Blockade of CTLA-4 promotes airway inflammation in naive mice exposed to aerosolized allergen but fails to prevent inhalation tolerance

Scandinavian Journal of Immunology

Volumn 62, Issue 5, 2005, Pages 437-444

  Alenmyr, L ^a   Matheu, V ^b   Uller, L ^b   Greiff, L ^a   Malm Erjefalt M ^a   Ljunggren, H G ^c   Persson, C G A ^a   Korsgren, M ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; OVALBUMIN; SODIUM CHLORIDE;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN FUNCTION; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; EOSINOPHIL; EXPOSURE; FEMALE; GOBLET CELL; IMMUNE RESPONSE; INFLAMMATION; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL;

AEROSOLS; ALLERGENS; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; BRONCHOALVEOLAR LAVAGE FLUID; EOSINOPHILS; FEMALE; IMMUNE TOLERANCE; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN E; INJECTIONS, INTRAPERITONEAL; LUNG; MICE; MICE, INBRED BALB C; OVALBUMIN; PNEUMONIA; RESPIRATORY MUCOSA;

EID: 28344454067     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2005.01682.x     Document Type: Article

References (42)

1. Bousquet J, Chanez P, Lacoste JY et al. Eosinophilic inflammation in asthma. N Engl J Med 1990;323:1033-9.
2. Stämpfli MR, Wiley RE, Neigh GS et al. GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice. J Clin Invest 1998;102:1704-14.
3. Renz H, Smith HR, Henson JE, Ray BS, Irvin CG, Gelfand EW. Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway hyperresponsiveness in the mouse. J Allergy Clin Immunol 1992;89:1127-38.
4. Hamada K, Goldsmith CA, Goldman A, Kobzik L. Resistance of very young mice to inhaled allergen sensitization is overcome by coexposure to an air-pollutant aerosol. Am J Respir Crit Care Med 2000;161:1285-93.
5. Holt PG, McMenamin C. Defence against allergic sensitization in the healthy lung: the role of inhalation tolerance. Clin Exp Allergy 1989;19:255-62.
6. + T cells or interferon (IFN)-γ in a murine model of allergen sensitization. J Exp Med 1998;187:721-31.
7. McMenamin C, Pimm C, McKersey M, Holt PG. Regulation of IgE responses to inhaled antigen in mice by antigen-specific γδ T cells. Science 1994;265:1869-71.
8. Robinson DS, Hamid Q, Ying S et al. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992;326:298-304.
9. Coyle AJ, Gutierrez-Ramos JC. The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function. Nature Immunol 2001;2:1-7.
10. Deurloo DT, Van Esch BCAM, Hofstra CL, Nijkamp FP, Van Oosterhout AJM. CTLA4-IgG reverses asthma manifestations in a mild but not in a more 'severe' ongoing murine model. Am J Respir Cell Mol Biol 2001;6:751-60.
11. Keane-Myers A, Gause WC, Linsley PS, Chen S-J, Wills-Karp M. B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens. J Immunol 1997;158:2042-9.
12. Padrid PA, Mathur M, Li X et al. CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma. Am J Respir Cell MoI Biol 1999;18:453-62.
13. Tsuyuki S, Tsuyuki J, Einsle K, Kopf M, Coyle AJ. Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness. J Exp Med 1997;185:1671-9.
14. Deurloo DT, Van Berkel MAT, Van Esch BCAM et al. CD28/ CTLA4 double deficient mice demonstrate crucial role for B7 co-stimulation in the induction of allergic lower airways disease. Clin Exp Allergy 2003;33:1297-304.
15. Krinzman SJ, De Sanctis GT, Cernadas M et al. Inhibition of T cell costimulation abrogates airway hyperresponsiveness in a murine model. J Clin Invest 1996;98:2693-9.
16. Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA. CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med 1991;174:561-9.
17. Walunas TL, Lenschow DJ, Bakker CY et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1994;1:405-13.
18. Perkins D, Wang Z, Donovan C et al. Regulation of CTLA-4 expression during T cell activation. J Immunol 1996;156:4154-9.
19. Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995;3:541-7.
20. Perez VL, Van Parijs L, Biuckians A, Zheng XX, Strom TB, Abbas AK. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 1997;6:411-7.
21. Samoilova EB, Horton JL, Zhang H, Khoury SJ, Weiner HL, Chen Y. CTLA-4 is required for the induction of high dose oral tolerance. Int Immunol 1998;10:491-8.
22. Van Oosterhout AJM, Deurloo DT, Groot PC. Cytotoxic T lymphocyte antigen 4 polymorphisms and allergic asthma. Clin Exp Allergy 2004;34:4-8.
23. Holgate ST. Genetic common ground between allergic and autoimmune disease. The role of cytotoxic T-lymphocyte antigen 4. J Allergy Clin Immunol 2004;114:277-9.
24. Korsgren M, Persson CGA, Sundler F et al. Natural killer cells determine development of allergen-induced eosinophilic airway inflammation in mice. J Exp Med 1999;189:553-62.
25. Korsgren M, Erjefält JS, Korsgren O, Sundler F, Persson CGA. Allergic eosinophil-rich inflammation develops in lungs and airways of B cell-deficient mice. J Exp Med 1997;185:885-92.
26. Tsitoura DC, DeKruyff RH, Lamb JR, Umetsu DT. Intranasal exposure to protein antigen induces immunological tolerance mediated by functionally disabled CD4+ T cells. J Immunol 1999;163:2592-600.
27. Hellings PW, Vandenberghe P, Kasran A et al. Blockade of CTLA-4 enhances allergic sensitization and eosinophilic airway inflammation in genetically predisposed mice. Eur J Immunol 2002;32:585-694.
28. Van Wijk F, Hoeks S, Nierkens S et al. CTLA-4 signaling regulates the intensity of hypersensitivity responses to food antigens, but is not decisive in the induction of sensitization. J Immunol 2005;174:174-9.
29. McCoy K, Camberis M, Le Gros G. Protective immunity to nematode infection is induced by CTLA-4 blockade. J Exp Med 1997;186:183-7.
30. Murphy ML, Cotterell SEJ, Gorak PMA, Engwerda CR, Kaye PM. Blockade of CTLA-4 enhances host resistance to the intracellular pathogen, Leishmania donovani. J Immunol 1998;161:4153-60.
31. Rulifson IC, Sperling AI, Fields PE, Fitch FW, Bluestone JA. CD28 costimulation promotes the production of Th2 cytokines. J Immunol 1997;158:658-65.
32. Oosterwegel MA, Mandelbrot DA, Boyd SD et al. The role of CTLA-4 in regulating Th2 differentiation. J Immunol 1999;163:2634-9.
33. Kato T, Nariuchi H. Polarization of naive CD4+ T cells toward the Th1 subset by CTLA-4 costimulation. J Immunol 2000;164:3554-62.
34. Takahashi T, Tagami T, Yamazaki S et al. Immunological self-tolerance maintained by CD25+CD4+ regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2000;192:303-10.
35. Read S, Malmstrom V, Powrie F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+CD4+ regulatory cells that control intestinal inflammation. J Exp Med 2000;192:295-302.
36. Akdis M, Verhagen J, Taylor A et al. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 2004;199:1567-75.
37. Greenwald RJ, Freeman GJ, Sharpe AH. The B7 family revisited. Annu Rev Immunol 2005;23:515-48.
38. Swirski FK, Gajewska BU, Robbins CS et al. Concomitant airway expression of granulocyte-macrophage colony-stimulating factor and decorin, a natural inhibitor of transforming growth factor-ß, breaks established inhalation tolerance. Eur J Immunol 2004;34:2375-86.
39. Tsitoura DC, Kim S, Dabbagh K, Berry G, Lewis DB, Umetsu DT. Respiratory infection with influenza A virus interferes with the induction of tolerance to aeroallergens. J Immunol 2000;165:3484-91.
40. Holt PG, Vines J, Bilyk N. Effect of influenza virus infection on allergic sensitization to inhaled antigen in mice. Int Archs Allergy Appl Immun 1988;86:121-3.
41. Wan GH, Li CS, Lin RH. Airborne endotoxin exposure and the development of airway antigen-specific allergic responses. Clin Exp Allergy 2000;30:426-32.
42. Wan GH, Li CS, Guo SP, Rylander R, Lin RH. An airbone mold-derived product, beta-1,3-D-glucan, potentiates airway allergic responses. Eur J Immunol 1999;29:2491-7.