Loss of Shaker K channel conductance in 0 K+ solutions: Role of the voltage sensor

Biophysical Journal

Volumn 75, Issue 4, 1998, Pages 1828-1835

  Melishchuk, Alexey ^a,b   Loboda, Andrey ^a   Armstrong, Clay M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL; POTASSIUM ION;

ARTICLE; CHANNEL GATING; CONTROLLED STUDY; ELECTRIC POTENTIAL; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; HYPERPOLARIZATION; MEMBRANE CURRENT; POINT MUTATION; POLYMERASE CHAIN REACTION; REPOLARIZATION; SODIUM CURRENT;

EID: 0031714063     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(98)77624-6     Document Type: Article

References (22)

1. +-free media. J. Gen. Physiol. 75:61-78.
2. Chandler, W. K., and H. Meves. 1970. Sodium and potassium currents in squid axons perfused with fluoride solutions. J. Physiol. (Lond.). 211: 623-652.
3. + channel deactivation. J. Gen. Physiol. 110:87-100.
4. + conduction and selectivity. Science. 280:69-77.
5. Frech, G. C., A. M. J. VanDongen, G. Schuster, A. M. Brown, and R. H. Joho. 1989. A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning. Nature. 340:642-645.
6. + solutions: a remarkably stable non-conducting state produced by membrane depolarizations. J. Physiol. (Lond.). 499:3-15.
7. Hamill, O. P., A. Marty, E. Neher, B. Sakmann, and F. G. Sigworth. 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 391:85-100.
8. Hille, B. 1992. Ion Channels of Excitable Membranes, 2nd Ed. Sinauer Associates. Sunderland, MA.
9. Hoshi, T., W. N. Zagotta, and R. W. Aldrich. 1990. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science. 250:533-538.
10. + channels: effects of alterations in the carboxy-terminal region. Neuron. 7:547-556.
11. + channels: evidence for non-conducting closed and non-conducting inactivated states. J. Physiol. (Lond.). 506:291-301.
12. Jurman, M. E., L. M. Boland, L. Y. Liu, and G. Yellen. 1994. Visual identification of individual transfected cells for electrophysiology using antibody-coated beads. BioTechniques. 17:876-881.
13. Kamb, A., J. C. L. Tseng-Crank, and M. A. Tanouye. 1988. Multiple products of the Drosophila Shaker gene may contribute to potassium channel diversity. Neuron. 1:421-430.
14. + at the potassium channel selectivity filter. Biophys. J. 74:1840-1849.
15. Korn, S. J., and S. R. Ikeda. 1995. Permeation selectivity by competition in a delayed rectifier potassium channel. Science. 269:410-412.
16. Lopez-Barneo, J., T. Hoshi, S. H. Heinemann, and R. W. Aldrich. 1993. Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors Channels. 1:61-71.
17. + channels during gating and assembly. Biophys. J. 65:1740-1748.
18. Ogielska, E. M., and R. W. Aldrich. 1997. A single amino acid substitution in the S6 of Shaker decreases potassium affinity and allows for sodium permeation in the absence of potassium. Biophys. J. 72:A233.
19. Olcese, R., R. Latorre, L. Toro, F. Bezanilla, and E. Stefani. 1997. Correlation between charge movement and ionic current during slow inactivation in Shaker channels. J. Gen. Physiol. 110:579-589.
20. Starkus, J., L. Kuschel, M. Rayner, and S. Heinemann. 1997. Ion conduction through C-type inactivated Shaker channels. J. Gen. Physiol. 110: 539-550.
21. + channels: ionic and gating currents. Biophys. J. 66:996-1010.
22. +. Nature. 291:427-429.