Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059: SB 203580 also inhibits thromboxane synthase

Journal of Biological Chemistry

Volumn 273, Issue 44, 1998, Pages 28766-28772

  Börsch Haubold, Angelika G ^a   Pasquet, Sophie ^a   Watson, Steve P ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE A2; THROMBOXANE SYNTHASE;

ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION;

ARACHIDONIC ACID; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; FLAVONOIDS; HUMANS; IMIDAZOLES; ISOENZYMES; MEMBRANE PROTEINS; PLATELET ACTIVATION; PROSTAGLANDIN H2; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS H; PYRIDINES; THROMBOXANE A2; THROMBOXANE-A SYNTHASE;

EID: 0032582678     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.44.28766     Document Type: Article

References (30)

1. Lee, J. C., and Young, P. R. (1996) J. Leukocyte Biol. 59, 152-157
2. Lee, J. C., Laydon, J. T., McDonnell, P. C., Gallagher, T. F., Kumar, S., Green, D., McNulty, D., Blumenthal, M. J., Keys, J. R., Landvatter, S. W., Strickler, J. E., McLaughlin, M. M., Siemens, I. R., Fisher, S. M., Livi, G, P., White, J. R., Adams, J. L., and Young, P. R. (1994) Nature 372, 739-746
3. Cuenda, A., Rouse, J., Doza, Y. N., Meier, R., Cohen, P., Gallagher, T. F., Young, P. R., and Lee, J. C. (1995) FEBS Lett. 364, 229-233
4. Jiang, Y., Chen, C., Li, Z., Quo, W., Gegner, J. A., Lin, S., and Han, J. (1996) J. Biol. Chem. 271, 17920-17926
5. Cuenda, A., Cohen, P., Buée-Scherrer, V., and Goedert, M. (1997) EMBO J. 16, 295-305
6. Goedert, M., Cuenda, A., Craxton, M., Jakes, R., and Cohen, P. (1997) EMBO J. 16, 3563-3571
7. Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J., and Saltiel, A. R. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 7686-7689
8. Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T., and Saltiel, A. R. (1995) J. Biol. Chem. 270, 27489-27494
9. Pang, L., Sawada, T., Decker, S. J., and Saltiel, A. R. (1995) J. Biol. Chem. 270, 13585-13588
10. Börsch-Haubold, A. G., Kramer, R. M., and Watson, S. P. (1996) Biochem. J. 318, 207-212
11. Borsch-Haubold, A. G., Kramer, R. M., and Watson, S. P. (1997) Eur. J. Biochem. 245, 751-759
12. Gresele, P., Deckmyn, H., Nenci, G. G., and Vermylen, J. (1991) Trends Pharmacol. Sci. 12, 158-163
13. Vezza, R., Roberti, R., Nenci, G. G., and Gresele, P. (1993) Blood 82, 2704-2713
14. Hamberg, M., Svensson, J., Wakabayashi, T., and Samuelsson, B. (1974) Proc. Natl. Acad. Sci. U. S. A. 71, 345-349
15. Maclouf, J. (1981) Methods Enzymol. 86, 273-286
16. Börsch-Haubold, A. G., Kramer, R. M., and Watson, S. P. (1995) J. Biol. Chem. 270, 25885-25892
17. Habib, A., and Maclouf, J. (1992) Arch. Biochem. Biophys. 298, 544-552
18. Daret, D., Blin, P., Dorian, B., Rigaud, M., and Larrue, J. (1993) J. Lipid Res. 34, 1473-1482
19. Karim, S., Habib, A., Lévy-Toledano, S., and Maclouf, J. (1996) J. Biol. Chem. 271, 12042-12048
20. Kramer, R. M., Roberts, E. F., Ulm, S. L., Börsch-Haubold, A. G., Watson, S. P., Fisher, M. J., and Jakubowski, J. A. (1996) J. Biol. Chem. 271, 27723-27729
21. Halenda, S. P., Zavoico, G. B., and Feinstein, M. B. (1985) J. Biol. Chem. 260, 12484-12491
22. Gorman, R. R., Johnson, R. A., Spilman, C. H., and Aiken, J. W. (1983) Prostaglandins 26, 325-342
23. Habib, A., Créminon, C., Frobert, Y., Grassi, J., Pradelles, P., and Maclouf, J. (1993) J. Biol. Chem. 268, 23448-23454
24. Saklatvala, J., Rawlinson, L., Waller, R. J., Sarsfield, S., Lee, J. C., Morton, L. F., Barnes, M. J., and Farndale, R. W. (1996) J. Biol. Chem. 271, 6586-6589
25. Marshall, P. J., Griswold, D. E., Breton, J., Webb, E. F., Hillegass, L. M., Sarau, H. M., Newton, J. J., Lee, J. C., Bender, P. E., and Hanna, N. (1991) Biochem. Pharmacol. 42, 813-824
26. Kramer, R. M. (1994) in Signal-activated Phospholipases (Liscovitch, M., ed) pp. 13-30, R. G. Landes Co., Austin, TX
27. Clark, J. D., Lin, L.-L., Kriz, R. W., Ramesha, C. S., Sultzman, L. A., Lin, A. Y., Milona, N., and Knopf, J. L. (1991) Cell 65, 1043-1051
28. Lin, L.-L., Wartmann, M., Lin, A. Y., Knopf, J. L., Seth, A., and Davis, R. J. (1993) Cell 72, 269-278
29. de Carvalho, M. G. S., McCormack, A. L., Olson, E., Ghomashchi, F., Gelb, M. H., Yates, J. R., III, and Leslie, C. C. (1996) J. Biol. Chem. 271, 6987-6997
30. Börsch-Haubold, A. G., Bartoli, F., Asselin, J., Dudler, T., Kramer, R. M., Apitz-Castro, R., Watson, S. P., and Gelb, M. H. (1998) J. Biol. Chem. 273, 4449-4458