Prevention of lymphocyte apoptosis - A potential treatment of sepsis?

Clinical Infectious Diseases

Volumn 41, Issue SUPPL. 7, 2005, Pages

  Hotchkiss, Richard S ^a   Coopersmith, Craig M ^a   Karl, Irene E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; DNA; FAS ANTIGEN; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN BCL 2; PROTEIN BID; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; BACTERIAL TRANSLOCATION; CELL DEATH; CONFERENCE PAPER; ENDOTOXEMIA; ESCHERICHIA COLI; HUMAN; INTENSIVE CARE UNIT; LYMPHOCYTE; NEWBORN MORTALITY; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SPLEEN CANCER; STOMACH EPITHELIUM; SURGICAL PATIENT;

ANIMALS; APOPTOSIS; CASPASE 8; CASPASE 9; ENDOTOXEMIA; ENZYME INHIBITORS; HUMANS; LYMPHOCYTES; MITOCHONDRIAL MEMBRANES; RECEPTORS, DEATH DOMAIN; SEPSIS; SIGNAL TRANSDUCTION; UNITED STATES;

EID: 27744464494     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/431998     Document Type: Conference Paper

References (46)

1. Hotchkiss RS, Swanson PE, Freeman BD, et al. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 1999;27:1230-51.
2. Coopersmith C, Stromberg PE, Dunne WM, et al. Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis. JAMA 2002; 287:1716-21.
3. + T lymphocytes in humans. J Immunol 2001; 166:6952-63.
4. Chung CS, Xu YX, Wang W, Chaudry IH, Ayala A. Is Fas ligand or endotoxin responsible for mucosal lymphocyte apoptosis in sepsis? Arch Surg 1998; 133:1213-20.
5. Oberholzer C, Oberholzer A, Bahjat FR, et al. Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves survival in murine sepsis. Proc Natl Acad Sci USA 2001; 98:11,503-8.
6. Le Tulzo Y, Pangault C, Gacouin A, et al. Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome. Shock 2002; 18:487-94.
7. Iwata A, Stevenson VM, Minard A, et al. Over-expression of Bcl-2 provides protection in septic mice by a trans effect. J Immunol 2003; 171:3136-41.
8. Hotchkiss RS, Swanson PE, Knudson CM, et al. Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. J Immunol 1999; 162:4148-56.
9. Hotchkiss RS, Chang KC, Swanson PE, et al. Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Nat Immunol 2000; 1:496-501.
10. Braun JS, Novak R, Herzog KH, Bodner SM, Cleveland JL, Tuomanen EI. Neuroprotection by a caspase inhibitor in acute bacterial meningitis. Nat Med 1999; 5:298-302.
11. Méthot N, Huang J, Coulombe N, et al. Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics. J Exp Med 2004; 199:199-207.
12. Mack A, Hacker G. Inhibition of caspase or FADD function blocks proliferation but not MAP kinase-activation and interleukin-2-production during primary stimulation of T cells. Eur J Immunol 2002; 32:1986-92.
13. Strasser A, Harris AW, Huang DC, Krammer PH, Cory S. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J 1995; 14:6136-47.
14. Krueger A, Fas SC, Baumann S, Krammer PH. The role of CD95 in the regulation of peripheral T-cell apoptosis. Immunol Rev 2003; 193:58-69.
15. Roy S, Nicholson DW. Cross-talk in cell death signaling. J Exp Med 2000; 192:F21-5.
16. Ayala A, Herdon CD, Lehman DL, DeMaso CM, Ayala CA, Chaudry IH. The induction of accelerated thymic programmed cell death during polymicrobial sepsis: control by corticosteroids but not tumor necrosis factor. Shock 1995; 3:259-67.
17. Efron PA, Tinsley K, Minnich DJ, et al. Increased lymphoid tissue apoptosis in baboons with bacteremic shock. Shock 2004; 21:566-71.
18. Wheeler AP, Bernard GR. Treating patients with severe sepsis. N Engl J Med 1999; 340:207-14.
19. Munford RS, Tracey KJ. Is severe sepsis a neuroendocrine disease? Mol Med 2002; 8:437-42.
20. Riedemann NC, Guo RF, Ward PA. The enigma of sepsis. J Clin Invest 2003; 112:460-7.
21. Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med 2003; 348:138-50.
22. Marsden VS, Strasser A. Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more. Annu Rev Immunol 2003; 21:71-105.
23. Finkel E. The mitochondrion: is it central to apoptosis? Science 2001; 292:624-6.
24. Wei MC, Zong WX, Cheng EH, et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 2001; 292:727-30.
25. Cheng EH, Wei MC, Weiler S, et al. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell 2001; 8:705-11.
26. Friedlander RM, Brown RH, Gagliardini V, Wang J, Yuan J. Inhibition of ICE slows ALS in mice. Nature 1997; 388:31.
27. Iwata A, Harlan JM, Vedder NB, Winn RK. The caspase inhibitor z-VAD is more effective than CD18 adhesion blockade in reducing muscle ischemia-reperfusion injury: implication for clinical trials. Blood 2002; 100:2077-80.
28. Nicholson DW, Thornberry NA. Apoptosis: life and death decisions. Science 2003; 299:214-5.
29. Higuchi H, Gores GJ. Mechanisms of liver injury: an overview. Curr Mol Med 2003; 3:483-90.
30. Valentine KL, Gutierrez M, Sanchez R, Winship MJ, Shapiro DA. First clinical trial of a novel caspase inhibitor: anti-apoptotic caspase inhibitor, IDN-6556, improves liver enzymes. Int J Clin Pharmacol Ther 2003; 41:441-9.
31. Zender L, Hutker S, Liedtke C, et al. Caspase 8 small interfering RNA prevents acute liver failure in mice. Proc Natl Acad Sci USA 2003; 100:7797-802.
32. Wesche-Soldato DE, Chung CS, Lomas-Neira J, Doughty LA, Gregory SH, Ayala A. In vivo delivery of caspase 8 or Fas siRNA improves the survival of septic mice. Blood 2005; 7 June [Epub ahead of print].
33. Endres M, Namura S, Shimizu-Sasamata M, et al. Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family. J Cereb Blood Flow Metab 1998; 18:238-47.
34. Daemen MA, van't Veer C, Denecker G, et al. Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation. J Clin Invest 1999; 104:541-9.
35. Fauvel H, Marchetti P, Chopin C, Formstecher P, Neviere R. Differential effects of caspase inhibitors on endotoxin-induced myocardial dysfunction and heart apoptosis. Am J Physiol Heart Circ Physiol 2001; 280:H1608-14.
36. Ma J, Qiu J, Hirt L, Dalkara T, Moskowitz MA. Synergistic protective effect of caspase inhibitors and bFGF against brain injury induced by transient focal ischaemia. Br J Pharmacol 2001; 133:345-50.
37. Hotchkiss RS, Tinsley KW, Swanson PE, et al. Prevention of lymphocyte cell death in sepsis improves survival in mice. Proc Natl Acad Sci USA 1999; 96:14541-6.
38. Newton K, Strasser A. Caspases signal not only apoptosis but also antigen-induced activation in cells of the immune system. Genes Dev 2003; 17:819-25.
39. Schwerk C, Schulze-Osthoff K. Non-apoptotic functions of caspases in cellular proliferation and differentiation. Biochem Pharmacol 2003; 66:1453-8.
40. Perfettini JL, Kroemer G. Caspase activation is not death. Nat Immunol 2003; 4:308-10.
41. Woo M, Hakem R, Furlonger C, et al. Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity. Nat Immunol 2003; 4:1016-22.
42. Olson NE, Graves JD, Shu GL, Ryan EJ, Clark EA. Caspase activity is required for stimulated B lymphocytes to enter the cell cycle. J Immunol 2003; 170:6065-72.
43. Beisner DR, Chu IH, Arechiga AF, Hedrick SM, Walsh CM. The requirements for Fas-associated death domain signaling in mature T cell activation and survival. J Immunol 2003; 171:247-56.
44. Cauwels A, Janssen B, Waeytens A, Cuvelier C, Brouckaert P. Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2. Nat Immunol 2003; 4:387-93.
45. Salmena L, Lemmers B, Hakem A, et al. Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev 2003; 17:883-95.
46. Chun HJ, Zheng L, Ahmad M, et al. Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature 2002; 419:395-9.