The diversity of rearranged immunoglobulin heavy chain variable region genes in peripheral blood B cells of preterm infants is restricted by short third complementarity-determining regions but not by limited gene segment usage

Blood

Volumn 97, Issue 5, 2001, Pages 1511-1513

  Zemlin, Michael ^a   Bauer, Karl ^a,b   Hummel, Michael ^a   Pfeiffer, Sabine ^a   Devers, Simone ^a   Zemlin, Cosima ^a   Stein, Harald ^a   Versmold, Hans T ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; IMMUNOGLOBULIN HEAVY CHAIN;

ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; GENE LOCUS; GENE REARRANGEMENT; HUMAN; IMMUNOGLOBULIN GENE; INFANT; PERIPHERAL LYMPHOCYTE; POLYMERASE CHAIN REACTION; PREMATURITY; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

EID: 0035283081     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.5.1511     Document Type: Article

References (16)

1. Immunoglobulin V regions and the B cell
2. Maturation of the immune response in germinal centers
3. Developmental regulation of the human antibody repertoire
4. IgM heavy chain complementary determining region 3 diversity is constrained by genetic and somatic mechanisms until two months after birth
5. The VDJ repertoire expressed in human pre B cells reflects the selection of bona fide heavy chains
6. Mechanisms that generate human immunoglobulin diversity operate from the 8th week of gestation in fetal liver
7. Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells
8. Hodkin's disease with a B-cell phenotype often shows a VDJ rearrangement and somatic mutations in the VH genes
9. The human immunoglobulin VH repertoire
10. Sequence of the human immunoglobulin diversity segment locus: A systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination
11. Vh gene usage in humans: Biased usage of the Vh6 gene in immature B lymphoid cells
12. Human cord blood antibody repertoire. Mixed population of VH gene segments and CDR3 distribution in the expressed Cα and Cγ repertoires
13. Efficient immune response in mice lacking N-region diversity
14. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction