Glial inflammation and neurodegeneration induced by candoxin, a novel neurotoxin from Bungarus candidus venom: Global gene expression analysis using microarray

Toxicon

Volumn 46, Issue 8, 2005, Pages 883-899

  Pachiappan, A ^a   Thwin, M M ^a   Manikandan, J ^b   Gopalakrishnakone, P ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Glial degeneration and real time PCR; Inflammation; Microarray; Three finger toxins; TUNEL assay

Indexed keywords

CANDOXIN; NEUROTOXIN; SNAKE VENOM; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; BRAIN REGION; BRAIN TISSUE; CELL DEATH; CELL LINE; CONCENTRATION (PARAMETERS); DNA DAMAGE; DNA MICROARRAY; FRONTAL CORTEX; GENE CONTROL; GENE EXPRESSION; GENE IDENTIFICATION; GENOME; GLIA CELL; HIPPOCAMPUS; HISTOCHEMISTRY; HUMAN; HUMAN CELL; INFLAMMATION; MITOCHONDRION; MOLECULE; NERVE DEGENERATION; NICK END LABELING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SNAKE;

ANALYSIS OF VARIANCE; ANIMALS; BRAIN; BUNGARUS; CELL LINE; CELL SURVIVAL; CLUSTER ANALYSIS; DNA PRIMERS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HISTOCYTOCHEMISTRY; HUMANS; IN SITU NICK-END LABELING; MASS SPECTROMETRY; MITOCHONDRIA; NEUROGLIA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, PROTEIN; SIGNAL TRANSDUCTION; SNAKE VENOMS; TOXICOGENETICS;

BUNGARUS CANDIDUS;

EID: 28444464017     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2005.08.017     Document Type: Article

References (54)

1. A. Abeliovich, Y. Schmitz, I. Farinas, D. Choi-Lundberg, W.H. Ho, P.E. Castillo, N. Shinsky, J.M. Verdugo, M. Armanini, A. Ryan, M. Hynes, H. Phillips, D. Sulzer, and A. Rosenthal Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system Neuron 25 2000 239 252
2. C. Ananth, S. Thameem Dheen, P. Gopalakrishnakone, and C. Kour Domoic acid-induced neuronal damage in the rat hippocampus: changes in apoptosis related genes (bcl-2, bax, caspase-3) and microglial response J. Neurosci. Res. 66 2001 177 190
3. Y. Ando, Y. Liang, S. Ishigaki, J. Niwa, Y. Jiang, Y. Kobayashi, M. Yamamoto, and M. Doyu Caspase-1 and -3 mRNAs are differentially upregulated in motor neurons and glial cells in mutant SOD1 transgenic mouse spinal cord: a study using laser microdissection and real-time RT-PCR Neurochem. Res. 28 2003 839 846
4. D. Blum, S. Torch, N. Lambeng, M. Nissou, A.L. Benabid, R. Sadoul, and J.M. Verna Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease Prog. Neurobiol. 65 2001 135 172
5. A. Brazma, P. Hingamp, J. Quackenbush, G. Sherlock, P. Spellman, C. Stoeckert, J. Aach, W. Ansorge, C.A. Ball, H.C. Causton, T. Gaasterland, P. Glenisson, F.C. Holstege, I.F. Kim, V. Markowitz, J.C. Matese, H. Parkinson, A. Robinson, U. Sarkans, S. Schulze-Kremer, J. Stewart, R. Taylor, J. Vilo, and M. Vingron Minimum information about a microarray experiment (MIAME)-toward standards for microarray data Nat. Genet. 29 2001 365 371
6. E. Bulbring Observations on the isolated phrenic nerve diaphragm preparations of the rat Br. J. Pharmacol. 1 1946 38 61
7. C.D. Cher, A. Armugam, R. Lachumanan, M.W. Coghlan, and K. Jeyaseelan Pulmonary inflammation and edema induced by phospholipase A2: global gene analysis and effects on aquaporins and Na+/K+-ATPase J. Biol. Chem. 278 2003 31352 31360
8. L. Cosenza, G. Gorgun, A. Urbano, and F. Foss Interleukin-7 receptor expression and activation in nonhaematopoietic neoplastic cell lines Cell Signal. 14 2002 317 325
9. J. Court, C. Martin-Ruiz, M. Piggott, D. Spurden, M. Griffiths, and E. Perry Nicotinic receptor abnormalities in Alzheimer's disease Biol. Psychiatry. 49 2001 175 184
10. R. Croxen, C. Young, C. Slater, S. Haslam, M. Brydson, and A. Vincent End-plate gamma- and epsilon-subunit mRNA levels in AChR deficiency syndrome due to epsilon-subunit null mutations Brain 124 2001 1362 1372
11. M. D'Ascenzo, M. Vairano, C. Andreassi, P. Navarra, G.B. Azzena, and C. Grassi Electrophysiological and Molecular Evidence of L-(Cav1), N-(Cav2.2), and R-(Cav2.3) Type Ca2+ channels in rat cortical astrocytes Glia 45 2004 354 363
12. M.J. Dufton Kill and cure: the promising future for venom research Endeavour. 17 1993 138 140
13. T. Dunckley, and R.J. Lukas Nicotine modulates the expression of a diverse set of genes in the neuronal SH-SY5Y cell line J. Biol. Chem. 278 2003 15633 15640
14. T.A. Endo, M. Masuhara, M. Yokouchi, R. Suzuki, H. Sakamoto, K. Mitsui, A. Matsumoto, S. Tanimura, M. Ohtsubo, H. Misawa, T. Miyazaki, N. Leonor, T. Taniguchi, T. Fujita, Y. Kanakura, S. Komiya, and A. Yoshimura A new protein containing an SH2 domain that inhibits JAK kinases Nature 387 1997 921 924
15. R.D. Fields, and B. Stevens-Graham New insights into neuron-glia communication Science 298 2002 556 562
16. M.E. Figueiredo-Pereira, and P. Rockwell N.L. Banik A. Lajtha M. Smith Proteolysis in the Pathophysiology of Neurodegenerative Disease 2001 New York Plenum
17. R.M. Friedlander Apoptosis and caspases in neurodegenerative diseases N. Engl. J. Med. 348 2003 1365 1375
18. P.G. Gallagher, Y. Bao, S.M. Serrano, A.S. Kamiguti, R.D. Theakston, and J.W. Fox Use of microarrays for investigating the subtoxic effects of snake venoms: insights into venom-induced apoptosis in human umbilical vein endothelial cells Toxicon 41 2003 429 440
19. M.T. Heneka, H. Wiesinger, L. Dumitrescu-Ozimek, P. Riederer, D.L. Feinstein, and T. Klockgether Neuronal and glial coexpression of argininosuccinate synthetase and inducible nitric oxide synthase in Alzheimer disease J. Neuropathol. Exp. Neurol. 60 2001 906 916
20. W.A. Holtz, and K.L. O'Malley Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons J. Biol. Chem. 278 2003 19367 19377
21. N. Howard-Jones A CIOMS ethical code for animal experimentation WHO Chron. 39 1985 51 56
22. M.D. Ikonomovic, K. Uryu, E.E. Abrahamson, J.R. Ciallella, J.Q. Trojanowski, V.M. Lee, R.S. Clark, D.W. Marion, and S.R. Wisniewski Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury Exp. Neurol. 190 2004 192 203
23. B.H. Joshi, G.E. Plautz, and R.K. Puri Interleukin-13 receptor alpha chain: a novel tumor-associated transmembrane protein in primary explants of human malignant gliomas Cancer Res. 60 2000 1168 1172
24. R. Kasher, M. Balass, T. Scherf, M. Fridkin, S. Fuchs, and E. Katchalski-Katzir Design and synthesis of peptides that bind alpha-bungarotoxin with high affinity Chem. Biol. 8 2001 147 155
25. S.H. Kim, W.H. Lee, B.S. Kwon, G.T. Oh, Y.H. Choi, and J.E. Park Tumor necrosis factor receptor superfamily 12 may destabilize atherosclerotic plaques by inducing matrix metalloproteinases Jpn. Circ. J. 65 2001 136 138
26. R.M. Kini Molecular moulds with multiple missions: functional sites in three-finger toxins Clin. Exp. Pharmacol. Physiol. 29 2002 815 822
27. S.G. Kircher, S.H. Kim, M. Fountoulakis, and G. Lubec Reduced levels of DEAD-box proteins DBP-RB and p72 in fetal Down syndrome brains Neurochem. Res. 27 2002 1141 1146
28. D.L. Krebs, and D.J. Hilton SOCS proteins: negative regulators of cytokine signaling Stem Cells. 19 2001 378 387
29. Z. Li, M. Jansen, S.R. Pierre, and M.E. Figueiredo-Pereira Neurodegeneration: linking ubiquitin/proteasome pathway impairment with inflammation Int. J. Biochem. Cell Biol. 35 2003 547 552
30. F. Lin, H.J. Kaminski, B.M. Conti-Fine, W. Wang, C. Richmonds, and M.E. Medof Markedly enhanced susceptibility to experimental autoimmune myasthenia gravis in the absence of decay-accelerating factor protection J. Clin. Invest. 110 2002 1269 1274
31. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 2001 402 408
32. J. Lowe, A. Blanchard, K. Morrell, G. Lennox, L. Reynolds, M. Billett, M. Landon, and R.J. Mayer Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease J. Pathol. 155 1988 9 15
33. P.L. McGeer, and E.G. McGeer Polymorphisms in inflammatory genes and the risk of Alzheimer disease Arch. Neurol. 58 2001 1790 1792
34. D.W. Miller, M.R. Cookson, and D.W. Dickson Glial cell inclusions and the pathogenesis of neurodegenerative diseases Neuron Glia Biol. 1 2004 13 21
35. S. Nirthanan, E. Charpantier, P. Gopalakrishnakone, M.C. Gwee, H.E. Khoo, L.S. Cheah, D. Bertrand, and R.M. Kini Candoxin, a novel toxin from Bungarus candidus, is a reversible antagonist of muscle (alphabetagammadelta) but a poorly reversible antagonist of neuronal α7 nicotinic acetylcholine receptor J. Biol. Chem. 277 2002 17811 17820
36. S. Nirthanan, P. Gopalakrishnakone, M.C. Gwee, H.E. Khoo, and R.M. Kini Non-conventional toxins from Elapid venoms Toxicon 41 2003 397 407
37. V.O. Ona, M. Li, J.P. Vonsattel, L.J. Andrews, S.Q. Khan, W.M. Chung, A.S. Frey, A.S. Menon, X.J. Li, P.E. Stieg, J. Yuan, J.B. Penney, A.B. Young, J.H. Cha, and R.M. Friedlander Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease Nature 399 1999 263 267
38. E. Paradis, S. Clement, P. Julien, and M.R. Ven Murthy Lipoprotein lipase affects the survival and differentiation of neural cells exposed to very low density lipoprotein J. Biol. Chem. 278 2003 9698 9705
39. Servent, D., Menez, A., 2001. Massaro EJ (Ed.) Handbook of Neurotoxicology, vol. 1, Humana, Totowa, New Jersey, pp 385-425.
40. D. Servent, V. Winckler-Dietrich, H.Y. Hu, P. Kessler, P. Drevet, D. Bertrand, and A. Menez Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal alpha7 nicotinic receptor J. Biol. Chem. 272 1997 24279 24286
41. S. Shaw, M. Bencherif, and M.B. Marrero Janus kinase 2, an early target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloid J. Biol. Chem. 277 2002 44920 44924
42. H. Shimura, M.G. Schlossmacher, N. Hattori, M.P. Frosch, A. Trockenbacher, R. Schneider, Y. Mizuno, K.S. Kosik, and D.J. Selkoe Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease Science 293 2000 263 269
43. C.R. Slater, C. Young, S.J. Wood, G.S. Bewick, L.V. Anderson, P. Baxter, P.R. Fawcett, M. Roberts, L. Jacobson, J. Kuks, A. Vincent, and J. Newsom-Davis Utrophin abundance is reduced at neuromuscular junctions of patients with both inherited and acquired acetylcholine receptor deficiencies Brain 120 1997 1513 1531
44. F.L. Smith, P.A. Smith, W.L. Dewey, and R.R. Javed Effects of mGlu1 and mGlu5 metabotropic glutamate antagonists to reverse morphine tolerance in mice Eur. J. Pharmacol. 492 2004 137 142
45. A.H. Stokes, W.M. Freeman, S.G. Mitchell, T.A. Burnette, G.M. Hellmann, and K.E. Vrana Induction of GADD45 and GADD153 in neuroblastoma cells by dopamine-induced toxicity Neurotoxicology. 23 2002 675 784
46. M.C. Sun, C.R. Honey, C. Berk, N.L. Wong, and J.K. Tsui Regulation of aquaporin-4 in a traumatic brain injury model in rats J. Neurosurg. 98 2003 565 569
47. P. Teismann, K. Tieu, O. Cohen, D.K. Choi, C. Wu du, D. Marks, M. Vila, V. Jackson-Lewis, and S. Przedborski Pathogenic role of glial cells in Parkinson's disease Mov. Disord. 18 2003 121 129
48. M.M. Thwin, P. Gopalakrishnakone, R.M. Kini, A. Armugam, and K. Jeyaseelan Recombinant antitoxic and antiinflammatory factor from the nonvenomous snake Python reticulatus: phospholipase A2 inhibition and venom neutralizing potential Biochemistry 39 2000 9604 9611
49. M.M. Thwin, R.L. Satish, S.T. Chan, and P. Gopalakrishnakone Functional site of endogenous phospholipase A2 inhibitor from python serum Eur. J. Biochem. 269 2002 719 727
50. T.M. Tuohy, N. Wallingford, Y. Liu, F.H. Chan, T. Rizvi, R. Xing, B. Bebo, M.S. Rao, and L.S. Sherman CD44 overexpression by oligodendrocytes: a novel mouse model of inflammation-independent demyelination and dysmyelination Glia 47 2004 335 345
51. T. Wyss-Coray, and L. Mucke Inflammation in neurodegenerative disease-a double-edged sword Neuron 35 2002 419 432
52. M. Yamazaki, T. Yajima, M. Tanabe, K. Fukui, E. Okada, R. Okamoto, S. Oshima, T. Nakamura, T. Kanai, M. Uehira, T. Takeuchi, H. Ishikawa, T. Hibi, and M. Watanabe Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis J. Immunol. 171 2003 1556 1563
53. M.S. Yoo, H.S. Chun, J.J. Son, L.A. DeGiorgio, D.J. Kim, C. Peng, and J.H. Son Oxidative stress regulated genes in nigral dopaminergic neuronal cells: correlation with the known pathology in Parkinson's disease Brain Res. Mol. Brain Res. 110 2003 76 84
54. T. Yoshihara, S. Ishigaki, M. Yamamoto, Y. Liang, J. Niwa, H. Takeuchi, M. Doyu, and G. Sobue Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis J. Neurochem. 80 2002 158 167