Endothelin 1 impairs oxygen delivery in livers from LPS-primed animals

Shock

Volumn 17, Issue 5, 2002, Pages 383-388

  Baveja, Rajiv ^a   Yokoyama, Yukihiro ^a   Korneszczuk, Katarzyna ^a   Zhang, Jian X ^a   Clemens, Mark G ^a  

^a UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

Author keywords

Endothelin 1; Endotoxemia; Fluorescence microscopy; Hypoxia; Liver blood flow; Oxygen delivery

Indexed keywords

ENDOTHELIN 1; LIPOPOLYSACCHARIDE; OXYGEN;

ANIMAL; ANOXIA; ARTICLE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ENDOTOXEMIA; HEMODYNAMICS; IN VITRO STUDY; LIVER; MALE; METABOLISM; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PERFUSION; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; ANOXIA; ENDOTHELIN-1; ENDOTOXEMIA; HEMODYNAMIC PROCESSES; LIPOPOLYSACCHARIDES; LIVER; MALE; OXYGEN; OXYGEN CONSUMPTION; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0036581719     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-200205000-00007     Document Type: Article

References (46)

1. McCuskey RS, Urbaschek R, McCuskey PA, Urbaschek B: In vivo microscopic studies of the responses of the liver to endotoxin. Klin Wochenschr 60:749-751, 1982.
2. Ince C, Sinaasappel M: Microcirculatory oxygenation and shunting in sepsis and shock. Crit Care Med 27(7):1369-1377, 1999.
3. Chun K, Zhang J, Biewer JE, Ferguson D, Clemens MG: Microcirculatory failure determines lethal hepatocyte injury in ischemic/reperfused rat livers. Shock 1:3-9, 1994.
4. Bauer M, Zhang JX, Bauer I, Clemens MG: Endothelin-1 induced alterations of hepatic microcirculation: sinusoidal and extrasinusoidal sites of action. Am J Physiol 267:G143-G149, 1994.
5. Clemens MG, Zhang JX: Regulation of sinusoidal perfusion: in vivo methodology and control by endothelins. Semin Liver Dis 19(4):383-396, 1999.
6. Zhang JX, Bauer M, Clemens MG: Vessel and target cell-specific actions of endothelin-1 and endothelin-3 in rat liver. Am J Physiol 269:G269-G277, 1995.
7. Zhang JX, Pegoli W, Clemens MG: Endothelin-1 induces direct constriction of hepatic sinusoids. Am J Physiol 266:G624-G632, 1994.
8. Okumura S, Takei Y, Kawano S, Nagano K, Masuda E, Goto M, Tsuji S, Michida T, Chen SS, Kashiwagi T: Vasoactive effect of endothelin-1 on rat liver in vivo. Hepatology 19(1):155-161, 1994.
9. Uhlmann D, Uhlmann S, Spiegel HU: Endothelin/nitric oxide balance influences hepatic ischemia-reperfusion injury. J Cardiovasc Pharmacol 36(5 Suppl 1):S212-S214, 2000.
10. Ito Y, Katori M, Majima M, Kakita A: Constriction of mouse hepatic venules and sinusoids by endothelins through ETB receptor subtype. Int J Microcirc Clin Exp 16(5):250-258, 1996.
11. Sonin NV, Garcia-Pagan JC, Nakanishi K, Zhang JX, Clemens MG: Patterns of vasoregulatory gene expression in the liver response to ischemia/reperfusion and endotoxemia. Shock 11(3):175-179, 1999.
12. Weitzberg E, Lundberg JM, Rudehill A: Elevated plasma levels of endothelin in patients with sepsis syndrome. Circ Shock 33(4):222-227, 1991.
13. Myhre U, Pettersen JT, Risoe C, Giercksky KE: Endothelin-1 and endotoxemia. J Cardiovasc Pharmacol 22(Suppl 8):S291-S294, 1993.
14. Pannen BHJ, Bauer M, Zhang JX, Robotham JL, Clemens MG: Endotoxin pretreatment enhances portal venous contractile response to endothelin-1. Am J Physiol 270:H7-H15, 1996.
15. Baveja R, Zhang JX, Clemens MG: In vivo assessment of endothelin induced heterogeneity of hepatic tissue perfusion. Shock 15(3):186-192, 2001.
16. Yaegashi K, Itoh T, Kosaka T, Fukushima H, Morimoto T: Diffusivity of oxygen in microvascular beds as determined from PO2 distribution maps. Am J Physiol 270(4 Pt 2):H1390-H1397, 1996.
17. Itoh T, Yaegashi K, Kosaka T, Kinoshita T, Morimoto T: In vivo visualization of oxygen transport in microvascular network. Am J Physiol 267(5 Pt 2):H2068-H2078, 1994.
18. 2-uptake relationship? Anaesthesist 49(5):451-454, 2000.
19. 2 dependency exist in critically ill septic patients? Am J Respir Crit Care Med 157(4 Pt 1):1219-1225, 1998.
20. Wilson RF: The pathophysiology of shock. Intensive Care Med 6(2):89-100, 1980.
21. Ba ZF, Wang P, Koo DJ, Cioffi WG, Bland KI, Chaudry IH: Alterations in tissue oxygen consumption and extraction after trauma and hemorrhagic shock. Crit Care Med 28(8):2837-2842, 2000.
22. Yang S, Cioffi WG, Bland KI, Chaudry IH, Wang P: Differential alterations in systemic and regional oxygen delivery and consumption during the early and late stages of sepsis. J Trauma 47(4):706-712, 1999.
23. Clemens MG, Chaudry IH, McDermott PH, Baue AE: Regulation of glucose production from lactate in experimental sepsis. Am J Physiol 244(6):R794-R800, 1983.
24. Pannen BHJ, Bauer M, Zhang JX, Robotham JL, Clemens MG: A time-dependent balance between endothelins and nitric oxide regulating portal resistance after endotoxin. Am J Physiol 271:H1953-H1961, 1996.
25. Garcia-Pagan JC, Zhang JX, Sonin N, Nakanishi K, Clemens MG: Ischemia/ reperfusion induces an increase in the hepatic portal vasoconstrictive response to endothelin-1. Shock 11(5):325-329, 1999.
26. Pannen BH, Bauer M, Noldge-Schomburg GF, Zhang JX, Robotham JL, Clemens MG, Geiger KK: Regulation of hepatic blood flow during resuscitation from hemorrhagic shock: role of NO and endothelins. Am J Physiol 272:H2736-H2745, 1997.
27. Reichen J, Gerbes AL, Steiner MJ, Sagesser H, Clozel M: The effect of endothelin and its antagonist bosentan on hemodynamics and microvascular exchange in cirrhotic rat liver. J Hepatol 28(6):1020-1030, 1998.
28. Gandhi CR, Stephenson K, Olson MS: Endothelin, a potent peptide agonist in the liver. J Biol Chem 265:17432-17435, 1990.
29. Rothe CF, Maass-Moreno R: Active and passive liver microvascular responses from angiotensin, endothelin, norepinephrine, and vasopressin. Am J Physiol Heart Circ Physiol 279(3):H1147-H1156, 2000.
30. Ekataksin W, Kaneda K: Liver microvascular architecture: an insight into the pathophysiology of portal hypertension. Semin Liver Dis 19(4):359-382, 1999.
31. Mitsuoka H, Suzuki S, Sakaguchi T, Baba S, Miwa M, Konno H, Nakamura S: Contribution of endothelin-1 to microcirculatory impairment in total hepatic ischemia and reperfusion injury. Transplantation 67(4):514-520, 1999.
32. Eakes AT, Olson MS: Regulation of endothelin synthesis in hepatic endothelial cells. Am J Physiol 274(6 Pt 1):G1068-G1076, 1998.
33. Bauer M, Bauer I, Sonin NV, Kresge N, Baveja R, Yokoyama Y, Harding D, Zhang JX, Clemens MG: Functional significance of endothelin B receptors in mediating sinusoidal and extrasinusoidal effects of endothelins in the intact rat liver. Hepatology 31(4):937-947, 2000.
34. Higuchi H, Satoh T: Endothelin-1 induces vasoconstriction and nitric oxide release via endothelin ET(B) receptors in isolated perfused rat liver. Eur J Pharmacol 328(2-3): 175-182, 1997.
35. Yokoyama Y, Baveja R, Sonin N, Nakanishi K, Zhang JX, Clemens MG: Altered endothelin receptor subtype expression in hepatic injury after ischemia/ reperfusion. Shock 13(1):72-78, 2000.
36. Yokoyama Y, Baveja R, Kresge N, Sonin N, Nakanishi K, Zhang JX, Gitzelmann CA, Clemens MG: Endothelin receptor remodeling induces the portal venous hyper-response to endothelin-1 following endotoxin pretreatment. Shock (in press).
37. Sokolovsky M, Ambar I, Galron R: A novel subtype of endothelin receptors. J Biol Chem 267(29):20551-20554, 1992.
38. Nambi P, Pullen M, Kincaid J, Nuthulaganti P, Aiyar N, Brooks DP, Gellai M, Kumar C: Identification and characterization of a novel endothelin receptor that binds both ETA- and ETB-selective ligands. Mol Pharmacol 52(4):582-589, 1997.
39. Rockey DC: Characterization of endothelin receptors mediating rat hepatic stellate cell contraction. Biochem Biophys Res Commun 207(2):725-731, 1995.
40. Smith PJ, Teichert-Kuliszewska K, Monge JC, Stewart DJ: Regulation of endothelin-B receptor mRNA expression in human endothelial cells by cytokines and growth factors. J Cardiovasc Pharmacol 31(Suppl 1):S158-S160, 1998.
41. Gandhi CR, Uemura T, Kuddus R: Endotoxin causes up-regulation of endothelin receptors in cultured hepatic stellate cells via nitric oxide-dependent and -independent mechanisms. Br J Pharmacol 131(2):319-327, 2000.
42. Gabriel A, Kuddus RH, Rao AS, Gandhi CR: Down-regulation of endothelin receptors by transforming growth factor beta1 in hepatic stellate cells. J Hepatol 30(3):440-450, 1999.
43. Schirmer WJ, Townsend MC, Schirmer JM, Hampton WW, Fry DE: Galactose elimination kinetics in sepsis: correlations of hepatic blood blow with function. Arch Surg 122(3):349-354, 1987.
44. Ohtake Y, Clemens MG: Interrelationship between hepatic ureagenesis and gluconeogenesis in early sepsis. Am J Physiol 260:E453-E458, 1991.
45. Clemens MG, Chaudry IH, Daigneau N, Baue AE: Insulin resistance and depressed gluconeogenic capability during early hyperglycemic sepsis. J Trauma 24:701-708, 1984.
46. Clemens MG, Chaudry IH, McDermott PH, Baue AE: Regulation of glucose production from lactate in experimental sepsis. Am J Physiol 244(6):R794-R800, 1983.