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Volumn 59, Issue 2, 1999, Pages 353-359

Genotype-phenotype correlation in murine Apc mutation: Differences in enterocyte migration and response to sulindac

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; SULINDAC;

EID: 0033556002     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (56)

References (55)
  • 1
    • 0029047954 scopus 로고
    • Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene
    • Oshima, M., Oshima, H., Kitagawa, K., Kobayashi, M., Itakura, C., and Taketo, M. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc. Natl. Acad. Sci. USA, 92: 4482-4486, 1995.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4482-4486
    • Oshima, M.1    Oshima, H.2    Kitagawa, K.3    Kobayashi, M.4    Itakura, C.5    Taketo, M.6
  • 5
    • 0031917031 scopus 로고    scopus 로고
    • APC genotype, polyp number, and surgical options in familial adenomatous polyposis
    • Wu, J. S., Paul, P., McGannon, E. A., and Church, J. M. APC genotype, polyp number, and surgical options in familial adenomatous polyposis. Ann. Surg., 227: 57-62, 1998.
    • (1998) Ann. Surg. , vol.227 , pp. 57-62
    • Wu, J.S.1    Paul, P.2    McGannon, E.A.3    Church, J.M.4
  • 6
    • 0026651826 scopus 로고
    • Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients
    • Nagase, H., Miyoshi, Y., Horii, A., Aoki, T., Ogawa, M., Utsunomiya, J., Baba, S., Sasazuki, T., and Nakamura, Y. Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients. Cancer Res., 52, 4055-4057, 1992.
    • (1992) Cancer Res. , vol.52 , pp. 4055-4057
    • Nagase, H.1    Miyoshi, Y.2    Horii, A.3    Aoki, T.4    Ogawa, M.5    Utsunomiya, J.6    Baba, S.7    Sasazuki, T.8    Nakamura, Y.9
  • 9
    • 19144362716 scopus 로고    scopus 로고
    • Correlation between the development of extracolonic manifestations in FAP patients and mutations beyond codon 1403 in the APC gene
    • Dobbie, Z., Spycher, M., Mary, J. L., Haner, M., Guldenschuh, I., Hurliman, R., Amman, R., Roth, J., Muller, H., and Scott, R. J. Correlation between the development of extracolonic manifestations in FAP patients and mutations beyond codon 1403 in the APC gene. J. Med. Genet., 33: 274-280, 1996.
    • (1996) J. Med. Genet. , vol.33 , pp. 274-280
    • Dobbie, Z.1    Spycher, M.2    Mary, J.L.3    Haner, M.4    Guldenschuh, I.5    Hurliman, R.6    Amman, R.7    Roth, J.8    Muller, H.9    Scott, R.J.10
  • 12
    • 0026562404 scopus 로고
    • Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
    • Washington DC
    • Su, L-K., Kinzler, K., Vogelstein, B., Preisinger, A. C., Moser, A. R., Luongo, C., Gould, K., and Dove, W. F. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science (Washington DC), 256: 668-670, 1992.
    • (1992) Science , vol.256 , pp. 668-670
    • Su, L.-K.1    Kinzler, K.2    Vogelstein, B.3    Preisinger, A.C.4    Moser, A.R.5    Luongo, C.6    Gould, K.7    Dove, W.F.8
  • 13
  • 15
    • 0028987249 scopus 로고
    • Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
    • Munemitsu, A., Albert, I., Souza, B., Rubinfeld, B., and Polakis, P. Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc. Natl. Acad. Sci. USA, 92: 3046-3050, 1995.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3046-3050
    • Munemitsu, A.1    Albert, I.2    Souza, B.3    Rubinfeld, B.4    Polakis, P.5
  • 16
    • 0029982877 scopus 로고    scopus 로고
    • The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration
    • Näthke, I. S., Adams, C. L., Polakis, P., Sellin, J. H., and Nelson, W. J. The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. J. Cell. Biol., 134: 165-179, 1996.
    • (1996) J. Cell. Biol. , vol.134 , pp. 165-179
    • Näthke, I.S.1    Adams, C.L.2    Polakis, P.3    Sellin, J.H.4    Nelson, W.J.5
  • 17
    • 0029835278 scopus 로고    scopus 로고
    • Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium
    • Wong, M. H., Hermiston, M. L., Syder, A. J., and Gordon, J. I. Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium. Proc. Natl. Acad. Sci. USA, 93: 9588-9593, 1996.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9588-9593
    • Wong, M.H.1    Hermiston, M.L.2    Syder, A.J.3    Gordon, J.I.4
  • 18
    • 0027938331 scopus 로고
    • Loss of APC+ in intestinal adenomas from Min mice
    • Luongo, C., Moser, A. R., Gledhill, S., and Dove, W. F. Loss of APC+ in intestinal adenomas from Min mice. Cancer Res., 54: 5947-5952, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 5947-5952
    • Luongo, C.1    Moser, A.R.2    Gledhill, S.3    Dove, W.F.4
  • 20
    • 0031823483 scopus 로고    scopus 로고
    • The sulfide metabolize of sulindac prevents tumors and restores enterocyte apoptosis in a murine model of familial adenomatous polyposis
    • Lond.
    • Mahmoud, N. N., Boolbol, S. K., Dannenberg, A. J., Mestre, J. R., Bilinski, R. T., Newmark, H. L., Chadburn, A., and Bertagnolli, M. M. The sulfide metabolize of sulindac prevents tumors and restores enterocyte apoptosis in a murine model of familial adenomatous polyposis. Carcinogenesis (Lond.), 19: 87-91, 1998.
    • (1998) Carcinogenesis , vol.19 , pp. 87-91
    • Mahmoud, N.N.1    Boolbol, S.K.2    Dannenberg, A.J.3    Mestre, J.R.4    Bilinski, R.T.5    Newmark, H.L.6    Chadburn, A.7    Bertagnolli, M.M.8
  • 21
    • 0020565187 scopus 로고
    • Sulindac for polyposis of the colon
    • Waddell, W. R., and Loughry, R. W. Sulindac for polyposis of the colon. J. Surg. Oncol., 24: 83-87, 1983.
    • (1983) J. Surg. Oncol. , vol.24 , pp. 83-87
    • Waddell, W.R.1    Loughry, R.W.2
  • 24
    • 0029664368 scopus 로고    scopus 로고
    • Binding of GSK3β to the APC-β-catenin complex and regulation of complex assembly
    • Washington DC
    • Rubinfeld, B., Albert, I., Porfiri, E., Fiol, C., Munemitsu, S., and Polakis, P. Binding of GSK3β to the APC-β-catenin complex and regulation of complex assembly. Science (Washington DC), 272: 1023-1026, 1996.
    • (1996) Science , vol.272 , pp. 1023-1026
    • Rubinfeld, B.1    Albert, I.2    Porfiri, E.3    Fiol, C.4    Munemitsu, S.5    Polakis, P.6
  • 25
    • 0031984227 scopus 로고    scopus 로고
    • β-Catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors
    • Takahashi, M., Fukuda, K., Sugimura, T., and Wakabayashi, K. β-Catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors. Cancer Res., 58: 42-46, 1998.
    • (1998) Cancer Res. , vol.58 , pp. 42-46
    • Takahashi, M.1    Fukuda, K.2    Sugimura, T.3    Wakabayashi, K.4
  • 26
    • 0030949463 scopus 로고    scopus 로고
    • Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
    • Washington DC
    • Morin, P. J., Sparks, A. B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B. and Kinzler, K. W. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science (Washington DC), 275: 1787-1790, 1997.
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Clevers, H.5    Vogelstein, B.6    Kinzler, K.W.7
  • 27
    • 0029964851 scopus 로고    scopus 로고
    • Signal transduction through β-catenin and specification of cell fate during embryogenesis
    • Miller, J. R., and Moon, R. T. Signal transduction through β-catenin and specification of cell fate during embryogenesis. Genes Dev., 10: 2527-2539, 1996.
    • (1996) Genes Dev. , vol.10 , pp. 2527-2539
    • Miller, J.R.1    Moon, R.T.2
  • 28
    • 0030975671 scopus 로고    scopus 로고
    • Constitutive transcriptional activation by a β-catenin-Tcf complex in APC / colon carcinoma
    • Washington DC
    • Kurinek, V., Barker, N., Morin, P. J., van Wichen, D., de Weger, R., Kinzler, K W., Vogelstein, B., and Clevers, H. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC / colon carcinoma. Science (Washington DC), 275: 1784-1787, 1997.
    • (1997) Science , vol.275 , pp. 1784-1787
    • Kurinek, V.1    Barker, N.2    Morin, P.J.3    Van Wichen, D.4    De Weger, R.5    Kinzler, K.W.6    Vogelstein, B.7    Clevers, H.8
  • 29
    • 0030944065 scopus 로고    scopus 로고
    • β-Catenin as oncogene: The smoking gun
    • Washington DC
    • Peifer, M. β-Catenin as oncogene: the smoking gun. Science (Washington DC), 275: 1752-1753, 1997.
    • (1997) Science , vol.275 , pp. 1752-1753
    • Peifer, M.1
  • 33
    • 0028266975 scopus 로고
    • A repeating amino acid motif shared by proteins with diverse cellular roles
    • Peifer, M., Berg, S., Reynolds, A. D. A repeating amino acid motif shared by proteins with diverse cellular roles. Cell, 76: 789-791, 1994.
    • (1994) Cell , vol.76 , pp. 789-791
    • Peifer, M.1    Berg, S.2    Reynolds, A.D.3
  • 34
    • 0028957642 scopus 로고
    • Mutations in the APC gene and their implications for protein structure and funtion
    • Polakis, P. Mutations in the APC gene and their implications for protein structure and funtion. Curr. Opin. Genet. Dev., 5: 66-71, 1995.
    • (1995) Curr. Opin. Genet. Dev. , vol.5 , pp. 66-71
    • Polakis, P.1
  • 36
    • 0027756014 scopus 로고
    • Association of the APC tumor suppressor protein with catenins
    • Washington DC
    • Su, L-K., Vogelstein, B., and Kinzler K. W. Association of the APC tumor suppressor protein with catenins. Science (Washington DC), 262: 1734-1737, 1993.
    • (1993) Science , vol.262 , pp. 1734-1737
    • Su, L.-K.1    Vogelstein, B.2    Kinzler, K.W.3
  • 38
    • 0028085264 scopus 로고
    • Regionally clustered APC mutations are associated with a severe phenotype and occur at a high frequency in new mutation cases of adenomatous polyposis coli
    • Gayther, S., Wells, D., SenGupta, S. B., Chapman, P., Neale, K., Tsioupra, K., and Delhanty, J. D. A. Regionally clustered APC mutations are associated with a severe phenotype and occur at a high frequency in new mutation cases of adenomatous polyposis coli. Hum. Mol. Genet., 3: 53-56, 1994.
    • (1994) Hum. Mol. Genet. , vol.3 , pp. 53-56
    • Gayther, S.1    Wells, D.2    SenGupta, S.B.3    Chapman, P.4    Neale, K.5    Tsioupra, K.6    Delhanty, J.D.A.7
  • 39
    • 0030871048 scopus 로고    scopus 로고
    • Loss of β-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene
    • Rubinfeld, B., Albert, I., Porfiri, E., Munemitsu, S., and Polakis, P. Loss of β-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene. Cancer Res., 57: 4624-4630, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 4624-4630
    • Rubinfeld, B.1    Albert, I.2    Porfiri, E.3    Munemitsu, S.4    Polakis, P.5
  • 40
    • 0027930066 scopus 로고
    • The APC gene product associates with microtubules in vivo and promotes their assembly in vitro
    • Munemitsu, S., Souza, B., Muller, O., Albert, I., Rubinfeld, B., and Polakis, P The APC gene product associates with microtubules in vivo and promotes their assembly in vitro. Cancer Res., 54: 3676-3681, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 3676-3681
    • Munemitsu, S.1    Souza, B.2    Muller, O.3    Albert, I.4    Rubinfeld, B.5    Polakis, P.6
  • 44
    • 6844252957 scopus 로고    scopus 로고
    • Germline mutations in the 3′ part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli
    • van der Luijt, R. B., Meera Khan, P., Vasen, H. F. A., Breukel, C., Tops, C. M. J., Scott, R. J., and Fodde, R. Germline mutations in the 3′ part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli. Hum. Genet., 98: 727-734, 1996.
    • (1996) Hum. Genet. , vol.98 , pp. 727-734
    • Van Der Luijt, R.B.1    Meera Khan, P.2    Vasen, H.F.A.3    Breukel, C.4    Tops, C.M.J.5    Scott, R.J.6    Fodde, R.7
  • 45
    • 0029897836 scopus 로고    scopus 로고
    • Attenuated familial adenomatous polyposis due to a mutation in the 3′ part of the APC gene. A clue for the understanding of the APC gene
    • Friedl, W., Meuschel, S., Caspari, R., Lamberti, C., Krieger, S., Sengteller, M., and Propping, P. Attenuated familial adenomatous polyposis due to a mutation in the 3′ part of the APC gene. A clue for the understanding of the APC gene. Hum. Genet., 97: 579-584, 1996.
    • (1996) Hum. Genet. , vol.97 , pp. 579-584
    • Friedl, W.1    Meuschel, S.2    Caspari, R.3    Lamberti, C.4    Krieger, S.5    Sengteller, M.6    Propping, P.7
  • 48
    • 0028813830 scopus 로고
    • Rectal cancer after prolonged sulindac chemoprevention
    • Phila.
    • Lynch, H. T., Thorson, A. G., and Smyrk, T. Rectal cancer after prolonged sulindac chemoprevention. Cancer (Phila.), 75: 936-938, 1995.
    • (1995) Cancer , vol.75 , pp. 936-938
    • Lynch, H.T.1    Thorson, A.G.2    Smyrk, T.3
  • 49
    • 0028063882 scopus 로고
    • Rectal cancer in FAP patient after sulindac
    • Thorson, A. G., Lynch, H. T., and Smyrk, T. C. Rectal cancer in FAP patient after sulindac. Lancet, 343: 180, 1994.
    • (1994) Lancet , vol.343 , pp. 180
    • Thorson, A.G.1    Lynch, H.T.2    Smyrk, T.C.3
  • 50
    • 0028000576 scopus 로고
    • Adenocarcinoma in the rectal segment in familial polyposis coli is not prevented by sulindac therapy
    • Niv, Y., and Fraser, G. M. Adenocarcinoma in the rectal segment in familial polyposis coli is not prevented by sulindac therapy. Gastroenterology, 107: 854-857, 1994.
    • (1994) Gastroenterology , vol.107 , pp. 854-857
    • Niv, Y.1    Fraser, G.M.2
  • 54
    • 0029115954 scopus 로고
    • Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence and induces apoptosis in HT-29 colon adenocarcinoma cells
    • Shiff, S. J., Qiao, L., Tsai, L., and Rigas, B. Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence and induces apoptosis in HT-29 colon adenocarcinoma cells. J. Clin. Investig., 96: 491-503, 1995.
    • (1995) J. Clin. Investig. , vol.96 , pp. 491-503
    • Shiff, S.J.1    Qiao, L.2    Tsai, L.3    Rigas, B.4
  • 55
    • 0028803728 scopus 로고
    • Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
    • Tsujii, M., and DuBois, R. N. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell, 83: 493-501, 1995.
    • (1995) Cell , vol.83 , pp. 493-501
    • Tsujii, M.1    DuBois, R.N.2


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