Chronic ethanol sensitizes the liver to endotoxin via effects on endothelial nitric oxide synthase regulation

Shock

Volumn 24, Issue 5, 2005, Pages 447-454

  Karaa, Amel ^a   Kamoun, Walid S ^a   Clemens, Mark G ^a  

^a UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

Author keywords

Chronic alcohol; Endothelin 1; eNOS; Focal necrosis; LPS

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; CAVEOLIN 1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN B RECEPTOR; ENDOTOXIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL LIVER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HEPATITIS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LIVER ISCHEMIA; LIVER NECROSIS; MALE; NONHUMAN; PATHOPHYSIOLOGY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIZATION; SEPTIC SHOCK; STRESS; VASODILATATION; WESTERN BLOTTING;

ALANINE TRANSAMINASE; ALCOHOL DRINKING; ANIMALS; BLOTTING, WESTERN; BODY WEIGHT; DOWN-REGULATION; DRUG SYNERGISM; ENDOTHELIN-1; ENDOTOXINS; ETHANOL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATITIS; IMMUNOHISTOCHEMISTRY; LIPOPOLYSACCHARIDES; LIVER; MALE; NECROSIS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, MESSENGER;

EID: 27644469905     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.shk.0000180616.13941.7d     Document Type: Article

References (43)

1. Johnson RD, Williams R: Genetic and environmental factors in the individual susceptibility to the development of alcoholic liver disease. Alcohol Alcohol 20:137-160, 1985.
2. De Torres M, Poynard T: Risk factors for liver fibrosis progression in patients with chronic hepatitis C. Ann Hepatol 2:5-11, 2003.
3. Balasubramanian S, Kowdley KV: Effect of alcohol on viral hepatitis and other forms of liver dysfunction. Clin Liver Dis 9:83-101, 2005.
4. Bauer I, Bauer M, Pannen BH, Leinwand MJ, Zhang JX, Clemens MG: Chronic ethanol consumption exacerbates liver injury following hemorrhagic shock: role of sinusoidal perfusion failure. Shock 4:324-331, 1995.
5. Zhong Z, Connor HD, Mason RP, Qu W, Gao W, Lemasters JJ, Thurman RG: Role of Kupffer cells in reperfusion injury in fat-loaded livers from ethanol-treated rats. J Pharmacol Exp Ther 275:1512-1517, 1995.
6. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H, Brenner DA, Thurman RG: Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Gastroenterology 115:443-451, 1998.
7. Day CP, James OF: Steatohepatitis: a tale of two "hits"? Gastroenterology 114:842-845, 1998.
8. Tsukamoto H, Takei Y, McClain CJ, Joshi-Barve S, Hill D, Schmidt J, Deaciuc I, Barve S, Colell A, Garcia-Ruiz C, Kaplowitz N, Fernandez-Checa JC, Yokoyama H, Okamura Y, Nakamura Y, Ishii H, Chawla RK, Watson W, Nelson W. Lin M, Ohata M, Motomura K, Enomoto N, Ikejima K, Kitamura T, Oide H, Hirose M, Bradford BU, Rivera CA, Kono H, Peter S, Yamashina S, Konno A, Ishikawa M, Shimizu H, Sato N, Thurman R: How is the liver primed or sensitized for alcoholic liver disease? Alcohol Clin Exp Res 25:1715-1815, 2001.
9. Bjarnason I, Peters TJ, Wise RJ: The leaky gut of alcoholism: possible route of entry for toxic compounds. Lancet 1:179-182, 1984.
10. 2. Am J Pathol 142:367-373, 1993.
11. Uesugi T, Froh M, Arteel GE, Bradford BU, Wheeler MD, Gabele E, Isayama F, Thurman RG: Role of lipopolysaccharide-binding protein in early alcohol-induced liver injury in mice. J Immunol 168:2963-2969, 2002.
12. Nanji AA, Khettry U, Sadrzadeh SM: Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver (disease). Proc Soc Exp Biol Med 205:243-247, 1994.
13. Enomoto N, Ikejima K, Bradford BU, Rivera C, Kono H, Goto M, Yamashina S, Schemmer P, Kitamura T, Oide H, Takei Y, Hirose M, Shimizu H, Miyazaki A, Brenner D, Sato N, Thurman R: Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. J Gastroenterol Hepatol 15(Suppl):D20-D25, 2000.
14. Enomoto N, Ikejima K, Yamashina S, Hirose M, Shimizu H, Kitamura T, Takei Y, Sato N, Thurman RG: Kupffer cell sensitization by alcohol involves increased permeability to gut-derived endotoxin. Alcohol Clin Exp Res 25:51S-54S, 2001.
15. Mathurin P, Deng QG, Keshavarzian A, Choudhary S, Holmes EW, Tsukamoto H: Exacerbation of alcoholic liver injury by enteral endotoxin in rats. Hepatology 32:1008-1017, 2000.
16. Uesugi T, Froh M, Arteel GE, Bradford BU, Thurman RG: Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology 34:101-108, 2001.
17. Yin M, Bradford BU, Wheeler MD, Uesugi T, Froh M, Goyert SM, Thurman RG: Reduced early alcohol-induced liver injury in CD14-deficient mice. J Immunol 166:4737-4742, 2001.
18. Baveja R, Yokoyama Y, Korneszczuk K, Zhang JX, Clemens MG: Endothelin 1 impairs oxygen delivery in livers from LPS-primed animals. Shock 17:383-388, 2002.
19. Eguchi H, Sato N, Minamiyama M, Matsumura T, Kawano S, Kamada T: Heterogeneous response in hepatic sinusoidal blood flow to acute ethanol ingestion in rats. Alcohol Alcohol (Suppl 1):519-521, 1987.
20. Fukui H, Sato N, Kawano S, Yoshihara H, Hijioka T, Eguchi H, Goto M, Matsunaga T, Kubota-Kashio S, Kamada T: Effect of ethanol on hepatic oxygenation: evidence of hepatic hypoxia. Adv Exp Med Biol 277:691-696, 1990.
21. Ohki E, Kato S, Horie Y, Mizukami T, Tamai H, Yokoyama H, Ito D, Fukuda M, Suzuki H, Kurose I, Ishii H: Chronic ethanol consumption enhances endotoxin-induced hepatic sinusoidal leukocyte adhesion. Alcohol Clin Exp Res 20:350A-355A, 1996.
22. Ashburn JH, Baveja R, Kresge N, Korneszczuk K, Keller S, Karaa A, Yokoyama Y, Zhang JX, Huynh T, Clemens MG: Remote trauma sensitizes hepatic microcirculation to endothelin via caveolin inhibition of eNOS activity. Shock 22: 120-130, 2004.
23. Bauer M, Paquette NC, Zhang JX, Bauer I, Pannen BH, Kleeberger SR, Clemens MG: Chronic ethanol consumption increases hepatic sinusoidal contractile response to endothelin-1 in the rat. Hepatology 22:1565-1576, 1995.
24. Ohara N, Futagawa S, Watanabe S, Fukasawa M, Takamori S: Clinical investigation of endothelin-1 and nitric oxide in patients with portal hypertension focusing on plasma levels and immunohistological staining of liver tissues. Hepatol Res 21:40-54, 2001.
25. Pannen BH, Bauer M, Zhang JX, Robotham JL, Clemens MG: Endotoxin pretreatment enhances portal venous contractile response to endothelin-1. Am J Physiol Heart Circ Physiol 270:H7-H15, 1996.
26. Baveja R, Kresge N, Ashburn JH, Keller S, Yokoyama Y, Sonin N, Zhang JX, Huynh T, Clemens MG: Potentiated hepatic microcirculatory response to endothelin-1 during polymicrobial sepsis. Shock 18:415-422, 2002.
27. Horie Y, Kato S, Ohki E, Tamai H, Ishii H: Role of endothelin in endotoxin-induced hepatic microvascular dysfunction in rats fed chronically with ethanol. J Gastroenterol Hepatol 16:916-922, 2001.
28. Rockey DC, Weisiger RA: Endothelin-induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance. Hepatology 24:233-240, 1996.
29. Liu S, Premont RT, Kontos CD, Huang J, Rockey DC: Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein βγ subunit signaling to protein J kinase B/Akt. J Biol Chem 278:49929-49935, 2003.
30. Shah V, Cao S, Hendrickson H, Yao J, Katusic ZS: Regulation of hepatic eNOS by caveolin and calmodulin after bile duct ligation in rats. Am J Physiol Gastrointest Liver Physiol 280:G1209-G1216, 2001.
31. De la P, Hall M, Lieber CS, DeCarli LM, French SW, Lindros KO, Jarvelainen H, Bode C, Parlesak A, Bode JC: Models of alcoholic liver disease in rodents: a critical evaluation. Alcohol Clin Exp Res 25:245S-261S, 2001.
32. Vos TA, Gouw AS, Klok PA, Havinga R, van Goor H, Huitema S, Roelofsen H, Kuipers F, Jansen PL, Moshage H: Differential effects of nitric oxide synthase inhibitors on endotoxin-induced liver damage in rats. Gastroenterology 113:1323-1333, 1997.
33. Hill DB, D'Souza NB, Lee EY, Burikhanov R, Deaciuc IV, de Villiers WJ: A role for interleukin-10 in alcohol-induced liver sensitization to bacterial lipopolysaccharide. Alcohol Clin Exp Res 26:74-82, 2002.
34. Friedman SL: Stellate cell activation in alcoholic fibrosis: an overview. Alcohol Clin Exp Res 23:904-910, 1999.
35. Paxian M, Keller SA, Baveja R, Korneszczuk K, Huynh TT, Clemens MG: Functional link between ETB receptors and eNOS maintain tissue oxygenation in the normal liver. Microcirculation 11:435-449, 2004.
36. Shah V, Toruner M, Haddad F, Cadelina G, Papapetropoulos A, Choo K, Sessa WC, Groszmann RJ: Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat. Gastroenterology 117:1222-1228, 1999.
37. Yokoyama Y, Baveja R, Sonin N, Nakanishi K, Zhang JX, Clemens MG: Altered endothelin receptor subtype expression in hepatic injury after ischemia/reperfusion. Shock 13:72-78, 2000.
38. Sonin NV, Garcia-Pagan JC, Nakanishi K, Zhang JX, Clemens MG: Patterns of vasoregulatory gene expression in the liver response to ischemia/reperfusion and endotoxemia. Shock 11:175-179, 1999.
39. Yokoyama Y, Baveja R, Kresge N, Sonin N, Nakanishi K, Zhang JX, Gitzelmann CA, Clemens MG: Endothelin receptor remodeling induces the portal venous hyper-response to endothelin-1 following endotoxin pretreatment. Shock 17:36-40, 2002.
40. Yokomori H, Oda M, Yasogawa Y, Nishi Y, Ogi M, Takahashi M, Ishii H: Enhanced expression of endothelin B receptor at protein and gene levels in human cirrhotic liver. Am J Pathol 159:1353-1362, 2001.
41. Dupuis J, Goresky CA, Fournier A: Pulmonary clearance of circulating endothelin-1 in dogs in vivo: exclusive role of ETB receptors. J Appl Physiol 81:1510-1515, 1996.
42. Karaa A, Kamoun W, Clemens M: Oxidative stress disrupts nitric oxide synthase activation in liver endothelial cells. Free Radical Biol Med 2005.
43. Merkel S, Kamoun W, Karaa A, Korneszczuk K, Schrum L, Clemens M: LPS inhibits endothelin-1-mediated eNOS translocation to the cell membrane in sinusoidal endothelial cells. Microcirculation 12:433-442, 2005.