메뉴 건너뛰기




Volumn 6, Issue 7, 2000, Pages 762-768

Effects of mycophenolic acid on human immunodeficiency virus infection in vitro and in vivo

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; AMPRENAVIR; ANTIRETROVIRUS AGENT; CD4 ANTIGEN; CD8 ANTIGEN; GUANOSINE; KI 67 ANTIGEN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PHYTOHEMAGGLUTININ; RNA DIRECTED DNA POLYMERASE;

EID: 0033942250     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/77489     Document Type: Article
Times cited : (184)

References (49)
  • 2
    • 0030869269 scopus 로고    scopus 로고
    • Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy
    • Gulick, R.M. et al. Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. N. Engl. J. Med. 337, 734-739 (1997).
    • (1997) N. Engl. J. Med. , vol.337 , pp. 734-739
    • Gulick, R.M.1
  • 3
    • 0442268112 scopus 로고    scopus 로고
    • A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS clinical trials group 320 study team
    • Hammer, S.M. et al. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS clinical trials group 320 study team. N. Engl. J. Med. 337, 725-733 (1997).
    • (1997) N. Engl. J. Med. , vol.337 , pp. 725-733
    • Hammer, S.M.1
  • 4
    • 0032580479 scopus 로고    scopus 로고
    • HIV-protease inhibitors
    • Flexner, C. HIV-protease inhibitors. N. Engl. J. Med. 338, 1281-1292 (1998).
    • (1998) N. Engl. J. Med. , vol.338 , pp. 1281-1292
    • Flexner, C.1
  • 5
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
    • Palella, F.J.J. et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N. Engl. J. Med. 338, 853-860 (1998).
    • (1998) N. Engl. J. Med. , vol.338 , pp. 853-860
    • Palella, F.J.J.1
  • 7
    • 15144342918 scopus 로고    scopus 로고
    • Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection
    • Cavert, W. et al. Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection. Science 276, 960-964 (1997).
    • (1997) Science , vol.276 , pp. 960-964
    • Cavert, W.1
  • 8
    • 0030952479 scopus 로고    scopus 로고
    • Decay characteristics of HIV-1-infected compartments during combination therapy
    • Perelson, A.S. et al. Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 387, 188-191 (1997).
    • (1997) Nature , vol.387 , pp. 188-191
    • Perelson, A.S.1
  • 9
    • 0030659177 scopus 로고    scopus 로고
    • Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
    • Chun, T.W. et al. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc. Natl. Acad. Sci. USA 94, 13193-13197 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 13193-13197
    • Chun, T.W.1
  • 10
    • 0030712305 scopus 로고    scopus 로고
    • Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
    • Wong, J.K. et al. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 278, 1291-1295 (1997).
    • (1997) Science , vol.278 , pp. 1291-1295
    • Wong, J.K.1
  • 11
    • 14444273439 scopus 로고    scopus 로고
    • Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
    • Finzi, D. et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 278, 1295-1300 (1997).
    • (1997) Science , vol.278 , pp. 1295-1300
    • Finzi, D.1
  • 12
    • 0034092561 scopus 로고    scopus 로고
    • Time of initiation of antiretroviral therapy: Impact on HIV-1 viraemia
    • Yearly, S. et al. Time of initiation of antiretroviral therapy: impact on HIV-1 viraemia. AIDS 14 (2000).
    • (2000) AIDS , vol.14
    • Yearly, S.1
  • 13
    • 0033520673 scopus 로고    scopus 로고
    • Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapy
    • Dornadula, G. et al. Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapy. J. Am. Med. Assoc. 282, 1663-1668 (1999).
    • (1999) J. Am. Med. Assoc. , vol.282 , pp. 1663-1668
    • Dornadula, G.1
  • 14
    • 0033609374 scopus 로고    scopus 로고
    • Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy
    • Furtado, M.R. et al. Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy. N. Engl. J. Med. 340, 1614-1622 (1999).
    • (1999) N. Engl. J. Med. , vol.340 , pp. 1614-1622
    • Furtado, M.R.1
  • 15
    • 0033609373 scopus 로고    scopus 로고
    • Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy
    • Zhang, L. et al. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N. Engl. J. Med. 340, 1605-1613 (1999).
    • (1999) N. Engl. J. Med. , vol.340 , pp. 1605-1613
    • Zhang, L.1
  • 16
    • 0030967544 scopus 로고    scopus 로고
    • How immune-based interventions can change HIV therapy
    • Pantaleo, G. How immune-based interventions can change HIV therapy. Nature Med. 3, 483-486 (1997).
    • (1997) Nature Med. , vol.3 , pp. 483-486
    • Pantaleo, G.1
  • 17
    • 0027948936 scopus 로고
    • Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication
    • Lori, F. et al. Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication. Science 266, 801-805 (1994).
    • (1994) Science , vol.266 , pp. 801-805
    • Lori, F.1
  • 18
    • 0028019710 scopus 로고
    • Anti-human immunodeficiency virus type 1 activity of hydroxyurea in combination with 2′,3⊄-dideoxynudeosides
    • Gao, W.Y., Johns, D.G. & Mitsuya, H. Anti-human immunodeficiency virus type 1 activity of hydroxyurea in combination with 2′,3⊄-dideoxynudeosides. Mol. Pharmacol. 46, 767-772 (1994).
    • (1994) Mol. Pharmacol. , vol.46 , pp. 767-772
    • Gao, W.Y.1    Johns, D.G.2    Mitsuya, H.3
  • 19
    • 0025847662 scopus 로고
    • In vitro immunosuppressive effects of mycophenolic acid and an ester pro-drug, RS-61443
    • Allison, A.C., Almquist, S.J., Muller, C.D. & Eugui, E.M. In vitro immunosuppressive effects of mycophenolic acid and an ester pro-drug, RS-61443. Transplant Proc. 23, 10-14 (1991).
    • (1991) Transplant Proc. , vol.23 , pp. 10-14
    • Allison, A.C.1    Almquist, S.J.2    Muller, C.D.3    Eugui, E.M.4
  • 21
    • 0032841022 scopus 로고    scopus 로고
    • Abacavir and mycophenolic acid, an inhibitor of inosine monophosphate dehydrogenase, have profound and synergistic anti-HIV activity
    • Margolis, D. et al. Abacavir and mycophenolic acid, an inhibitor of inosine monophosphate dehydrogenase, have profound and synergistic anti-HIV activity. J. Acquir. Immune Defic. Syndr. 21, 362-370 (1999).
    • (1999) J. Acquir. Immune Defic. Syndr. , vol.21 , pp. 362-370
    • Margolis, D.1
  • 22
    • 0030074991 scopus 로고    scopus 로고
    • Mycophenolate mofetil. A review of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in renal transplantation
    • Fulton, B. & Markham, A. Mycophenolate mofetil. A review of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in renal transplantation. Drugs 51, 278-298 (1996).
    • (1996) Drugs , vol.51 , pp. 278-298
    • Fulton, B.1    Markham, A.2
  • 23
    • 0029116425 scopus 로고
    • Polymerase substrate depletion: A novel strategy for inhibiting the replication of the human immunodeficiency virus
    • Ichimura, H. & Levy, J.A. Polymerase substrate depletion: a novel strategy for inhibiting the replication of the human immunodeficiency virus. Virology 211, 554-560 (1995).
    • (1995) Virology , vol.211 , pp. 554-560
    • Ichimura, H.1    Levy, J.A.2
  • 24
    • 0031884993 scopus 로고    scopus 로고
    • In vitro replication kinetics of human immunodeficiency virus type 1 (HIV-1) variants in relation to virus load in long-term survivors of HIV-1 infection
    • Blaak, H., Brouwer, M., Ran, L.J., de Wolf, F. & Schuitemaker, H. In vitro replication kinetics of human immunodeficiency virus type 1 (HIV-1) variants in relation to virus load in long-term survivors of HIV-1 infection. J. Infect. Dis. 177, 600-610 (1998).
    • (1998) J. Infect. Dis. , vol.177 , pp. 600-610
    • Blaak, H.1    Brouwer, M.2    Ran, L.J.3    De Wolf, F.4    Schuitemaker, H.5
  • 25
    • 0026034886 scopus 로고
    • Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: Role of deoxyguanosine nucleotide depletion
    • Eugui, E.M., Almquist, S.J., Muller, C.D. & Allison, A.C. Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depletion. Scand. J Immunol. 33, 161-173 (1991).
    • (1991) Scand. J Immunol. , vol.33 , pp. 161-173
    • Eugui, E.M.1    Almquist, S.J.2    Muller, C.D.3    Allison, A.C.4
  • 26
    • 0026081633 scopus 로고
    • Lymphocyte-selective antiproliferative and immunosuppressive effects of mycophenolic acid in mice
    • erratum: 48, 45 (1998)
    • Eugui, E.M., Mirkovich, A. & Allison, A.C. Lymphocyte-selective antiproliferative and immunosuppressive effects of mycophenolic acid in mice. Scand. J. Immunol. 33, 175-183 (1991); erratum: 48, 45 (1998).
    • (1991) Scand. J. Immunol. , vol.33 , pp. 175-183
    • Eugui, E.M.1    Mirkovich, A.2    Allison, A.C.3
  • 27
    • 0029043888 scopus 로고
    • A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V
    • Vermes, I., Haanen, C., Steffens-Nakken, H. & Reutelingsperger, C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V. J. Immunol. Meth. 184, 39-51 (1995).
    • (1995) J. Immunol. Meth. , vol.184 , pp. 39-51
    • Vermes, I.1    Haanen, C.2    Steffens-Nakken, H.3    Reutelingsperger, C.4
  • 28
    • 0028800947 scopus 로고
    • Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl
    • Martin, S.J. et al. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J. Exp. Med. 182, 1545-1556 (1995).
    • (1995) J. Exp. Med. , vol.182 , pp. 1545-1556
    • Martin, S.J.1
  • 29
    • 0027433559 scopus 로고
    • Bottleneck acts as a regulator of the microfilament network governing cellularization of the Drosophila embryo
    • Schejter, E.D. & Wieschaus, E. Bottleneck acts as a regulator of the microfilament network governing cellularization of the Drosophila embryo. Cell 75, 373-385 (1993).
    • (1993) Cell , vol.75 , pp. 373-385
    • Schejter, E.D.1    Wieschaus, E.2
  • 30
    • 0027976331 scopus 로고
    • TOTO and YOYO: New very bright fluorochromes for DNA content analyses by flow cytometry
    • Hirons, G.T., Fawcett, J.J. & Crissman, H.A. TOTO and YOYO: new very bright fluorochromes for DNA content analyses by flow cytometry. Cytometry 15, 129-140 (1994).
    • (1994) Cytometry , vol.15 , pp. 129-140
    • Hirons, G.T.1    Fawcett, J.J.2    Crissman, H.A.3
  • 31
    • 0029006409 scopus 로고
    • G. Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection
    • European Mycophenolate Mofetil Cooperative Study, G. Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection. Lancet 345, 1321-1325 (1995).
    • (1995) Lancet , vol.345 , pp. 1321-1325
  • 32
    • 0031024728 scopus 로고    scopus 로고
    • Mycophenolate mofetil in renal allograft recipients: A pooled efficacy analysis of three randomized, double-blind, clinical studies in prevention of rejection. The international mycophenolate mofetil renal transplant study groups
    • erratum: 63, 618 (1997)
    • Halloran, P. et al. Mycophenolate mofetil in renal allograft recipients: a pooled efficacy analysis of three randomized, double-blind, clinical studies in prevention of rejection. The international mycophenolate mofetil renal transplant study groups. Transplantation 63, 39-47 (1997); erratum: 63, 618 (1997).
    • (1997) Transplantation , vol.63 , pp. 39-47
    • Halloran, P.1
  • 33
    • 0031873665 scopus 로고    scopus 로고
    • Limited CD4+ T-cell renewal in early HIV-1 infection: Effect of highly active anti-retroviral therapy
    • Fleury, S. et al. Limited CD4+ T-cell renewal in early HIV-1 infection: effect of highly active anti-retroviral therapy. Nature Med. 4, 794-801 (1998).
    • (1998) Nature Med. , vol.4 , pp. 794-801
    • Fleury, S.1
  • 34
    • 12944312755 scopus 로고    scopus 로고
    • Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy
    • Fleury, S. et al. Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy. Proc. Natl. Acad. Sci. USA 97, 5393-5398 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 5393-5398
    • Fleury, S.1
  • 35
    • 17444379333 scopus 로고    scopus 로고
    • Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans
    • Hellerstein, M. et al. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans. Nature Med 5, 83-89 (1999).
    • (1999) Nature Med , vol.5 , pp. 83-89
    • Hellerstein, M.1
  • 36
    • 0033214567 scopus 로고    scopus 로고
    • Measurement of T-cell kinetics: Recent methodologic advances
    • Hellerstein, M.K. Measurement of T-cell kinetics: recent methodologic advances. Immunol. Today 20, 438-441 (1999).
    • (1999) Immunol. Today , vol.20 , pp. 438-441
    • Hellerstein, M.K.1
  • 37
    • 0029980114 scopus 로고    scopus 로고
    • Host-parasite dynamics and outgrowth of virus containing a single K70R amino acid change in reverse transcriptase are responsible for the loss of human immunodeficiency virus type 1 RNA load suppression by zidovudine
    • de Jong, M.D. et al. Host-parasite dynamics and outgrowth of virus containing a single K70R amino acid change in reverse transcriptase are responsible for the loss of human immunodeficiency virus type 1 RNA load suppression by zidovudine. Proc. Natl. Acad. Sci USA 93, 5501-5506 (1996).
    • (1996) Proc. Natl. Acad. Sci USA , vol.93 , pp. 5501-5506
    • De Jong, M.D.1
  • 38
    • 0032504930 scopus 로고    scopus 로고
    • Target cell availability and the successful suppression of HIV by hydroxyurea and didanosine
    • De Boer, R.J., Boucher, C.A. & Perelson, A.S. Target cell availability and the successful suppression of HIV by hydroxyurea and didanosine. AIDS 12, 1567-1570 (1998).
    • (1998) AIDS , vol.12 , pp. 1567-1570
    • De Boer, R.J.1    Boucher, C.A.2    Perelson, A.S.3
  • 39
    • 0025342694 scopus 로고
    • HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure
    • Zack, J.A. et al. HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell 61, 213-222 (1990).
    • (1990) Cell , vol.61 , pp. 213-222
    • Zack, J.A.1
  • 40
    • 0032742547 scopus 로고    scopus 로고
    • Sexual transmission and propagation of SIV and HIV in resting and activated CD4(+) T cells
    • Zhang, Z. et al. Sexual transmission and propagation of SIV and HIV in resting and activated CD4(+) T cells. Science 286, 1353-1357 (1999).
    • (1999) Science , vol.286 , pp. 1353-1357
    • Zhang, Z.1
  • 41
    • 0030712305 scopus 로고    scopus 로고
    • Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
    • Wong, J.K. et al. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 278, 1291-1295 (1997).
    • (1997) Science , vol.278 , pp. 1291-1295
    • Wong, J.K.1
  • 42
    • 14444273439 scopus 로고    scopus 로고
    • Identification of a reservoir for HIV-1 in patients on highly active anti-retroviral therapy
    • Finzi, D. et al. Identification of a reservoir for HIV-1 in patients on highly active anti-retroviral therapy. Science 278, 1295-1300 (1997).
    • (1997) Science , vol.278 , pp. 1295-1300
    • Finzi, D.1
  • 43
    • 0030659177 scopus 로고    scopus 로고
    • Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
    • Chun, T.W. et al. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc. Natl. Acad. Sci U.S.A. 94, 13193-13197 (1997).
    • (1997) Proc. Natl. Acad. Sci U.S.A. , vol.94 , pp. 13193-13197
    • Chun, T.W.1
  • 44
    • 0032953920 scopus 로고    scopus 로고
    • + T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
    • + T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nature Med. 5, 512-517 (1999).
    • (1999) Nature Med. , vol.5 , pp. 512-517
    • Finzi, D.1
  • 45
    • 0033609373 scopus 로고    scopus 로고
    • Quantifying residual HIV-1 replication in patients receiving potent antiretroviral therapy
    • Zhang, L. et al. Quantifying residual HIV-1 replication in patients receiving potent antiretroviral therapy. N. Engl. J. Med. 340, 1605-1613 (1999).
    • (1999) N. Engl. J. Med. , vol.340 , pp. 1605-1613
    • Zhang, L.1
  • 46
    • 7144257857 scopus 로고    scopus 로고
    • A placebo-controlled trial of didanosine plus stavudine, with and without hydroxyurea, for HIV infection. The Swiss HIV cohort study
    • Rutschmann, O.T. et al. A placebo-controlled trial of didanosine plus stavudine, with and without hydroxyurea, for HIV infection. The Swiss HIV cohort study. AIDS 12, F71-77 (1998).
    • (1998) AIDS , vol.12
    • Rutschmann, O.T.1
  • 47
    • 0021271862 scopus 로고
    • The interleukin-2 T-cell system: A new cell growth model
    • Cantrell, D.A. & Smith, K.A. The interleukin-2 T-cell system: a new cell growth model. Science 224, 1312-1316 (1984).
    • (1984) Science , vol.224 , pp. 1312-1316
    • Cantrell, D.A.1    Smith, K.A.2
  • 49
    • 0030913366 scopus 로고    scopus 로고
    • Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
    • Chun, T.W. et al. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 387, 183-188 (1997).
    • (1997) Nature , vol.387 , pp. 183-188
    • Chun, T.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.