Location, location, location: The role of cyclin D1 nuclear localization in cancer

Journal of Cellular Biochemistry

Volumn 96, Issue 5, 2005, Pages 906-913

  Gladden, Andrew B ^a,b   Diehl, J Alan ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cancer; CDK4; Cyclin D1; GSK 3 ; Nuclear export

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE; GROWTH FACTOR; PROTEIN P130; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

ARTICLE; CANCER CELL; CANCER LOCALIZATION; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; GENE OVEREXPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; TRANSCRIPTION REGULATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL CYCLE PROTEINS; CELL NUCLEUS; CELL PROLIFERATION; CRK-ASSOCIATED SUBSTRATE PROTEIN; CYCLIN D1; CYCLIN E; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; F-BOX PROTEINS; G1 PHASE; GENE EXPRESSION REGULATION; HUMANS; MICE; MODELS, BIOLOGICAL; NEOPLASMS; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA-LIKE PROTEIN P107; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; UBIQUITIN-PROTEIN LIGASES;

EID: 28044464730     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.20613     Document Type: Article

References (47)

1. Alt JR, Cleveland JL, Hannink M, Diehl JA. 2000. Phosphorylation- dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Genes Dev 14:3102-3114.
2. Benzeno S, Diehl JA. 2004. Carboxyl terminal sequences direct cyclin D1-CRM1 binding. J Biol Chem 279:56061-56066.
3. Berthet C, Aleem E, Coppola V, Tessarollo L, Kaldis P. 2003. Cdk2 knockout mice are viable. Curr Biol 13:1775-1785.
4. Betticher DC, Thatcher N, Altermatt HJ, Hoban P, Ryder WD, Heighway J. 1995. Alternate splicing produces a novel cyclin D1 transcript. Oncogene 11:1005-1011.
5. Bjornsti MA, Houghton PJ. 2004. Lost in translation: Dysregulation of cap-dependent translation and cancer. Cancer Cell 5:519-523.
6. Bodrug SE, Warner BJ, Bath ML, Lindeman GJ, Harris AW, Adams JM. 1994. Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene. EMBO J 13:2124-2130.
7. Cheng M, Olivier P, Diehl JA, Fero M, Roussel MF, Roberts JM, Sherr CJ. 1999. The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J 18:1571-1583.
8. Di Cristofano A, Pandolfi PP. 2000. The multiple roles of PTEN in tumor suppression. Cell 100:387-390.
9. Diehl JA, Sherr CJ. 1997. A dominant-negative cyclin D1 mutant prevents nuclear import of cyclin-dependent kinase 4 (CDK4) and its phosphorylation by CDK-activating kinase. Mol Cell Biol 17:7362-7374.
10. Diehl JA, Zindy F, Sherr CJ. 1997. Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev 11:957-972.
11. Diehl JA, Cheng M, Roussel MF, Sherr CJ. 1998. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 12:3499-3511.
12. Fantl V, Stamp G, Andrews A, Rosewell I, Dickson C. 1995. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes Dev 9:2364-2372.
13. Franca-Koh J, Yeo M, Fraser E, Young N, Dale TC. 2002. The regulation of glycogen synthase kinase-3 nuclear export by Frat/GBP. J Biol Chem 277:43844-43848.
14. Gunthert U, Hofmann M, Rudy W, Reber S, Zoller M, Haussmann I, Matzku S, Wenzel A, Ponta H, Herrlich P. 1991. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 65:13-24.
15. Howe D, Lynas C. 2001. The cyclin D1 alternative transcripts (a) and (b) are expressed in normal and malignant lymphocytes and their relative levels are influenced by the polymorphism at codon 241. Haematologica 86:563-569.
16. Kato J, Matsushime H, Hiebert SW, Ewen ME, Sherr CJ. 1993. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev 7:331-342.
17. Kato JY, Matsuoka M, Strom DK, Sherr CJ. 1994. Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. Mol Cell Biol 14:2713-2721.
18. Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E, Geng Y, Yu Q, Bhattacharya S, Bronson RT, Akashi K, Sicinski P. 2004. Mouse development and cell proliferation in the absence of D-cyclins. Cell 118:477-491.
19. LaBaer J, Garrett MD, Stevenson LF, Slingerland JM, Sandhu C, Chou HS, Fattaey A, Harlow E. 1997. New functional activities for the p21 family of CDK inhibitors. Genes Dev 11:847-862.
20. Lovec H, Grzeschiczek A, Kowalski MB, Moroy T. 1994. Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice. EMBO J 13:3487-3495.
21. Lu F, Gladden AB, Diehl JA. 2003. An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene. Cancer Res 63:7056-7061.
22. Lundberg AS, Weinberg RA. 1998. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol 18:753-761.
23. Malumbres M, Sotillo R, Santamaria D, Galan J, Cerezo A, Ortega S, Dubus P, Barbacid M. 2004. Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell 118:493-504.
24. Matsushime H, Roussel MF, Ashmun RA, Sherr CJ. 1991. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 65:701-713.
25. Matsuura I, Denissova NG, Wang G, He D, Long J, Liu F. 2004. Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 430:226-231.
26. Moberg KH, Bell DW, Wahrer DC, Haber DA, Hariharan IK. 2001. Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines. Nature 413:311-316.
27. Moreno-Bueno G, Rodriguez-Perales S, Sanchez-Estevez C, Hardisson D, Sarrio D, Prat J, Cigudosa JC, Matias-Guiu X, Palacios J. 2003. Cyclin D1 gene (CCND1) mutations in endometrial cancer. Oncogene 22:6115-6118.
28. Ortega S, Prieto I, Odajima J, Martin A, Dubus P, Sotillo R, Barbero JL, Malumbres M, Barbacid M. 2003. Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Natl Genet 35:25-31.
29. Quelle DE, Ashmun RA, Shurtleff SA, Kato JY, Bar-Sagi D, Roussel MF, Sherr CJ. 1993. Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes Dev 7:1559-1571.
30. Radu A, Neubauer V, Akagi T, Hanafusa H, Georgescu MM. 2003. PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1. Mol Cell Biol 23:6139-6149.
31. Rane SG, Dubus P, Mettus RV, Galbreath EJ, Boden G, Reddy EP, Barbacid M. 1999. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Natl Genet 22:44-52.
32. Resnitzky D, Gossen M, Bujard H, Reed SI. 1994. Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol Cell Biol 14:1669-1679.
33. Sherr CJ. 1993. Mammalian G1 cyclins. Cell 73:1059-1065.
34. Sherr CJ, Roberts JM. 1999. CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev 13:1501-1512.
35. Shi Y, Massague J. 2003. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113:685-700.
36. Sicinska E, Aifantis I, Le Cam L, Swat W, Borowski C, Yu Q, Ferrando AA, Levin SD, Geng Y, von Boehmer H, Sicinski P. 2003. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell 4:451-461.
37. Sicinski P, Donaher JL, Parker SB, Li T, Fazeli A, Gardner H, Haslam SZ, Bronson RT, Elledge SJ, Weinberg RA. 1995. Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 82:621-630.
38. Sicinski P, Donaher JL, Geng Y, Parker SB, Gardner H, Park MY, Robker RL, Richards JS, McGinnis LK, Biggers JD, Eppig JJ, Bronson RT, Elledge SJ, Weinberg RA. 1996. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature 384:470-474.
39. Solomon DA, Wang Y, Fox SR, Lambeck TC, Giesting S, Lan Z, Senderowicz AM, Knudsen ES. 2003. Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation. J Biol Chem 278:30339-30347.
40. Soos TJ, Kiyokawa H, Yan JS, Rubin MS, Giordano A, DeBlasio A, Bottega S, Wong B, Mendelsohn J, Koff A. 1996. Formation of p27-CDK complexes during the human mitotic cell cycle. Cell Growth Differ 7:135-146.
41. Stickeler E, Kittrell F, Medina D, Berget SM. 1999. Stage-specific changes in SR splicing factors and alternative splicing in mammary tumorigenesis. Oncogene 18:3574-3582.
42. Strohmaier H, Spruck CH, Kaiser P, Won KA, Sangfelt O, Reed SI. 2001. Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature 413:316-322.
43. Tsutsui T, Hesabi B, Moons DS, Pandolfi PP, Hansel KS, Koff A, Kiyokawa H. 1999. Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity. Mol Cell Biol 19:7011-7019.
44. Wang TC, Cardiff RD, Zukerberg L, Lees E, Arnold A, Schmidt EV. 1994. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature 369:669-671.
45. Yamaguchi F, Saya H, Bruner JM, Morrison RS. 1994. Differential expression of two fibroblast growth factor-receptor genes is associated with malignant progression in human astrocytomas. Proc Natl Acad Sci U S A 91:484-488.
46. Yu Q, Geng Y, Sicinski P. 2001. Specific protection against breast cancers by cyclin D1 ablation. Nature 411:1017-1021.
47. Zheng Y, Shen H, Sturgis EM, Wang LE, Eicher SA, Strom SS, Frazier ML, Spitz MR, Wei Q. 2001. Cyclin D1 polymorphism and risk for squamous cell carcinoma of the head and neck: A case-control study. Carcinogenesis 22:1195-1199.