Mechanism underlying slow kinetics of the off gating current in Shaker potassium channel

Biophysical Journal

Volumn 80, Issue 5, 2001, Pages 2167-2175

  Melishchuk, Alexey ^a,b   Armstrong, Clay M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; CESIUM ION; MEGLUMINE; MONOVALENT CATION; MUTANT PROTEIN; POTASSIUM CHANNEL; POTASSIUM ION; QUATERNARY AMMONIUM DERIVATIVE; RUBIDIUM ION; TETRYLAMMONIUM;

ARTICLE; CHANNEL GATING; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; KINETICS; MOLECULAR INTERACTION; PERMEABILITY; POTASSIUM CURRENT; PROTEIN STRUCTURE;

EID: 0035040714     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(01)76189-9     Document Type: Article

References (12)

1. Akabas, M. H., D. A. Stauffer, M. Xu, and A. Karlin. 1992. Acetylcholine receptor channel structure probed in cysteine-substitution mutants. Science. 258:307-310.
2. +-induced anomalous rectification in squid giant axons. J. Gen. Physiol. 50:491-503.
3. Armstrong, C. M. 1971. Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons. J. Gen. Physiol. 58: 413-437.
4. + channels. Science. 258:1152-1155.
5. + channel signature sequence. Biophys. J. 66:1061-1067.
6. Hille, B., and W. Schwartz. 1978. Potassium channels as multi-ion single file pores. J. Gen. Physiol. 72:409-442.
7. Hodgkin, A. L., and R. D. Keynes. 1995. The potassium permeability of a giant nerve fiber. J. Physiol. (Lond.) 128:61-88.
8. + channels: evidence for a trap door mechanism of activation gating. J. Gen. Physiol. 109:527-535.
9. Jurman, M. E., L. M. Boland, L. Y. Liu, and G. Yellen. 1994. Visual identification of individual transfected cells for electrophysiology using antibody-coated beads. BioTechniques. 17:876-881.
10. + channel. Neuron. 19:175-184.
11. MacKinnon, R., R. W. Aldrich, and A. W. Lee. 1993. Functional stoichiometry of Shaker potassium channel inactivation. Science. 262:757-759.
12. MacKinnon, R., S. L. Cohen, A. Kuo, A. Lee, and B. T. Chait. 1998. Structural conservation in prokaryotic and eukaryotic potassium channels. Science. 280:106-109.