Enhanced secretion of amylase from exocrine pancreas of connexin32- deficient mice

Journal of Cell Biology

Volumn 141, Issue 5, 1998, Pages 1267-1275

  Chanson, Marc ^a,d   Fanjul, Marjorie ^b   Bosco, Domenico ^a   Nelles, Eric ^c   Suter, Susanne ^a   Willecke, Klaus ^c   Meda, Paolo ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b UNIVERSITÉ PAUL SABATIER   (France)

^c UNIVERSITY OF BONN   (Germany)

^d HUG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLASE; CARBACHOL; CONNEXIN 32; GAP JUNCTION PROTEIN; LUCIFER YELLOW;

ACINAR CELL; AMYLASE RELEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL COMMUNICATION; CONTROLLED STUDY; HEMOLYTIC PLAQUE ASSAY; MOUSE; MOUSE MUTANT; NONHUMAN; PANCREAS SECRETION; PRIORITY JOURNAL;

AMYLASES; ANIMALS; CELL COMMUNICATION; CONNEXINS; FEMALE; GAP JUNCTIONS; GENE DELETION; MALE; MICE; MICE, INBRED C57BL; PANCREAS;

ANIMALIA;

EID: 0032101281     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.141.5.1267     Document Type: Article

References (44)

1. Amsterdam, A., and J.D. Jamieson. 1974. Studies on dispersed pancreatic exocrine cells. II. Functional characteristics of separated cells. J. Cell Biol. 63: 1057-1073.
2. Anzini, P., D.-H. Neuberg, M. Schachner, E. Nelles, K. Willecke, J. Zielasek, K.V. Toyka, U. Suter, and R. Martini. 1997. Structural abnormalities and deficient maintenance of peripheral nerve myelin in mice lacking the gap junction protein Cx32. J. Neurosci. 17:4545-4551.
3. Barrio, L.C., T. Suchyna, T. Bargiello, L.X. Xu, R.S. Roginski, M.V.L. Bennett, and B.J. Nicholson. 1991. Gap junctions formed by connexins 26 and 32 alone and in combination are differently affected by voltage. Proc. Natl. Acad. Sci. USA. 88:8410-8414.
4. Beaudoin, A.R., A. Vachereau, and P. St-Jean. 1983. Evidence that amylase is released from two distinct pools of secretory proteins in the pancreas. Biochim. Biophys. Acta. 757:302-305.
5. Bendayan, M. 1985. Morphometrical and immunocytchemical characterization of peri-insular and tele-insular acinar cells in rat pancreas. Eur. J. Cell Biol. 36:263-268.
6. Berridge, M.J. 1997. Elementary and global aspect of calcium signaling. J. Physiol. 499:291-306.
7. Bosco, D., M. Chanson, R. Bruzzone, and P. Meda. 1988. Visualization of amylase secretion from individual pancreatic acini. Am. J. Physiol. 254:664-670.
8. Bosco, D.J.S. Soriano, M. Chanson, and P. Meda. 1994. Heterogeneity and contact-dependent regulation of amylase release by individual acinar cells. J. Cell Physiol. 160:378-388.
9. Bruzzone, R., P.A. Halban, A. Gjinovci, and E.R. Trimble. 1985. A new, rapid, method for preparation of dispersed pancreatic acini. Biochem. J. 226:621-624.
10. Bruzzone, R., E.R. Trimble, A. Gjinovci, O. Traub, K. Willecke, and P. Meda. 1987. Regulation of pancreatic exocrine function: a role for cell-to-cell communication? Pancreas. 2:262-271.
11. Bukauskas, F.F., C. Elfgang, K. Willecke, and R. Weingart. 1995. Heterotypic gap junction channels (connexin26-connexin32) violate the paradigm of unitary conductance. Pfluegers Arch. 429:870-872.
12. Burt, J.M., and D.C. Spray. 1991. Inotropic agents modulate gap junctional conductance between cardiac myocytes. Am. J. Physiol. 254:1206-1210.
13. Chanson, M., R. Bruzzone, D. Bosco, and P. Meda. 1989. Effects of n-alcohols on junctional coupling and amylase secretion of pancreatic acinar cells. J. Cell Physiol. 139:147-156.
14. Chanson, M., L. Orci, and P. Meda. 1991. Extent and modulation of junctional communication between pancreatic acinar cells in vivo. Am. J. Physiol. 261: 28-36.
15. Dermietzel, R., A. Leibstein, U. Frixen, U. Janssen-Timmen, O. Traub, and K. Willecke. 1984. Gap junctions in several tissues share antigenic determinants with liver gap junctions. EMBO (Eur. Mol. Biol. Organ.) J. 3:2261-2270.
16. Falk, M.M., N.M. Kumar, and N.G. Gilula. 1994. Membrane insertion of gap junction connexins: Polytopic channel forming membrane proteins. J. Cell Biol. 127:343-355.
17. Gardner, J.D., and M.J. Jackson. 1977. Regulation of amylase release from dispersed pancreatic acinar cells. J. Physiol. 270:439-454.
18. Hellman, B., A. Wallgren, and B. Petersson. 1962. Cytosolic characteristics of the exocrine pancreatic cells with regards to their position in relation to the islets of Langherans. Acta. Endocrinol. 39:465-473.
19. Iwatsuki, N. and O.H. Petersen. 1978. Acetylcholine-evoked electrical uncoupling and its ionic dependency. J. Physiol. 274:81-96.
20. Kwak, B.R., M.M.P. Hermans, H.R. De Jonge, S.M. Lohmann, H.J. Jongsma, and M. Chanson. 1995. Differential regulation of distinct types of gap junction channels by similar phosphorylating treatments. Mol. Biol. Cell. 6:989-1002.
21. Laing, J.G., and E.C. Beyer. 1995. The gap junction protein connexin43 is degraded via the ubiquitin proteasome pathway. J. Biol. Chem. 270:26399-26403.
22. Lampe, P. 1994. Analyzing phorbol ester effect on gap junctional communication: a dramatic inhibition of assembly. J. Cell Biol. 127:1895-1905.
23. i oscillations and enzyme secretion in pancreatic acini. J. Biol. Chem. 268:19769-19775.
24. Meda, P., R. Bruzzone, S. Knodel, and L. Orci. 1986. Blockage of cell-to-cell communication within pancreatic acini is associated with increased basal release of amylase. J. Cell Biol. 103:475-483.
25. Meda, P., R. Bruzzone, M. Chanson, D. Bosco, and L. Orci. 1987. Junctional coupling modulates secretion of exocrine pancreas. Proc. Natl. Acad. Sci. USA. 84:4901-4904.
26. Meda, P., R. Bruzzone, M. Chanson, and D. Bosco. 1988. Junctional coupling and secretion of pancreatic acinar cells. Mod. Cell Biol. 7:353-364.
27. Meda. P., M.S. Pepper, O. Traub, K. Willecke, D. Gros, E.C. Beyer, B.J. Nicholson, D. Paul, and L. Orci. 1993. Differential expression of gap junction connexins in endocrine and exocrine glands. Endocrinology. 133:2371-2378.
28. Musil, L.S., and D.A. Goodenough. 1991. Biochemical analysis of connexin43 intracellular transport, phosphorylation, and assembly into gap junctional plaques. J. Cell Biol. 115:1357-1374.
29. 2+ wave propagation in pancreatic acinar cells. J. Biol. Chem. 267:18118-18121.
30. Nelles, E., C. Bützler, D. Jung, A. Temme, H-D. Gabriel, U. Dahl, O. Traub, F. Stümpel, K. Jungermann, J. Zielasek, K.V. Toyka, R. Dermietzel, and K. Willecke. 1996. Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice. Proc. Natl. Acad. Sci. USA. 93:9565-9570.
31. Neyton, J., and A. Trautmann. 1985. Single-channel currents of an intercellular junction. Nature. 317:331-335.
32. Ngezahayo, A., and H.-A. Kolb. 1993. Gap junctional conductance tunes phase difference of cholecystokinin evoked calcium oscillations in pairs of pancreatic acinar cells. Pfluegers Arch. 422:413-415.
33. Nicholson, B.J., R. Dermietzel, D. Teplow, O. Traub, K. Willecke, and J.P. Revel. 1987. Two homologous protein components of hepatic gap junctions. Nature. 329:283-295.
34. Nishizuka, Y. 1986. Studies and perspectives of protein kinase C. Science. 233: 305-312.
35. Petersen, O.H. and N. Iwatsuki. 1979. Hormonal control of cell to cell coupling in the exocrine pancreas. In Hormone Receptors in Digestion and Nutrition. G. Rosselin, P. Fromageot, and S. Bonfils, editors. Elsevier/North Holland Biomedical Press, Amsterdam. 191-202.
36. Petersen, O.H., and N. Ueda. 1976. Pancreatic acinar cells: the role of calcium in stimulus-secretion coupling. J. Physiol. 254:583-606.
37. Rothman, S.S. 1976. Independent secretion of different digestive enzymes by the pancreas. Am. J. Physiol. 231:1847-1851.
38. Stevensen, B.R., J.D. Siciliano, M.S. Mooseker, and D.A. Goodenough. 1986. Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J. Cell Biol. 103:755-766.
39. Temme, A., A. Buchmann, H.-D. Gabriel, E. Nelles, M. Schwarz, and K. Willecke. 1997. High incidence of spontaneous and chemically induced liver tumors in mice deficient for Cx32. Curr. Biol. 7:713-716.
40. Traub, O., J. Look, R. Dermietzel, F. Brümmer, D. Hülser, and K. Willecke. 1989. Comparative characterization of the 21-kD and 26-kD gap junction proteins in murine liver and cultured hepatocytes. J. Cell Biol. 108:1039-1051.
41. Vozzi, C., S. Ullrich, A. Charollais, J. Philippe, L. Orci, and P. Meda. 1995. Adequate connexin-mediated coupling is required for proper insulin production. J. Cell Biol. 131:1561-1572.
42. Willems, P.H.G.M., S.E. Van Emst-De-Vries, C.H Van Os, and J.J.H.H.M. De Pont. 1993. Dose-dependent recruitment of pancreatic acinar cells during receptor-mediated calcium mobilization. Cell Calcium. 14:145-159.
43. Yule, D.I., and J.A. Williams. 1994. Stimulus-secretion coupling in the pancreatic acinus. In Physiology of the Gastrointestinal Tract (3rd ed.). L.R. Johnson, editor. Raven Press, New York. 1447-1472.
44. Yule, D.I., E. Stuenkel, and J.A. Williams. 1996. Intercellular calcium waves in rat pancreatic acini: mechanism of transmission. Am. J. Physiol. 271:1285-1294.