Life-threatening interaction between the root extract of Pueraria lobata and methotrexate in rats

Toxicology and Applied Pharmacology

Volumn 209, Issue 3, 2005, Pages 263-268

  Chiang, Hsiu Mei ^a,b   Fang, Shih Hua ^c   Wen, Kuo Ching ^a   Hsiu, Su Lan ^a   Tsai, Shang Yuan ^a   Hou, Yu Chi ^a   Chi, Ying Chang ^a   Lee Chao, Pei Dawn ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b JEN TEH JUNIOR COLLEGE OF MEDICINE   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Isoflavone; Methotrexate; Multidrug resistance protein; Pueraria lobata

Indexed keywords

ANTIMETABOLITE; ISOFLAVONE; METHOTREXATE; PLANT EXTRACT; PUERARIA LOBATA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CALCULATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG EFFECT; DRUG EXPOSURE; DRUG FATALITY; DRUG HALF LIFE; DRUG SAFETY; FLUORESCENCE POLARIZATION IMMUNOASSAY; HERB; HERB DRUG INTERACTION; MALE; MEAN RESIDENCE TIME; NONHUMAN; PLANT ROOT; PUNCTURE; RAT;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; ASTHENIA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HALF-LIFE; HERB-DRUG INTERACTIONS; INJECTIONS, INTRAVENOUS; ISOFLAVONES; MALE; METHOTREXATE; MOLECULAR STRUCTURE; PILOERECTION; PLANT EXTRACTS; PLANT ROOTS; PUERARIA; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; PUERARIA MONTANA VAR. LOBATA;

EID: 28244438003     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2005.04.015     Document Type: Article

References (56)

1. I. Aquerreta, A. Aldaz, J. Giraldez, and L. Sierrasesumaga Methotrexate pharmacokinetics and survival in osteosarcoma Pediatr. Blood Cancer 42 2004 52 58
2. T. Arao, J. Kinjo, T. Nohara, and R. Isobe Oleanene-type triterpene glycosides from Puerariae Radix. IV. Six new saponins from Pueraria lobata Chem. Pharm. Bull. 45 1997 362 366
3. W.A. Bleyer The clinical pharmacology of methotrexate: new applications of an old drug Cancer 41 1978 36 51
4. G. Burchini, and C. Orsi Rheumatoid arthritis N. Engl. J. Med. 351 2004 1360 1361
5. B.A. Carneiro-Filho, I.P. Lima, D.H. Araujo, M.C. Cavalcante, G.H. Carvalho, G.A. Brito, V. Lima, S.M. Monteiro, F.N. Santos, R.A. Ribeiro, and A.A. Lima Intestinal barrier function and secretion in methotrexate-induced rat intestinal mucositis Dig. Dis. Sci. 49 2004 65 72
6. P.D.L. Chao, S.L. Hsiu, and Y.C. Hou Flavonoids in herbs: biological fates and potential interactions with xenobiotics J. Food Drug Anal. 11 2002 135 145
7. Z.S. Chen, K. Lee, S. Walther, R.B. Raftogianis, M. Kuwano, H. Zeng, and G.D. Kruh Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system Cancer Res. 62 2002 3144 3150
8. J. Chladek, J. Grim, J. Martinkova, M. Simkova, J. Vaniekova, V. Koudelkova, and M. Noiekova Pharmacokinetics and pharmacodynamics of low-dose methotrexate in the treatment of psoriasis Br. J. Clin. Pharmacol. 54 2002 147 156
9. Y. Cui, J. Konig, J.K. Buchholz, H. Spring, I. Leier, and D. Keppler Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells Mol. Pharmacol. 55 1999 929 937
10. A.J. Day, M.S. Dupont, S. Ridley, M. Rhodes, M.J. Rhodes, M.R. Morgan, and G. Williamson Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity FEBS Lett. 436 1998 71 75
11. P.O. Ekstrom, K.E. Giercksky, A. Andersen, and L. Slordal Alterations in methotrexate pharmacokinetics by naproxen in the rat as measured by microdialysis Life Sci. 60 1997 359 364
12. W.E. Evans, W.R. Crom, M. Abromowitch, R. Dodge, A.T. Look, W.P. Bowman, S.L. George, and C.H. Pui Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia. Identification of a relation between concentration and effect N. Engl. J. Med. 314 1986 471 477
13. D.E. Furst Practical clinical pharmacology and drug interactions of low-dose methotrexate therapy in rheumatoid arthritis Br. J. Rheumatol. 34 Suppl. 2 1995 20 25
14. J. Galivan Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate Mol. Pharmacol. 14 1980 1143 1147
15. L. Genestier, R. Paillot, L. Quemeneur, K. Izeradjene, and J.P. Revillard Mechanisms of action of methotrexate Immunopharmacology 47 2000 247 257
16. J. Grim, J. Chladek, and J. Martinkova Pharmacokinetics and pharmacodynamics of methotrexate in non-neoplastic diseases Clin. Pharmacokinet. 42 2003 139 151
17. T. Hirohashi, H. Suzuki, and Y. Sugiyama Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3) J. Biol. Chem. 274 1999 15181 15185
18. K. Ito, C.J. Oleschuk, C. Westlake, M.Z. Vasa, R.G. Deeley, and S.P. Cole Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity J. Biol. Chem. 276 2001 38108 38114
19. J. Jolivet, R.L. Schilsky, B.D. Bailey, J.C. Darke, and B.A. Chabner Synthesis, retention, and biological activity of methotrexate polyglutamates in cultured human breast cancer cells J. Clin. Investig. 70 1982 351 360
20. T. Kawabe, Z.S. Chen, M. Wada, T. Uchiumi, M. Ono, S. Akiyama, and M. Kuwano Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2) FEBS Lett. 456 1999 327 331
21. H. Kazuhiro, M. Makoto, N. Kaoru, S. Koh, T. Koji, N. Kazuaki, I. Yukinobu, M. Maruno, and M. Okada Phenolic glucosides from the root of Pueraria lobata Phytochemistry 46 1997 921 928
22. K. Kondo, Y. Suzuki, Y. Ikeda, and K. Umemura Genistein, an isoflavone included in soy, inhibits thrombotic vessel occlusion in the mouse femoral artery and in vitro platelet aggregation Eur. J. Clin. Pharmacol. 455 2002 53 57
23. M. Kool, M. van der Linden, M. de Haas, G.L. Scheffer, J.M. de Vree, A.J. Smith, G. Jansen, G.J. Peters, N. Ponne, R.J. Scheper, R.P. Elferink, F. Baas, and P. Borst MRP3, an organic anion transporter able to transport anti-cancer drugs Proc. Natl. Acad. Sci. U.S.A. 96 1999 6914 6919
24. G.D. Kruh, H. Zeng, P.A. Rea, G. Liu, Z.S. Chen, K. Lee, and M.G. Belinsky MRP subfamily transporters and resistance to anticancer agents J. Bioenerg. Biomembr. 33 2001 493 501
25. A.L. Kuijpers, and P.C. van de Kerkhof Risk-benefit assessment of methotrexate in the treatment of severe psoriasis Am. J. Clin. Dermatol. 1 2000 27 39
26. H. Kusuhara, and Y. Sugiyama Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney J. Controlled Release 78 2002 43 54
27. R. Mackey, A. Ekangaki, and J.A. Eden The effects of soy protein in women and men with elevated plasma lipids BioFactors 12 2000 251 257
28. M. Masuda, Y. Tizuka, M. Yamazaki, R. Nishigaki, Y. Kato, K. Ni'inuma, H. Suzuki, and Y. Sugiyama Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats Cancer Res. 57 1997 3506 3510
29. R.J. McKendry The remarkable spectrum of methotrexate toxicities Rheum. Dis. Clin. North Am. 23 1997 939 954
30. M.J. Messina, V. Persky, K.D. Setchell, and S. Barnes Soy intake and cancer risk: a review of the in vitro and in vivo data Nutr. Cancer 21 1994 113 131
31. K. Nemeth, G.W. Plumb, J.G. Berrin, N. Juge, R. Jacob, H.Y. Naim, G. Williamson, D.M. Swallow, and P.A. Kroon Deglycosylation by small intestinal epithelial cell β-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans Eur. J. Nutr. 42 2003 28 42
32. K.A. O'Leary, A.J. Day, P.W. Needs, F.A. Mellon, N.M. O'Brien, and G. Williamson Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism Biochem. Pharmacol. 65 2003 479 491
33. M.K. Piskula Factors affecting flavonoids absorption BioFactors 12 2000 175 180
34. J.K. Prasain, K. Jones, M. Kirk, L. Wilson, M. Smith-Johnson, C. Weaver, and S. Barnes Profiling and quantification of isoflavonoids in kudzu dietary supplements by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry J. Agric. Food Chem. 51 2003 4213 4218
35. M.V. Relling, D. Fairclough, D. Ayers, W.R. Crom, J.H. Rodman, C.H. Pui, and W.E. Evans Patient characteristics associated with high-risk methotrexate concentrations and toxicity J. Clin. Oncol. 12 1994 667 672
36. D.J. Rickard, D.G. Monroe, T.J. Ruesink, S. Khosla, B.L. Riggs, and T.C. Spelsberg Phytoestrogen genistein acts as an estrogen agonist on human osteoblastic cells through estrogen receptors alpha and beta J. Cell. Biochem. 89 2003 633 646
37. G. Rimbach, S. De Pascual-Teresa, B.A. Ewins, S. Matsugo, Y. Uchida, A.M. Minihane, R. Turner, K. VafeiAdou, and P.D. Weinberg Antioxidant and free radical scavenging activity of isoflavone metabolites Xenobiotica 33 2003 913 925
38. M. Saxena, and G.B. Henderson Identification of efflux system for large anions and anionic conjugates as the mediators of methotrexate efflux in L1210 cells Biochem. Pharmacol. 51 1996 974 982
39. R.L. Schleicher, C.A. Lamartiniere, M. Zheng, and M. Zhang The inhibitory effect of genistein on the growth and metastasis of a transplantable rat accessory sex gland carcinoma Cancer Lett. 136 1999 195 201
40. F. Sczesny, G. Hempel, J. Boos, and G. Blaschke Capillary electrophoretic drug monitoring of methotrexate and leucovorin and their metabolites J. Chromatogr., B, Biomed. Sci. Appl. 718 1998 177 185
41. P. Seideman, O. Beck, S. Eksborg, and M. Wennberg The pharmacokinetics of methotrexate and its 7-hydroxy metabolite in patients with rheumatoid arthritis Br. J. Clin. Pharmacol. 35 1993 409 412
42. T. Sekine, S.H. Cha, M. Tsuda, N. Apiwattanakul, N. Nakajima, Y. Kanai, and H. Endou Identification of multispecific organic anion transporter 2 expressed predominantly in the liver FEBS Lett. 429 1998 179 182
43. T. Sekine, S.H. Cha, and H. Endou The multispecific organic anion transporter (OAT) family Pflugers Archiv-Eur. J. Physiol. 440 2000 337 350
44. P. Sonneveld, F.W. Schultz, K. Nooter, and K. Hahlen Pharmacokinetics of methotrexate and 7-hydroxy-methotrexate in plasma and bone marrow of children receiving low-dose oral methotrexate Cancer Chemother. Pharmacol. 18 1986 111 116
45. R.A. Van Aubel, M.A. van Kuijck, J.B. Koenderink, P.M. Deen, C.H. van Os, and F.G. Russel Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein Mrp2 expressed in insect cells Mol. Pharmacol. 53 1998 1062 1067
46. R.A. Van Aubel, R. Masereeuw, and F.G. Russel Molecular pharmacology of renal organic anion transporters Am. J. Physiol. 279 2000 F216 F232
47. M.M. Ward Trends in the use of disease modifying anti-rheumatic medications in rheumatoid arthritis, 1980-1995: results from the National Ambulatory Care Surveys J. Rheumatol. 26 1999 546 550
48. A.P. Wilkinson, J.M. Gee, M.S. Dupont, P.W. Needs, F.A. Mellon, G. Williamson, and I.T. Johnson Hydrolysis by lactase phlorizin hydrolase is the first step in the uptake of daidzein glucosides by rat small intestine in vitro Xenobiotica 33 2003 255 264
49. X. Xu, A.M. Duncan, B.E. Merz, and M.S. Kurzer Effect of soy isoflavone on estrogen and phytoestrogen metabolism in postmenopausal woman Cancer Epidemiol., Biomarkers Prev. 7 1998 1101 1108
50. T. Yasuda, Y. Kano, K. Saito, and K. Ohsawa Urinary and biliary metabolites of daidzin and daidzein in rats Biol. Pharm. Bull. 17 1994 1369 1374
51. T. Yasuda, S. Mizunuma, Y. Kano, K. Saito, and K. Oshawa Urinary and biliary metabolites of genistein in rats Biol. Pharm. Bull. 19 1996 413 417
52. G. You The role of organic ion transporters in drug disposition: an update Curr. Drug Metab. 5 2004 55 62
53. M.I. Yousef, K.I. Kamel, A.M. Esmail, and H.H. Baghdadi Antioxidant activities and lipid lowering effects of isoflavone in male rabbits Food Chem. Toxicol. 42 2004 1497 1503
54. H. Zeng, G. Liu, P.A. Rea, and G.D. Kruh Transport of amphipathic anions by human multidrug resistance protein 3 Cancer Res. 60 2000 4779 4784
55. H. Zeng, Z.S. Chen, M.G. Belinsky, P.A. Rea, and G.D. Kruh Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport Cancer Res. 61 2001 7225 7232
56. J.R. Zhou, E.T. Gugger, T. Tanaka, Y. Guo, G.L. Blackburn, and S.K. Clinton Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice J. Nutr. 129 1999 1628 1635