Modeling the signaling endosome hypothesis: Why a drive to the nucleus is better than a (random) walk

Theoretical Biology and Medical Modelling

Volumn 2, Issue , 2005, Pages

  Howe, Charles L ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CLATHRIN; DYNEIN ADENOSINE TRIPHOSPHATASE; GROWTH FACTOR; LIGAND; MEMBRANE RECEPTOR; NOCODAZOLE; PHOSPHOTYROSINE; RECEPTOR PROTEIN; STAT3 PROTEIN;

ARTICLE; CELL MEMBRANE; CELL NUCLEUS; CELL ORGANELLE; COMPLEX FORMATION; CYTOSKELETON; DEPHOSPHORYLATION; DIFFUSION; DIFFUSION COEFFICIENT; ENDOCYTOSIS; ENDOSOME; INFORMATION; KINETICS; MICROTUBULE; MOLECULE; MONTE CARLO METHOD; NONHUMAN; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; SIMULATION; THEORY; ACTIVE TRANSPORT; ANIMAL; BIOLOGICAL MODEL; COMPARATIVE STUDY; COMPUTER SIMULATION; HUMAN; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; STATISTICAL MODEL;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CELL MEMBRANE; CELL NUCLEUS; COMPUTER SIMULATION; DIFFUSION; ENDOSOMES; HUMANS; KINETICS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; MONTE CARLO METHOD; PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 27744490085     PISSN: 17424682     EISSN: 17424682     Source Type: Journal    
DOI: 10.1186/1742-4682-2-43     Document Type: Article

References (58)

1. Agutter PS, Malone PC, Wheatley DN: Intracellular transport mechanisms: a critique of diffusion theory. J Theor Biol 1995, 176:261-272.
2. Agutter PS, Malone PC, Wheatley DN: Diffusion theory in biology: a relic of mechanistic materialism. J Hist Biol 2000, 33:71-111.
3. Agutter PS, Wheatley DN: Random walks and cell size. Bioessays 2000, 22:1018-1023.
4. Kholodenko BN: MAP kinase cascade signaling and endocytic trafficking: a marriage of convenience? Trends Cell Biol 2002, 12:173-177.
5. Kholodenko BN: Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors. J Exp Biol 2003, 206:2073-2082.
6. Sofroniew MV, Howe CL, Mobley WC: Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci 2001, 24:1217-1281.
7. Howe CL, Mobley WC: Signaling endosome hypothesis: A cellular mechanism for long distance communication. J Neurobiol 2004, 58:207-216.
8. Miaczynska M, Pelkmans L, Zerial M: Not just a sink: endosomes in control of signal transduction. Curr Opin Cell Biol 2004, 16:400-406.
9. Guzik BW, Goldstein LS: Microtubule-dependent transport in neurons: steps towards an understanding of regulation, function and dysfunction. Curr Opin Cell Biol 2004, 16:443-450.
10. Zweifel LS, Kuruvilla R, Ginty DD: Functions and mechanisms of retrograde neurotrophin signalling. Nat Rev Neurosci 2005, 6:615-625.
11. Weible MW, Hendry IA: What is the importance of multivesicular bodies in retrograde axonal transport in vivo? J Neurobiol 2004, 58:230-243.
12. Howe CL, Mobley WC: Long-distance retrograde neurotrophic signaling. Curr Opin Neurobiol 2005, 15:40-48.
13. Carpenter G: The EGF receptor: a nexus for trafficking and signaling. Bioessays 2000, 22:697-707.
14. Sorkin A: Internalization of the epidermal growth factor receptor: role in signalling. Biochem Soc Trans 2001, 29:480-484.
15. Sorkin A, Von Zastrow M: Signal transduction and endocytosis: close encounters of many kinds. Nat Rev Mol Cell Biol 2002, 3:600-614.
16. Le Roy C, Wrana JL: Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling. Nat Rev Mol Cell Biol 2005, 6:112-126.
17. Sorkin A, McClure M, Huang F, Carter R: Interaction of EGF receptor and grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy. Curr Biol 2000, 10:1395-1398.
18. Wiley HS, Burke PM: Regulation of receptor tyrosine kinase signaling by endocytic trafficking. Traffic 2001, 2:12-18.
19. Roy S, Wyse B, Hancock JF: H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis. Mol Cell Biol 2002, 22:5128-5140.
20. Pol A, Calvo M, Enrich C: Isolated endosomes from quiescent rat liver contain the signal transduction machinery. Differential distribution of activated Raf-1 and Mek in the endocytic compartment. FEBS Lett 1998, 441:34-38.
21. Jiang X, Sorkin A: Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells. Mol Biol Cell 2002, 13:1522-1535.
22. Chiu VK, Bivona T, Hach A, Sajous JB, Silletti J, Wiener H, Johnson RL, Cox AD, Philips MR: Ras signalling on the endoplasmic reticulum and the Golgi. Nat Cell Biol 2002, 4:343-350.
23. Burke P, Schooler K, Wiley HS: Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking. Mol Biol Cell 2001, 12:1897-1910.
24. Wang Y, Pennock S, Chen X, Wang Z: Endosomal signaling of epidermal growth factor receptor stimulates signal transduction pathways leading to cell survival. Mol Cell Biol 2002, 22:7279-7290.
25. Bild AH, Turkson J, Jove R: Cytoplasmic transport of Stat3 by receptor-mediated endocytosis. Embo J 2002, 21:3255-3263.
26. Howe CL, Valletta JS, Rusnak AS, Mobley WC: NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway. Neuron 2001, 32:801-814.
27. Kikushima K, Yagi T, Kamiya R: Slow ADP-dependent acceleration of microtubule translocation produced by an axonemal dynein. FEBS Lett 2004, 563:119-122.
28. Becker S, Groner B, Muller CW: Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature 1998, 394:145-151.
29. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res 2000, 28:235-242.
30. Haak RA, Kleinhans FW, Ochs S: The viscosity of mammalian nerve axoplasm measured by electron spin resonance. J Physiol 1976, 263:115-137.
31. Luby-Phelps K: Cytoarchitecture and physical properties of cytoplasm: volume, viscosity, diffusion, intracellular surface area. Int Rev Cytol 2000, 192:189-221.
32. Luby-Phelps K, Lanni F, Taylor DL: The submicroscopic properties of cytoplasm as a determinant of cellular function. Annu Rev Biophys Biophys Chem 1988, 17:369-396.
33. Guo GG, Patel K, Kumar V, Shah M, Fried VA, Etlinger JD, Sehgal PB: Association of the chaperone glucose-regulated protein 58 (GRP58/ER-60/ERp57) with Stat3 in cytosol and plasma membrane complexes. J Interferon Cytokine Res 2002, 22:555-563.
34. Ndubuisi MI, Guo GG, Fried VA, Etlinger JD, Sehgal PB: Cellular physiology of STAT3: Where's the cytoplasmic monomer? J Biol Chem 1999, 274:25499-25509.
35. Kholodenko BN, Brown GC, Hoek JB: Diffusion control of protein phosphorylation in signal transduction pathways. Biochem J 2000, 350 Pt 3:901-907.
36. Haugh JM, Lauffenburger DA: Physical modulation of intracellular signaling processes by locational regulation. Biophys J 1997, 72:2014-2031.
37. Zhao Y, Zhang ZY: The mechanism of dephosphorylation of extracellular signal-regulated kinase 2 by mitogen-activated protein kinase phosphatase 3. J Biol Chem 2001, 276:32382-32391.
38. Todd JL, Tanner KG, Denu JM: Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem 1999, 274:13271-13280.
39. Denu JM, Zhou G, Wu L, Zhao R, Yuvaniyama J, Saper MA, Dixon JE: The purification and characterization of a human dual-specific protein tyrosine phosphatase. J Biol Chem 1995, 270:3796-3803.
40. Wheatley DN: Diffusion theory, the cell and the synapse. Biosystems 1998, 45:151-163.
41. Hunter T: Signaling - 2000 and beyond. Cell 2000, 100:113-127.
42. Blume-Jensen P, Hunter T: Oncogenic kinase signalling. Nature 2001, 411:355-365.
43. Perlson E, Hanz S, Ben-Yaakov K, Segal-Ruder Y, Seger R, Fainzilber M: Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve. Neuron 2005, 45:715-726.
44. L'Ecuyer P: Random Number Generation. In Handbook of Computational Statistics Edited by: Gentle JE, Haerdle W and Mori Y. , Springer-Verlag; 2004:35-70.
45. Matsumoto M, Nishimura T: Mersenne Twister: A 623-dimensionally equidistributed uniform pseudo-random number generator. ACM Transactions on Modeling and Computer Simulation 1998, 8:3-30.
46. L'Ecuyer P, Blouin F, Couture R: A search for good multiple recursive random number generators. ACM Transactions on Modeling and Computer Simulation 1993, 3:87-98.
47. Goresky M, Klapper A: Efficient multiply-with-carry random number generators with maximal period. ACM Transactions on Modeling and Computer Simulation 2003, 13:1-12.
48. Delcroix JD, Valletta JS, Wu C, Hunt SV, Kowal AS, Mobley WC: NGF Signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. Neuron 2003, 39:69-84.
49. Valetti C, Wetzel DM, Schrader M, Hasbani MJ, Gill SR, Kreis TE, Schroer TA: Role of dynactin in endocytic traffic: effects of dynamitin overexpression and colocalization with CLIP-170. Mol Biol Cell 1999, 10:4107-4120.
50. Quintyne NJ, Gill SR, Eckley DM, Crego CL, Compton DA, Schroer TA: Dynactin is required for microtubule anchoring at centrosomes. J Cell Biol 1999, 147:321-334.
51. King SJ, Brown CL, Maier KC, Quintyne NJ, Schroer TA: Analysis of the dynein-dynactin interaction in vitro and in vivo. Mol Biol Cell 2003, 14:5089-5097.
52. Burkhardt JK, Echeverri CJ, Nilsson T, Vallee RB: Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution. J Cell Biol 1997, 139:469-484.
53. Lakadamyali M, Rust MJ, Babcock HP, Zhuang X: Visualizing infection of individual influenza viruses. Proc Natl Acad Sci U S A 2003, 100:9280-9285.
54. Heerssen HM, Pazyra MF, Segal RA: Dynein motors transport activated Trks to promote survival of target-dependent neurons. Nat Neurosci 2004, 7:596-604.
55. Watson FL, Heerssen HM, Moheban DB, Lin MZ, Sauvageot CM, Bhattacharyya A, Pomeroy SL, Segal RA: Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex. J Neurosci 1999, 19:7889-7900.
56. Yano H, Lee FS, Kong H, Chuang J, Arevalo J, Perez P, Sung C, Chao MV: Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor. J Neurosci 2001, 21:RC125.
57. Bhattacharyya A, Watson FL, Pomeroy SL, Zhang YZ, Stiles CD, Segal RA: High-resolution imaging demonstrates dynein-based vesicular transport of activated Trk receptors. J Neurobiol 2002, 51:302-312.
58. Ehlers MD, Kaplan DR, Price DL, Koliatsos VE: NGF-stimulated retrograde transport of trkA in the mammalian nervous system. J Cell Biol 1995, 130:149-156.