Stress-induced p53 runs a transcription-independent death program

Biochemical and Biophysical Research Communications

Volumn 331, Issue 3, 2005, Pages 843-850

  Erster, Susan ^a   Moll, Ute M ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

bcl2 protein family; Mitochondria; p53

Indexed keywords

CYTOCHROME C; ETOPOSIDE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P53;

APOPTOSIS; CANCER INHIBITION; GAMMA IRRADIATION; GENE TRANSLOCATION; GENOTOXICITY; HUMAN; HYPOXIA; IMMUNOFLUORESCENCE; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; REVIEW; STRESS; TRANSCRIPTION REGULATION; WILD TYPE;

ANIMALIA;

EID: 18144421236     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.03.187     Document Type: Review

References (28)

1. N.D. Marchenko, A. Zaika, and U.M. Moll Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling. J. Biol. Chem. 275 2000 16202 16212
2. C. Sansome, A. Zaika, N.D. Marchenko, and U.M. Moll Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells FEBS Lett. 488 2001 110 115
3. M. Mihara, S. Erster, A. Zaika, O. Petrenko, T. Chittenden, P. Pancoska, and U.M. Moll p53 has a direct apoptogenic role at the mitochondria Mol. Cell. 11 2003 577 590
4. M. Bonafe, S. Salvioli, C. Barbi, C. Trapassi, F. Tocco, G. Storci, L. Invidia, I. Vannini, M. Rossi, E. Marzi, M. Mishto, M. Capri, F. Olivieri, R. Antonicelli, M. Memo, D. Uberti, B. Nacmias, S. Sorbi, D. Monti, and C. Franceschi The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death Cell Death Differ. 11 2004 962 973
5. P. Dumont, J.I. Leu, A.C. Della Pietra 3rd, D.L. George, and M. Murphy The codon 72 polymorphic variants of p53 have markedly different apoptotic potential Nat. Genet. 33 2003 357 365
6. A. Nemajerova, S. Erster, and U.M. Moll The post-translational phosphorylation and acetylation modification profile is not the determining factor in targeting endogenous stress-induced p53 to mitochondria Cell Death Differ. 12 2005 197 200
7. M. Mahyar-Roemer, C. Fritzsche, S. Wagner, M. Laue, and K. Roemer Mitochondrial p53 levels parallel total p53 levels independent of stress response in human colorectal carcinoma and glioblastoma cells Oncogene 23 2004 6226 6236
8. H. Yamaguchi, J. Chen, K. Bhalla, and H.G. Wang Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways J. Biol. Chem. 279 2004 39431 39437
9. L. Zhang, J. Yu, B.H. Park, K.W. Kinzler, and B. Vogelstein Role of BAX in the apoptotic response to anticancer agents Science 2000 989 992
10. 2+ ions J. Cell Biol. 143 1998 217 224
11. D.R. Green, and G.I. Evan A matter of life and death Cancer Cell 1 2002 19 30
12. J.E. Chipuk, T. Kuwana, L. Bouchier-Hayes, N.M. Droin, D.D. Newmeyer, M. Schuler, and D.R. Green Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis Science 303 2004 1010 1014
13. J.I. Leu, P. Dumont, M. Hafey, M.E. Murphy, and D.L. George Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex Nat. Cell Biol. 6 2004 443 450
14. A.M. Petros, A. Gunasekera, N. Xu, E.T. Olejniczak, and S.W. Fesik Defining the p53 DNA-binding domain/Bxl-xL binding interface using NMR FEBS Lett. 28073 2004 1 4
15. B.-W.E. Schuler, M. Goldstein, J.C. Fitzgerald, and P. Green p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release J. Biol. Chem. 275 2000 7337 7342
16. R. Eskes, S. Desagher, B. Antonsson, and J.C. Martinou Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane Mol. Cell. Biol. 20 2000 929 935
17. E. Appella, and C.W. Anderson Post-translational modifications and activation of p53 by genotoxic stresses Eur. J. Biochem. 268 2001 2764 2772
18. W. Gu, and R.G. Roeder Activation of p53 sequence-specific DNA-binding by acetylation of the p53 C-terminal domain Cell 90 1997 595 606
19. D.A. Freedman, and A.J. Levine Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6 Mol. Cell. Biol. 18 1998 7288 7293
20. T.R. Shirangi, A. Zaika, and U.M. Moll Nuclear degradation of p53 occurs during down-regulation of the p53 response after DNA damage FASEB J. 16 2002 420 422
21. T.W. Joseph, A. Zaika, and U.M. Moll Nuclear and cytoplasmic degradation of endogenous p53 and HDM2 occurs during down-regulation of the p53 response after multiple types of DNA damage FASEB J. 17 2003 1622 1630
22. J.E. Chipuk, U. Maurer, D.R. Green, and M. Schuler Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription Cancer Cell 4 2003 371 381
23. S. Erster, M. Mihara, R.H. Kim, O. Petrenko, and U.M. Moll In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation Mol. Cell. Biol. 24 2004 6728 6741
24. B.-M.V. Sugars, K.L. Packham, and G. Latchman A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53. Nucleic Acids Res. 29 2001 4530 4540
25. K.J. Kelly, Z. Plotkin, S.L. Vulgamott, and P.C. Dagher P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor J. Am. Soc. Nephrol. 14 2003 128 138
26. P.G. Komarov, E.A. Komarova, R.V. Kondratov, K. Christov-Tselkov, J.S. Coon, M.V. Chernov, and A.V. Gudkov A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy Science 285 1999 1733 1737
27. P. Bonini, S. Cicconi, A. Cardinale, C. Vitale, A.L. Serafino, M.T. Ciotti, and L.N. Marlier Oxidative stress induces p53-mediated apoptosis in glia: p53 transcription-independent way to die J. Neurosci. Res. 75 2004 83 95
28. C.P. Gilman, S.L. Chan, Z. Guo, X. Zhu, N. Greig, and M.P. Mattson p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults Neuromolecular Med. 3 2003 159 172