A mimic of p21WAF1/CIP1 ameliorates murine lupus

Journal of Immunology

Volumn 175, Issue 10, 2005, Pages 6959-6967

  Goulvestre, Claire ^a   Chéreau, Christiane ^a   Nicco, Carole ^a   Mouthon, Luc ^a   Weill, Bernard ^a   Batteux, Frédéric ^a  

^a Université Paris 5 ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CYCLIN D; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1; DOUBLE STRANDED DNA; EPITOPE; HISTONE; IMMUNOGLOBULIN G ANTIBODY; ANTINUCLEAR ANTIBODY; CDK4 PROTEIN, MOUSE; CDK6 PROTEIN, MOUSE; CDKN1A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE ACTIVATION; CELL SUBPOPULATION; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INCIDENCE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; SPLEEN CELL; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION; TREATMENT OUTCOME; AMINO ACID SEQUENCE; ANIMAL; B LYMPHOCYTE; BIOSYNTHESIS; GENETICS; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOLECULAR GENETICS; MOLECULAR MIMICRY; NEW ZEALAND BLACK MOUSE; PATHOLOGY; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, ANTINUCLEAR; APOPTOSIS; B-LYMPHOCYTES; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; FEMALE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED NZB; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; T-LYMPHOCYTES;

EID: 27744519535     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.10.6959     Document Type: Article

References (51)

1. Kotzin, B. L. 1996. Systemic lupus erythematosus. Cell 85: 303-306.
2. Eilat, D., and Y. Naparstek. 1999. Anti-DNA autoantibodies: a puzzle of autoimmune phenomena. Immunol. Today 20: 339-342.
3. Singh, R. R., and B. H. Hahn. 1998. Reciprocal T-B determinant spreading develops spontaneously in murine lupus: implications for pathogenesis. Immunol. Rev. 164: 201-208.
4. 1-phase progression. Genes Dev. 13: 1501-1512.
5. Mohan, C., S. Adams, V. Stanik, and S. K. Datta. 1993. Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus. J. Exp. Med. 177: 1367-1381.
6. Sherr, C. J. 1996. Cancer cell cycles. Science 274: 1672-1677.
7. Santiago-Raber, M. L., B. R. Lawson, W. Dummer, M. Barnhouse, S. Koundouris, C. B. Wilson, D. H. Kono, and A. N. Theofilopoulos. 2001. Role of cyclin kinase inhibitor p21 in systemic autoimmunity. J. Immunol. 167: 4067-4074.
8. WAF1. Oral Oncol. 36: 3-7.
9. WAF1/Cip1: more than a break to the cell cycle? Biochim. Biophys. Acta 1471: M43-M46.
10. Gartel, A. L., and A. L. Tyner. 2002. The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol. Cancer Ther. 1: 639-649.
11. Fahraeus, R., P. Fischer, E. Krausz, and D. P. Lane. 1999. New approaches to cancer therapies. J. Pathol. 187: 138-146.
12. Balomenos, D., J. Martin-Caballero, M. I. Garcia, I. Prieto, J. M. Flores, M. Serrano, and A. C. Martinez. 2000. The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development. Nat. Med. 6: 171-176.
13. Bouneaud, C., P. Kourilsky, and P. Bousso. 2000. Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity 13: 829-840.
14. Suda, T., and S. Nagata. 1997. Why do defects in the Fas-Fas ligand system cause autoimmunity? J. Allergy Clin. Immunol. 100: S97-S101.
15. Salvador, J. M., M. C. Hollander, A. T. Nguyen, J. B. Kopp, L. Barisoni, J. K. Moore, J. D. Ashwell, and A. J. Fornace, Jr. 2002. Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome. Immunity 16: 499-504.
16. ras pathway in lymphocytes of SLE patients. J. Autoimmun. 19: 63-70.
17. WAF-1/CIP-1 promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoimmunity. J. Exp. Med. 199: 547-557.
18. Jarver, P., and U. Langel. 2004. The use of cell-penetrating peptides as a tool for gene regulation. Drug Discov. Today 9: 395-402.
19. WAF1. Curr. Biol. 7: 71-82.
20. Console, S., C. Marty, C. Garcia-Echeverria, R. Schwendener, and K. Ballmer-Hofer. 2003. Antennapedia and HIV transactivator of transcription (TAT) "protein transduction domains" promote endocytosis of high molecular weight cargo upon binding to cell surface glycosaminoglycans. J. Biol. Chem. 278: 35109-35114.
21. Preud'homme, J. L., E. Rochard, D. Gouet, F. Danon, M. Alcalay, G. Touchard, and P. Aucouturier. 1988. Isotypic distribution of anti-double stranded DNA antibodies: a diagnostic evaluation by enzyme-linked immunosorbent assay. Diag. Clin. Immunol. 5: 256-261.
22. Dong, L., S. Ito, K. J. Ishii, and D. M. Klinman. 2005. Suppressive oligodeoxynucleotides delay the onset of glomeralonephritis and prolong survival in lupus-prone NZB × NZW mice. Arthritis Rheum. 52: 651-658.
23. Wernick, R. M., D. L. Smith, D. C. Houghton, D. S. Phillips, J. L. Booth, D. N. Runckel, D. S. Johnson, K. K. Brown, and C. L. Gaboury. 1993. Reliability of histologic scoring for lupus nephritis: a community-based evaluation. Ann. Intern. Med. 119: 805-811.
24. Zarkowska, T., S. U., E. Harlow, and S. Mittnacht. 1997. Monoclonal antibodies specific for underphosphorylated retinoblastoma protein identify a cell cycle regulated phosphorylation site targeted by CDKs. Oncogene 14: 249-254.
25. Teixeira, A., N. Chaverot, A. D. Strosberg, and S. Cazaubon. 2000. Differential regulation of cyclin D1 and D3 expression in the control of astrocyte proliferation induced by endothelin-1. J. Neurochem. 74: 1034-1040.
26. Trébéden-Nègre, H., B. Weill, C. Fournier, and F. Batteux. 2003. B cell apoptosis accelerates the onset of murine lupus. Eur. J. Immunol. 33: 1603-1612.
27. Kaliyaperumal, A., C. Mohan, W. Wu, and S. K. Datta. 1996. Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus. J. Exp. Med. 183: 2459-2469.
28. 1/S cyclin-dependent kinases. J. Biol. Chem. 272: 12738-12746.
29. Parry, D., D. Mahony, K. Wills, and E. Lees. 1999. Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors. Mol. Cell Biol. 19: 1775-1783.
30. Kip1 CDK "inhibitors" are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J. 18: 1571-1583.
31. kip1 expression in human peripheral T lymphocytes. Eur. J. Immunol. 29: 789-798.
32. Nagasawa, M., I. Melamed, A. Kupfer, E. W. Gelfand, and J. J. Lucas. 1997. Rapid nuclear translocation and increased activity of cyclin-dependent kinase 6 after T cell activation. J. Immunol. 158: 5146-5154.
33. Laliberte, J., A. Yee, Y. Xiong, and B. S. Mitchell. 1998. Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes. Blood 91: 2896-2904.
34. cdk4, during cell cycle entry and progression in normal human T lymphocytes. J. Cell. Physiol. 165: 406-416.
35. Hieb, M., S. Murphy, E. F. Wagner, N. N. Hanna, N. Sharma, J. Park, X. C. Li, T. B. Strom, J. F. Padbury, Y. T. Tseng, and S. Sharma. 2004. Evidence for cyclin D3 as a novel target of rapamycin in human T lymphocytes. J. Biol. Chem. 279: 31948-31955.
36. Henderson, D. J., I. Naya, R. V. Bundick, G. M. Smith, and J. A. Schmidt. 1991. Comparison of the effects of FK-506, cyclosporin A and rapamycin on IL-2 production. Immunology 73: 316-321.
37. PSK-J3/cdk4) for the major D-type cyclin in mature B lymphocytes. J. Immunol. 156: 539-548.
38. Solvason, N., W. W. Wu, N. Kabra, X. Wu, E. Lees, and M. C. Howard. 1996. Induction of cell cycle regulatory proteins in anti-immunoglobulin-stimulated mature B lymphocytes. J. Exp. Med. 184: 407-417.
39. Lam, E. W., J. Glassford, L. Banerji, N. S. Thomas, P. Sicinski, and G. G. Klaus. 2000. Cyclin D3 compensates for loss of cyclin D2 in mouse B-lymphocytes activated via the antigen receptor and CD40. J. Biol. Chem. 275: 3479-3484.
40. Tangye, S. G., A. Ferguson, D. T. Avery, C. S. Ma, and P. D. Hodgkin. 2002. Isotype switching by human B cells is division-associated and regulated by cytokines. J. Immunol. 169: 4298-4306.
41. Severinson, E., S. Bergstedt-Lindqvist, W. van der Loo, and C. Fernandez. 1982. Characterization of the IgG response induced by polyclonal B cell activators. Immunol. Rev. 67: 73-85.
42. Borchers, A., A. A. Ansari, T. Hsu, D. H. Kono, and M. E. Gershwin. 2000. The pathogenesis of autoimmunity in New Zealand mice. Semin. Arthritis Rheum. 29: 385-399.
43. Tarlinton, D. M., and P. D. Hodgkin. 2004. Targeting plasma cells in autoimmune diseases. J. Exp. Med. 199: 1451-1454.
44. Hoyer, B. F., K. Moser, A. E. Hauser, A. Peddinghaus, C. Voigt, D. Eilat, A. Radbruch, F. Hiepe, and R. A. Manz. 2004. Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice. J. Exp. Med. 199: 1577-1584.
45. + T cells. J. Exp. Med. 194: 1711-1719.
46. WAF1/CIP1 in receptor-mediated apoptosis of WEHI 231 B lymphoma cells. J. Exp. Med. 187: 1671-1679.
47. CIP1/WAF-1 which promotes apoptosis. J. Immunol. 164: 4032-4036.
48. Manfredi, J. J. 2003. p53 and apoptosis: it's not just in the nucleus anymore. Mol. Cell 11: 552-554.
49. Miyashita, T., and J. C. Reed. 1995. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293-299.
50. WAF-1/Cip1 does not induce systemic autoimmunity in female BXSB mice. J. Immunol. 168: 5928-5932.
51. waf1/cip1 transgene on radiation induced apoptosis in T cells. Oncogene 18: 3652-3658.