On the relevance of TCR rearrangement circles as molecular markers for thymic output during experimental graft-versus-host disease

Journal of Immunology

Volumn 172, Issue 12, 2004, Pages 7359-7367

  Krenger, Werner ^a,b   Schmidlin, Heike ^a   Cavadini, Gionata ^a   Holländer, Georg A ^a  

^a UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; T LYMPHOCYTE RECEPTOR;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL DIVISION; FEMALE; FLOW CYTOMETRY; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SPLEEN; T LYMPHOCYTE; THYMUS;

EID: 2942538082     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.12.7359     Document Type: Article

References (55)

1. Mackall, C. L., and R. E. Gress. 1997. Pathways of T-cell regeneration in mice and humans: implications for bone marrow transplantation and immunotherapy. Immunol. Rev. 157:61.
2. Haynes, B. F., M. L. Markert, G. D. Sempowski, D. D. Patel, and L. P. Hale. 2000. The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu. Rev. Immunol. 18:529.
3. Hakim, F. T., and R. E. Gress. 2002. Reconstitution of thymic function after stem cell transplantation in humans. Curr. Opin. Hematol. 9:490.
4. Douek, D. C., R. A. Vescio, M. R. Betts, J. M. Brenchley, B. J. Hill, L. Zhang, J. R. Berenson, R. H. Collins, and R. A. Koup. 2000. Assessment of thymic output in adults after hematopoietic stem cell transplantation and prediction of T-cell reconstitution. Lancet 355:1875.
5. Patel, D. D., M. E. Gooding, R. E. Parrott, K. M. Curtis, B. F. Haynes, and R. H. Buckley. 2000. Thymic function after hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency. N. Engl. J. Med. 342:1325.
6. Dumont-Girard, F., E. Roux, R. A. van Lier, G. Hale, C. Helg, B. Chapuis, M. Starobinski, and E. Roosnek. 1998. Reconstitution of the T-cell compartment after bone marrow transplantation: restoration of the repertoire by thymic emigrants. Blood 92:4464.
7. Roux, E., F. Dumont-Girard, M. Starobinski, C. A. Siegrist, C. Helg, B. Chapuis, and E. Roosnek. 2000. Recovery of immune reactivity after T-cell-depleted bone marrow transplantation depends on thymic activity. Blood 96:2299.
8. Weinberg, K., B. R. Blazar, J. E. Wagner, E. Agura, B. J. Hill, M. Smogorzewska, R. A. Koup, M. R. Betts. R. H. Collins, and D. C. Douek. 2001. Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation. Blood 97:1458.
9. Storek, J., A. Joseph, M. A. Dawson, D. Douek, B. Storer, and D. G. Maloney. 2002. Factors influencing T-lymphopoiesis after allogeneic hematopoietic stem cell transplantation. Transplantation 73:1154.
10. Hazenberg, M. D., S. A. Otto, E. S. de Pauw, H. Roelofs, W. E. Fibbe, D. Hamann, and F. Miedema. 2002. T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events. Blood 99:3449.
11. Blazar, B. R., R. Komgold, and D. Vallera. 1997. Recent advances in graft-versus-host disease (GVHD) prevention. Immunol. Rev. 157:79.
12. Krenger, W., G. R. Hill, and J. L. M. Ferrara. 1997. Cytokine cascades in acute graft-versus-host disease. Transplantation 64:553.
13. Hakim, F. T., and C. L. Mackall. 1997. The immune system: effector and target of graft-versus-host disease. In Graft-vs-Host Disease. J. L. M. Ferrara, H. J. Deeg, and S. J. Burakoff, eds. Marcel Dekker, New York, p. 257.
14. Dulude, G., D. C. Roy, and C. Perreault. 1999. The effect of graft-versus-host disease on T cell production and homeostasis. J. Exp. Med. 189:1329.
15. Ghayur, T., T. Seemayer, and W. S. Lapp. 1990. Histologic correlates of immune functional deficits in graft-vs-host disease. In Graft-vs.-Host Disease: Immunology, Pathophysiology, and Treatment. S. J. Burakoff, H. J. Deeg, J. Ferrara, and K. Atkinson, eds. Marcel Dekker, New York, p. 109.
16. Holländer, G. A., B. Widmer, and S. J. Burakoff. 1994. Loss of normal thymic repertoire selection and persistence of autoreactive T cells in graft vs. host disease. J. Immunol. 152:1609.
17. Van den Brink, M. R., E. Moore, J. L. Ferrara, and S. J. Burakoff. 2000. Graft-versus-host-disease-associated thymic damage results in the appearance of T cell clones with anti-host reactivity. Transplantation 69:446.
18. Krenger, W., S. Rossi, L. Piali, and G. A. Holländer. 2000. Thymic atrophy in murine acute graft-versus-host disease is affected by impaired cell cycle progression of host pro- and pre-T cells. Blood 96:347.
19. Krenger, W., S. Rossi, and G. A. Holländer. 2000. Apoptosis of thymocytes during acute graft-versus-host disease is independent of glucocorticoids. Transplantation 69:2190.
20. Rossi, S., B. R. Blazar, C. L. Farrell, D. M. Danilenko, D. L. Lacey, K. Weinberg, W. Krenger, and G. A. Holländer. 2002. Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease. Blood 100:682.
21. Van Ewijk, W., B. Wang, G. Holländer, H. Kawamoto, E. Spanopoulou, M. Itoi, T. Amagai, Y. F. Jiang, W. T. Germeraad, W. F. Chen, and Y. Katsura. 1999. Thymic microenvironments, 3-D versus 2-D? Semin. Immunol. 11:57.
22. Douek, D. C., R. D. McFarland, P. H. Keiser, E. A. Gage, J. M. Massey, B. F. Haynes, M. A. Polis, A. T. Haase, M. B. Feinberg, J. L. Sullivan, et al. 1998. Changes in thymic function with age and during the treatment of HIV infection. Nature 396:690.
23. Hochberg, E. P., A. C. Chillemi, and C. J. Wu. 2001. Quantitation of T-cell neogenesis in vivo after allogeneic bone marrow transplantation. Blood 98:1116.
24. Lewin, S. R., G. Heller, L. Zhang, E. Rodrigues, E. Skulsky, M. R. van den Brink, T. N. Small, N. A. Kernan, R. J. O'Reilly, D. D. Ho, and J. W. Young. 2002. Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantation. Blood 100:2235.
25. Markert, M. L., C. B. Hicks, J. A. Bartlett, J. L. Harmon, L. P. Hale, M. L. Greenberg, G. Ferrari, J. Ottinger, A. Boeck, A. L. Kloster, et al. 2000. Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection. AIDS Res. Hum. Retroviruses 16:403.
26. Ye, P., and D. E. Kirschner. 2002. Reevaluation of T cell receptor excision circles as a measure of human recent thymic emigrants. J. Immunol. 169:4968.
27. Svaldi, M., A. J. Lanthaler, M. Dugas, P. Lohse, N. Pescosta, C. Straka, and M. Mitterer. 2003. T-cell receptor excision circles: a novel prognostic parameter for the outcome of transplantation in multiple myeloma patients. Br. J. Haematol. 122:795.
28. Hockett, R. D., G. Nunez, and S. J. Korsmeyer. 1989. Evolutionary comparison in murine and human δ T-cell receptor deleting elements. New Biol. 1:266.
29. Verschuren, M. C., I. L. Wolvers-Tettero, T. M. Breit, J. Noordzij, E. R. van Wering, and J. J. van Dongen. 1997. Preferential rearrangements of the T cell receptor-δ-deleting elements in human T cells. J. Immunol. 158:1208.
30. Poulin, J. F., M. Sylvestre, P. Champagne, M. L. Dion, N. Kettaf, A. Dumont, M. Lainesse, P. Fontaine, D. C. Roy, C. Perreault, et al. 2003. Evidence for adequate thymic function but impaired naive T-cell survival following allogeneic hematopoietic stem cell transplantation in the absence of chronic graft-versus-host disease. Blood 102:4600.
31. Talvensaari, K., E. Clave, C. Douay, C. Rabian, L. Garderet, M. Busson, F. Garnier, D. Douek, E. Gluckman, D. Charron, and A. Toubert. 2002. A broad T-cell repertoire diversity and an efficient thymic function indicate a favorable long-term immune reconstitution after cord blood stem cell transplantation. Blood 99:1458.
32. Fallen, P. R., L. McGreavey, J. A. Madrigal, M. Potter, M. Ethell, H. G. Prentice, A. Guimaraes, and P. J. Travers. 2003. Factors affecting reconstitution of the T-cell compartment in allogeneic hematopoietic cell transplant recipients. Bone Marrow Transplant. 32:1001.
33. Storek, J., A. Joseph, G. Espino, M. A. Dawson, D. C. Douek, K. M. Sullivan, M. E. Flowers, P. Martin, G. Mathioudakis, R. A. Nash, et al. 2001. Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation. Blood 98:3505.
34. Bahceci, E., D. Epperson, D. C. Douek, J. J. Melenhorst, R. C. Childs, and A. J. Barrett. 2003. Early reconstitution of the T-cell repertoire after non-myeloablative peripheral blood stem cell transplantation is from post-thymic T-cell expansion and is unaffected by graft-versus-host disease or mixed chimerism. Br. J. Haematol. 122:934.
35. Hazenberg, M. D., M. C. Verschuren, D. Hamann, F. Miedema, and J. J. van Dongen. 2001. T cell receptor excision circles as markers for recent thymic emigrants: basic aspects, technical approach, and guidelines for interpretation. J. Mol. Med. 79:631.
36. Hazenberg, M. D., J. A. Borghans, R. J. de Boer, and F. Miedema. 2003. Thymic output: a bad TREC record. Nat. Immunol. 4:97.
37. Dutilh, B. E., and R. J. De Boer. 2003. Decline in excision circles requires homeostatic renewal or homeostatic death of naive T cells. J. Theor. Biol. 224:351.
38. Itano, A., and E. Robey. 2000. Highly efficient selection of CD4 and CD8 lineage thymocytes supports an instructive model of lineage commitment. Immunity 12:383.
39. Penit, C., and F. Vasseur. 1997. Expansion of mature thymocyte subsets before emigration to the periphery. J. Immunol. 159:4848.
40. Penit, C., and F. Vasseur. 1993. Phenotype analysis of cycling and postcycling thymocytes: evaluation of detection methods for BrdUrd and surface proteins. Cytometry 14:757.
41. Sempowski, G. D., M. E. Gooding, H. X. Liao, P. T. Le, and B. F. Haynes. 2001. T cell receptor excision circle assessment of thymopoiesis in aging mice. Mol. Immunol. 38:841.
42. Broers, A. E. C., S. J. Posthumus, H. Spits, B. Löwenberg, E. Braakman, and J. J. Cornelissen. 2003. Interleukin-7 improves T-cell recovery after experimental T-cell depleted bone marrow transplantation by thymopoiesis and strong expansion of recent thymic emigrants. Blood 102:1534.
43. Speck, N. A. 2001. Core binding factor and its role in normal hematopoietic development. Curr. Opin. Hematol. 8:192.
44. Von Boehmer, H. I. Aifantis, J. Feinberg, O. Lechner, C. Saint-Ruf, U. Walter, J. Buer, and O. Azogui. 1999. Pleiotropic changes controlled by the pre-T-cell receptor. Curr. Opin. Immunol. 11:135.
45. Berzins, S. P., R. L. Boyd, and J. F. Miller. 1998. The role of the thymus and recent thymic migrants in the maintenance of the adult peripheral lymphocyte pool. J. Exp. Med. 187:1839.
46. Berzins, S. P., D. I. Godfrey, J. F. Miller, and R. L. Boyd. 1999. A central role for thymic emigrants in peripheral T cell homeostasis. Proc. Natl. Acad. Sci. USA 96:9787.
47. Holländer, G. A. 1997. Thymic T-cell development. In Graft-versus-Host Disease, 2nd ed. J. L. M. Ferrara, H. L. Deeg, and S. J. Burkoff, eds. Marcel Dekker, New York, p. 1.
48. Gerdes, J., H. Lemke, H. Baisch, H. H. Wacker, U. Schwab, and H. Stein. 1984. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J. Immunol. 133:1710.
49. Carcelain, G., P. Saint-Mezard, H. Altes, R. Tubiana, P. Grenot, C. Rabian, R. DeBoer, D. Costagliola, C. Katlama, P. Debre, and B. Autran. 2003. IL-2 therapy and thymic production of naive CD4 T cells in HIV-infected patients with severe CD4 lymphopenia. AIDS 17:841.
50. Lewin, S. R., R. M. Ribeiro, G. R. Kaufmann, D. R. Smith, J. Zaunders, M. Law, A. Solomon, P. U. Cameron, D. Cooper, and A. S. Perelson. 2002. Dynamics of T cells and TCR excision circles differ after treatment of acute and chronic HIV infection. J. Immunol 169:4657.
51. Douek, D. C., M. R. Betts, B. J. Hill, S. J. Little, R. Lempicki, J. A. Metcalf, J. Casazza, C. Yoder, J. W. Adelsberger, R. A. Stevens, et al. 2001. Evidence for increased T cell turnover and decreased thymic output in HIV infection. J. Immunol. 167:6663.
52. Hassan, J., and D. J. Reen. 2001. Human recent thymic emigrants: identification, expansion, and survival characteristics. J. Immunol. 167:1970.
53. Hug, A., M. Korporal, I. Schröder, J. Haas, L. Glatz, B. Storch-Hagenlocher, and B. Wildemann. 2003. Thymic export function and T-cell homeostasis in patients with relapsing remitting multiple sclerosis. J. Immunol. 171:432.
54. Aladdin, H., T. L. Katzenstein, A. M. Dreves, L. Ryder, J. Gerstoft, P. Skinhoj, B. K. Pedersen, and H. Ullum. 2003. T-cell receptor excisional circles, telomere length, proliferation and apoptosis in peripheral blood mononuclear cells of human immunodeficiency virus-infected individuals after 18 months of treatment induced viral suppression. Scand. J. Immunol. 57:485.
55. Hazenberg, M. D., S. A. Otto, J. W. Stuart, M. C. Verschuren, J. C. Borleffs, C. A. Boucher, R. A. Coutinho, J. M. Lange, T. F. de Wit, A. Tsegaye, et al. 2000. Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection. Nat. Med. 6:1036.