Hydroxynonenal and uncoupling proteins: A model for protection against oxidative damage

BioFactors

Volumn 24, Issue 1-4, 2005, Pages 119-130

  Echtay, Karim S ^a   Pakay, Julian L ^b   Esteves, Telma C ^b   Brand, Martin D ^b  

^a UNIVERSITY OF BALAMAND   (Lebanon)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Ageing; Hydroxynonenal; Lipid peroxidation; Mitochondria; Proton leak; Superoxide; Tetinoic acid; UCP

Indexed keywords

4 HYDROXYNONENAL; ALDEHYDE; CARRIER PROTEIN; DNA; NUCLEOTIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

ENERGY YIELD; LIPID PEROXIDATION; MITOCHONDRION; MODEL; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTECTION; PROTON MOTIVE FORCE; PROTON TRANSPORT; SHORT SURVEY;

EID: 28644449676     PISSN: 09516433     EISSN: None     Source Type: Journal    
DOI: 10.1002/biof.5520240114     Document Type: Short Survey

References (78)

1. G. Argyropoulos and M.E. Harper, Uncoupling proteins and thermoregulation, Journal of Applied Physiology 92 (2002), 2187-2198.
2. D. Arsenijevic, H. Onuma, C. Pecqueur, S. Raimbault, B.S. Manning, B. Miroux, E. Couplan, M.C. Alves-Guerra, M. Goubern, R. Surwit, F. Bouillaud, D. Richard, S. Collins and D. Ricquier, Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production, Nat. Genet. 26 (2000), 435-439.
3. O. Boss, S. Samec, A. Paoloni Giacobino, C. Rossier, A. Dulloo, J. Seydoux, P. Muzzin and J.P. Giacobino, Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression, FEBS Lett. 408 (1997), 39-42.
4. O. Boss, T. Hagen and B.B. Lowell, Uncoupling proteins 2 and 3 - potential regulators of mitochondrial energy metabolism, Diabetes 49 (2000), 143-156.
5. F. Bouillaud, E. Couplan, C. Pecqueur and D. Ricquier, Homologues of the uncoupling protein from brown adipose tissue (UCP1): UCP2, UCP3, BMCP1 and UCP4, Biochim. Biophys. Acta 1504 (2001), 107-119.
6. M.D. Brand, The proton leak across the mitochondrial inner membrane, Biochim. Biophys. Acta 1018 (1990), 128-133.
7. M.D. Brand, L.F. Chien, E.K. Ainscow, D.F.S. Rolfe and R.K. Porter, The causes and functions of mitochondrial proton leak, Biochim. Biophys. Acta. 30 (1994), 132-139.
8. M.D. Brand, Uncoupling to survive? The role of mitochondrial inefficiency in ageing, Exp. Gerontol. 35 (2000), 811-820.
9. M.D. Brand, R. Pamplona, M. Portero-Otin, J.R. Requena, S.J. Roebuck, J.A. Buckingham, J.C. Clapham and S. Cadenas, Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3, Biochem. J. 368 (2002), 597-603.
10. M.D. Brand, A.J. Buckingham, T.C. Esteves, K. Green, A.J. Lambert, S. Miwa, M.P. Murphy, J.L. Pakay, D.A. Talbot and K.S. Echtay, Mitochondrial superoxide and aging: Uncoupling-protein activity and superoxide production, Biochem. Soc. Symp. 71 (2004), 203-213.
11. M.D. Brand, C. Affourtit, T.C. Esteves, K. Green, A.J. Lambert, S. Miwa, J.L. Pakay and N. Parker, Mitochondrial superoxide: Production, biological effects, and activation of uncoupling proteins, Free Radic. Biol. Med. 37 (2004), 755-767.
12. S. Cadenas, K.S. Echtay, J.A. Harper, M.B. Jekabsons, J.A. Buckingham, E. Grau, A. Abuin, H. Chapman, J.C. Clapham and M.D. Brand, The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3, J. Biol. Chan. 277 (2002), 2773-2778.
13. J.J. Chen, H. Bertrand and B.P. Yu, Inhibition of adenine nucleotide translocator by lipid peroxidation products, Free Radic. Biol. Med. 19 (1995), 583-590.
14. J. Chen, G.I. Henderson and G.I. Freeman, Role of 4-hydroxynonenal in modification of cytochrome c oxidase in ischemia/reperfused rat heart, J. Mol. Cell Cardiol. 33 (2001), 1919-1927.
15. M.J. Considine, M. Goodman, K.S. Echtay, M. Laloi, J. Whelan, M.D. Brand and L.J. Sweetlove, Superoxide stimulates a proton leak in potato mitochondria that is related to the activity of uncoupling protein, J. Biol. Chem. 278 (2003), 22298-22302.
16. .-generation in the complex III of the electron transport chain, Mol. Cell Biochem. 184 (1998), 21-33.
17. C. Duval, A. Negre-Salvayre, A. Dogilo, R. Salvayre, L. Penicaud and L. Casteilla, Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells, Biochem. Cell Biol. 80 (2002), 757-764.
18. P. Eaton, J.M. Li, D.J. Hearse and M. Shattock, Formation of 4-hydroxy-2-nonenal-modified proteins in ischemic rat heart, Am. J. Physiol. 276 (1999), H935-H943.
19. K.S. Echtay, Q.Y. Liu, T. Caskey, E. Winkler, K. Frischmuth, M. Bienengraber and M. Klingenberg, Regulation of UCP3 by nucleotides is different from regulation of UCP1, FEBS Lett. 450 (1999), 8-12.
20. K.S. Echtay, E. Winkler and M. Klingenberg, Coenzyme Q is an obligatory cofactor for uncoupling protein function, Nature 408 (2000), 609-613.
21. K.S. Echtay and M.D. Brand, Coenzyme Q induces GDP-sensitive proton conductance in kidney mitochondria, Biochem. Soc. Trans. 29 (2001), 763-768.
22. K.S. Echtay, D. Roussel, J. St Pierre, M.B. Jekabsons, S. Cadenas, J.A. Stuart, J.A. Harper, S.J. Roebuck, A. Morrison, S. Pickering, J.C. Clapham and M.D. Brand, Superoxide activates mitochondrial uncoupling proteins, Nature 415 (2002), 96-99.
23. K.S. Echtay, E. Winkler, K. Frischmuth and M. Klingenberg, Uncoupling proteins 2 and 3 are highly active H+ transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone), Proc. Natl. Acad. Sci. USA 98 (2001), 1416-1421.
24. K.S. Echtay, M.P. Murphy, R.A.J. Smith, D.A. Talbot and M.D. Brand, Superoxide activates mitochondrial uncoupling protein 2 from the matrix side - studies using targeted antioxidants, J. Biol. Chem. 277 (2002), 47129-47135.
25. K.S. Echtay, T.C. Esteves, J.L. Pakay, M.B. Jekabsons, A.J. Lambert, M. Portero-Otin, R. Pamplona, A.J. Vidal-Puig, S. Wang, S.J. Roebuck and M.D. Brand, A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling, EMBO J. 22 (2003), 4103-4110.
26. H. Esterbauer, R.J. Schaur and H. Zollner, Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes, Free Radic. Biol. Med. 11 (1991), 81-128.
27. T.C. Esteves, K.S. Echtay, T. Jonassen, C.F. Clarke and M.D. Brand, Ubiquinone is not required for proton conductance by uncoupling protein 1 in yeast mitochondria, Biochem. J. 379 (2004), 309-315.
28. F. Felipe, M.L. Bonet, J. Ribot and A. Palou, Up-regulation of muscle uncoupling protein 3 gene expression in mice following high fat diet, dietary vitamin A supplementation and acute retinoic acid treatment, Int. J. Obesity 27 (2003), 60-69.
29. C. Fleury, M. Neverova, S. Collins, S. Raimbault, O. Champigny, C. Levi-Meyrueis, F. Bouillaud, M.F. Seldin, R.S. Surwit, D. Ricquier and C.H. Warden, Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia, Nat. Genet. 5 (1997), 269-272.
30. Y.-W.C. Fridell, A. Sanchez-Blanco, B.A. Silvia and S.L. Helfand, Functional characterization of a Drosophila mitochondrial uncoupling protein, J. Bioenerg. Biomemb. 36 (2004), 219-228.
31. 2+/tert-butyl hydroperoxide treated mitochondria, Biochemistry 35 (1996), 15440-15446.
32. D.W. Gong, S. Monemdjou, O. Gavrilova, L.R. Leon, B. Marcus-Samuels, C.J. Chou, C. Everett, L.P. Kozak, C. Li, C. Deng, M.E. Harper and M.L. Reitman, Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3, J. Biol. Chem. 275 (2000), 16251-16257.
33. T. Hagen and B.B. Lowell, Chimeric proteins between UCP1 and UCP3: The middle third of UCP1 is necessary and sufficient for activation by fatty acids, Biochem. Biophys. Res. Commun. 276 (2000), 642-648.
34. J.A. Harper, J.A. Stuart, M.B. Jekabsons, D. Roussel, K.M. Brindle, K. Dickinson, R.B. Jones and M.D. Brand, Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria, Biochem. J. 361 (2002), 49-56.
35. + transport, FEBS Lett. 480 (2000), 265-270.
36. S. Iossa, M.P. Mollica, L. Lionetti, R. Crescenzo, M. Botta, S. Samec, G. Solinas, D. Mainieri, A.G. Dulloo and G. Liverini, Skeletal muscle mitochondrial efficiency and uncoupling protein 3 in overeating rats with increased thermogenesis, Pflugers Arch.-Eur. J. Physiol. 445 (2002), 431-436.
37. A.L. Isom, S. Barnes, L. Wilson, M. Kirk, L. Coward and V. Darley-Usmar, Modification of Cytochrome c by 4-hydroxy-2-nonenal: Evidence for histidine, lysine, and arginine-aldehyde adducts, J. Am. Soc. Mass Spectrom. 15 (2004), 1136-1147.
38. M. Jaburek, M. Varecha, R.E. Gimeno, M. Dembski, P. Jezek, M. Zhang, P. Burn, L.A. Tartaglia and K.D. Garlid, Transport function and regulation of mitochondrial uncoupling proteins 2 and 3, J. Biol. Chem. 274 (1999), 26003-26007.
39. P.B. Jakus, K. Sipos, G. Kispal and A. Sandor, Opposite regulation of uncoupling protein 1 and uncoupling protein 3 in vivo in brown adipose tissue of cold exposed rats, FEBS Lett. 519 (2002), 210-214.
40. P. Jezek, Possible physiological roles of mitochondrial uncoupling proteins - UCPn, Int. J. Biochem. Cell Biol. 34 (2002), 1190-1206.
41. J.S. Kim-Han, S.A. Reichert, K.L. Quick and L.L. Dugan, BMCP1: A mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production, J. Neurochem. 79 (2001), 658-668.
42. M. Klingenberg, Nucleotide binding to uncoupling protein. Mechanism of control by protonation, Biochemistry 27 (1988), 781-791.
43. M. Klingenberg, Mechanism and evolution of the uncoupling protein of brown adipose tissue, Trends Biochem. Sci. 15 (1990), 108-112.
44. M. Klingenberg and K.S. Echtay, Uncoupling proteins: The issues from a biochemist point of view, Biochim. Biophys. Acta. 1504 (2001), 128-143.
45. S.S. Korshunov, V.P. Skulachev and A.A. Starkov, High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria, FEBS Lett. 416 (1997), 15-18.
46. S. Krauss, C.Y. Zhang and B.B. Lowell, A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2, Proc. Natl. Acad. Sci. USA 99 (2002), 118-122.
47. S. Krauss, C.Y. Zhang, L. Scorrano, L.T. Dalgaard, J. St-Pierre, S.T. Grey and B.B. Lowell, Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction, J. Clin. Invest. 112 (2003), 1831-1842.
48. A.J. Lambert and M.D. Brand, Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane, Biochem. J. 382 (2004), 511-517.
49. S.S. Liu, Generating, partitioning, targeting and functioning of superoxide in mitochondria, Biosci. Rep. 17 (1997), 259-272.
50. W.G. Mao, X.X. Yu, A. Zhong, W.L. Li, J. Brush, S.W. Sherwood, S.H. Adams and G.H. Pan, UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells, FEBS Lett. 443 (1999), 326-330.
51. M.P. Murphy, K.S. Echtay, F.H. Blaikie, J. Asin-Cayuela, H.M. Cocheme, K. Green, J.A. Buckingham, E.R. Taylor, F. Hurrell, G. Hughes, S. Miwa, C.E. Cooper, D.A. Svistunenko, R.A. Smith and M.D. Brand, Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: Studies using a mitochondria-targeted spin trap derived from α-phenyl-N-tert-butylnitrone, J. Biol. Chem. 278 (2003), 48534-48545.
52. A. Musatov, C.A. Carroll, Y.C. Liu, G.I. Henderson, S.T. Weintraub and N.C. Robinson, Identification of bovine heart cytochrome c oxidase subunits modified by the lipid peroxidation product 4-hydroxy-2-nonenal, Biochemistry 41 (2002), 8212-8220.
53. J. Nedergaard, V. Golozoubova, A. Matthias, I. Shabalina, K.I. Ohba, K. Ohlson, A. Jacobsson and B. Cannon, Life without UCPI: Mitochondrial, cellular and organismal characteristics of the UCPI-ablated mice, Biochem. Soc. Trans. 29 (2001), 756-763.
54. A. Negre-Salvayre, C. Hirtz, G. Carrera, R. Cazenave, M. Troly, R. Salvayre, L. Penicaud and L. Casteilla, A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation, FASEB J. 11 (1997), 809-815.
55. D.G. Nicholls, The influence of respiration and ATP hydrolysis on the proton-electrochemical gradient across the inner membrane of rat-liver mitochondria as determined by ion distribution, Eur. J. Biochem. 50 (1974), 305-315.
56. D.G. Nicholls and R.M. Locke, The proton leak across the mitochondrial inner membrane, Physiol. Rev. 64 (1984), 1-64.
57. D.G. Nicholls and E. Rial, A history of the first uncoupling protein, UCP1, J. Bioenerg. Biomembr. 31 (1999), 399-406.
58. E. Rial, M. Gonzalez-Barroso, C. Fleury, S. Iturrizaga, D. Sanchis, J. Jimenez-Jimenez, D. Ricquier, M. Goubern and F. Bouillaud. Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2, EMBO J. 18 (1999). 5827-5833.
59. D.F.S. Rolfe and M.D. Brand, The physiological significance of mitochondrial proton leak in animal cells and tissues, Biosci. Rep. 17 (1997), 9-16.
60. D. Sanchis, C. Fleury, N. Chomiki, M. Goubern, Q. Huang, M. Neverova, F. Gregoire, J. Easlick, S. Raimbault, C. Levi-Meyrueis, B. Miroux, S. Collins, M. Seldin, D. Richard, C. Warden, F. Bouillaud and D. Ricquier, BMCP1, a novel mitochondrial carrier with high expression n the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast, J. Biol. Chem. 273 (1998), 34611-34615.
61. P. Sbraccia, M. D'Adamo, F. Leonetti, A. Buongiorno, G. Silecchia, M.S. Basso, G. Tamburrano, D. Lauro, M. Federici, N. Di Daniele and R. Lauro, Relationship between plasma free fatty acids and uncoupling protein-3 gene expression in skeletal muscle of obese subjects: In vitro evidence of a causal link, Clin. Endocrinol. 57 (2002), 199-207.
62. V.P. Skulachev, Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants, Q. Rev. Biophys. 29 (1996), 169-202.
63. V.P. Skulachev, Barbara Cannon's data on the UCP1-ablated mice: "non-cannonical" point of view, Bioscience Reports 21 (2001), 189-194.
64. D. Stock, A.G.W. Leslie and J.E. Walker, Molecular architecture of the rotary motor in ATP synthase, Science 286 (1999), 1700-1705.
65. J. St Pierre, J.A. Buckingham, S.J. Roebuck and M.D. Brand, Topology of superoxide production from different sites in the mitochondrial electron transport chain, J. Biol. Chem. (2002), 44784-44790.
66. D.A. Talbot, N. Hanuise, B. Rey, J.-L. Rouanet, C. Duchamp and M.D. Brand, Superoxide activates a GDP-sensitive proton conductance in skeletal muscle mitochondria from king penguin (Aptenodytes patagonicus), Biochem. Biophys. Res. Commun. 376 (2003), 741-748.
67. D.A. Talbot, C. Duchamp, B. Rey, N. Hanuise, J.L. Rouanet, B. Sibille and M.D. Brand, Uncoupling protein and ADP/ATP carrier increase mitochondrial proton conductance after cold adaptation of king penguins, J. Physiol (Lond) 558(1) (2004), 123-135.
68. D.A. Talbot, A.J. Lambert and M.D. Brand, Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3, FEBS Lett. 556 (2004), 111-115.
69. P. Tomas, A. Ledesma and E. Rial, Photoaffinity labeling of the uncoupling protein UCP1 with retinoic acid: Ubiquinone favors binding, FEBS Lett. 526 (2002), 63-65.
70. S. Toyokuni, S. Yamada, M. Kashima, Y. Ihara, Y. Yamada, T. Tanaka, H. Hiai, Y. Seino and K. Uchida, Serum 4-hydroxy-2-nonenal-modified albumin is elevated in patients with type 2 diabetes mellitus, Antioxid. Redox Signal 2 (2000), 681-685.
71. K. Uchida, 4-Hydroxy-2-nonenal: A product and mediator of oxidative stress, Prog. Lipid Res. 42 (2003), 318-343.
72. A.J. Vidal-Puig, D. Grujic, C.Y. Zhang, T. Hagen, O. Boss, Y. Ido, A. Szczepanik, J. Wade, V. Mootha, R. Cortright, D.M. Muoio and B.B. Lowell, Energy metabolism in uncoupling protein 3 gene knockout mice, J. Biol. Chem. 275 (2000), 16258-16266.
73. + transport activity of the reconstituted uncoupling protein, J. Biol. Chem. 269 (1994), 2508-2515.
74. L.J. Yan and R.S. Sohal, Mitochondrial adenine nucleotide translocase is modified oxidatively during aging, Proc. Natl. Acad. Sci. USA 95 (1998), 12896-12901.
75. A. Yoritaka, N. Hattori, K. Uchida, M. Tanaka, E.R. Stadtman and Y. Mizuno, Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease, Proc. Natl. Acad. Sci. USA 93 (1996), 2696-2701.
76. X.X. Yu, W.G. Mao, A. Zhong, P. Schow, J. Brush, S.W. Sherwood, S.H. Adams and G.H. Pan, Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation, FASEB J. 14 (2000), 1611-1618.
77. C.Y. Zhang, G. Baffy, P. Perret, S. Krauss, O. Peroni, D. Grujic, T. Hagen, A.J. Vidal-Puig, O. Boss, Y.B. Kim, X.X. Zheng, M.B. Wheeler, G.I. Shulman, C.B. Chan and B.B. Lowell, Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes, Cell 105 (2001), 745-755.
78. C.W. Zwizinski and H.H. Schmid, Peroxidative damage to cardiac mitochondria: Identification and purification of modified adenine nucleotide translocase, Arch. Biochem. Biophys. 294 (1992), 178-183.