Truncated mouse adenomatous polyposis coli reduces connexin32 content and increases matrilysin secretion from Paneth cells

European Journal of Cancer

Volumn 40, Issue 10, 2004, Pages 1599-1603

  Husøy, Trine ^a   Ølstørn, Hege B ^a   Knutsen, Helle K ^a   Løberg, Else Marit ^b   Cruciani, Véronique ^c   Mikalsen, Svein Ole ^c   Goverud, Ingeborg L ^b   Alexander, Jan ^a  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^b ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Adenomatous polyposis coli; Colon cancer; Connexin; Matrilysin; Paneth cells

Indexed keywords

CONNEXIN 32; LYSOZYME; MATRILYSIN;

ADENOMA; ALLELE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; COLON POLYPOSIS; CONTROLLED STUDY; GENE MUTATION; IMMUNOHISTOCHEMISTRY; INTESTINE EPITHELIUM; INTESTINE TUMOR; MOUSE; NONHUMAN; PANETH CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; WILD TYPE;

EID: 2942577650     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2004.02.024     Document Type: Article

References (32)

1. Smith K.J., Johnson K.A., Bryan T.M., et al. The APC gene product in normal and tumor cells. Proc. Natl. Acad. Sci. USA. 90:1993;2846-2850
2. Munemitsu S., Albert I., Souza B., Rubinfeld B., Polakis P. Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc. Natl. Acad. Sci. USA. 92:1995;3046-3050
3. Huelsken J., Behrens J. The Wnt signalling pathway. J. Cell Sci. 115:2002;3977-3978
4. Min mutation have decreased gap junctional intercellular communication and connexin43 level, and reduced microtubule polymerisation. Carcinogenesis. 24:2003;643-650
5. Maretto S., Cordenonsi M., Dupont S., et al. Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc. Natl. Acad. Sci. USA. 100:2003;3299-3304
6. Zumbrunn J., Kinoshita K., Hyman A.A., Nathke I.S. Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. Curr. Biol. 11:2001;44-49
7. Su L.K., Johnson K.A., Smith K.J., Hill D.E., Vogelstein B., Kinzler K.W. Association between wild type and mutant APC gene products. Cancer Res. 53:1993;2728-2731
8. Mahmoud N.N., Bilinski R.T., Churchill M.R., Edelmann W., Kucherlapati R., Bertagnolli M.M. Genotype-phenotype correlation in murine Apc mutation: differences in enterocyte migration and response to sulindac. Cancer Res. 59:1999;353-359
9. Evans W.H., Martin P.E. Gap junctions: structure and function (Review). Mol. Membr. Biol. 19:2002;121-136
10. Trosko J.E., Ruch R.J. Cell-cell communication in carcinogenesis. Front. Biosci. 3:1998;D208-D236
11. Temme A., Buchmann A., Gabriel H.D., Nelles E., Schwarz M., Willecke K. High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32. Curr. Biol. 7:1997;713-716
12. Dubina M.V., Iatckii N.A., Popov D.E., Vasil'ev S.V., Krutovskikh V.A. Connexin 43, but not connexin 32, is mutated at advanced stages of human sporadic colon cancer. Oncogene. 21:2002;4992-4996
13. Eghbali B., Kessler J.A., Reid L.M., Roy C., Spray D.C. Involvement of gap junctions in tumorigenesis: transfection of tumor cells with connexin 32 cDNA retards growth in vivo. Proc. Natl. Acad. Sci. USA. 88:1991;10701-10705
14. Olson D.J., Christian J.L., Moon R.T. Effect of wnt-1 and related proteins on gap junctional communication in Xenopus embryos. Science. 252:1991;1173-1176
15. Ai Z., Fischer A., Spray D.C., Brown A.M., Fishman G.I. Wnt-1 regulation of connexin43 in cardiac myocytes. J. Clin. Invest. 105:2000;161-171
16. van der Heyden M.A., Rook M.B., Hermans M.M., et al. Identification of connexin43 as a functional target for Wnt signalling. J. Cell Sci. 111(Pt 12):1998;1741-1749
17. Moser A.R., Pitot H.C., Dove W.F. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science. 247:1990;322-324
18. Steffensen I.L., Paulsen J.E., Eide T.J., Alexander J. 2-Amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine increases the numbers of tumors, cystic crypts and aberrant crypt foci in multiple intestinal neoplasia mice. Carcinogenesis. 18:1997;1049-1054
19. Husøy T., Mikalsen S.O., Sanner T. Effects of five phorbol esters on gap junctional intercellular communication, morphological transformation and epidermal growth factor binding in Syrian hamster embryo cells. Carcinogenesis. 14:1993;73-77
20. Ayabe T., Satchell D.P., Wilson C.L., Parks W.C., Selsted M.E., Ouellette A.J. Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria. Nat. Immunol. 1:2000;113-118
21. Leschelle X., Robert V., Delpal S., et al. Isolation of pig colonic crypts for cytotoxic assay of luminal compounds: effects of hydrogen sulfide, ammonia, and deoxycholic acid. Cell Biol. Toxicol. 18:2002;193-203
22. Mikkelsen H.B., Huizinga J.D., Thuneberg L., Rumessen J.J. Immunohistochemical localization of a gap junction protein (connexin43) in the muscularis externa of murine, canine, and human intestine. Cell Tissue Res. 274:1993;249-256
23. Reinacher-Schick A., Gumbiner B.M. Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the β-catenin destruction complex in polarized epithelial cells. J. Cell Biol. 152:2001;491-502
24. Chanson M., Fanjul M., Bosco D., et al. Enhanced secretion of amylase from exocrine pancreas of connexin32- deficient mice. J. Cell Biol. 141:1998;1267-1275
25. Temme A., Stumpel F., Sohl G., et al. Dilated bile canaliculi and attenuated decrease of nerve-dependent bile secretion in connexin32-deficient mouse liver. Pflugers Arch. 442:2001;961-966
26. Charollais A., Gjinovci A., Huarte J., et al. Junctional communication of pancreatic β cells contributes to the control of insulin secretion and glucose tolerance. J. Clin. Invest. 106:2000;235-243
27. Wilson C.L., Heppner K.J., Labosky P.A., Hogan B.L., Matrisian L.M. Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. Proc. Natl. Acad. Sci. USA. 94:1997;1402-1407
28. Brabletz T., Jung A., Dag S., Hlubek F., Kirchner T. β-Catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am. J. Pathol. 155:1999;1033-1038
29. Paulsen J.E., Elvsaas I.K., Steffensen I.L., Alexander J. A fish oil derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl ester suppresses the formation and growth of intestinal polyps in the Min mouse. Carcinogenesis. 18:1997;1905-1910
30. Noe V., Fingleton B., Jacobs K., et al. Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1. J. Cell Sci. 114:2001;111-118
31. Davies G., Jiang W.G., Mason M.D. Matrilysin mediates extracellular cleavage of E-cadherin from prostate cancer cells: a key mechanism in hepatocyte growth factor/scatter factor-induced cell-cell dissociation and in vitro invasion. Clin. Cancer Res. 7:2001;3289-3297
32. Carothers A.M., Melstrom K.A. Jr., Mueller J.D., Weyant M.J., Bertagnolli M.M. Progressive changes in adherens junction structure during intestinal adenoma formation in Apc mutant mice. J. Biol. Chem. 276:2001;39094-39102