Expansion of Mature Thymocyte Subsets before Emigration to the Periphery

Journal of Immunology

Volumn 159, Issue 10, 1997, Pages 4848-4856

  Pénit, Claude ^a   Vasseur, Florence ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE;

ANIMAL; ARTICLE; C57BL MOUSE; CELL CYCLE; CELL DIFFERENTIATION; CELL MOTION; CYTOLOGY; FLOW CYTOMETRY; IMMUNOLOGY; KINETICS; METABOLISM; MOUSE; MOUSE MUTANT; T LYMPHOCYTE SUBPOPULATION; THYMUS;

ANIMALS; BROMODEOXYURIDINE; CELL CYCLE; CELL DIFFERENTIATION; CELL MOVEMENT; FLOW CYTOMETRY; KINETICS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; T-LYMPHOCYTE SUBSETS; THYMUS GLAND;

EID: 0031573129     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Zuniga-Pflucker, J. C., and M. J. Leonardo. 1996. Regulation of thymocyte development from immature progenitors. Curr. Opin. Immunol. 8:215.
2. Bhatia, S. K., L. T. Tygrett, K. H. Grabstein, and T. J. Waldschmidt. 1995. The effect of in vivo IL-7 deprivation on T cell maturation. J. Exp. Med. 181:1399.
3. - thymocyte differentiation. J. Immunol. 152:4783.
4. Dudley, E. R., H. T. Petrie, L. M. Shah, M. J. Owen, and A. C. Hayday. 1994. T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice. Immunity 1:83.
5. Petrie, H. T., F. Livak, D. G. Schatz, A. Strasser, N. Crispe, and K. Shortman. 1993. Multiple rearrangements in T cell receptor α chains genes maximize the production of useful thymocytes. J. Exp. Med. 178:615.
6. Lucas, B., F. Vasseur, and C. Pénit. 1993. Normal sequence of phenotypic transitions in one cohort of 5-bromo-2′-deoxyuridine-pulse-labeled thymocytes. J. Immunol. 151:4574.
7. +) thymocytes in normal and genetically modified mice. J. Immunol. 154:5103.
8. Lucas, B., F. Vasseur, and C. Pénit. 1994. Production, selection, and maturation of thymocytes with high surface density of TCR. J. Immunol. 153:53.
9. Ceredig, R. 1990. Intrathymic proliferation of perinatal mouse αα and γδ T cell receptor-expressing mature T cells. Int. Immunol. 2:859.
10. Tough, D. T., and J. Sprent. 1994. Turnover of naive- and memory-phenotype T cells. J. Exp. Med. 179:1127
11. Scollay, R., and D. I. Godfrey. 1995. Thymic emigration: conveyor belts or lucky dips? Immunol. Today 16:268,
12. Shinkai, Y., G. Rathbun, K.-P. Lam, E. M. Oltz, V. Stewart, M. Mendelsohn, J. Charron, M. Datta, F. Young, A. M. Stall, and F. W. Alt. 1992. Rag-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68:855.
13. Pénit, C., and F. Vasseur. 1993. Phenotype analysis of cycling and postcycling thymocytes: evaluation of detection methods for BrdUrd and surface proteins. Cytometry 14:757.
14. Porstmann, T., T. Ternynck, and S. Avrameas. 1985. Quantitation of bromodeoxyuridine incorporation into DNA: an enzyme immunoassay for the assessment of the lymphoid cell proliferative response. J. Immunol. Methods 82:169.
15. Pénit, C. 1986. In vivo thymocyte maturation: BUdr labeling of cycling thymocytes and phenotypic analysis of their progeny support the single lineage model. J. Immunol. 137:2115.
16. Baron, C., and C, Pénit. 1990. Study of the thymocyte cell cycle by bivariate analysis of incorporated bromodeoxyuridine and DNA content. Eur J. Immunol. 20:1231.
17. int thymocytes do not belong to the CD8 lineage maturation pathway. J. Immunol. 156:1743.
18. Pénit, C., and F. Vasseur. 1988. Sequential events in thymocyte differentiation and thymus regeneration revealed by a combination of bromodeoxyuridine DNA labeling and antimitotic drug treatment. J. Immunol. 140:3315.
19. - thymocytes: proliferation, renewal and differentiation of different cell subsets studied by DNA biosynthetic labeling and surface antigen detection. Eur. J. Immunol 18:1343.
20. Agus, D. B., C. D. Surh, and J. Sprent. 1991. Reentry of T cells to the adult thymus is restricted to activated T cells. J. Exp. Med. 173:1039.
21. Scollay, R. G., E. C. Butcher, and I. L. Weissman. 1980. Thymus cell migration: quantitative aspects of cellular traffic from the thymus to the periphery in mice. Eur. J. Immunol. 10:210.
22. Kelly, K. A., and R. Scollay. 1990. Analysis of recent thymic emigrants with subset- and maturity-related markers. Int. Immunol. 2:419.
23. Kelly, K. A., H. Pircher, H. Von Bochmer, M. M. Davis, and R. Scollay. 1993. Regulation of T cell production in T cell receptor transgenic mice. Eur. J. Immunol. 23:1922.
24. Egerton, M., R. Scollay, and K. Shonman. 1990. The kinetics of mature T cell development in the thymus. Proc. Natl. Acad. Sci. USA 87:2579.
25. Surh, C. D., and J. Sprent. 1994. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372:100.
26. Laufer, T. M., J. DeKoning, J. S. Markowitz, D. Lo, and L. H. Glimcher. 1996. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature 383:81.
27. Ernst, B., C. D. Surh, and J. Sprent. 1995. Thymic selection and cell division. J. Exp. Med. 182:961.
28. Suhr, C. D., J. Sprent, and S. Webb. 1993. Exclusion of circulating T cells from the thymus does not apply in the neonatal period. J. Exp. Med. 177:379.
29. Hilbert, D. M., K. L. Holmes, A. O. Anderson, and S. Rudikoff. 1943. Long-term thymic reconstitution by peripheral CD4 and CD8 single-positive lymphocytes. Eur. J. Immunol. 23:2-412.
30. Yagi, H., M. Matsumoto, M. Nakamura, S. Makino, R. Suzuki, M. Harada, and T. Itoh. 1996. Defect of thymocyte emigration in a T cell deficiency strain (CTS) of the mouse. J. Immunol. 157:3412.
31. Suhr, C. D., B. Ernst, and J. Sprent. 1992. Growth of epithelial cells in the thymic medulla is under the control of mature T cells. J. Exp. Med. 176:611.
32. Shores, H. W., W. Van Ewijk, and A. Singer. 1994. Maturation of medullary thymic epithelium requires thymocytes expressing fully assembled CD3-TCR complexes. Int. Immunol. 6:1393.
33. Pénit, C., B. Lucas, F. Vasseur, T. Rieker, and R. L. Boyd. 1996. Thymic medulla epithelial cells acquire specific markers by post-mitotic maturation. Dev. Immunol. 5:25.
34. Rocha, B., C. Pénit, C. Baron, F. Vasseur, N. Dautigny, and A. A. Freitas. 1990. Accumulation of bromodeoxyuridine-labeled cells in central and peripheral lymphoid organs: minimal estimates of production and turnover rates of mature lymphocytes. Eur. J. Immunol. 20:1697.
35. Modigliani, Y., G. Coutinho, O. Burlen-Defranoux, A. Coutinho, and A. Bandeira. 1994. Differential contribution of thymic outputs and peripheral expansion in the development ot peripheral T cell pools. Eur. J. Immunol. 24:1223.
36. Sprent, J., and D. F. Tough. 1994. Lymphocyte life-span and memory. Science 265:1395.
37. Ho, D. D., A. U. Neumann, A. S. Perelson, W. Chen, J. M. Leonard, and M. Markowitz. 1995. Rapid turnover of plasma virions and CD4 lymphocytes in HlV-1 infection. Nature 373:123.
38. Perelson, A. S., A. U. Neumann, M. Markowitz, J. M. Leonard, and D. D. Ho. 1996. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science 271:1582.
39. Wei, X., S. K. Ghosh, M. E. Tuylor, V. A. Johnson, E. A. Emini, P. Deutsch, J. D. Lifson, S. Bonhoeffer, M. A. Nowak, B. H. Hahn, M. S. Saag, and G. M. Shaw. 1995. Viral dynamics in human immunodeficiency virus type I infection. Nature 373:117.
40. + T cell turnover. Science 274:1543.