Polyglutamine tract-binding protein-1 dysfunction induces cell death of neurons through mitochondrial stress

Journal of Neurochemistry

Volumn 95, Issue 3, 2005, Pages 858-870

  Marubuchi, Shigeki ^a,b,c   Wada, Yo Ichi ^a   Okuda, Tomohiro ^b,c   Hara, Yukiko ^b   Qi, Mei Ling ^a,b,e   Hoshino, Masataka ^a,b   Nakagawa, Masaya ^c   Kanazawa, Ichiro ^d   Okazawa, Hitoshi ^a,b,e  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^c TOYAMA CHEMICAL CO LTD   (Japan)

^d NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Degeneration; Neuron; Polyglutamine; Polyglutamine tract binding protein 1; Transcription; Transgenic mouse

Indexed keywords

ADENOVIRUS VECTOR; CASPASE 3; CYTOCHROME C; CYTOCHROME C OXIDASE; CYTOCHROME C OXIDASE 1; CYTOCHROME C OXIDASE 2; MUTANT PROTEIN; NUCLEAR PROTEIN; POLYGLUTAMINE; POLYGLUTAMINE TRACT BINDING PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DNA MICROARRAY; ELECTRON MICROSCOPY; ENZYME ACTIVATION; ENZYME RELEASE; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MEMBRANE POTENTIAL; MITOCHONDRION; MOTOR NEURON DISEASE; MOUSE; NERVE CELL NECROSIS; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SPINAL CORD; SPINAL CORD VENTRAL HORN; STRESS; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; ANTERIOR HORN CELLS; CARRIER PROTEINS; CASPASES; CELL DEATH; CYTOCHROMES C; ELECTRON TRANSPORT COMPLEX IV; HUMANS; MEMBRANE POTENTIALS; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; MITOCHONDRIA; MOTOR NEURON DISEASE; MOTOR NEURONS; NERVE DEGENERATION; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; UP-REGULATION;

ADENOVIRIDAE; ANIMALIA; MUS MUSCULUS;

EID: 27644590078     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03405.x     Document Type: Article

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