Severe diabetes prohibits elevations in muscle protein synthesis after acute resistance exercise in rats

Journal of Applied Physiology

Volumn 88, Issue 1, 2000, Pages 102-108

  Fedele, Mark J ^b   Hernandez, Jazmir M ^b   Lang, Charles H ^b   Vary, Thomas C ^b   Kimball, Scot R ^b   Jefferson, Leonard S ^b   Farrell, Peter A ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b NONE

Author keywords

Anabolic factors; Hypoinsulinemia; Stress

Indexed keywords

GLUCOSE; INSULIN; MUSCLE PROTEIN; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; EXERCISE; GLUCOSE BLOOD LEVEL; HORMONE DETERMINATION; INSULIN BLOOD LEVEL; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN SYNTHESIS; RAT;

EID: 0033970749     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2000.88.1.102     Document Type: Article

References (58)

1. Al-Dujaili, E. A. S., B. C. Williams, and C. R. W. Edwards. The development and application of a direct radioimmunoassay for corticosterone. Steroids 37: 157-176, 1981.
2. Armstrong, R. B., and R. O. Phelps. Muscle fiber type composition of the rat hindlimb. Am. J. Anat. 171: 259-272, 1984.
3. Balon, T. W., A. Zorzano, J. L. Treadway, M. N. Goodman, and N. B. Ruderman. Effect of insulin on protein synthesis and degradation in skeletal muscle after exercise. Am. J. Physiol. Endocrinol. Metab. 258: E92-E97, 1990.
4. 13C]leucine. Diabetologia 33: 43-51, 1990.
5. Bereket, A., C. H. Lang, S. L. Blethen, J. Fan, R. A. Frost, and T. A. Wilson. Insulin-like growth factor binding protein (IGFBP)-3 proteolysis in children with insulin-dependent diabetes mellitus: a possible role for insulin in the regulation of IGFBP-3 protease activity. J. Clin. Endocrinol. Metab. 80: 2282-2288, 1995.
6. Bereket, A., C. H. Lang, S. L. Blethen, M. C. Gelato, J. Fan, R. A. Frost, and T. A. Wilson. Effect of insulin on the insulin-like growth factor system in children with new-onset insulin-dependent diabetes mellitus. J. Clin. Endocrinol. Metab. 80: 1312-1317, 1995.
7. Biolo, G., S. P. Maggi, B. D. Williams, K. D. Tipton, and R. E. Wolfe. Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans. Am. J. Physiol. Endocrinol. Metab. 268: E514-E520, 1995.
8. Booth, F., and D. B. Thomason. Molecular and cellular adaptation of muscle in response to exercise: perspectives of various models. Physiol. Rev. 71: 541-584, 1991.
9. Coleman, M. E., F. DeMayo, K. C. Yin, H. M. Lee, and R. Geske. Myogenic vector expression of insulin like growth factor-I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice. J. Biol. Chem 270: 12109-12116, 1995.
10. Davis, T. A., D. G. Burrin, M. L. Fiorotto, P. J. Reeds, and F. Jahoor. Roles of insulin and amino acids in the regulation of protein synthesis in the neonate. J. Nutr. 128: 347S-350S, 1998.
11. Davis, T. A., M. L. Fiorotto, H. V. Nguyen, and D. G. Burrin. Aminoacyl-tRNA and tissue free amino acid pools are equilibrated after a flooding dose of phenylalanine. Am. J. Physiol. Endocrinol. Metab. 277: E103-E109, 1999.
12. Drenevich, D., and T. C. Vary. Analysis of physiological amino acids using dabsyl derivatization and reversed-phase liquid chromatography. J. Chromatogr. 613: 137-144, 1993.
13. Elphick, M. C. Modified colorimetric ultramicro method for estimating NEFA in serum. J. Clin. Pathol. 21: 567-570, 1968.
14. Fan, J., P. E. Molina, M. C. Gelato, and C. H. Lang. Differential tissue regulation of insulin-like growth factor-1 content and binding proteins after endotoxin. Endocrinology 134: 1682-1692, 1994.
15. Farrell, P. A., A. L. Caston, and D. Rodd. Changes in insulin response to glucose after exercise training in partially pancreactectomized rats. J. Appl. Physiol. 70: 1563-1569, 1991.
16. Farrell, P. A., M. J. Fedele, J. Hernandez, J. D. Fluckey, J. L. Miller III, C. H. Lang, T. C. Vary, S. R. Kimball, and L. S. Jefferson. Hypertrophy of skeletal muscle in diabetic rats in response to chronic resistance exercise. J. Appl. Physiol. 87: 1075-1082, 1999.
17. Farrell, P. A., M. J. Fedele, T. C. Vary, S. R. Kimball, and L. S. Jefferson. Effects of intensity of acute resistance exercise on rates of protein synthesis in diabetic rats. J. Appl. Physiol. 85: 2291-2297, 1998.
18. Farrell, P. A., M. J. Fedele, T. C. Vary, S. R. Kimball, C. H. Lang, and L. S. Jefferson. Regulation of protein synthesis after acute resistance exercise in diabetic rats. Am. J. Physiol. Endocrinol. Metab. 276: E721-E727, 1999.
19. Flaim, K. E., M. E. Copenhaver, and L. S. Jefferson. Effects of diabetes on protein synthesis in fast- and slow-twitch rat skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 239: E88-E95, 1980.
20. Fluckey, J. D., W. J. Kraemer, and P. A. Farrell. Pancreatic islet insulin secretion is increased after resistance exercise in rats. J. Appl. Physiol. 79: 1100-1105, 1995.
21. Fluckey, J. D., T. C. Vary, L. S. Jefferson, W. J. Evans, and P. A. Farrell. Insulin stimulation of protein synthesis in rat skeletal muscle following resistance exercise is maintained with advancing age. J. Gerontol. A Biol. Sci. 51: B323-B330, 1996.
22. Fluckey, J. D., T. C. Vary, L. S. Jefferson, and P. A. Farrell. Augmented insulin action on rates of protein synthesis after resistance exercise in rats. Am. J. Physiol. Endocrinol. Metab. 270: E313-E319, 1996.
23. Foglia, V. A. Caracteristicas del la diabetes en la rata. Rev. Soc. Argentina Biol. 20: 21-37, 1944.
24. Garlick, P. J., M. Fern, and V. R. Preedy. The effect of insulin infusion and food intake on muscle protein synthesis in postabsorptive rats. Biochem. J. 210: 669-676, 1983.
25. Garlick, P. J., M. A. McNurlan, P. Essén, and J. Wernerman. Measurement of tissue protein synthesis rates in vivo: a critical analysis of contrasting methods. Am. J. Physiol. Endocrinol. Metab. 266: E287-E297, 1994.
26. 3H]phenylalanine. Biochem. J. 192: 719-723, 1980.
27. Gautsch, T. A., J. C. Anthony, S. R. Kimball, G. L. Paul, D. K. Layman, and L. S. Jefferson. Availability of eIF4E regulates skeletal muscle protein synthesis during recovery from exercise. Am. J. Physiol. Cell Physiol. 274: C409-C414, 1998.
28. Gelfand, R., and E. J. Barrett. Effect of physiological hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man. J. Clin. Invest. 80: 1-6, 1987.
29. Green, H. J., M. Ball-Burnett, S. Symon, S. Grant, and G. Jamieson. Short-term training, muscle glycogen, and cycle endurance. Can. J. Appl. Physiol. 20: 315-324, 1995.
30. Hossenloop, P., D. Seurin, B. Segonia-Quinson, S. Hardouin, and M. Binoux. Analysis of serum insulin-like growth factor binding proteins using Western blotting: use of the method for titration of the binding proteins and competitive binding sites. Anal. Biochem. 154: 138-143, 1986.
31. Jefferson, L. S. Role of insulin in the regulation of protein synthesis. Diabetes 29: 487-496, 1980.
32. Jefferson, L. S., D. E. Rannels, B. L. Munger, and H. E. Morgan. Insulin in the regulation of protein turnover in heart and skeletal muscle. Federation Proc. 33: 1098-1104, 1974.
33. Jepson, M. M., J. M. Pell, P. C. Bates, and D. J. Millward. The effects of endotoxaemia on protein metabolism in skeletal muscle and liver of fed and fasted rats. Biochem. J. 235: 329-336, 1986.
34. Jurasinski, C. V., and T. C. Vary. Insulin-like growth factor I accelerates protein synthesis in skeletal muscle during sepsis. Am. J. Physiol. Endocrinol. Metab. 269: E977-E981, 1995.
35. Kimball, S. R., L. S. Jefferson, P. Fadden, T. A. Haystead, and J. C. Lawrence, Jr. Insulin and diabetes cause reciprocal changes in the association of eIF-4E and PHAS-I in rat skeletal muscle. Am. J. Physiol. Cell Physiol. 270: C705-C709, 1996.
36. Kimball, S. R., T. C. Vary, and L. S. Jefferson. Regulation of protein synthesis by insulin. Annu. Rev. Physiol. 56: 321-348, 1994.
37. Koziris, L. P., R. C. Hickson, R. T. Chatterton, R. T. Groseth, J. M. Christie, D. G. Goldflies, and T. G. Unterman. Serum levels of total and free IGF-I and IGFBP-3 are increased and maintained in long-term training. J. Appl. Physiol. 86: 1436-1442, 1999.
38. Lang, C. H., J. Fan, R. Cooney, and T. C. Vary. Interleukin-1 receptor antagonist attenuates sepsis-induced alterations in the insulin-like growth factor system and protein synthesis. Am. J. Physiol. Endocrinol. Metab. 270: E430-E437, 1996.
39. Li, Y. H., J. Fan, and C. H. Lang. Differential role of glucocorticoids in mediating endotoxin-induced changes in IGF-I and IGFBP-I. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 272: R1990-R1997, 1997.
40. McCusker, R. H., and D. R. Clemmons. The insulin-like growth factor binding proteins: structure and biological functions. In: The Insulin-Like Growth Factors: Structure and Biological Functions, edited by P. N. Schofielf. New York: Oxford University Press, 1992, p. 110-150.
41. McNulty, P. H., L. H. Young, and E. J. Barrett. Response of rat heart and skeletal muscle protein in vivo to insulin and amino acid infusion. Am. J. Physiol. Endocrinol. Metab. 264: E958-E965, 1993.
42. 3H]phenylalanine. Am. J. Physiol. Endocrinol. Metab. 267: E102-E108, 1994.
43. Morgan, C. R., and A. Lazarow. Immunoassay of insulin: two antibody system. Plasma levels of normal, subdiabetic and diabetic rats. Diabetes 12: 115-126, 1963.
44. Nguyen, U. N., F. Mougin, M. L. Simon-Rigaud, J. D. Rouillon, P. Marguet, and J. Regnard. Influence of exercise duration on serum insulin-like growth factor and its binding proteins in athletes. J. Appl. Physiol. 78: 533-537, 1998.
45. Pacy, P. J., K. S. Nair, C. Ford, and D. Halliday. Failure of insulin infusion to stimulate fractional muscle protein synthesis in type 1 diabetic patients: anabolic effect of insulin and decreased proteolysis. Diabetes 38: 618-624, 1989.
46. Pain, V. M., and P. J. Garlick. Effect of streptozotocin diabetes and insulin treatment on the rate of protein synthesis in tissues of the rat in vivo. J. Biol. Chem 249: 4510-4514, 1974.
47. Rannels, S. R., D. E. Rannels, A. E. Pegg, and L. S. Jefferson. Glucocorticoid effects on peptide-chain initiation in skeletal muscle and heart. Am. J. Physiol. Endocrinol. Metab. 235: E134-E139, 1978.
48. Rennie, M. J., K. Smith, and P. W. Watt. Measurement of human tissue protein synthesis: an optimal approach. Am. J. Physiol. Endocrinol. Metab. 266: E298-E307, 1994.
49. Steenbergh, P. H., E. Jansen, F. M. A. van Schiak, and J. S. Sussenbach. Functional analysis of the human IGF-I gene promoters. Mol. Reprod. Dev. 35: 365-367, 1993.
50. Tomas, F. M., S. E. Knowles, P. C. Owens, L. C. Read, C. S. Chandler, S. E. Gargosky, and F. J. Ballard. Increased weight gain, nitrogen retention and muscle protein synthesis following treatment of diabetic rats with insulin-like growth factor (IGF)-I and des(1-3)IGF-I. Biochem. J. 276: 547-554, 1991.
51. Vary, T. C., D. Dardevet, J. Grizard, L. Voisin, C. Buffiere, P. Denis, D. Breuille, and C. Obled. Differential regulation of skeletal muscle protein synthesis turnover by insulin and IGF-I after bacteremia. Am. J. Physiol. Endocrinol. Metab. 275: E584-E593, 1998.
52. Wojnar, M. M., J. Fan, Y. H. Li, and C. H. Lang. Endotoxin-induced changes in IGF-I differ in rats provided enteral vs. parenteral nutrition. Am. J. Physiol. Endocrinol. Metab. 276: E455-E464, 1999.
53. Wong, T. S., and F. W. Booth. Protein metabolism in rat gastrocnemius muscle after stimulated chronic concentric exercise. J. Appl. Physiol. 69: 1709-1717, 1990.
54. Wong, T. S., and F. W. Booth. Protein metabolism in rat tibialis anterior muscle after stimulated chronic eccentric exercise. J. Appl. Physiol. 69: 1718-1724, 1990.
55. Wray-Cahen, D., H. V. Nguyen, D. G. Burrin, P. R. Beckett, M. L. Fiorotto, P. J. Reeds, T. J. Wester, and T. A. Davis. Response of skeletal muscle protein synthesis to insulin in suckling pigs decreases with development. Am. J. Physiol. Endocrinol. Metab. 275: E602-E609, 1998.
56. Yan, Z., R. Biggs, and F. Booth. Insulin-like growth factor immunoreactivity increases in muscle after acute eccentric exercise. J. Appl. Physiol. 74: 410-414, 1993.
57. Yang, S., M. Alnaqeeb, H. Simpson, and G. Goldspink. Cloning and characterization of an IGF-I isoform expressed in skeletal muscle subjected to stretch. J. Muscle Res. Cell Motil. 17: 487-495, 1996.
58. Young, L. H., W. Stirewalt, P. H. McNulty, J. H. Revkin, and E. J. Barrett. Effect of insulin on rat heart and skeletal muscle phenylalanyl-tRNA labeling and protein synthesis in vivo. Am. J. Physiol. Endocrinol. Metab. 267: E337-E342, 1994.