Reevaluation of T cell receptor excision circles as a measure of human recent thymic emigrants

Journal of Immunology

Volumn 168, Issue 10, 2002, Pages 4968-4979

  Ye, Ping ^a   Kirschner, Denise E ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR;

AGING; ARTICLE; CELL DIVISION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KINETICS; LIFESPAN; MATHEMATICAL MODEL; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOCYTE; THYMUS;

EID: 0037093992     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.10.4968     Document Type: Article

References (60)

1. T-cell regeneration: All repertoires are not created equal
2. The involution of the ageing human thymic epithelium is independent of puberty: A morphometric study
3. Generation of functional thymocytes in the human adult
4. Direct evidence for thymic function in adult humans
5. Thymic function can be accurately monitored by the level of recent T cell emigrants in the circulation
6. The role of the thymus and recent thymic migrants in the maintenance of the adult peripheral lymphocyte pool
7. Recent thymic emigrants are distinct from most medullary thymocytes
8. Recent thymic emigrants in the rat express a unique antigenic phenotype and undergo post-thymic maturation in peripheral lymphoid tissues
9. Changes in thymic function with age and during the treatment of HIV infection
10. Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy
11. Quantification of thymic function by measuring T cell receptor excision circles within peripheral blood and lymphoid tissues in monkeys
12. Identification of a human recent thymic emigrant phenotype
13. Effect of HIV on thymic function before and after antiretroviral therapy in children
14. Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution
15. Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation
16. Effect of thymectomy on human peripheral blood T cell pools in myasthenia gravis
17. Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection
18. Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction-enzyme linked immunosorbent assay (PCR-ELISA)
19. - intermediate
20. Selective thymocyte depletion in neonatal HIV-1 thymic infection
21. Genetic control of the CD4/CD8 T-cell ratio in humans
22. The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection
23. The generation and fate of thymocytes
24. Both age and gender affect thymic output: More recent thymic migrants in females than males as they age
25. + T cell turnover in HIV-infected patients
26. Multiparametric analysis of peripheral blood in the normal pediatric population by flow cytometry
27. Age-dependent changes in T cell homeostasis and SIV load in sooty mangabeys
28. Early progression of disease in HIV-infected infants with thymus dysfunction
29. Lymphocyte subsets identified by monoclonal antibodies in healthy children
30. T-cell regeneration after bone marrow transplantation: Differential CD45 isoform expression on thymic-derived versus thymic-independent progeny
31. Age-related changes in human blood lymphocyte subpopulations. II. Varying kinetics of percentage and absolute count measurements
32. The importance of lymphocyte trafficking in regulating blood lymphocyte levels during HIV and SIV infections
33. + T cell demographics and dynamics in lymphatic tissues
34. The physiology of lymphocyte migration through the single lymph node in vivo
35. Evidence for increased T cell turnover and decreased thymic output in HIV infection
36. Sensitivity and uncertainty analysis of complex models of disease transmission: An HIV model, as an example
37. - populations suggest regulatory responses linked to loss of CD4 lymphocytes: The Multicenter AIDS Cohort Study
38. Evaluation of T cell receptor gene rearrangement excision circles after antiretroviral therapy in children infected with human immunodeficiency virus
39. HIV-1-induced thymocyte depletion is associated with indirect cytopathogenicity and infection of progenitor cells in vivo
40. The interaction of macrophage and non-macrophage tropic isolates of HIV-1 with thymic and tonsillar dendritic cells in vitro
41. Productive and persistent infection of human thymic epithelial cells in vitro with HIV-1
42. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans
43. Factors influencing T-cell turnover in HIV-1-seropositive patients
44. Normal T-cell turnover in sooty mangabeys harboring active simian immunodeficiency virus infection
45. Evaluation of thymopoiesis using T cell receptor excision circles (TRECs): Differential correlation between adult and pediatric TRECs and naive phenotypes
46. Human recent thymic emigrants: Identification, expansion, and survival characteristics
47. T cell receptor gene deletion circles identify recent thymic emigrants in the peripheral T cell pool
48. +) continuously migrate through lymphoid organs: Within the tissue they alter surface molecule expression
49. Blind T-cell homeostasis and the CD4/CD8 ratio in the thymus and peripheral blood
50. The human thymic microenvironment: New approaches to functional analysis
51. Thymic involution with ageing: Obsolescence or good housekeeping?
52. Role of the thymus in pediatric HIV-1 infection
53. Requirement of residual thymus to restore normal T-cell subsets after human allogeneic bone marrow transplantation
54. Recovery of immune reactivity after T-cell-depleted bone marrow transplantation depends on thymic activity
55. Kinetics of mature T-cell development in the thymus
56. The human thymus. A chimeric organ comprised of central and peripheral lymphoid components
57. In vivo estimates of division and death rates of human T lymphocytes