Genomics of the fungal kingdom: Insights into eukaryotic biology

Genome Research

Volumn 15, Issue 12, 2005, Pages 1620-1631

  Galagan, James E ^a   Henn, Matthew R ^a   Ma, Li Jun ^a   Cuomo, Christina A ^a   Birren, Bruce ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT;

ALTERNATIVE RNA SPLICING; ASPERGILLUS; CRYPTOCOCCUS NEOFORMANS; CYTOLOGY; DRUG TARGETING; ENVIRONMENT; EUKARYOTIC CELL; EVOLUTION; FUNGAL CELL; FUNGAL GENE; FUNGAL STRAIN; GENE SEQUENCE; GENETIC ANALYSIS; HISTORY; HUMAN; INTRON; MEDICAL INFORMATION SYSTEM; MYCOSIS; NONHUMAN; PATHOGENESIS; PHYLOGENY; PLANT DISEASE; POINT MUTATION; PREDICTION; PRIORITY JOURNAL; RETROPOSON; REVIEW; RNA INTERFERENCE; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; SIDE EFFECT; TANDEM REPEAT;

DNA, FUNGAL; EUKARYOTIC CELLS; FUNGI; GENOME, FUNGAL; GENOMICS; PHYLOGENY; SEQUENCE ANALYSIS, DNA;

ASPERGILLUS; EUKARYOTA; FILOBASIDIELLA NEOFORMANS; FUNGI; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE;

EID: 28844492079     PISSN: 10889051     EISSN: 15495469     Source Type: Journal    
DOI: 10.1101/gr.3767105     Document Type: Review

References (122)

1. Aparicio, S., Chapman, J., Stupka, E., Putnam, N., Chia, J.M., Dehal, P., Christoffels, A., Rash, S., Hoon, S., Smit, A., et al. 2002. Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes. Science 297: 1301-1310.
2. Aramayo, R. and Metzenberg, R.L. 1996. Meiotic transvection in fungi. Cell 86: 103-113.
3. Archer, D.B. and Dyer, P.S. 2004. From genomics to post-genomics in Aspergillus. Curr. Opin. Microbiol. 7: 499-504.
4. Ast, G. 2004. How did alternative splicing evolve? Nat. Rev. Genet. 5: 773-782.
5. Barrass, J.D. and Beggs, J.D. 2003. Splicing goes global. Trends Genet. 19: 295-298.
6. Batzoglou, S., Jaffe, D.B., Stanley, K., Butler, J., Gnerre, S., Mauceli, E., Berger, B., Mesirov, J.P., and Lander, E.S. 2002. ARACHNE: A whole-genome shotgun assembler. Genome Res. 12: 177-189.
7. Beck-Sague, C. and Jarvis, W.R. 1993. Secular trends in the epidemiology of nosocomial fungal infections in the United States, 1980-1990. National Nosocomial Infections Surveillance System. J. Infect. Dis. 167: 1247-1251.
8. Bell-Pedersen, D., Cassone, V.M., Earnest, D.J., Golden, S.S., Hardin, P.E., Thomas, T.L., and Zoran, M.J. 2005. Circadian rhythms from multiple oscillators: Lessons from diverse organisms. Nat. Rev. Genet. 6: 544-556.
9. Berbee, M.L. and Taylor, J.W. 2000. The Mycota, vol VIIB, systematics and evolution. Springer-Verlag, New York.
10. Boeke, J.D., Garfinkel, D.J., Styles, C.A., and Fink, G.R. 1985. Ty elements transpose through an RNA intermediate. Cell 40: 491-500.
11. Bon, E., Casaregola, S., Blandin, G., Llorente, B., Neuveglise, C., Munsterkotter, M., Guldener, U., Mewes, H.W., Van Helden, J., Dujon, B., et al. 2003. Molecular evolution of eukaryotic genomes: Hemiascomycetous yeast spliceosomal introns. Nucleic Acids Res. 31: 1121-1135.
12. Borkovich, K.A., Alex, L.A., Yarden, O., Freitag, M., Turner, G.E., Read, N.D., Seiler, S., Bell-Pedersen, D., Paietta, J., Plesofsky, N., et al. 2004. Lessons from the genome sequence of Neurospora crassa: Tracing the path from genomic blueprint to multicellular organism. Microbiol. Mol. Biol. Rev. 68: 1-108.
13. Braun, B.R., van Het Hoog, M., d'Enfert, C., Martchenko, M., Dungan, J., Kuo, A., Inglis, D.O., Uhl, M.A., Hogues, H., Berriman, M., et al. 2005. A human-curated annotation of the Candida albicans genome. PLoS Genet. 1: E1.
14. Carlton, J.M., Angiuoli, S.V., Suh, B.B., Kooij, T.W., Pertea, M., Silva, J.C., Ermolaeva, M.D., Allen, J.E., Selengut, J.D., Koo, H.L., et al. 2002. Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature 419: 512-519.
15. Chiller, T.M., Galgiani, J.N., and Stevens, D.A. 2003. Coccidioidomycosis. Infect. Dis. Clin. North Am. 17: 41-57, viii.
16. Coghlan, A. and Wolfe, K.H. 2002. Fourfold faster rate of genome rearrangement in nematodes than in Drosophila. Genome Res. 12: 857-867.
17. Cogoni, C., Irelan, J.T., Schumacher, M., Schmidhauser, T.J., Selker, E.U., and Macino, G. 1996. Transgene silencing of the al-1 gene in vegetative cells of Neurospora is mediated by a cytoplasmic effector and does not depend on DNA-DNA interactions or DNA methylation. EMBO J. 15: 3153-3163.
18. Dasbach, E.J., Davies, G.M., and Teutsch, S.M. 2000. Burden of aspergillosis-related hospitalizations in the United States. Clin. Infect. Dis. 31: 1524-1528.
19. Davis, C.A., Grate, L., Spingola, M., and Ares Jr., M. 2000. Test of intron predictions reveals novel splice sites, alternatively spliced mRNAs and new introns in meiotically regulated genes of yeast. Nucleic Acids Res. 28: 1700-1706.
20. De Backer, M.D., Nelissen, B., Logghe, M., Viaene, J., Loonen, I., Vandoninck, S., de Hoogt, R., Dewaele, S., Simons, F.A., Verhasselt, P., et al. 2001. An antisense-based functional genomics approach for identification of genes critical for growth of Candida albicans. Nat. Biotechnol. 19: 235-241.
21. Dean, R.A., Talbot, N.J., Ebbole, D.J., Farman, M.L., Mitchell, T.K., Orbach, M.J., Thon, M., Kulkarni, R., Xu, J.R., Pan, H., et al. 2005. The genome sequence of the rice blast fungus Magnaporthe grisea. Nature 434: 980-986.
22. Dear, P.H. and Cook, P.R. 1989. Happy mapping: A proposal for linkage mapping the human genome. Nucleic Acids Res. 17: 6795-6807.
23. _. 1993. Happy mapping: Linkage mapping using a physical analogue of meiosis. Nucleic Acids Res. 21: 13-20.
24. Dujon, B., Sherman, D., Fischer, G., Durrens, P., Casaregola, S., Lafontaine, I., De Montigny, J., Marck, C., Neuveglise, C., Talla, E., et al. 2004. Genome evolution in yeasts. Nature 430: 35-44.
25. Dunham, M.J., Badrane, H., Ferea, T., Adams, J., Brown, P.O., Rosenzweig, F., and Botstein, D. 2002. Characteristic genome rearrangements in experimental evolution of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. 99: 16144-16149.
26. Ebbole, D.J., Jin, Y., Thon, M., Pan, H., Bhattarai, E., Thomas, T., and Dean, R. 2004. Gene discovery and gene expression in the rice blast fungus, Magnaporthe grisea: Analysis of expressed sequence tags. Mol. Plant Microbe Interact. 17: 1337-1347.
27. Farman, M.L. and Leong, S.A. 1995. Genetic and physical mapping of telomeres in the rice blast fungus, Magnaporthe grisea. Genetics 140: 479-492.
28. Fedorov, A., Roy, S., Fedorova, L., and Gilbert, W. 2003. Mystery of intron gain. Genome Res. 13: 2236-2241.
29. Fink, G.R. 1987. Pseudogenes in yeast? Cell 49: 5-6.
30. Fire, A., Xu, S., Montgomery, M.K., Kostas, S.A., Driver, S.E., and Mello, C.C. 1998. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391: 806-811.
31. Fraser, J.A. and Heitman, J. 2004. Evolution of fungal sex chromosomes. Mol. Microbiol. 51: 299-306.
32. Frey, S.D., Elliott, E.T., and Paustian, K. 1999. Bacterial and fungal abundance and biomass in conventional and no-tillage agroecosystems along two climatic gradients. Soil Biol. Biochem. 31: 573-585.
33. Galagan, J.E. and Selker, E.U. 2004. RIP: The evolutionary cost of genome defense. Trends Genet. 20: 417-423.
34. Galagan, J.E., Calvo, S.E., Borkovich, K.A., Selker, E.U., Read, N.D., Jaffe, D., FitzHugh, W., Ma, L.J., Smirnov, S., Purcell, S., et al. 2003. The genome sequence of the filamentous fungus Neurospora crassa. Nature 422: 859-868.
35. Galagan, J.E., Calvo, S., Cuomo, C., Ma, L.J., Wortman, J., Batzoglou, S., Lee, S.I., Basturkmen, M., Spevak, C., Clutterbuck, J., et al. 2005. Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae. Nature. (in press)
36. Gehrig, H., Schussler, A., and Kluge, M. 1996. Geosiphon pyriforme, a fungus forming endocytobiosis with Nostoc (cyanobacteria), is an ancestral member of the Glomales: Evidence by SSU rRNA analysis. J. Mol. Evol. 43: 71-81.
37. Georgopapadakou, N.H. 1998. Antifungals: Mechanism of action and resistance, established and novel drugs. Curr. Opin. Microbiol. 1: 547-557.
38. Gilbert, W. 1978. Why genes in pieces? Nature 271: 501.
39. Goffeau, A., Barrell, B.G., Bussey, H., Davis, R.W., Dujon, B., Feldmann, H., Galibert, F., Hoheisel, J.D., Jacq, C., Johnston, M., et al. 1996. Life with 6000 genes. Science 274: 546, 563-567.
40. Grate, L. and Ares Jr., M. 2002. Searching yeast intron data at Ares lab Web site. Methods Enzymol. 350: 380-392.
41. Gudlaugsson, O., Gillespie, S., Lee, K., Vande Berg, J., Hu, J., Messer, S., Herwaldt, L., Pfaller, M., and Diekema, D. 2003. Attributable mortality of nosocomial candidemia, revisited. Clin. Infect. Dis. 37: 1172-1177.
42. Guigo, R., Knudsen, S., Drake, N., and Smith, T. 1992. Prediction of gene structure. J. Mol. Biol. 226: 141-157.
43. Hawksworth, D.L. 1991. The fungal dimension of biodiversity-magnitude, significance, and conservation. Mycol. Res. 95: 641.
44. Heckman, D.S., Geiser, D.M., Eidell, B.R., Stauffer, R.L., Kardos, N.L., and Hedges, S.B. 2001. Molecular evidence for the early colonization of land by fungi and plants. Science 293: 1129-1133.
45. Hoang, L.M., Maguire, J.A., Doyle, P., Fyfe, M., and Roscoe, D.L. 2004. Cryptococcus neoformans infections at Vancouver Hospital and Health Sciences Centre (1997-2002): Epidemiology, microbiology and histopathology. J. Med. Microbiol. 53: 935-940.
46. Hutvagner, G. and Zamore, P.D. 2002. RNAi: Nature abhors a double-strand. Curr. Opin. Genet. Dev. 12: 225-232.
47. Huynen, M.A., Snel, B., and Bork, P. 2001. Inversions and the dynamics of eukaryotic gene order. Trends Genet. 17: 304-306.
48. Jaffe, D.B., Butler, J., Gnerre, S., Mauceli, E., Lindblad-Toh, K., Mesirov, J.P., Zody, M.C., and Lander, E.S. 2003. Whole-genome sequence assembly for mammalian genomes: Arachne 2. Genome Res. 13: 91-96.
49. Johnson, J.M., Castle, J., Garrett-Engele, P., Kan, Z., Loerch, P.M., Armour, C.D., Santos, R., Schadt, E.E., Stoughton, R., and Shoemaker, D.D. 2003. Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Science 302: 2141-2144.
50. Jones, T., Federspiel, N.A., Chibana, H., Dungan, J., Kalman, S., Magee, B.B., Newport, G., Thorstenson, Y.R., Agabian, N., Magee, P.T., et al. 2004. The diploid genome sequence of Candida albicans. Proc. Natl. Acad. Sci. 101: 7329-7334.
51. Kampa, D., Cheng, J., Kapranov, P., Yamanaka, M., Brubaker, S., Cawley, S., Drenkow, J., Piccolboni, A., Bekiranov, S., Helt, G., et al. 2004. Novel RNAs identified from an in-depth analysis of the transcriptome of human chromosomes 21 and 22. Genome Res. 14: 331-342.
52. Kellis, M., Patterson, N., Endrizzi, M., Birren, B., and Lander, E.S. 2003. Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature 423: 241-254.
53. Kellis, M., Birren, B.W., and Lander, E.S. 2004. Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae. Nature 428: 617-624.
54. Kempken, F. and Kuck, U. 1998. Transposons in filamentous fungi - facts and perspectives. Bioessays 20: 652-659.
55. Ketting, R.F. and Plasterk, R.H. 2000. A genetic link between co-suppression and RNA interference in C. elegans. Nature 404: 296-298.
56. Korf, I. 2004. Gene finding in novel genomes. BMC Bioinform. 5: 59.
57. Korf, I., Flicek, P., Duan, D., and Brent, M.R. 2001. Integrating genomic homology into gene structure prediction. Bioinformatics 17: S140-S148.
58. Koszul, R., Caburet, S., Dujon, B., and Fischer, G. 2004. Eucaryotic genome evolution through the spontaneous duplication of large chromosomal segments. EMBO J. 23: 234-243.
59. Kroken, S., Glass, N.L., Taylor, J.W., Yoder, O.C., and Turgeon, B.G. 2003. Phylogenomic analysis of type I polyketide synthase genes in pathogenic and saprobic ascomycetes. Proc. Natl. Acad. Sci. 100: 15670-15675.
60. Lephart, P.R., Chibana, H., and Magee, P.T. 2005. Effect of the major repeat sequence on chromosome loss in Candida albicans. Eukaryot. Cell 4: 733-741.
61. Li, W., Rehmeyer, C.J., Staben, C., and Farman, M.L. 2005. TERMINUS-Telomeric end-read mining in unassembled sequences. Bioinformatics 21: 1695-1698.
62. Loftus, B.J., Fung, E., Roncaglia, P., Rowley, D., Amedeo, P., Bruno, D., Vamathevan, J., Miranda, M., Anderson, I.J., Fraser, J.A., et al. 2005. The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. Science 307: 1321-1324.
63. Logsdon Jr., J.M., Stoltzfus, A., and Doolittle, W.F. 1998. Molecular evolution: Recent cases of spliceosomal intron gain? Curr. Biol. 8: R560-R563.
64. Lowy, B. 1971. New records of mushroom stones from Guatemala. Mycologia 63: 983-993.
65. Lynch, M. and Richardson, A.O. 2002. The evolution of spliceosomal introns. Curr. Opin. Genet. Dev. 12: 701-710.
66. Madden, L.V. and Wheelis, M. 2003. The threat of plant pathogens as weapons against U.S. crops. Annu. Rev. Phytopathol. 41: 155-176.
67. Martinez, D., Larrondo, L.F., Putnam, N., Gelpke, M.D., Huang, K., Chapman, J., Helfenbein, K.G., Ramaiya, P., Detter, J.C., Larimer, F., et al. 2004. Genome sequence of the lignocellulose degrading fungus Phanerochaete chrysosporium strain RP78. Nat. Biotechnol. 22: 695-700.
68. Metting, F.B. 1993. Structure and physiological ecology of soil microbial communities. In Soil microbial ecology: Applications in agricultural and environmental management, pp. 3-25. Dekker, New York.
69. Modrek, B. and Lee, C. 2002. A genomic view of alternative splicing. Nat. Genet. 30: 13-19.
70. Moss, M.O. 1987. Fungal biotechnology roundup. Mycologist 21: 55-58.
71. Mourier, T. and Jeffares, D.C. 2003. Eukaryotic intron loss. Science 300: 1393.
72. Mullikin, J.C. and Ning, Z. 2003. The phusion assembler. Genome Res. 13: 81-90.
73. Myers, E.W., Sutton, G.G., Delcher, A.L., Dew, I.M., Fasulo, D.P., Flanigan, M.J., Kravitz, S.A., Mobarry, C.M., Reinert, K.H., Remington, K.A., et al. 2000. A whole-genome assembly of Drosophila. Science 287: 2196-2204.
74. Napoli, C., Lemieux, C., and Jorgensen, R. 1990. Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. Plant Cell 2: 279-289.
75. Nelson, M.A. 2004. EST evidence for alternative splicing in Neurospora crassa. In Annual Neurospora Convention.
76. Newell, S.Y. 1992. Estimating fungal biomass and productivity in decomposing litter. In The fungal community: Its organization and role in the ecosystem (eds. G.C. Carroll and D.T. Wicklow), pp. 521-561. Dekker, New York.
77. Nielsen, C.B., Friedman, B., Birren, B., Burge, C.B., and Galagan, J.E. 2004. Patterns of intron gain and loss in fungi. PLoS Biol. 2: E422.
78. Odds, F.C., Brown, A.J., and Gow, N.A. 2004. Candida albicans genome sequence: A platform for genomics in the absence of genetics. Genome Biol. 5: 230.
79. Parra, G., Blanco, E., and Guigo, R. 2000. GeneID in Drosophila. Genome Res. 10: 511-515.
80. Rensberger, B. 1992. The Iceman: Now the research is on ice. J. NIIT Res. 4: 25-27.
81. Romfo, C.M., Alvarez, C.J., van Heeckeren, W.J., Webb, C.J., and Wise, J.A. 2000. Evidence for splice site pairing via intron definition in Schizosaccharomyces pombe. Mol. Cell. Biol. 20: 7955-7970.
82. Roy, S.W. and Gilbert, W. 2005a. Complex early genes. Proc. Natl. Acad. Sci. 102: 1986-1991.
83. _. 2005b. The pattern of intron loss. Proc. Natl. Acad. Sci. 102: 713-718.
84. Ryan, M.J. and Smith, D. 2004. Fungal genetic resource centres and the genomic challenge. Mycol. Res. 108: 1351-1362.
85. Salamov, A.A. and Solovyev, V.V. 2000. Ab initio gene finding in Drosophila genomic DNA. Genome Res. 10: 516-522.
86. Salzberg, S.L., Pertea, M., Delcher, A.L., Gardner, M.J., and Tettelin, H. 1999. Interpolated Markov models for eukaryotic gene finding. Genomics 59: 24-31.
87. Sambrook, J. 1977. Adenovirus amazes at Cold Spring Harbor. Nature 268: 101-104.
88. Schechtman, M.G. 1990. Characterization of telomere DNA from Neurospora crassa. Gene 88: 159-165.
89. Selker, E.U. 1990. Premeiotic instability of repeated sequences in Neurospora crassa. Annu. Rev. Genet. 24: 579-613.
90. _. 2002. Repeat-induced gene silencing in fungi. Adv. Genet. 46: 439-450.
91. Seoighe, C., Federspiel, N., Jones, T., Hansen, N., Bivolarovic, V., Surzycki, R., Tamse, R., Komp, C., Huizar, L., Davis, R.W., et al. 2000. Prevalence of small inversions in yeast gene order evolution. Proc. Natl. Acad. Sci. 97: 14433-14437.
92. Shiu, P.K. and Metzenberg, R.L. 2002. Meiotic silencing by unpaired DNA: Properties, regulation and suppression. Genetics 161: 1483-1495.
93. Shiu, P.K., Raju, N.B., Zickler, D., and Metzenberg, R.L. 2001. Meiotic silencing by unpaired DNA. Cell 107: 905-916.
94. Slater, G.S. and Birney, E. 2005. Automated generation of heuristics for biological sequence comparison. BMC Bioinform. 6: 31.
95. Stanke, M. and Morgenstern, B. 2005. AUGUSTUS: A web server for gene prediction in eukaryotes that allows user-defined constraints. Nucleic Acids Res. 33: W465-W467.
96. Stanke, M. and Waack, S. 2003. Gene prediction with a hidden Markov model and a new intron submodel. Bioinformatics 19: II215-II225.
97. Stanke, M., Steinkamp, R., Waack, S., and Morgenstern, B. 2004. AUGUSTUS: A web server for gene finding in eukaryotes. Nucleic Acids Res. 32: W309-W312.
98. Strange, R.N. and Scott, P.R. 2005. PLANT DISEASE: A threat to global food security. Annu. Rev. Phytopathol. 43: 83-116.
99. Swartz, M.N. 1994. Hospital-acquired infections: Diseases with increasingly limited therapies. Proc. Natl. Acad. Sci. 91: 2420-2427.
100. Taylor, T.N., Hass, H., and Kerp, H. 1999. The oldest fossil ascomycetes. Nature 399: 648.
101. Tenney, A.E., Brown, R.H., Vaske, C., Lodge, J.K., Doering, T.L., and Brent, M.R. 2004. Gene prediction and verification in a compact genome with numerous small introns. Genome Res. 14: 2330-2335.
102. Toth, G., Gaspari, Z., and Jurka, J. 2000. Microsatellites in different eukaryotic genomes: Survey and analysis. Genome Res. 10: 967-981.
103. Trappe, J.M. 1987. Phylogenetic and ecologic aspects of mycotrophy in the angiosperms from an evolutionary standpoint. In Ecophysiology of VA mycrorrhizal plants (ed. G.R. Safir), pp. 5-25. CRC Press, Boca Raton, FL.
104. Veneault-Fourrey, C. and Talbot, N.J. 2005. Moving toward a systems biology approach to the study of fungal pathogenesis in the rice blast fungus Magnaporthe grisea. Adv. Appl. Microbiol. 57: 177-215.
105. Vinson, J.P., Jaffe, D.B., O'Neill, K., Karlsson, E.K., Stange-Thomann, N., Anderson, S., Mesirov, J.P., Satoh, N., Satou, Y., Nusbaum, C., et al. 2005. Assembly of polymorphic genomes: Algorithms and application to Ciona savignyi. Genome Res. 15: 1127-1135.
106. Wolfe, K.H. and Shields, D.C. 1997. Molecular evidence for an ancient duplication of the entire yeast genome. Nature 387: 708-713.
107. Wood, V.R., Gwilliam, M.A., Rajandream, M., Lyne, R., Lyne, A., Stewart, J., Sgouros, N., Peat, J., Hayles, S., Baker, D., et al. 2002. The genome sequence of Schizosaccharomyces pombe. Nature 415: 871-880.
108. Xu, J., Vilgalys, R., and Mitchell, T.G. 2000. Multiple gene genealogies reveal recent dispersion and hybridization in the human pathogenic fungus Cryptococcus neoformans. Mol. Ecol. 9: 1471-1481.
109. Yu, J.H. and Keller, N. 2005. Regulation of secondary metabolism in filamentous fungi. Annu. Rev. Phytopathol. 43: 437-458.
110. Zeigler, R.S., Leong, S.A., and Teeng, P.S. 1994. Rice Blast Disease. CAB International, Wallingford, UK.
111. Zhou, S., Kile, A., Kvikstad, E., Bechner, M., Severin, J., Forrest, D., Runnheim, R., Churas, C., Anantharaman, T.S., Myler, P., et al. 2004. Shotgun optical mapping of the entire Leishmania major Friedlin genome. Mol. Biochem. Parasitol. 138: 97-106.
112. http://fungal.genome.duke.edu/; Duke Fungal Genomics Resource.
113. http://genolist.pasteur.fr/CandidaDB/; CandidaDB.
114. http://img.jgi.doe.gov/pub/main.cgi; JGI Integrated Microbial Resource Database.
115. http://mips.gsf.de/projects/fungi/; the Munich Information Center for Protein Sequences.
116. http://www.broad.mit.edu/annotation/fgi/; The Broad Institute Fungal Genome Initiative web site.
117. http://www.ebi.ac.uk/Wise2/index.html; GeneWise program.
118. http://www.fgsc.net/; Fungal Genetics Stock Center.
119. http://www.genomesonline.org/; The Genomes Online database.
120. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=genomeprj; the TIGR fungal database (www.tigr.org/tdb/fungal), NCBI Entrez.
121. http://www.neurotransmitter.net/metadb/; the Munich Information Center for Protein Sequences.
122. http://www.yeastgenome.org/; Saccharomyces Genome Database.