Expression and regulation of antimicrobial peptides in articular joints

Annals of Anatomy

Volumn 187, Issue 5-6, 2005, Pages 499-508

  Varoga, Deike ^a,b   Pufe, Thomas ^b   Mentlein, Rolf ^b   Kohrs, Susanne ^b   Grohmann, Susanne ^b   Tillmann, Bernhard ^b   Hassenpflug, Joachim ^a   Paulsen, Friedrich ^c  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Antimicrobial peptides; Articular joints

Indexed keywords

BETA DEFENSIN 2; BETA DEFENSIN 3; CATHELICIDIN; LACTOFERRIN; LYSOZYME; PHOSPHOLIPASE A2; RIBONUCLEASE; TOLL LIKE RECEPTOR;

ARTICULAR CARTILAGE; BACTERIAL ARTHRITIS; CELLULAR DISTRIBUTION; DISEASE PREDISPOSITION; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; IMMUNE SYSTEM; IN VITRO STUDY; INFECTIOUS ARTHRITIS; NONHUMAN; OSTEOARTHRITIS; PATHOLOGICAL ANATOMY; PATHOPHYSIOLOGY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; REVIEW; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; SYNOVIUM;

BACTERIA (MICROORGANISMS);

EID: 28344449498     PISSN: 09409602     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aanat.2005.03.004     Document Type: Article

References (81)

1. Andriamanalijaona, R., Felisaz, N., Kim, S.J., King-Jones, K., Lehmann, M., Pujol, J.P., Boumediene, K., 2003. Mediation of interleukin-1beta-induced transforming growth factor beta1 expression by activator protein 4 transcription factor in primary cultures of bovine articular chondrocytes: possible cooperation with activator protein 1. Arthritis Rheum. 48, 1569-1581.
2. Baker, A.H., Edwards, D.R., Murphy, G., 2002. Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J. Cell Sci. 115, 3719-3727.
3. Bals, R., Wang, X., Wu, Z., Freeman, T, Bafna, V., Zasloff, M., Wilson, J.M., 1998. Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J. Clin. Invest. 102, 874-880.
4. Bals, R., Wang, X., Meegalla, R.L., Wattler, S., Weiner, D.J., Nehls, M.C., Wilson, J.M., 1999. Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs. Infect. Immun. 67, 3542-3547.
5. Becker, M.N., Diamond, G., Verghese, M.W., Randell, S.H., 2000. CD-14-dependent lipopolysaccharide-induced beta-defensin-2 expression in human tracheo-bronchial epithelium. J. Biol. Chem. 275, 29731-29736.
6. Bensch, K.W., Raida, M., Magert, H.J., Schulz-Knappe, P., Forssmann, W.G., 1995. HBD-1: a novel beta-defensin from human plasma. FEBS Lett. 68, 331-335.
7. Burd, R.S., Furrer, J.L., Sullivan, J., Smith, A.L., 2002. Murine beta-defensin-3 is an inducible peptide with limited tissue expression and broad-spectrum anti-microbial activity. Shock 18, 461-464.
8. Chambers, M.G., Bayliss, M.T, Mason, R.M., 1997. Chondrocyte cytokine and growth factor expression in murine osteoarthritis. Osteoarthr. Cartilage 5, 301-308.
9. Chertov, O., Yang, D., Zack Howard, O.M., Oppenheim, J.J., 2000. Leukocyte granule proteins mobilize innate host defenses and adaptive immune responses. Immunol. Rev. 177, 68-78.
10. Conforti, L., Petrovic, M., Mohammad, D., Lee, S., Ma, Q., Barone, S., Fitipovich, A.H., 2003. Hypoxia regulates expression and activity of Kv1.3 channels in T lymphocytes: a possible role in T cell proliferation. J. Immunol. 170, 695-702.
11. Cook, D.N., Pisetsky, D.S., Schwartz, D.A., 2004. Toll-like receptors in the pathogenesis of human disease. Nat. Immunol. 5, 975-979.
12. Dorschner, R.A., Lin, K.H., Murakami, M., Gallo, R.L., 2003. Neonatal skin in mice and humans expresses increased levels of antimicrobial peptides: innate immunity during development of the adaptive response. Pediatr. Res. 53, 566-572.
13. Flannelly, J., Chambers, M.G., Dudhia, J., Hembry, J.M., Murphy, G., Mason, R.M., Bayliss, M.T., 2002. Metalloproteinase and tissue inhibitor of metalloproteinase expression in the murine STR/ort model of osteoarthritis. Osteoarthr. Cartilage 10, 722-733.
14. Ganz, T., Lehrer, R.I., 1995. Defensins. Pharmacol. Ther. 66, 191-205.
15. Ganz, T., Selsted, M.E., Szklarek, D., Harwig, S.S., Daher, K., Bainton, D.F., Lehrer, R.I., 1985. Defensins: natural peptide antibiotics of human neutrophils. J. Clin. Invest. 76, 1427-1435.
16. Garcia, J.R., Krause, A., Schulz, S., Rodriguez-Jimenez, F.J., Kluver, E., Adermann, K., Forssmann, U., Frimpong-Boateng, A., Bals, R., Forssmann, W.G., 2001. Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. FASEB J. 15, 1819-1821.
17. Goldring, M.B., 2000a. The role of the chondrocyte in osteoarthritis. Arthritis Rheum. 43, 1916-1926.
18. Goldring, M.B., 2000b. Osteoarthritis and cartilage: the role of cytokines. Curr. Rheumatol. Rep. 2, 459-465.
19. Goldring, M.B., 2001. Anticytokine therapy for osteoarthritis. Expert Opin. Biol. Ther. 1, 817-829.
20. Hancock, R.E.W., Lehrer, R., 1998. Cationic peptides: a new source of antibiotics. Trends Biotechnol. 16, 8585-8589.
21. Harder, J., Schröder, J.M., 2002. RNase-7, a novel innate immune defense antimicrobial protein of healthy human skin. J. Biol. Chem. 277, 46779-46784.
22. Harder, J., Bartels, J., Christophers, E., Schröder, J.M., 1998. A peptide antibiotic from human skin. Nature 387, 861.
23. Harder, J., Meyer-Hoffert, U., Teran, L.M., Schwichtenberg, L., Bartels, J., Maune, S., Schröder, J.M., 2000. Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1-beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia. Am. J. Respir. Cell. Mol. Biol. 22, 714-721.
24. Harder, J., Bartels, J., Christophers, E., Schröder, J.M., 2001. Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic. J. Biol. Chem. 276, 5707-5713.
25. Haynes, J.H., Tighe, P.J., Dua, H.S., 1998. Innate defence of the eye by antimicrobial defensin peptides. Lancet 352, 451-452.
26. Hill, C.P., Yee, J., Selsted, M.E., Eisenberg, D., 1991. Crystal structure of defensins HNP-3, an amphiphilic dimer. Mechanisms of membrane permeabilisation. Science 251, 1481-1485.
27. Hoover, D.M., Rajashankar, K.R., Blumenthal, R., Puri, A., Oppenheim, J.J., Chertov, O., Lubkowski, J., 2000. The structure of human β-defensin-2 shows evidence of higher order oligomerization. J. Biol. Chem. 275, 32911-32918.
28. Hultgren, O.H., Stenson, M., Tarkowski, A., 2001. Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis. Arthritis Res. 3, 41-47.
29. Islam, D., Bandholtz, L., Nilsson, J., Wigzell, H., Christensson, B., Agerberth, B., Gudmundsson, G.H., 2001. Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator. Nat. Med. 7, 180-185.
30. Jia, H.P., Wowk, S.A., Schutte, B.C., Lee, S.K., Vivado, A., Tack, B.F., Bevins, C.L., McCray Jr, P.B., 2000. A novel murine beta-defensin expressed in tongue, esophagus, and trachea. J. Biol. Chem. 275, 33314-33320.
31. Kagan, B.L., Ganz, T, Lehrer, R.I., 1994. Defensins: a family of antimicrobial and cytotoxic peptides. Toxicology 87, 131-149.
32. Kijlstra, A., 1990. The role of lactoferrin in the nonspecific immune response on the ocular surface. Regul. Immunol. 3, 193-197.
33. Koczulla, R., von Degenfeld, G., Kupatt, C., Krotz, F., Zahler, S., Gloe, T, Issbrucker, K., Unterberger, P., Zaiou, M., Lebherz, C., Karl, A., Raake, R, Pfosser, A., Boekstegers, R, Welsch, U., Hiemstra, P.S., Vogelmeier, C., Gallo, R.L., Clauss, M., Bals, R., 2003. An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J. Clin. Invest. 11, 1665-1672.
34. Kyburz, D., Rethage, J., Seibl, R., Lauener, R., Gay, R.E., Carson, D.A., Gay, S., 2003. Bacterial peptidoglycans but not CpG oligodeoxynucleotides activate synovial fibroblasts by Toll-like receptor signaling. Arthritis Rheum. 48, 642-650.
35. Lehrer, R.I., Barton, A., Daher, K.A., Harwig, S.S., Ganz, T., Selsted, ME., 1989. Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. J. Clin. Invest. 84, 553-561.
36. Liu, L., Roberts, A.A., Ganz, T., 2003. By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide. J. Immunol. 170, 575-580.
37. Martel-Pelletier, J., Pelletier, J.P., 1987. Neutral proteases in human osteoarthritic synovium: quantification and characterization. J. Rheumatol. 14, 38-40.
38. Mason, R.M., Chambers, M.G., Flannelly, J., Gaffen, J.D., Dudhia, J., Bayliss, J.T., 2001. The STR/ort mouse and its use as a model of osteoarthritis. Osteoarthr. Cartilage 9, 85-91.
39. McDermott, A.M., Redfern, R.L., Zhang, B., 2001. Human beta-defensin 2 is up-regulated during re-epitheliatization of the cornea. Curr. Eye Res. 22, 64-67.
40. Merrihew, C., Soeder, S., Rueger, D.C., Kuettner, K.E., Chubinskaya, S.E., 2003. Modulation of endogenous osteogenic protein-1 (OP-1) by interleukin-1 in adult human articular cartilage. J. Bone Jt. Surg. Am. Suppl. 3, 67-74.
41. Mitchell, P.J., Magna, H.A., Reeves, L.M., Lopresti-Morrow, L.L., Yocum, S.A., Rosner, P.J., Geoghegan, K.F., Hambor, J.E., 1996. Cloning, expression, and Type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. J. Clin. Invest. 97, 761-768.
42. Morrison, G.M., Davidson, D.J., Dorin, J.R., 1999. A novel mouse beta defensin, Defb2, which is upregutated in the airways by lipopolysaccharide. FEBS Lett. 442, 112-116.
43. Murphy, C.J., Foster, B.A., Mannis, M.J., Selsted, M.E., Reid, T.W., 1993. Defensins are mitogenic for epithelial cells and fibroblasts. J. Cell. Physiol. 155, 408-413.
44. O'Neil, D.A., Porter, E.M., Elewaut, D., Anderson, G.M., Eckmann, L., Ganz, T, Kagnoff, M.F., 1999. Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium. J. Immunol. 163, 6718-6724.
45. O'Neill, L.A., Dunne, A., Edjeback, M., Gray, P., Jefferies, C., Wietek, C., 2003. Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors. J. Endotoxin. Res. 9, 55-59.
46. Ong, P.Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R.L., Leung, D.Y., 2002. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. Engl. J. Med. 347, 1151-1160.
47. Oram, J., Reiter, B., 1979. Inhibition of bacteria by lactoferrin and other iron-chelating agents. Biochim. Biophys. Acta 170, 351-353.
48. Paulsen, F., Pufe, T., Petersen, W., Tillmann, B., 2001a. Expression of natural peptide antibiotics in human articular cartilage and synovial membrane. Clin. Diagn. Lab. Immunol. 8, 1021-1023.
49. Paulsen, F., Pufe, T., Schaudig, U., Held-Feindt, J., Lehmann, J., Schröder J-, M., Tillmann, B., 2001b. Detection of natural peptide antibiotics in human nasolacrimal ducts. Invest. Ophthalmol. Vis. Sci. 42, 2157-2163.
50. Paulsen, F., Pufe, T, Conradi, L., Varoga, D., Tsokos, M., Papendieck, J., Petersen, W., 2002. Antimicrobial peptides are expressed and produced in healthy and inflamed human synovial membranes. J. Pathol. 198, 369-377.
51. Pelletier, J.P., Martel-Pelletier, J., Abramson, S.B., 2001. Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. Arthritis Rheum. 44, 1237-1247.
52. Pierer, M., Rethage, J., Seibl, R., Lauener, R., Brentano, F., Wagner, U., Hantzschel, H., Michel, B.A., Gay, R.E., Gay, S., Kyburz, D., 2004. Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 Ligands. J. Immunol. 172, 1256-1265.
53. Prohaszka, Z., Nemet, K., Csermely, R, Hudecz, F., Mezo, G., Fust, G., 1997. Defensins purified from human granulocytes bind C1q and activate the classical complement pathway like the transmembrane glycoprotein gp41 of HIV-1. Mol. Immunol. 34, 809-816.
54. Pufe, T., Harde, V., Petersen, W., Goldring, M.B., Tillmann, B., Mentlein, R., 2004. VEGF induces matrix metalloproteinase expression in chondrocytes. J. Pathol. 202, 367-374.
55. Putsep, K., Carlsson, G., Boman, H.G., Andersson, M., 2002. Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study. Lancet 360, 1116-1117.
56. 2 is the principal bactericide for staphylococci and other Gram-positive bacteria in human tears. Infect. Immun. 66, 2791-2797.
57. Ryan, M.J., Kavanagh, R., Wall, P.G., Hazleman, B.L., 1997. Bacterial joint infections in England and Wales: analysis of bacterial isolates over a four year period. Br. J. Rheumatol. 36, 370-373.
58. Salzman, N.H., Ghosh, D., Huttner, K.M., Paterson, Y., Bevins, C.L., 2003. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature 422, 478-479.
59. Schröder, J.M., Harder, J., 1999. Human beta-defensin-2. Int. J. Biochem. Cell. Biol. 31, 645-651.
60. Shafer, W.M., Martin, L.E., Spitznagel, J.K., 1986. Late intraphagosomal hydrogen ion concentration favors the in vitro antimicrobial capacity of a 37-kilodalton cationic granule protein of human neutrophil granules. Infect. Immun. 53, 651-655.
61. Shelburne, C.E., Coulter, W.A., Olguin, D., Lantz, M.S., Lopatin, D.E., 2005. Induction of β-defensin resistance in the oral anaerobe Porphyromonas gingivalis. Antimicrob. Agents Chemother. 49 (1), 183-187.
62. Singh, P.K., Jia, H.P., Wiles, K., Hessetberth, J., Liu, L., Conway, B.A., Greenberg, E.P., Valore, E.V., Welsh, M.J., Ganz, T., Tack, B.F., McCray Jr., P.B., 1998. Production of beta-defensins by human airway epithelia. Proc. Natl. Acad. Sci. USA 95, 14961-14966.
63. Sorensen, O.E., Cowland, J.B., Theilgaard-Monch, K., Liu, L., Ganz, T., Borregaard, N., 2003. Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors. J. Immunol. 170, 5583-5589.
64. Spitznagel, J.K., 1990. Antibiotic proteins of human neutrophils. J. Clin. Invest. 86, 1381-1386.
65. Takeda, K., Kaisho, T., Akira, S., 2003. Toll-like receptors. Annu. Rev. Immunol. 21, 335-376.
66. Territo, M.C., Ganz, T., Selsted, M.E., Lehrer, R.I., 1989. Monocyte-chemotactic activity of defensins from human neutrophils. J. Clin. Invest. 84, 2017-2020.
67. Thibault, M., Poole, A.R., Buschmann, M.D., 2002. Cyclic compression of cartilage/bone explants in vitro leads to physical weakening, mechanical breakdown of collagen and release of matrix fragments. J. Orthop. Res. 20, 1265-1273.
68. Tsutsumi-Ishii, Y., Nagaoka, I., 2002. NF-kappa B-mediated transcriptional regulation of human beta-defensin-2 gene following lipopolysaccharide stimulation. J. Leukoc. Biol. 71, 154-162.
69. Valore, E.V., Park, C.H., Quale, A.J., Wiles, K.R., McCray, P.B., Ganz, T., 1998. Human β-defensin-1: an antimicrobial peptide of urogenital tissue. J. Clin. Invest. 101, 1633-1642.
70. Varoga, D., Pufe, T., Harder, J., Meyer-Hoffert, U., Schröder, J.M., Mentlein, R., Petersen, W., Tillmann, B., Proksch, E., Goldring, M.B., Paulsen, F., 2004. Production of endogenous antibiotics in articular cartilage. Arthritis Rheum. 50, 3526-3534.
71. Varoga, D., Pufe, T., Harder, J., Schröder, J.M., Mentlein, R., Meyer-Hoffert, U., Goldring, M.B., Tillmann, B., Hassenpflug, J., Paulsen, F., 2005a. Human beta-defensin-3 mediates tissue remodeling processes in articular cartilage by increasing metalloproteinases and reducing their endogenous inhibitors. Arthritis Rheum 52, 1736-1745.
72. Varoga, D., Paulsen, F., Mentlein, R., Fay, J., Kurz, B., Schütz, R., Grohmann, S., Goldring, M.B., Hassenpflug, J., Pufe, T., 2005b. Induction of vascular endothetial growth factor (VEGF) in septic joint disease. Am. J. Pathol. in revision.
73. Vincenti, M.P., Brinckerhoff, C.E., 2002. Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors. Arthritis Res. 4, 157-164.
74. Walton, M., 1977. Studies of degenerative joint disease in the mouse knee joint; scanning electron microscopy. J. Pathol. 123, 21.
75. Withelmus, K.R., 1985. The importance of having lysozyme. Cornea 4, 69-70.
76. Wu, Z., Hoover, D.M., Yang, D., Boulege, C., Santamaria, F., Oppenheim, J., Lubkowski, J., Lu, W., 2003. Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3. Proc. Natl. Acad. Sci. USA 100, 8880-8885.
77. Yamaguchi, Y., Nagase, T., Makita, R., Fukuhara, S., Tomita, T., Tominaga, T., Kurihara, H., Ouchi, Y., 2002. Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice. J. Immunol. 169, 2516-2523.
78. Yang, D., Chertov, O., Bykovskaia, S.N., Chen, Q., Buffo, M.J., Shogan, J., Anderson, M., Schröder, J.M., Wang, J.M., Howard, O.M., Oppenheim, J.J., 1999. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286, 525-528.
79. Yang, D., Chen, Q., Chertov, O., Oppenheim, J.J., 2000a. Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells. J. Leukoc. Biol. 68, 9-14.
80. Yang, H., Young, D.W., Gusovsky, F., Chow, J.C., 2000b. Cellular events mediated by lipopolysaccharide-stimulated Toll-like receptor 4.MD-2 is required for activation of mitogen-activated protein kinases and Elk-1. J. Biol. Chem. 275, 20861-20866.
81. Zasloff, M., 2002. Antimicrobial peptides of multicellular organisms. Nature 415, 389-395.