Selective open-channel block of Shaker (Kv1) potassium channels by S-nitrosodithiothreitol (SNDTT)

Journal of General Physiology

Volumn 118, Issue 1, 2001, Pages 113-133

  Brock, Mathew W ^a   Mathes, Chris ^a,b   Gilly, William F ^a  

^a STANFORD UNIVERSITY   (United States)

^b Axon Instruments Inc   (United States)

Author keywords

Inactivation; Ion channel gating; Nitrosylation; Quaternary ammonium compounds; Voltage gated potassium channels

Indexed keywords

DITHIOTHREITOL; POTASSIUM CHANNEL; QUATERNARY AMMONIUM DERIVATIVE; S NITROSODITHIOTHREITOL; SODIUM CHANNEL; SULFUR; TETRYLAMMONIUM; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CONCENTRATION RESPONSE; CYTOPLASM; DISSOCIATION CONSTANT; DOSE RESPONSE; HUMAN; HUMAN CELL; HYDROPHOBICITY; NERVE CELL; REACTION ANALYSIS; STEADY STATE; STOICHIOMETRY; STRUCTURE ANALYSIS; VOLTAGE CLAMP;

ANIMALS; BINDING SITES; CELL LINE; CELL MEMBRANE; CYTOSOL; DECAPODIFORMES; DITHIOTHREITOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; ION CHANNEL GATING; KINETICS; NEURONS; NITROSO COMPOUNDS; PATCH-CLAMP TECHNIQUES; PLASMIDS; POTASSIUM CHANNELS; QUATERNARY AMMONIUM COMPOUNDS; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; SPODOPTERA; TRANSFECTION;

EID: 0034937456     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.118.1.113     Document Type: Article

References (51)

1. Inactivation of the potassium conductance and related phenomena caused by quaternary ammonium injection in squid axons
2. Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons
3. Potassium pores of nerve and muscle membrane
4. - donation by S-nitrosothiols: Implications for regulation of physiological functions by S-nitrosylation and acceleration of disulfide formation
5. + channel are not essential for channel activity or zinc modulation
6. Mechanism of verapamil block of a neuronal delayed rectifier K channel: Active form of the blocker and location of its binding domain
7. + channels
8. The internal quaternary ammonium receptor site of Shaker potassium channels
9. Dithiothreitol, a new protective reagent for SH groups
10. A Q-matrix cookbook
11. + channel block by verapamil and related compounds in rat alveolar epithelial cells
12. + channel and its structural implications
13. Characterization and functional expression of a rat genomic DNA clone encoding a lymphocyte potassium channel
14. + conduction and selectivity
15. Blockage of squid axon potassium conductance by internal tetra-N-alkylammonium ions of various sizes
16. Control of the spatial distribution of sodium channels in giant fiber lobe neurons of the squid
17. Redox and nitric oxide (NO)-dependent modulation of potassium channels of squid stellate ganglion neurons
18. + channels in human T lymphocytes
19. + channel gene
20. The aromatic binding site for tetraethylammonium ion on potassium channels
21. + channel
22. + current in squid giant fiber lobe neurons
23. Biophysical and molecular mechanisms of Shaker potassium channel inactivation
24. + channels
25. The decomposition of S-nitrosated dithiols: A model for vicnal nitrosothiols in enzymes
26. Functional differences among nonerythroid anion exchangers expressed in a transfected human cell line
27. + channel
28. Structural determinants of potency and stereo-selective block of hKv1.5 channels induced by local anesthetics
29. Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels
30. + channels
31. Mechanism of clofilium block of the human Kv1.5 delayed rectifier potassium channel
32. + channel cloned from human heart
33. + channel cloned from human heart
34. Evidence for an internal phenylalkylamine action on the voltage-gated potassium channel Kv1.3
35. Molecular identification of SqKv1A. A candidate for the delayed rectifier K channel in squid giant axon
36. + channel: Electrostatic stabilization of monovalent cations
37. Diversity and ubiquity of K channels
38. Polynitrosylated proteins: Characterization, bioactivity, and functional consequences
39. Determinants of antiarrhythmic drug action. Electrostatic and hydrophobic components of block of the human cardiac hKv1.5 channel
40. Time-, voltage-, and state-dependent block by quinidine of a cloned human cardiac potassium channel
41. Biochemistry of nitric oxide and its redox-activated forms
42. Inactivation of potassium current in squid axon by a variety of quaternary ammonium ions
43. Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers
44. Ionic blockage of sodium channels in nerve
45. Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers
46. Immobilisation of gating charge by a substance that simulates inactivation
47. The moving parts of voltage-gated ion channels
48. + channel
49. + channel. Role of S6 in antiarrhythmic drug binding
50. Endogenous voltage-gated potassium channels in human embryonic kidney (HEK293) cells