Gene expression profiling of the PPAR-alpha agonist ciprofibrate in the cynomolgus monkey liver

Toxicological Sciences

Volumn 88, Issue 1, 2005, Pages 250-264

  Cariello, Neal F ^a   Romach, Elizabeth H ^a   Colton, Heidi M ^a   Ni, Hong ^a   Yoon, Lawrence ^a   Falls, J Greg ^a   Casey, Warren ^a   Creech, Donald ^a   Anderson, Steven P ^a,b   Benavides, Gina R ^a   Hoivik, Debie J ^a   Brown, Roger ^a   Miller, Richard T ^a  

^a GLAXOSMITHKLINE   (United States)

^b BAYER CORPORATION   (United States)

Author keywords

Ciprofibrate; PPAR

Indexed keywords

CIPROFIBRATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEASOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; DNA MICROARRAY; DOWN REGULATION; ENZYME SYNTHESIS; FATTY ACID METABOLISM; FATTY ACID OXIDATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HYPERPLASIA; HYPERTROPHY; LIVER CARCINOGENESIS; LIVER MITOCHONDRION; LIVER TOXICITY; LIVER WEIGHT; NONHUMAN; ONCOGENE C JUN; ONCOGENE MYC; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PATHOPHYSIOLOGY; REGULATOR GENE; RIBOSOME; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; CLOFIBRIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; LIVER; MACACA FASCICULARIS; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEROXISOME PROLIFERATORS; PPAR ALPHA; SPECIES SPECIFICITY; TRANSCRIPTION, GENETIC;

ANIMALIA; MACACA FASCICULARIS; PRIMATES; RODENTIA;

EID: 27644519691     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfi273     Document Type: Article

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