WJ, Volek JS, Bush JA, Putukian M & Sebastianelli WJ (1998) Hormonal responses to consecutive days of heavy-resistance exercise with or without nutritional supplementation. Journal of Applied Physiology 85, 1544-1555.
25. Manning BD & Cantley LC (2003) United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling. Biochemical Society Transactions 31, 573-578.
26. Meyuhas O (2000) Synthesis of the translational apparatus is regulated at the translational level. European Journal of Biochemistry 267, 6321-6330.
27. Nader GA & Esser KA (2001) Intracellular signaling specificity in skeletal muscle in response to different modes of exercise. Journal of Applied Physiology 90, 1936-1942.
28. Nave BT, Ouwens DM, Withers DJ, Alessi DR & Shepherd PR (1999) Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino acid deficiency on protein translation. Biochemical Journal 344, 427-431.
29. Patti M-E, Brambilla E, Luzi L, Landaker EJ & Kahn CR (1998) Bidirectional modulation of insulin action by amino acids. Journal of Clinical Investigation 101, 1519-1529.
30. Rasmussen BB, Tipton KD, Miller SL, Wolf SE & Wolfe RR (2000) An oral essential amino acid-carbohydrate supplement enhances muscle protein anabolism after resistance exercise. Journal of Applied Physiology 88, 386-392.
31. 2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load. Journal of Biological Chemistry 277, 17657-17662.
32. Rommel C, Bodine SC, Clarke BA, Rossman R, Nunez L, Stitt TN, Yancopoulous GD & Glass DJ (2001) Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nature Cell Biology 3, 1009-1013.
33. Sakamoto K, Aschenbach WG, Hirshman MF & Goodyear LJ (2003) Akt signaling in skeletal muscle: Regulation by exercise and passive stretch. American Journal of Physiology 285, E1081-E1088.
34. Saucedo LJ, Gao X, Chiarelli DA, Li L, Pan D & Edgar BA (2003) Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nature Cell Biology 5, 566-571.
35. Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC & Blenis J (2002) Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proceedings of the National Academy of Sciences USA 99, 13571-13576.
36. Tipton KD, Rasmussen BB, Miller SL, Wolf SE, Owens-Stovall SK, Petrini BE & Wolfe RR (2001) Timing of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exercise. American Journal of Physiology 281, E197-E206.
37. Welsh GI, Miller CM, Loughlin AJ, Price NT & Proud CG (1998) Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin. FEBS Letters 421, 125-130.
38. Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA & Pan D (2003) Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nature Cell Biology 5, 578-581.