A gastropod toxin selectively slows early transitions in the Shaker K channel's activation pathway

Journal of General Physiology

Volumn 123, Issue 6, 2004, Pages 685-696

  Sack, Jon T ^a,b   Aldrich, Richard W ^b   Gilly, William F ^a  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gating; Kv; Neurotoxin; Potassium channel; Shaker

Indexed keywords

6 BROMO 2 MERCAPTOTRYPTAMINE; NEUROTOXIN; POTASSIUM CHANNEL; POTASSIUM ION; TOXIN; TRYPTAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHANNEL GATING; CONDUCTANCE; CONTROLLED STUDY; GASTROPOD; KINETICS; NONHUMAN; POTASSIUM TRANSPORT; PROTEIN CONFORMATION; SENSOR; VOLTAGE CLAMP;

ANIMALS; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DROSOPHILA; DROSOPHILA PROTEINS; ION CHANNEL GATING; MARINE TOXINS; MEMBRANE POTENTIALS; OOCYTES; POTASSIUM; POTASSIUM CHANNELS; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; SNAILS; TRYPTAMINES; XENOPUS LAEVIS;

EID: 2942656853     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.200409047     Document Type: Article

References (36)

1. +-induced anomalous rectification in squid giant axons. J. Gen. Physiol. 50:491-503.
2. Armstrong, C.M. 1971. Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons. J. Gen. Physiol. 58:413-437.
3. Armstrong, C.M., and A. Loboda. 2001. A model for 4-aminopyridine action on k channels: similarities to tetraethylammonium ion action. Biophys. J. 81:895-904.
4. + channel gating. Neuron. 20:1283-1294.
5. + channels: II. The components of gating currents and a model of channel activation. Biophys. J. 66:1011-1021.
6. Brock, M.W., C. Mathes, and W.F. Gilly. 2001. Selective open-channel block of Shaker (Kv1) potassium channels by s-nitrosodithiothreitol (SNDTT). J. Gen. Physiol. 118:113-134.
7. Choi, K.L., C. Mossman, J. Aube, and G. Yellen. 1993. The internal quaternary ammonium receptor site of Shaker potassium channels. Neuron. 10:533-541.
8. Gilly, W.F., and C.M. Armstrong. 1982. Divalent cations and the activation kinetics of potassium channels in squid giant axons. J. Gen. Physiol. 79:965-996.
9. + channel. Biophys. J. 65:1613-1619.
10. Hamill, O.P., A. Marty, E. Neher, B. Sakmann, and F.J. Sigworth. 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391:85-100.
11. + channel. J. Gen. Physiol. 108:195-206.
12. + channels: evidence for a trap door mechanism of activation gating. J. Gen. Physiol. 109:527-535.
13. Hoshi, T., W.N. Zagotta, and R.W. Aldrich. 1990. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science. 250:533-538.
14. Hoshi, T., W.N. Zagotta, and R.W. Aldrich. 1994. Shaker potassium channel gating. I: Transitions near the open state. J. Gen. Physiol. 103:249-278.
15. Kelley, W.P., A.M. Wolters, J.T. Sack, R.A. Jockusch, J.C. Jurchen, E.R. Williams, J.V. Sweedler, and W.F. Gilly. 2003. Characterization of a novel gastropod toxin (6-bromo-2-mercaptotryptamine) that inhibits shaker K channel activity. J. Biol. Chem. 278:34934-34942.
16. Ledwell, J.L., and R.W. Aldrich. 1999. Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation. J. Gen. Physiol. 113:389-414.
17. Loboda, A., and C.M. Armstrong. 2001. Resolving the gating charge movement associated with late transitions in K channel activation. Biophys. J. 81:905-916.
18. Lopez-Barneo, J., T. Hoshi, S.H. Heinemann, and R.W. Aldrich. 1993. Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors Channels. 1:61-71.
19. + channel. J. Gen. Physiol. 91:335-349.
20. Mannuzzu, L.M., and E.Y. Isacoff. 2000. Independence and cooperativity in rearrangements of a potassium channel voltage sensor revealed by single subunit fluorescence. J. Gen. Physiol. 115:257-268.
21. Melishchuk, A., and C.M. Armstrong. 2001. Mechanism underlying slow kinetics of the OFF gating current in Shaker potassium channel. Biophys. J. 80:2167-2175.
22. + solutions: role of the voltage sensor. Biophys. J. 75:1828-1835.
23. Schoppa, N.E., and F.J. Sigworth. 1998a. Activation of shaker potassium channels. I. Characterization of voltage-dependent transitions. J. Gen. Physiol. 111:271-294.
24. Schoppa, N.E., and F.J. Sigworth. 1998b. Activation of Shaker potassium channels. II. Kinetics of the V2 mutant channel. J. Gen. Physiol. 111:295-311.
25. Schoppa, N.E., and F.J. Sigworth. 1998c. Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels. J. Gen. Physiol. 111:313-342.
26. Sigworth, F.J., and S.M. Sine. 1987. Data transformations for improved display and fitting of single-channel dwell time histograms. Biophys. J. 52:1047-1054.
27. Smith-Maxwell, C.J., J.L. Ledwell, and R.W. Aldrich. 1998a. Role of the S4 in cooperativity of voltage-dependent potassium channel activation. J. Gen. Physiol. 111:399-420.
28. Smith-Maxwell, C.J., J.L. Ledwell, and R.W. Aldrich. 1998b. Uncharged S4 residues and cooperativity in voltage-dependent potassium channel activation. J. Gen. Physiol. 111:421-439.
29. Spires, S., and T. Begenisich. 1994. Modulation of potassium channel gating by external divalent cations. J. Gen. Physiol. 104:675-692.
30. 2+ modulates slow gating transitions and the opening of Drosophila ether-a-Go-Go potassium channels. J. Gen. Physiol. 115:319-338.
31. 2+ regulates activation of rat eag potassium channel. Pflugers Arch. 432:301-312.
32. Yang, Y., Y. Yan, and F.J. Sigworth. 1997. How does the W434F mutation block current in Shaker potassium channels? J. Gen. Physiol. 109:779-789.
33. Zagotta, W.N., T. Hoshi, and R.W. Aldrich. 1994a. Shaker potassium channel gating. III: Evaluation of kinetic models for activation. J. Gen. Physiol. 103:321-362.
34. Zagotta, W.N., T. Hoshi, J. Dittman, and R.W. Aldrich. 1994b. Shaker potassium channel gating. II: Transitions in the activation pathway. J. Gen. Physiol. 103:279-319.
35. Zhang, S., S.J. Kehl, and D. Fedida. 2001. Modulation of Kv1.5 potassium channel gating by extracellular zinc. Biophys. J. 81:125-136.
36. Zheng, J., L. Vankataramanan, and F.J. Sigworth. 2001. Hidden Markov model analysis of intermediate gating steps associated with the pore gate of shaker potassium channels. J. Gen. Physiol. 118:547-564.