메뉴 건너뛰기




Volumn 103, Issue 12, 2004, Pages 4602-4609

Utilization of Ig heavy chain variable, diversity, and joining gene segments in children with B-lineage acute lymphoblastic leukemia: Implications for the mechanisms of VDJ recombination and for pathogenesis

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

EID: 2942614692     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-11-3857     Document Type: Article
Times cited : (38)

References (69)
  • 2
    • 0021442649 scopus 로고
    • Ordered rearrangement of immunoglobulin heavy chain variable region segments
    • Alt FW, Yancopoulos GD, Blackwell TK, et al. Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J. 1984;3:1209-1219.
    • (1984) EMBO J , vol.3 , pp. 1209-1219
    • Alt, F.W.1    Yancopoulos, G.D.2    Blackwell, T.K.3
  • 3
    • 0030272590 scopus 로고    scopus 로고
    • Developmental regulation of V(D)J recombination and lymphocyte differentiation
    • Willerford DM, Swat W, Alt FW. Developmental regulation of V(D)J recombination and lymphocyte differentiation. Curr Opin Genet Dev. 1996;6:603-609.
    • (1996) Curr Opin Genet Dev , vol.6 , pp. 603-609
    • Willerford, D.M.1    Swat, W.2    Alt, F.W.3
  • 4
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa S. Somatic generation of antibody diversity. Nature. 1983;302:575-581.
    • (1983) Nature , vol.302 , pp. 575-581
    • Tonegawa, S.1
  • 5
    • 0025201204 scopus 로고
    • Analysis of junctional diversity during B lymphocyte development
    • Meek K. Analysis of junctional diversity during B lymphocyte development. Science. 1990;250:820-823.
    • (1990) Science , vol.250 , pp. 820-823
    • Meek, K.1
  • 6
    • 0025781883 scopus 로고
    • Multipie mechanisms participate in the generation of diversity of human H chain CDR3 regions
    • Sanz I. Multipie mechanisms participate in the generation of diversity of human H chain CDR3 regions. J Immunol. 1991;147:1720-1729.
    • (1991) J Immunol , vol.147 , pp. 1720-1729
    • Sanz, I.1
  • 7
    • 0027535651 scopus 로고
    • P nucleotides in V(D)J recombination: A fine-structure analysis
    • Meier JT, Lewis SM. P nucleotides in V(D)J recombination: a fine-structure analysis. Mol Cell Biol. 1993;13:1078-1092.
    • (1993) Mol Cell Biol , vol.13 , pp. 1078-1092
    • Meier, J.T.1    Lewis, S.M.2
  • 8
    • 0030864457 scopus 로고    scopus 로고
    • Human Ig heavy chain CDR3 regions in adult bone marrow pre-B cells display an adult phenotype of diversity: Evidence for structural selection of DH amino acid sequences
    • Raaphorst FM, Raman CS, Tami J, Fischbach M, Sanz I. Human Ig heavy chain CDR3 regions in adult bone marrow pre-B cells display an adult phenotype of diversity: evidence for structural selection of DH amino acid sequences. Int Immunol. 1997;9:1503-1515.
    • (1997) Int Immunol , vol.9 , pp. 1503-1515
    • Raaphorst, F.M.1    Raman, C.S.2    Tami, J.3    Fischbach, M.4    Sanz, I.5
  • 9
    • 0028986982 scopus 로고
    • The human immunoglobulin VH repertoire
    • Cook GP, Tomlinson IM. The human immunoglobulin VH repertoire. Immunol Today. 1995;16:237-242.
    • (1995) Immunol Today , vol.16 , pp. 237-242
    • Cook, G.P.1    Tomlinson, I.M.2
  • 10
    • 0031775443 scopus 로고    scopus 로고
    • The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus
    • Matsuda F, Ishii K, Bourvagnet P, et al. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. J Exp Med. 1998;188:2151-2162.
    • (1998) J Exp Med , vol.188 , pp. 2151-2162
    • Matsuda, F.1    Ishii, K.2    Bourvagnet, P.3
  • 11
    • 0031586221 scopus 로고    scopus 로고
    • Sequence of the human immunoglobulin diversity (D) segment locus: A systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination
    • Corbett SJ, Tomlinson IM, Sonnhammer EL, Buck D, Winter G. Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination. J Mol Biol. 1997;270:587-597.
    • (1997) J Mol Biol , vol.270 , pp. 587-597
    • Corbett, S.J.1    Tomlinson, I.M.2    Sonnhammer, E.L.3    Buck, D.4    Winter, G.5
  • 12
    • 0026099589 scopus 로고
    • Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes
    • Yamada M, Wasserman R, Reichard BA, Shane S, Caton AJ, Rovera G. Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes. J Exp Med. 1991;173:395-407.
    • (1991) J Exp Med , vol.173 , pp. 395-407
    • Yamada, M.1    Wasserman, R.2    Reichard, B.A.3    Shane, S.4    Caton, A.J.5    Rovera, G.6
  • 13
    • 0029164605 scopus 로고
    • Extensive allelic sequence variation in the J region of the human immunoglobulin heavy chain gene locus
    • Mattila PS, Schugk J, Wu H, Makela O. Extensive allelic sequence variation in the J region of the human immunoglobulin heavy chain gene locus. Eur J Immunol. 1995;25:2578-2582.
    • (1995) Eur J Immunol , vol.25 , pp. 2578-2582
    • Mattila, P.S.1    Schugk, J.2    Wu, H.3    Makela, O.4
  • 14
    • 0026552320 scopus 로고
    • Characterization of the immunoglobulin heavy chain complementarity determining region (CDR)-III sequences from human B cell precursor acute lymphoblastic leukemia cells
    • Kiyoi H, Naoe T, Horibe K, Ohno R. Characterization of the immunoglobulin heavy chain complementarity determining region (CDR)-III sequences from human B cell precursor acute lymphoblastic leukemia cells. J Clin Invest. 1992;89:739-746.
    • (1992) J Clin Invest , vol.89 , pp. 739-746
    • Kiyoi, H.1    Naoe, T.2    Horibe, K.3    Ohno, R.4
  • 15
    • 0028100367 scopus 로고
    • Distinctive features of immunoglobulin heavy chain variable region gene rearrangement in multiple myeloma
    • Baker BW, Deane M, Gilleece MH, Johnston D, Scarffe JH, Norton JD. Distinctive features of immunoglobulin heavy chain variable region gene rearrangement in multiple myeloma. Leuk Lymphoma. 1994;14:291-301.
    • (1994) Leuk Lymphoma , vol.14 , pp. 291-301
    • Baker, B.W.1    Deane, M.2    Gilleece, M.H.3    Johnston, D.4    Scarffe, J.H.5    Norton, J.D.6
  • 17
    • 0033181326 scopus 로고    scopus 로고
    • Biased VH gene usage in early lineage human B cells: Evidence for preferential Ig gene rearrangement in the absence of selection
    • Rao SP, Riggs JM, Friedman DF, Scully MS, Le-Bien TW, Silberstein LE. Biased VH gene usage in early lineage human B cells: evidence for preferential Ig gene rearrangement in the absence of selection. J Immunol. 1999;163:2732-2740.
    • (1999) J Immunol , vol.163 , pp. 2732-2740
    • Rao, S.P.1    Riggs, J.M.2    Friedman, D.F.3    Scully, M.S.4    Le-Bien, T.W.5    Silberstein, L.E.6
  • 18
    • 0031570413 scopus 로고    scopus 로고
    • The human heavy chain Ig V region gene repertoire is biased at all stages of B cell ontogeny, including early pre-B cells
    • Kraj P, Rao SP, Glas AM; Hardy RR, Milner EC, Silberstein LE. The human heavy chain Ig V region gene repertoire is biased at all stages of B cell ontogeny, including early pre-B cells. J Immunol. 1997;158:5824-5832.
    • (1997) J Immunol , vol.158 , pp. 5824-5832
    • Kraj, P.1    Rao, S.P.2    Glas, A.M.3    Hardy, R.R.4    Milner, E.C.5    Silberstein, L.E.6
  • 19
    • 0031132875 scopus 로고    scopus 로고
    • V(H) repertoire maturation during B cell development in vitro: Differential selection of Ig heavy chains by fetal and adult B cell progenitors
    • Marshall AJ, Paige CJ, Wu GE. V(H) repertoire maturation during B cell development in vitro: differential selection of Ig heavy chains by fetal and adult B cell progenitors. J Immunol. 1997;158:4282-4291.
    • (1997) J Immunol , vol.158 , pp. 4282-4291
    • Marshall, A.J.1    Paige, C.J.2    Wu, G.E.3
  • 20
    • 0021951340 scopus 로고
    • Developmentally controlled expression of immunoglobulin VH genes
    • Perlmutter RM, Kearney JF, Chang SP, Hood LE. Developmentally controlled expression of immunoglobulin VH genes. Science. 1985;227:1597-1601.
    • (1985) Science , vol.227 , pp. 1597-1601
    • Perlmutter, R.M.1    Kearney, J.F.2    Chang, S.P.3    Hood, L.E.4
  • 21
    • 0025922273 scopus 로고
    • Comparison of D, JH, and junctional diversity in the fetal, adult, and aged B cell repertoires
    • Bangs LA, Sanz IE, Teale JM. Comparison of D, JH, and junctional diversity in the fetal, adult, and aged B cell repertoires. J Immunol. 1991;146:1996-2004.
    • (1991) J Immunol , vol.146 , pp. 1996-2004
    • Bangs, L.A.1    Sanz, I.E.2    Teale, J.M.3
  • 22
    • 0025027662 scopus 로고
    • Immunoglobuiin heavy chain variable region family usage is independent of tumor cell phenotype in human B lineage leukemias
    • Deane M, Norton JD. Immunoglobuiin heavy chain variable region family usage is independent of tumor cell phenotype in human B lineage leukemias. Eur J Immunol. 1990;20:2209-2217.
    • (1990) Eur J Immunol , vol.20 , pp. 2209-2217
    • Deane, M.1    Norton, J.D.2
  • 23
    • 0029664523 scopus 로고    scopus 로고
    • VH gene usage is multiple myeloma: Complete absence of the VH4.21 (VH4-34) gene
    • Rettig MB, Vescio RA, Cao J, et al. VH gene usage is multiple myeloma: complete absence of the VH4.21 (VH4-34) gene. Blood. 1996;87:2846-2852.
    • (1996) Blood , vol.87 , pp. 2846-2852
    • Rettig, M.B.1    Vescio, R.A.2    Cao, J.3
  • 24
    • 0037588965 scopus 로고    scopus 로고
    • Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphoma
    • Walsh SH, Thorselius M, Johnson A, et al. Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphoma. Blood. 2003;101:4047-4054.
    • (2003) Blood , vol.101 , pp. 4047-4054
    • Walsh, S.H.1    Thorselius, M.2    Johnson, A.3
  • 25
    • 0012605914 scopus 로고    scopus 로고
    • Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations
    • Camacho FI, Algara P, Rodriguez A, et al. Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations. Blood. 2003;101:4042-4046.
    • (2003) Blood , vol.101 , pp. 4042-4046
    • Camacho, F.I.1    Algara, P.2    Rodriguez, A.3
  • 26
    • 0033567968 scopus 로고    scopus 로고
    • Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • Damle RN, Wasil T, Fais F, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 1999;94:1840-1847.
    • (1999) Blood , vol.94 , pp. 1840-1847
    • Damle, R.N.1    Wasil, T.2    Fais, F.3
  • 27
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94:1848-1854.
    • (1999) Blood , vol.94 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3    Oscier, D.G.4    Stevenson, F.K.5
  • 28
    • 0038281374 scopus 로고    scopus 로고
    • Features of the overexpressed V1-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire
    • Potter KN, Orchard J, Critchley E, Mockridge CI, Jose A, Stevenson FK. Features of the overexpressed V1-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire. Blood. 2003;101:3082-3084.
    • (2003) Blood , vol.101 , pp. 3082-3084
    • Potter, K.N.1    Orchard, J.2    Critchley, E.3    Mockridge, C.I.4    Jose, A.5    Stevenson, F.K.6
  • 29
    • 10744230550 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: Implicating recognition of a common antigen epitope
    • Tobin G, Thunberg U, Johnson A, et al. Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope. Blood. 2003;101:4952-4957.
    • (2003) Blood , vol.101 , pp. 4952-4957
    • Tobin, G.1    Thunberg, U.2    Johnson, A.3
  • 30
    • 0025921739 scopus 로고
    • VH gene usage in humans: Biased usage of the VH6 gene in immature B lymphoid cells
    • Berman JE, Nickerson KG, Pollock RR, et al. VH gene usage in humans: biased usage of the VH6 gene in immature B lymphoid cells. Eur J Immunol. 1991;21:1311-1314.
    • (1991) Eur J Immunol , vol.21 , pp. 1311-1314
    • Berman, J.E.1    Nickerson, K.G.2    Pollock, R.R.3
  • 31
    • 0026492572 scopus 로고
    • Predominance of fetal type DJH joining in young children with B precursor lymphoblastic leukemia as evidence for an in utero transforming event
    • Wasserman R, Galili N, Ito Y, Reichard BA, Shane S, Rovera G. Predominance of fetal type DJH joining in young children with B precursor lymphoblastic leukemia as evidence for an in utero transforming event. J Exp Med. 1992;176:1577-1581.
    • (1992) J Exp Med , vol.176 , pp. 1577-1581
    • Wasserman, R.1    Galili, N.2    Ito, Y.3    Reichard, B.A.4    Shane, S.5    Rovera, G.6
  • 32
    • 0035353183 scopus 로고    scopus 로고
    • Immunoglobulin heavy-chain gene rearrangement in adult acute lymphoblastic leukemia reveals preferential usage of J(H)-proximal variable gene segments
    • Mortuza FY, Moreira IM, Papaioannou M, et al. Immunoglobulin heavy-chain gene rearrangement in adult acute lymphoblastic leukemia reveals preferential usage of J(H)-proximal variable gene segments. Blood. 2001;97:2716-2726.
    • (2001) Blood , vol.97 , pp. 2716-2726
    • Mortuza, F.Y.1    Moreira, I.M.2    Papaioannou, M.3
  • 33
    • 0028203977 scopus 로고
    • B precursor acute lymphoblastic leukemia third complementarity-determining regions predominantly represent an unbiased recombination repertoire: Leukemic transformation frequently occurs in fetal life
    • Steenbergen EJ, Verhagen OJ, van Leeuwen EF, et al. B precursor acute lymphoblastic leukemia third complementarity-determining regions predominantly represent an unbiased recombination repertoire: leukemic transformation frequently occurs in fetal life. Eur J Immunol. 1994;24:900-908.
    • (1994) Eur J Immunol , vol.24 , pp. 900-908
    • Steenbergen, E.J.1    Verhagen, O.J.2    Van Leeuwen, E.F.3
  • 34
    • 0029737426 scopus 로고    scopus 로고
    • Molecular analysis of the leukaemic B cell in adult and childhood acute lymphoblastic leukaemia
    • Coyle LA, Papaioannou M, Yaxley JC, et al. Molecular analysis of the leukaemic B cell in adult and childhood acute lymphoblastic leukaemia. Br J Haematol. 1996;94:685-693.
    • (1996) Br J Haematol , vol.94 , pp. 685-693
    • Coyle, L.A.1    Papaioannou, M.2    Yaxley, J.C.3
  • 35
    • 0025767278 scopus 로고
    • An improved method for detection of B-lymphoid clonality by polymerase chain reaction
    • Deane M, McCarthy KP, Wiedemann LM, Norton JD. An improved method for detection of B-lymphoid clonality by polymerase chain reaction. Leukemia. 1991;5:726-730.
    • (1991) Leukemia , vol.5 , pp. 726-730
    • Deane, M.1    McCarthy, K.P.2    Wiedemann, L.M.3    Norton, J.D.4
  • 36
    • 9544236183 scopus 로고    scopus 로고
    • Eradication of polymerase chain reaction-detectable chronic lymphocytic leukemia cells is associated with improved outcome after bone marrow transplantation
    • Provan D, Bartlett-Pandite L, Zwicky C, et al. Eradication of polymerase chain reaction-detectable chronic lymphocytic leukemia cells is associated with improved outcome after bone marrow transplantation. Blood. 1996;88:2228-2235.
    • (1996) Blood , vol.88 , pp. 2228-2235
    • Provan, D.1    Bartlett-Pandite, L.2    Zwicky, C.3
  • 39
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457-481.
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 40
    • 0000957062 scopus 로고
    • Asymptotically efficient rank invariance test procedures [with discussion]
    • Peto R, Peto J. Asymptotically efficient rank invariance test procedures [with discussion]. J R Stat Assoc. 1972;135:185-206.
    • (1972) J R Stat Assoc , vol.135 , pp. 185-206
    • Peto, R.1    Peto, J.2
  • 41
    • 0029956161 scopus 로고    scopus 로고
    • Lymphocytic progenitor cell origin and clonal evolution of human B-lineage acute lymphoblastic leukemia
    • Davi F, Gocke C, Smith S, Sklar J. Lymphocytic progenitor cell origin and clonal evolution of human B-lineage acute lymphoblastic leukemia. Blood. 1996;88:609-621.
    • (1996) Blood , vol.88 , pp. 609-621
    • Davi, F.1    Gocke, C.2    Smith, S.3    Sklar, J.4
  • 42
    • 0027509308 scopus 로고
    • Immunoglobulin heavy chain gene VH-D junctional diversity at diagnosis in patients with acute lymphoblastic leukemia
    • Kitchingman GR. Immunoglobulin heavy chain gene VH-D junctional diversity at diagnosis in patients with acute lymphoblastic leukemia. Blood. 1993;81:775-782.
    • (1993) Blood , vol.81 , pp. 775-782
    • Kitchingman, G.R.1
  • 43
    • 0029986332 scopus 로고    scopus 로고
    • Clonal evolution in B-lineage acute lymphoblastic leukemia by contemporaneous VH-VH gene replacements and VH-DJH gene rearrangements
    • Choi Y, Greenberg SJ, Du TL, et al. Clonal evolution in B-lineage acute lymphoblastic leukemia by contemporaneous VH-VH gene replacements and VH-DJH gene rearrangements. Blood. 1996;87:2506-2512.
    • (1996) Blood , vol.87 , pp. 2506-2512
    • Choi, Y.1    Greenberg, S.J.2    Du, T.L.3
  • 44
    • 0027313155 scopus 로고
    • Distinct ongoing Ig heavy chain rearrangement processes in childhood B-precursor acute lymphoblastic leukemia
    • Steenbergen EJ, Verhagen OJ, van Leeuwen EF, von dem Borne AE, van der Schoot CE. Distinct ongoing Ig heavy chain rearrangement processes in childhood B-precursor acute lymphoblastic leukemia. Blood. 1993;82:581-589.
    • (1993) Blood , vol.82 , pp. 581-589
    • Steenbergen, E.J.1    Verhagen, O.J.2    Van Leeuwen, E.F.3    Von Dem Borne, A.E.4    Van Der Schoot, C.E.5
  • 45
    • 0023816799 scopus 로고
    • Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements
    • Schroeder HW Jr, Walter MA, Hofker MH, et al. Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements. Proc Natl Acad Sci U S A. 1988;85:8196-8200.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 8196-8200
    • Schroeder Jr., H.W.1    Walter, M.A.2    Hofker, M.H.3
  • 46
    • 0025041887 scopus 로고
    • Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life
    • Schroeder HW Jr, Wang JY. Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life. Proc Natl Acad Sci U S A. 1990;87:6146-6150.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 6146-6150
    • Schroeder Jr., H.W.1    Wang, J.Y.2
  • 47
    • 0026558787 scopus 로고
    • Restricted utilization of germ-line VH3 genes and short diverse third complementarity-determining regions (CDR3) in human fetal B lymphocyte immunoglobulin heavy chain rearrangements
    • Raaphorst FM, Timmers E, Kenter MJ, Van Tol MJ, Vossen JM, Schuurman RK. Restricted utilization of germ-line VH3 genes and short diverse third complementarity-determining regions (CDR3) in human fetal B lymphocyte immunoglobulin heavy chain rearrangements. Eur J Immunol. 1992;22:247-251.
    • (1992) Eur J Immunol , vol.22 , pp. 247-251
    • Raaphorst, F.M.1    Timmers, E.2    Kenter, M.J.3    Van Tol, M.J.4    Vossen, J.M.5    Schuurman, R.K.6
  • 48
    • 0027491836 scopus 로고
    • Analysis of Ig H chain gene segment utilization in human fetal liver. Revisiting the "proximal utilization hypothesis"
    • Pascual V, Verkruyse L, Casey ML, Capra JD. Analysis of Ig H chain gene segment utilization in human fetal liver. Revisiting the "proximal utilization hypothesis." J Immunol. 1993;151:4164-4172.
    • (1993) J Immunol , vol.151 , pp. 4164-4172
    • Pascual, V.1    Verkruyse, L.2    Casey, M.L.3    Capra, J.D.4
  • 49
    • 0025335831 scopus 로고
    • Estimation of D segment usage in initial D to JH joinings in a murine immature B cell line. Preferential usage of DFL16.1, the most 5′ D segment and DQ52, the most JH-proximal D segment
    • Tsukada S, Sugiyama H, Oka Y, Kishimoto S. Estimation of D segment usage in initial D to JH joinings in a murine immature B cell line. Preferential usage of DFL16.1, the most 5′ D segment and DQ52, the most JH-proximal D segment. J Immunol. 1990;144:4053-4059.
    • (1990) J Immunol , vol.144 , pp. 4053-4059
    • Tsukada, S.1    Sugiyama, H.2    Oka, Y.3    Kishimoto, S.4
  • 50
    • 0026687789 scopus 로고
    • The basis for the mechanistic bias for deletional over inversional V(D)J recombination
    • Gauss GH, Lieber MR. The basis for the mechanistic bias for deletional over inversional V(D)J recombination. Genes Dev. 1992;6:1553-1561.
    • (1992) Genes Dev , vol.6 , pp. 1553-1561
    • Gauss, G.H.1    Lieber, M.R.2
  • 51
    • 0027237601 scopus 로고
    • Coding end sequence can markedly affect the initiation of V(D)J recombination
    • Gerstein RM, Lieber MR. Coding end sequence can markedly affect the initiation of V(D)J recombination. Genes Dev. 1993;7:1459-1469.
    • (1993) Genes Dev , vol.7 , pp. 1459-1469
    • Gerstein, R.M.1    Lieber, M.R.2
  • 52
    • 0029814965 scopus 로고    scopus 로고
    • DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences
    • Cuomo CA, Mundy CL, Oettinger MA. DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences. Mol Cell Biol. 1996;16:5683-5690.
    • (1996) Mol Cell Biol , vol.16 , pp. 5683-5690
    • Cuomo, C.A.1    Mundy, C.L.2    Oettinger, M.A.3
  • 53
    • 0030889121 scopus 로고    scopus 로고
    • The role of recombination signal sequences in the preferential joining by deletion in DH-JH recombination and in the ordered rearrangement of the IgH locus
    • Pan PY, Lieber MR, Teale JM. The role of recombination signal sequences in the preferential joining by deletion in DH-JH recombination and in the ordered rearrangement of the IgH locus. Int Immunol. 1997;9:515-522.
    • (1997) Int Immunol , vol.9 , pp. 515-522
    • Pan, P.Y.1    Lieber, M.R.2    Teale, J.M.3
  • 54
    • 0026612911 scopus 로고
    • The pattern of joining (JH) gene usage in the human IgH chain is established predominantly at the B precursor cell stage
    • Wasserman R, Ito Y, Galili N, et al. The pattern of joining (JH) gene usage in the human IgH chain is established predominantly at the B precursor cell stage. J Immunol. 1992;149:511-516.
    • (1992) J Immunol , vol.149 , pp. 511-516
    • Wasserman, R.1    Ito, Y.2    Galili, N.3
  • 55
    • 0035283081 scopus 로고    scopus 로고
    • The diversity of rearranged immunoglobulin heavy chain variable region genes in peripheral blood B cells of preterm infants is restricted by short third complementarity-determining regions but not by limited gene segment usage
    • Zemlin M, Bauer K, Hummel M, et al. The diversity of rearranged immunoglobulin heavy chain variable region genes in peripheral blood B cells of preterm infants is restricted by short third complementarity-determining regions but not by limited gene segment usage. Blood. 2001;97:1511-1513.
    • (2001) Blood , vol.97 , pp. 1511-1513
    • Zemlin, M.1    Bauer, K.2    Hummel, M.3
  • 56
    • 0035679747 scopus 로고    scopus 로고
    • B-cell precursors differentiated from cord blood CD34+ cells are more immature than those derived from granulocyte colony-stimulating factor-mobilized peripheral blood CD34+ cells
    • Hirose Y, Kiyoi H, Itoh K, Kato K, Saito H, Naoe T. B-cell precursors differentiated from cord blood CD34+ cells are more immature than those derived from granulocyte colony-stimulating factor-mobilized peripheral blood CD34+ cells. Immunology. 2001;104:410-417.
    • (2001) Immunology , vol.104 , pp. 410-417
    • Hirose, Y.1    Kiyoi, H.2    Itoh, K.3    Kato, K.4    Saito, H.5    Naoe, T.6
  • 57
    • 0034660137 scopus 로고    scopus 로고
    • Evidence that terminal deoxynucleotidyltransferase expression plays a role in Ig heavy chain gene segment utilization
    • Tuaillon N, Capra JD. Evidence that terminal deoxynucleotidyltransferase expression plays a role in Ig heavy chain gene segment utilization. J Immunol. 2000;164:6387-6397.
    • (2000) J Immunol , vol.164 , pp. 6387-6397
    • Tuaillon, N.1    Capra, J.D.2
  • 58
    • 0026018170 scopus 로고
    • Immunoglobulin heavy chain gene fingerprinting reveals wide-spread oligoclonality in B-lineage acute lymphoblastic leukaemia
    • Deane M, Pappas H, Norton JD. Immunoglobulin heavy chain gene fingerprinting reveals wide-spread oligoclonality in B-lineage acute lymphoblastic leukaemia. Leukemia. 1991;5:832-838.
    • (1991) Leukemia , vol.5 , pp. 832-838
    • Deane, M.1    Pappas, H.2    Norton, J.D.3
  • 59
    • 0034781581 scopus 로고    scopus 로고
    • Heterogeneity of VH-JH gene rearrangement patterns: An insight into the biology of B cell precursor ALL
    • Moreira I, Papaioannou M, Mortuza FY, et al. Heterogeneity of VH-JH gene rearrangement patterns: an insight into the biology of B cell precursor ALL. Leukemia. 2001;15:1527-1536.
    • (2001) Leukemia , vol.15 , pp. 1527-1536
    • Moreira, I.1    Papaioannou, M.2    Mortuza, F.Y.3
  • 60
    • 0022612915 scopus 로고
    • Biologic and prognostic significance of the presence of more than two mu heavy-chain genes in childhood acute lymphoblastic leukemia of B precursor cell origin
    • Kitchingman GR, Mirro J, Stass S, et al. Biologic and prognostic significance of the presence of more than two mu heavy-chain genes in childhood acute lymphoblastic leukemia of B precursor cell origin. Blood. 1986;67:698-703.
    • (1986) Blood , vol.67 , pp. 698-703
    • Kitchingman, G.R.1    Mirro, J.2    Stass, S.3
  • 61
    • 0025880325 scopus 로고
    • Multiple rearranged immunoglobulin genes in childhood acute lymphoblastic leukemia of precursor B-cell origin
    • Beishuizen A, Hahlen K, Hagemeijer A, et al. Multiple rearranged immunoglobulin genes in childhood acute lymphoblastic leukemia of precursor B-cell origin. Leukemia. 1991;5:657-667.
    • (1991) Leukemia , vol.5 , pp. 657-667
    • Beishuizen, A.1    Hahlen, K.2    Hagemeijer, A.3
  • 62
    • 0028325932 scopus 로고
    • Simultaneous immunogiobulin/T-cell receptor gene rearrangements and multiclonality in childhood acute lymphoblastic leukemia
    • Forestier E, Nordenson I, Lindstrom A, Roos G, Lindh J. Simultaneous immunogiobulin/T-cell receptor gene rearrangements and multiclonality in childhood acute lymphoblastic leukemia. Acta Paediatr. 1994;83:319-326.
    • (1994) Acta Paediatr , vol.83 , pp. 319-326
    • Forestier, E.1    Nordenson, I.2    Lindstrom, A.3    Roos, G.4    Lindh, J.5
  • 63
    • 0028960706 scopus 로고
    • Clonal diversity, measured by heterogeneity of Ig and TCR gene rearrangements, in some acute leukaemias of childhood is associated with a more aggressive disease
    • Stankovic T, Mann JR, Darbyshire PJ, Taylor AM. Clonal diversity, measured by heterogeneity of Ig and TCR gene rearrangements, in some acute leukaemias of childhood is associated with a more aggressive disease. Eur J Cancer. 1995;31A:394-401.
    • (1995) Eur J Cancer , vol.31 A , pp. 394-401
    • Stankovic, T.1    Mann, J.R.2    Darbyshire, P.J.3    Taylor, A.M.4
  • 64
    • 0032147013 scopus 로고    scopus 로고
    • Clonal diversity of Ig and T-cell-receptor gene rearrangements identifies a subset of childhood B-precursor acute lymphoblastic leukemia with increased risk of relapse
    • Green E, McConville CM, Powell JE, et al. Clonal diversity of Ig and T-cell-receptor gene rearrangements identifies a subset of childhood B-precursor acute lymphoblastic leukemia with increased risk of relapse. Blood. 1998;92:952-958.
    • (1998) Blood , vol.92 , pp. 952-958
    • Green, E.1    McConville, C.M.2    Powell, J.E.3
  • 65
    • 0037195805 scopus 로고    scopus 로고
    • Prevalent involvement of illegitimate V(D)J recombination in chromosome 9p21 deletions in lymphoid leukemia
    • Kitagawa Y, Inoue K, Sasaki S, et al. Prevalent involvement of illegitimate V(D)J recombination in chromosome 9p21 deletions in lymphoid leukemia. J Biol Chem. 2002;277:46289-46297.
    • (2002) J Biol Chem , vol.277 , pp. 46289-46297
    • Kitagawa, Y.1    Inoue, K.2    Sasaki, S.3
  • 66
    • 0029824245 scopus 로고    scopus 로고
    • Comparison of the immunoglobulin heavy-chain complementarity determining region-3 structure among the DNA sequences and the mu- and gamma-transcripts in human B-lineage cells
    • Kiyoi H, Mori H, Horibe K, Ohno R, Naoe T. Comparison of the immunoglobulin heavy-chain complementarity determining region-3 structure among the DNA sequences and the mu- and gamma-transcripts in human B-lineage cells. Immunology. 1996;89:324-330.
    • (1996) Immunology , vol.89 , pp. 324-330
    • Kiyoi, H.1    Mori, H.2    Horibe, K.3    Ohno, R.4    Naoe, T.5
  • 67
    • 0029029375 scopus 로고
    • Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire
    • Kraj P, Friedman DF, Stevenson F, Silberstein LE. Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire. J Immunol. 1995;154:6406-6420.
    • (1995) J Immunol , vol.154 , pp. 6406-6420
    • Kraj, P.1    Friedman, D.F.2    Stevenson, F.3    Silberstein, L.E.4
  • 68
    • 0026610470 scopus 로고
    • VH4-21, a human VH gene segment overrepresented in the autoimmune repertoire
    • Pascual V, Capra JD. VH4-21, a human VH gene segment overrepresented in the autoimmune repertoire. Arthritis Rheum. 1992;35:11-18.
    • (1992) Arthritis Rheum , vol.35 , pp. 11-18
    • Pascual, V.1    Capra, J.D.2
  • 69
    • 0027360335 scopus 로고
    • V gene usage by seven hybrids derived from CD5+ B-cell chronic lymphocytic leukemia and displaying autoantibody activity
    • Pritsch O, Magnac C, Dumas G, Egile C, Dighiero G. V gene usage by seven hybrids derived from CD5+ B-cell chronic lymphocytic leukemia and displaying autoantibody activity. Blood. 1993;82:3103-3112.
    • (1993) Blood , vol.82 , pp. 3103-3112
    • Pritsch, O.1    Magnac, C.2    Dumas, G.3    Egile, C.4    Dighiero, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.