메뉴 건너뛰기




Volumn 57, Issue 5, 2003, Pages 485-492

T-cell receptor excisional circles, telomere length, proliferation and apoptosis in peripheral blood mononuclear cells of human immunodeficiency virus-infected individuals after 18 months of treatment induced viral suppression

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; DIDANOSINE; INDINAVIR; LAMIVUDINE; PHYTOHEMAGGLUTININ; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR; STAVUDINE; T LYMPHOCYTE RECEPTOR; ZIDOVUDINE;

EID: 0038363474     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.2003.01258.x     Document Type: Article
Times cited : (12)

References (46)
  • 1
    • 0027220174 scopus 로고
    • HIV induces thymus depletion in vivo
    • Bonyhadi ML, Rabin L, Salimi S et al. HIV induces thymus depletion in vivo. Nature 1993;363:728-32.
    • (1993) Nature , vol.363 , pp. 728-732
    • Bonyhadi, M.L.1    Rabin, L.2    Salimi, S.3
  • 2
    • 0028267677 scopus 로고
    • Turnover of naïve- and memory-phenotype T cells
    • Tough DF, Sprent J, Haynes BF et al. Turnover of naïve- and memory-phenotype T cells. J Exp Med 1994;179:1127-35.
    • (1994) J Exp Med , vol.179 , pp. 1127-1135
    • Tough, D.F.1    Sprent, J.2    Haynes, B.F.3
  • 3
    • 0032250194 scopus 로고    scopus 로고
    • The human thymus. A chimeric organ comprised of central and peripheral lymphoid components
    • Haynes BF, Hale LP, Kong F et al. The human thymus. A chimeric organ comprised of central and peripheral lymphoid components. Immunol Rev 1998;18:175-92.
    • (1998) Immunol Rev , vol.18 , pp. 175-192
    • Haynes, B.F.1    Hale, L.P.2    Kong, F.3
  • 4
    • 0023661686 scopus 로고
    • Isolation of an excision product of T-cell receptor alpha-chain gene rearrangements
    • Fujimoto S, Yamagishi H. Isolation of an excision product of T-cell receptor alpha-chain gene rearrangements. Nature 1987;327:242-3.
    • (1987) Nature , vol.327 , pp. 242-243
    • Fujimoto, S.1    Yamagishi, H.2
  • 5
    • 0023662338 scopus 로고
    • T cell receptor beta gene sequences in the circular DNA of thymocyte nuclei: Direct evidence for intramolecular DNA deletion in V-D-J joining
    • Okazaki K, Davis DD, Sakano H. T cell receptor beta gene sequences in the circular DNA of thymocyte nuclei: direct evidence for intramolecular DNA deletion in V-D-J joining. Cell 1987;49:477-85.
    • (1987) Cell , vol.49 , pp. 477-485
    • Okazaki, K.1    Davis, D.D.2    Sakano, H.3
  • 6
    • 0031885673 scopus 로고    scopus 로고
    • Thymic function can be accurately monitored by the level of recent T cell emigrants in the circulation
    • Kong F, Chen CH, Cooper MD et al. Thymic function can be accurately monitored by the level of recent T cell emigrants in the circulation. Immunity 1998;8:97-104.
    • (1998) Immunity , vol.8 , pp. 97-104
    • Kong, F.1    Chen, C.H.2    Cooper, M.D.3
  • 7
    • 0033573914 scopus 로고    scopus 로고
    • T cell receptor gene deletion circles identify recent thymic emigrants in the peripheral T cell pool
    • Kong FK, Chen CL, Six A, Hockett RD, Cooper MD. T cell receptor gene deletion circles identify recent thymic emigrants in the peripheral T cell pool. Proc Natl Acad Sci USA 1999;96:1536-40.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1536-1540
    • Kong, F.K.1    Chen, C.L.2    Six, A.3    Hockett, R.D.4    Cooper, M.D.5
  • 8
    • 0030069149 scopus 로고    scopus 로고
    • T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells
    • Livak F, Schatz DG. T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells. Mol Cell Biol 1996;16:609-18.
    • (1996) Mol Cell Biol , vol.16 , pp. 609-618
    • Livak, F.1    Schatz, D.G.2
  • 9
    • 0013462065 scopus 로고
    • A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
    • Moyzis RK, Buckingham JM, Cram LS et al. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci USA 1988;85:6622-6.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 6622-6626
    • Moyzis, R.K.1    Buckingham, J.M.2    Cram, L.S.3
  • 10
    • 0025731583 scopus 로고
    • Structure and function of telomeres
    • Blackburn EH. Structure and function of telomeres. Nature 1991;350:569-73.
    • (1991) Nature , vol.350 , pp. 569-573
    • Blackburn, E.H.1
  • 12
    • 0028850465 scopus 로고
    • Human naïve and memory T lymphocytes differ in telomeric length and replicative potential
    • Weng NP, Levine BL, June CH, Hodes RJ. Human naïve and memory T lymphocytes differ in telomeric length and replicative potential. Proc Natl Acad Sci USA 1995;92:11091-4.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11091-11094
    • Weng, N.P.1    Levine, B.L.2    June, C.H.3    Hodes, R.J.4
  • 13
    • 10544220422 scopus 로고    scopus 로고
    • T cell telomere length in HIV-1 infection: No evidence for increased CD4+ T cell turnover
    • Wolthers KC, Bea G, Wisman A et al. T cell telomere length in HIV-1 infection: no evidence for increased CD4+ T cell turnover. Science 1996;274:1543-7.
    • (1996) Science , vol.274 , pp. 1543-1547
    • Wolthers, K.C.1    Bea, G.2    Wisman, A.3
  • 14
    • 0027315279 scopus 로고
    • Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells
    • Wesselborg S, Janssen O, Kabelitz D et al. Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells. Immunol Today 1993;150:4338-45.
    • (1993) Immunol Today , vol.150 , pp. 4338-4345
    • Wesselborg, S.1    Janssen, O.2    Kabelitz, D.3
  • 17
    • 0030913366 scopus 로고    scopus 로고
    • Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
    • Chun TW, Carruth L, Finzi D et al. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 1997;387:183-8.
    • (1997) Nature , vol.387 , pp. 183-188
    • Chun, T.W.1    Carruth, L.2    Finzi, D.3
  • 18
    • 0030868897 scopus 로고    scopus 로고
    • + T cell homeostasis and function in advanced HIV disease
    • + T cell homeostasis and function in advanced HIV disease. Science 1997;277:112-6.
    • (1997) Science , vol.277 , pp. 112-116
    • Autran, B.1    Carcelain, G.2    Li, T.S.3
  • 19
    • 0033999127 scopus 로고    scopus 로고
    • Different immunologic profiles characterize HIV infection in highly active antiretroviral therapy-treated and antiretroviral-naïve patients with undetectable viraemia
    • Clerici M, Seminari E, Suter F et al. Different immunologic profiles characterize HIV infection in highly active antiretroviral therapy-treated and antiretroviral-naïve patients with undetectable viraemia. AIDS 2000;14:109-16.
    • (2000) AIDS , vol.14 , pp. 109-116
    • Clerici, M.1    Seminari, E.2    Suter, F.3
  • 20
    • 0035875871 scopus 로고    scopus 로고
    • T cell expansions in lymph nodes and peripheral blood in HIV-1-infected individuals: Effect of antiretroviral therapy
    • Kostense S, Raaphorst FM, Joling J et al. T cell expansions in lymph nodes and peripheral blood in HIV-1-infected individuals: effect of antiretroviral therapy. AIDS 2001;15:1097-107.
    • (2001) AIDS , vol.15 , pp. 1097-1107
    • Kostense, S.1    Raaphorst, F.M.2    Joling, J.3
  • 21
    • 0037268516 scopus 로고    scopus 로고
    • Virological and immunological profiles among patients with undetectable viral load followed prospectively for 24 months
    • Katzenstein TL, Ullum H, Røge BT et al. Virological and immunological profiles among patients with undetectable viral load followed prospectively for 24 months. HIV Med 2003;4:53-61.
    • (2003) HIV Med , vol.4 , pp. 53-61
    • Katzenstein, T.L.1    Ullum, H.2    Røge, B.T.3
  • 22
    • 17444372347 scopus 로고    scopus 로고
    • Changes in thymic function with age and during the treatment of HIV infection
    • Douek DC, McFarland RD, Keiser PH et al. Changes in thymic function with age and during the treatment of HIV infection. Nature 1998;396:690-5.
    • (1998) Nature , vol.396 , pp. 690-695
    • Douek, D.C.1    McFarland, R.D.2    Keiser, P.H.3
  • 23
    • 0027486732 scopus 로고
    • Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
    • Vaziri H, Schachter F, Uchida I et al. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet 1993;52:661-7.
    • (1993) Am J Hum Genet , vol.52 , pp. 661-667
    • Vaziri, H.1    Schachter, F.2    Uchida, I.3
  • 24
    • 0032858367 scopus 로고    scopus 로고
    • Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy
    • Zhang L, Lewin SR, Markowitz M et al. Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy. J Exp Med 1999;190:725-32.
    • (1999) J Exp Med , vol.190 , pp. 725-732
    • Zhang, L.1    Lewin, S.R.2    Markowitz, M.3
  • 26
    • 0034685170 scopus 로고    scopus 로고
    • Effect of recent thymic emigrants on progression of HIV-1 disease
    • Hatzakis A, Touloumi G, Karanicolas R et al. Effect of recent thymic emigrants on progression of HIV-1 disease. Lancet 2000;355:599-604.
    • (2000) Lancet , vol.355 , pp. 599-604
    • Hatzakis, A.1    Touloumi, G.2    Karanicolas, R.3
  • 27
    • 0035964724 scopus 로고    scopus 로고
    • T cell receptor excision circle (TREC) content following maximum HIV suppression is equivalent in HIV-infected and HIV-uninfected individuals
    • Steffens CM, Smith KY, Landay A et al. T cell receptor excision circle (TREC) content following maximum HIV suppression is equivalent in HIV-infected and HIV-uninfected individuals. AIDS 2001;15:1757-64.
    • (2001) AIDS , vol.15 , pp. 1757-1764
    • Steffens, C.M.1    Smith, K.Y.2    Landay, A.3
  • 28
    • 0035964691 scopus 로고    scopus 로고
    • Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function
    • Teixeira L, Valdez H, McCune JM et al. Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function. AIDS 2001;15:1749-56.
    • (2001) AIDS , vol.15 , pp. 1749-1756
    • Teixeira, L.1    Valdez, H.2    McCune, J.M.3
  • 29
    • 0035941402 scopus 로고    scopus 로고
    • T cell receptor excision circles and HIV-1 2-LTR episomal DNA to predict AIDS in patients not receiving effective therapy
    • Goedert JJ, O'Brien TR, Hatzakis A, Kostrikis LG. T cell receptor excision circles and HIV-1 2-LTR episomal DNA to predict AIDS in patients not receiving effective therapy. AIDS 2001;15:2245-50.
    • (2001) AIDS , vol.15 , pp. 2245-2250
    • Goedert, J.J.1    O'Brien, T.R.2    Hatzakis, A.3    Kostrikis, L.G.4
  • 30
    • 0036566535 scopus 로고    scopus 로고
    • T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events
    • Hazenberg MD, Otto SA, de Pauw ES et al. T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events. Blood 2002;99:3449-53.
    • (2002) Blood , vol.99 , pp. 3449-3453
    • Hazenberg, M.D.1    Otto, S.A.2    De Pauw, E.S.3
  • 31
    • 0033019850 scopus 로고    scopus 로고
    • Apoptosis and the CD95 system in HIV disease: Impact of highly active anti-retroviral therapy (HAART)
    • Gougeon ML, Lecoeur H, Sasaki Y. Apoptosis and the CD95 system in HIV disease: impact of highly active anti-retroviral therapy (HAART). Immunol Lett 1999;66:97-103.
    • (1999) Immunol Lett , vol.66 , pp. 97-103
    • Gougeon, M.L.1    Lecoeur, H.2    Sasaki, Y.3
  • 32
    • 0033537355 scopus 로고    scopus 로고
    • HIV-1 replication in patients with undetectable plasma virus receiving HAART
    • Natarajan V, Bosche M, Metcalf JA, Ward DJ, Lane C, Kovacs JA. HIV-1 replication in patients with undetectable plasma virus receiving HAART. Lancet 1999;353:119-20.
    • (1999) Lancet , vol.353 , pp. 119-120
    • Natarajan, V.1    Bosche, M.2    Metcalf, J.A.3    Ward, D.J.4    Lane, C.5    Kovacs, J.A.6
  • 33
    • 0033609374 scopus 로고    scopus 로고
    • Persistence of HIV transcription in peripheral blood mononuclear cells in patients receiving potent antiretroviral therapy
    • Furtado M, Gallaway D, Phair JP et al. Persistence of HIV transcription in peripheral blood mononuclear cells in patients receiving potent antiretroviral therapy. N Engl J Med 1999;340:1614-22.
    • (1999) N Engl J Med , vol.340 , pp. 1614-1622
    • Furtado, M.1    Gallaway, D.2    Phair, J.P.3
  • 34
    • 0021792148 scopus 로고
    • Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. Evidence for a selective defect in soluble antigen recognition
    • Lane HC, Depper JM, Greene WC, Whalen G, Waldmann TA, Fauci AS. Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. Evidence for a selective defect in soluble antigen recognition. N Engl J Med 1985;313:79-84.
    • (1985) N Engl J Med , vol.313 , pp. 79-84
    • Lane, H.C.1    Depper, J.M.2    Greene, W.C.3    Whalen, G.4    Waldmann, T.A.5    Fauci, A.S.6
  • 35
    • 0032976857 scopus 로고    scopus 로고
    • Immunological changes in human immunodeficiency virus (HIV)-infected individuals during HIV-specific protease inhibitor treatment
    • Ullum H, Katzenstein T, Aladdin H et al. Immunological changes in human immunodeficiency virus (HIV)-infected individuals during HIV-specific protease inhibitor treatment. Scand J Immunol 1999;49:539-47.
    • (1999) Scand J Immunol , vol.49 , pp. 539-547
    • Ullum, H.1    Katzenstein, T.2    Aladdin, H.3
  • 36
    • 17344365057 scopus 로고    scopus 로고
    • Immunologic responses associated with 12 weeks of combination antiretroviral therapy consisting of zidovudine, lamivudine, and ritonavir
    • Lederman MM, Connick E, Landay A et al. Immunologic responses associated with 12 weeks of combination antiretroviral therapy consisting of zidovudine, lamivudine, and ritonavir. J Infect Dis 1998;178:70-9.
    • (1998) J Infect Dis , vol.178 , pp. 70-79
    • Lederman, M.M.1    Connick, E.2    Landay, A.3
  • 37
    • 0035964725 scopus 로고    scopus 로고
    • Decreased HIV-specific CD4 T cell proliferation in long-term HIV-infected individuals on antiretroviral therapy
    • Ghanekar SA, Stranford SA, Ong JC, Walker JM, Maino VC, Levy JA. Decreased HIV-specific CD4 T cell proliferation in long-term HIV-infected individuals on antiretroviral therapy. AIDS 2001;15:1885-7.
    • (2001) AIDS , vol.15 , pp. 1885-1887
    • Ghanekar, S.A.1    Stranford, S.A.2    Ong, J.C.3    Walker, J.M.4    Maino, V.C.5    Levy, J.A.6
  • 38
    • 0032505665 scopus 로고    scopus 로고
    • Lack of T-cell proliferative response to HIV-1 antigens after 1 year of highly active antiretroviral treatment in early HIV-1 disease
    • Plana M, Garcia F, Gallart T, Miro JM, Gatell JM. Lack of T-cell proliferative response to HIV-1 antigens after 1 year of highly active antiretroviral treatment in early HIV-1 disease. Lancet 1998;352:1194-5.
    • (1998) Lancet , vol.352 , pp. 1194-1195
    • Plana, M.1    Garcia, F.2    Gallart, T.3    Miro, J.M.4    Gatell, J.M.5
  • 39
    • 0034623019 scopus 로고    scopus 로고
    • Immunological benefits of antiretroviral therapy in very early stages of asymptomatic chronic HIV-1 infection
    • Plana M, Garcia F, Gallart T et al. Immunological benefits of antiretroviral therapy in very early stages of asymptomatic chronic HIV-1 infection. AIDS 2000;14:1921-33.
    • (2000) AIDS , vol.14 , pp. 1921-1933
    • Plana, M.1    Garcia, F.2    Gallart, T.3
  • 41
    • 0033572371 scopus 로고    scopus 로고
    • Telomere loss in peripheral blood mononuclear cells may be moderately accelerated during highly active antiretroviral therapy (HAART)
    • Hotchkiss G, Pehrson PO, Larsson S, Ahrlund-Richter L, Britton S. Telomere loss in peripheral blood mononuclear cells may be moderately accelerated during highly active antiretroviral therapy (HAART). AIDS 1999;22:445-52.
    • (1999) AIDS , vol.22 , pp. 445-452
    • Hotchkiss, G.1    Pehrson, P.O.2    Larsson, S.3    Ahrlund-Richter, L.4    Britton, S.5
  • 43
    • 0035720327 scopus 로고    scopus 로고
    • T-cell mean telomere length changes in treatment naïve HIV-infected patients randomized to G-CSF or placebo simultaneously with initiation of HAART
    • Aladdin H, Von Essen M, Schjerling P et al. T-cell mean telomere length changes in treatment naïve HIV-infected patients randomized to G-CSF or placebo simultaneously with initiation of HAART. Scand J Immunol 2001;54:301-305.
    • (2001) Scand J Immunol , vol.54 , pp. 301-305
    • Aladdin, H.1    Von Essen, M.2    Schjerling, P.3
  • 44
    • 0037159921 scopus 로고    scopus 로고
    • Reconstitution of naïve T cells during antiretroviral treatment of HIV-infected adults is dependent on age
    • Cohen Stuart J, Hamann D, Borleffs J et al. Reconstitution of naïve T cells during antiretroviral treatment of HIV-infected adults is dependent on age. AIDS 2002;22:2263-6.
    • (2002) AIDS , vol.22 , pp. 2263-2266
    • Cohen Stuart, J.1    Hamann, D.2    Borleffs, J.3
  • 45
    • 0033966504 scopus 로고    scopus 로고
    • Persistence of episomal HIV-1 infection intermediates in patients on highly active antiretroviral therapy
    • Sharkey ME, Teo I, Greenough T et al. Persistence of episomal HIV-1 infection intermediates in patients on highly active antiretroviral therapy. Nat Med 2000;6:76-81.
    • (2000) Nat Med , vol.6 , pp. 76-81
    • Sharkey, M.E.1    Teo, I.2    Greenough, T.3
  • 46
    • 0036200163 scopus 로고    scopus 로고
    • Intrinsic stability of episomal circles formed during human immunodeficiency virus type 1 replication
    • Pierson TC, Kieffer TL, Ruff CT, Buck C, Gange SJ, Siliciano RF. Intrinsic stability of episomal circles formed during human immunodeficiency virus type 1 replication. J Virol 2002;76:4138-44.
    • (2002) J Virol , vol.76 , pp. 4138-4144
    • Pierson, T.C.1    Kieffer, T.L.2    Ruff, C.T.3    Buck, C.4    Gange, S.J.5    Siliciano, R.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.