The merits of bipartite transition-state mimics for inhibition of uracil DNA glycosylase

Bioorganic Chemistry

Volumn 32, Issue 4, 2004, Pages 244-262

  Jiang, Yu Lin ^a   Cao, Chunyang ^a   Stivers, James T ^a   Song, Fenhong ^b   Ichikawa, Yoshi ^c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

^c Optimer Pharmaceuticals Inc   (United States)

Author keywords

1 Azadeoxyribose; Enzyme inhibition; Transition state mimics; Uracil DNA glycosylase

Indexed keywords

ANION; BIPARTITE TRANSITION STATE 2 INHIBITOR; CATION; GLYCOSYLTRANSFERASE INHIBITOR; SUGAR; UNCLASSIFIED DRUG; URACIL DNA GLYCOSYLTRANSFERASE; WATER;

ARTICLE; BINDING AFFINITY; CHEMICAL BINDING; CHEMICAL BOND; ENZYME INHIBITION; HYDROLYSIS; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; SYNTHESIS;

AMIDES; BINDING, COMPETITIVE; DNA GLYCOSYLASES; DNA REPAIR; ENZYME INHIBITORS; ESCHERICHIA COLI PROTEINS; HYDROGEN-ION CONCENTRATION; MOLECULAR MIMICRY; OLIGONUCLEOTIDES; PHOSPHORIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP; URACIL-DNA GLYCOSIDASE; URIDINE;

EID: 2942701874     PISSN: 00452068     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bioorg.2004.03.001     Document Type: Article

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