HGF triggers activation of the COX-2 gene in rat gastric epithelial cells: Action mediated through the ERK2 signaling pathway

FASEB Journal

Volumn 13, Issue 15, 1999, Pages 2186-2194

  Jones, Michael K ^a,b   Sasaki, Eiji ^a,b,c   Halter, Fred ^a,b   Pai, Rama ^a,b   Nakamura, Toshikazu ^d   Arakawa, Tetsuo ^c   Kuroki, Tetsuo ^c   Tarnawski, Andrzej S ^a,b  

^a VA LONG BEACH HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

c Met HGF receptor; Receptor phosphorylation; RGM1 cells

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYCLOOXYGENASE 2; MITOGEN ACTIVATED PROTEIN KINASE; SCATTER FACTOR; SCATTER FACTOR RECEPTOR;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EPITHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; STOMACH EPITHELIUM;

EID: 0032787558     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.13.15.2186     Document Type: Article

References (63)

1. Tarnawski, A., and Halter, F. (1995) Cellular mechanisms, interactions, and dynamics of gastric ulcer healing. J. Clin. Gastroenterol. 2, S93-S97
2. Basson, M. D., Modlin, I. M., and Madri, J. A. (1992) Human enterocyte (Caco-2) migration is modulated in vitro by extracellular matrix composition and epidermal growth factor. J. Clin. Invest 90, 15-23
3. Majumdar, A. P. N., Fligiel, S. E. G., Jaszewski, R., Tureaud, J., Dutta, S., and Chelluderai, B. (1996) Inhibition of gastric mucosal regeneration by tryphostin: evaluation of the role of epidermal growth factor receptor tyrosine kinase. J. Lab. Clin. Med 128, 173-180
4. Tsuji, S., Kawano, S., Tsujii, M., Fusamoto, H., and Kamada, T. (1995) Roles of hepatocyte growth factor and its receptor in gastric mucosa. Dig. Dis. Sci 40, 1132-1139
5. Schmassmann, A., Hirschi, C., Stettler, C., Poulsom, R., and Halter, F. (1997) Recent work with hepatocyte growth/scatter factor. In The Gut as a Model in Cell and Molecular Biology (Halter, F., Winton, D., and Wright, N. A., eds) pp. 180-193, Kluwer Academic Press, Dordrecht
6. Matsumoto K., and Nakamura, T. (1997) Breakthroughs and views: hepatocyte growth factor (HGF) as a tissue organizer for organogenesis and regeneration. Biochem. Biophys. Res. Commun. 239, 639-644
7. Kinoshita Y., Nakata, H., Hassan, S., Asahara, M., Kawanami, C., Matsushima, Y., Naribayashi Inomoto, Y., Ping, C. Y., Min, D., Nakamura, A., and Chiba T. (1995) Gene expression of keratinocyte and hepatocyte growth factors during the healing of rat gastric mucosal lesions. Gastroenterology 109, 1068-1077
8. Schmassmann, A., Stettler, C., Poulsom, R., Tarasova, N., Hirschi, C., Flogerzi, B., Matsumoto, K., Nakamura, T., and Halter F. (1997) Roles of hepatocyte growth factor and its receptor Met during gastric ulcer healing in rat. Gastroenterology 113, 1858-1872
9. Inauen, W., Wyss, P. A., Kayser, S., Baumgartner, A., Schürer-Maly, C. C., Koelz, H. R., and Halter, F. (1988) Influence of prostaglandins, omeprazole and indomethacin on healing of experimental gastric ulcers in the rat. Gastroenterology 95, 636-641
10. Schmassmann, A., Tarnawski, A., Peskar, B. M., Varga, L., Flogerzi, B., and Halter, F. (1995) Influence of acid and angiogenesis on kinetics of gastric ulcer healing in rats: Interaction with indomethacin. Am. J. Physiol. 268, G276-G285
11. 2 treatment on the rat gastrointestinal mucosa. Gastroenterology 85, 1003-1010
12. Tytgat, G. N., Offerhaus, G. J., van Minnen, A. J., Everts, V., Hensen-Logmans, S. C., and Samson, G. (1986) Influence of oral 15(R)-15-methyl prostaglandin E2 on human gastric mucosa. A light microscopic, cell kinetic, and ultrastructural study. Gastroenterology 90, 1111-1120
13. Giardiello, F. M., Spannhake, E. W., DuBois, R. N., Hylind, L. M., Robinson, C. R., Hubhard, W. C., Hamilton, S. R., and Yang, V. (1998) Prostaglandin levels in human colorectal mucosa: effects of sulindac in patients with familial adenomatous polyposis. Dig. Dis. Sci. 43, 311-316
14. Matsumoto, K., Okazaki, H., and Nakamura, T. (1995) Novel function of prostaglandins as inducers of gene expression of HGF and putative mediators of tissue regeneration. J. Biochem. 117, 458-464
15. Takahashi, M., Ota, S., Hata, Y., Mikami, Y., Azuma, N., Nakamura, T., Terano, A., and Omata, M. (1996) Hepatocyte growth factor as a key to modulate antiulcer action of prostaglandins in stomach. J. Clin. Invest. 98, 2604-2611
16. Hori, T., Shibamoto, S., Hayakawa, M., Tacheuki, K., Oku, N., Miyazawa, K., Kitamura, N., and Ito, F. (1993) Stimulation of prostaglandin production by hepatocyte growth factor in human gastric carcinoma cells. FEBS Lett. 34, 333-334
17. Adachi, T., Nakashima, S., Saji, S., Nakamura, T., and Nozawa, Y. (1995) Roles of prostaglandin production and mitogen-activated protein kinase activation in hepatocyte growth factor-mediated rat hepatocyte proliferation. Hepatology 21, 1668-1674
18. Sawaoka, H., Tsuji, S., Tsujii, M., Gunawan, E. S., Nakama, A., Takei, Y., Nagano, K., Matsui, H., Kawano, S., and Hori, M. (1997) Expression of the cyclooxygenase-2-gene in gastric epithelium. J. Clin. Gastroenterol. 25 (Suppl. 1), S105-S110
19. Sasaki, E., Pai, R., Halter, F., Komurasaki, T., Arakawa, T., Kobayashi, K., Kuroki, T., and Tarnawski, A. (1998) Induction of cyclooxygenase-2 in rat gastric epithelial cell line by epiregulin and basic fibroblast growth factor. J. Clin. Gastroenterol. 27 (Suppl. 1), S21-S27
20. Horie-Sakata, K., Shimada, T., Hiraishi, H., and Terano, A. (1998) Role of cyclooxygenase-2 in hepatocyte growth factor-mediated gastric epithelial restitution. J. Clin. Gastroenterol. 27 (Suppl. 1), S40-S46
21. Schmassmann, A., Peskar, B. M., Stettler, C., Netzer, P., Stroff, T., Flogerzi, B., and Halter, F. (1998) Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats. Br. J. Pharmacol 123, 795-804
22. Pai, R., Ohta, M., Itani, R. M., Sarfeh, I. J., and Tarnawski, A. S. (1998) Induction of mitogen-activated protein kinase signal transduction pathway during gastric ulcer healing in rats. Gastroenterology 114, 706-713
23. Watanabe, S., Hirose, M., Wang, X. E., Machiro, K., Murai, T., Kobayashi, O., Nagahara, A., and Sato, N. (1993) Hepatocyte growth factor accelerates the wound repair of cultured gastric mucosal cells. Biochem. Biophys. Res. Commun. 19, 1452-1460
24. Chomczynski, P., and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidiniumthiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159
25. Ohta, M., Tanoue, K., Tarnawski, A. S., Pai, R., Itani, R. M., Sander, F. C., Sugimachi, K., and Sarfeh, I. J. (1997) Overexpressed nitric oxide synthase in portal-hypertensive stomach of rat: a key to increase susceptibility to damage? Gastroenterology 112, 1920-1930
26. Kramer, M. F., and Coen, D. M. (1995) The polymerase chain reaction. In Current Protocols in Molecular Biology, 4th Ed (Ausubel, R., Brent, R., Kingston, R. E., More, D. D., Seidman, J. G., Smith, J. A., and Struhl, K., eds) Vol. 2, John Wiley & Sons, New York
27. Saiki, P. K., Gelfand, D. H., and Stoffel, S. (1988) Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239, 487-491
28. Gustafson, S. C., Lilja, I., Hallbook, O., and Sjodahl, R. (1996) Cyclooxygenase-1 and cyclooxygenase-2 gene expression in human colorectal adenocarcinomas and in azoxymethane induced colonic tumors in rats. Gut 38, 79-84
29. Nudel, U., Zakut, R., Shani, M., Neuman, S., Levy, Z., and Yaffe, D. (1983) The nucleotide sequence of the rat cytoplasmic β-actin gene. Nucleic Acids Res. 11, 1759-1771
30. Gilliand, G. S., Perrin, S., Blanchard, K., and Bunn, H. F. (1990) Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction. Proc. Natl. Acad. Sci. USA 87, 2725-2729
31. Siebert, P. D., and Larrick, J. W. (1993) PCR MIMICS: competitive DNA fragments for use as internal standards in quantitative PCR. BioTerhniques 14, 244-249
32. Tanoue, K., Ohta, M., Tarnawski, A. S., Wahlstrom, K. J., Sugimachi, K., and Sarfeh, I. J. (1996) Portal hypertension activates the nitric oxide synthase genes in the esophageal mucosa of rats. Gastroenterology 110, 549-557
33. Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Oloson, B. J., and Klenk, D. C. (1985) Measurement of protein using bicinchoninic acid. Anal Biochem. 150, 76-85
34. Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of bacteriophage T4. Nature (London) 272, 680-685
35. Tarnawski, A.. Brzozowski, T. J., Sarfeh, I. J., Krause, W. J., Ulich, T. R., Gergely, H., and Hollander, D. (1988) Prostaglandin protection of human isolated gastric glands against indomethacin and alcohol injury. J. Clin. Invest. 81, 1081-1089
36. Xie, W., Chipman, J. G., Rohertson, D. L., Erikson, R. L., and Simmons, D. L. (1991) Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc. Natl. Acad. Sci. USA 88, 2692-2696
37. Vane, J. R. (1994) Towards a better aspirin. Nature (London) 367, 215-216
38. Vane, J. R., and Botting, R. M. (1998) Mechanism of action of nonsteroidal anti-inflammatory drugs. Am. J. Med. 104, 2S-8S
39. DuBois, R. N., Abramson, S. B., Croford, L., Gupta, R. A., Simon, L. S., Van de Putate, L. B. A., and Lisky, P. E. (1998) Cyclooxygenase in biology and disease. FASEB J. 12, 1062-1073
40. Stolz, D. B., and Michalopoulos, G. K. (1994) Comparative effects of hepatocyte growth factor and epidermal growth factor on motility, morphology, mitogenesis, and signal transduction of primary rat hepatocytes. J. Cell. Biochem. 55, 445-464
41. Ridley, S. H., Sarsfield, S. J., Lee, J. C., Bigg, H. F., Cawston, T. E., Taylor, D. J., DeWitt, D. L., and Saklatvala, J. (1997) Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels. J. Immunol. 158, 3165-3173
42. Dean, J. L. E., Brook, M., Clark, A. R., and Saklatvala, J. (1999) p3H mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability transcription in lipopolysaccharide-treated human monocytes. J. Biol. Chem. 274, 264-269
43. Rainsford, K. D., Tsang, S., Hunt, R. H., and Al-Jehani, N. (1995) Effects of non-steroidal antiinflammatory drugs on prostaglandin H synthase isoenzyme 2 (cyclo-oxygenase 2) production by porcine gastric mucosa in organ culture. Inflammatopharmacology 3, 299-300
44. Iseki, S. (1995) Immunocytochemical localization of cyclooxygenase-1 and cyclooxygenase-2 in the rat. Histochem. J. 27, 323-328
45. Tarnawski, A., Wahlstrom, K., Gergely, H., and Sarfeh, I. J. (1996) Expression of cyclooxygenase-1 and -2 (COX-1 and COX-2) in normal gastric mucosa. Effect of antacid (hydrotalcit) treatment. Gastroenterology 110, A275
46. Tarnawski, A. S., Kidao, J., Jaafar, S., Itani, R. M., Pai, R., Gergely, H., and Sarfeh, I. J. (1997) Expression and localization of cyclooxygenase-2 in normal and ulcerated human gastric mucosa and in cultured human endothelial cells. Gastroenterology 112, A309 (abstr.)
47. Davies, N. M., Sharkey, K. A., Asfaha, S., MacNaughton, W. K., and Wallace, J. L. (1997) Aspirin causes rapid up-regulation of cyclooxygenase-2 expression in the stomach of rats. Aliment. Pharmacol. Ther. 11, 1101-1108
48. Donnelly, M. T., Hull, M. A., Jenkins, D., and Hawkey, C. J. (1997) Immunohistochemical distribution of constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2) in healing and malignant gastric mucosa. Gastroenterology 112, A10 (abstr.)
49. O'Neill, G. P., and Ford-Huchinson, A. W. (1993) Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett. 350, 156-160
50. Ferraz, J. G., Sharkey, K. A., Reuter, B. K., Asfaha, A., Tigley, A. W., Brown, M. L., McKnight, W., and Wallace, J. L. (1997) Induction of cyclooxygenasc 1 and 2 in rat stomach during endotoxemia: role of resistance to damage. Gastroenterology 113, 195-204
51. Kishimoto, Y., Wada, K., Nakamoto, K., Kawasaki, H., and Hasegawa, J. L. (1998) Levels of cyclooxygenase-1 and -2 mRNA expression at various stages of acute gastric injury induced by ischemia-reperfusion in rats. Arch. Biochem. Biophys. 352, 153-157
52. Ukawa, H., Yamakuni, H., Kato, S., and Takeuchi, K. (1998) Effects of cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal antiinflammatory drugs on mucosal ulcerogenic and healing responses of the stomach. Dig. Dis. Sci. 43, 2003-2011
53. Mizuno, H., Sakamoto, C., Matusda, K., Wada, K., Uchida, T., Noguchi, H.. Akamatsu, T., and Kasuga, M. (1997) Induction of cyclooxygenase-2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology 112, 387-397
54. Lee, S. H., Soyoola, E., Chanmugam, P., Hart, S., Sun, W., Zhong, H., Liou, D., Simmons, D., and Hwang, D. (1992) Selective expression of mitogen/inducible cyclooxygenase and macrophages stimulated with lipopolysaccharide. J. Biol. Chem. 267, 25934-25938
55. Karim, S., Habib, A., Levy-Toledano, S., and Maclouf, J. (1996) Cyclooxygenase-1 and-2 of endothelial cells utilize exogenous or endogenous arachidonic acid for transcellular production of thromboxane. J. Biol. Chem. 271, 12042-12048
56. Langenbach, R., Morham, S. G., Tiano, H. F., Loftin, C. D., Ghanayem, B. I., Chulada, P. C., Mahler, J. F., Lee, C. A., Goulding, E. H., Kimberly, D., Kluckman, K. D., Kim, H. S., and Smithies, O. (1995) Prostaglandin synthase 1-gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell 83, 483-492
57. Morham, S. G., Langenbach, R., Loftin, C. D., Tiano, H. F., Vouloumanos, N., Jennette, J. C., Mahler, J. F., Kluckman, K. D., Ledford, A., Lee, C. A., and Smithies, O. (1995) Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell 83, 437-482
58. Serhan, C. N., Haeggstsrom, J. Z., and Leslie, C. C. (1996) Lipid mediator networks in cell signaling: update and impact of cytokines. FASEB J. 10, 1147-1158
59. Boyce, S., Chan, C. C., Gordon, R., Li, C. S., Rodger, I. W., Webb, J. K., Rupniak, N. M., and Hill, R. G. (1994) L-745,337: a selective inhibitor of cyclooxygenase-2 elicits antinociception but not gastric ulceration in rats. Neuropharmacology 33, 1609-1611
60. Chan, C. C., Boyce, S., Brideau, C., Ford-Hutchinson, A. W., Gordon, R., Guay, D., Hill, R. G., Li, C. S., Manchini, J., Penneton, M., Prasit, P., Rasori, R., Reindeau, D., Rox, P., Tagari, P., Vickers, P., Wong, E., and Rodger, I. W. (1995) Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach. J. Pharmacol. Exp. Ther. 274, 1531-1537
61. Yeomans, N. D., Cook, G. A., and Giraud, A. S. (1998) Selective COX-2 inhibitors: are they safe for the stomach? Gastroenterology 115, 227-228
62. Ehrlich, K., Plate, S., Stroff, T., Gretzer, B., Respondek, M., and Peskar, B. M. (1998) Peptidergic and cholinergic neurons and mediators in peptone induced gastroprotection: role of cyclooxygenase-2. Am. J. Physiol. 247, G955-G964
63. Gretzer, B., Ehrlich, K., Maricic, N., Lambrecht, N., Respondek, M., and Peskar, B. M. (1998) Selective cyclo-oxygenase-2 inhibitors and their influence on the protective effect of a mild irritant in the rat stomach. Br. J. Pharmacol. 123, 927-935