Photoreceptor cell apoptosis induced by the 2-nitroimidazole radiosensitizer, CI-1010, is mediated by p53-linked activation of caspase-3

NeuroToxicology

Volumn 27, Issue 1, 2006, Pages 44-59

  Miller, Terry J ^a   Schneider, Randal J ^a   Miller, James A ^a   Martin, Brad P ^a   Al Ubaidi, Muayyad R ^b   Agarwal, Neeraj ^c   Dethloff, Lloyd A ^d   Philbert, Martin A ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^d PFIZER INC   (United States)

Author keywords

Apoptosis; Caspase 3; CI 1010; p53; Photoreceptor

Indexed keywords

1 (2 BROMOETHYLAMINO) 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; 2 NITROIMIDAZOLE DERIVATIVE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AGAROSE; CASPASE 3; CASPASE 8; CASPASE INHIBITOR; CYTOCHROME C; FAS ANTIGEN; FAS LIGAND; FLUORESCENT DYE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL XL; PROTEIN P53; RADIOSENSITIZING AGENT; SERINE; TETRAMETHYLRHODAMINE METHYL ESTER;

ANIMAL CELL; APOPTOSIS; CELL CYCLE; CELL DEATH; CELL LINE; CELL STRUCTURE; CELL ULTRASTRUCTURE; CELL VIABILITY; CONFERENCE PAPER; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; DNA CROSS LINKING; DNA DAMAGE; DRUG MECHANISM; ELECTROPHORESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MOUSE; NICK END LABELING; NONHUMAN; PHOTORECEPTOR; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RETINA DEGENERATION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CASPASE 3; CELL CYCLE; CELL LINE, TRANSFORMED; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FAS LIGAND PROTEIN; FLOW CYTOMETRY; MICE; NITROIMIDAZOLES; PHOTORECEPTOR CELLS; PHOTORECEPTORS; POLY(ADP-RIBOSE) POLYMERASES; RADIATION-SENSITIZING AGENTS; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 28544433163     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2005.06.001     Document Type: Conference Paper

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