Oxidative stress and lung inflammation in airways disease

European Journal of Pharmacology

Volumn 429, Issue 1-3, 2001, Pages 195-207

  MacNee, William ^a,b,c  

^a ELEGI   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Antioxidant; Asthma; Chronic obstructive pulmonary disease; Oxidant; Oxidative stress

Indexed keywords

3 NITROTYROSINE; 4 HYDROXYNONENAL; ACETYLCYSTEINE; ALPHA 1 ANTITRYPSIN; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CATALASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ENDOTHELIN 1; GLUTATHIONE; GLUTATHIONE PEROXIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 8; LIPID PEROXIDE; METALLOTHIONEIN; MITOGEN ACTIVATED PROTEIN KINASE; N ACYSTELIN; NITRIC OXIDE; PROTEIN TYROSINE PHOSPHATASE; RAC PROTEIN; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG; XANTHINE OXIDASE;

ANTIOXIDANT ACTIVITY; ASTHMA; CELL MEMBRANE PERMEABILITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; CLINICAL TRIAL; DRUG BIOAVAILABILITY; DRUG POTENCY; ENZYME ACTIVITY; FORCED EXPIRATORY VOLUME; HUMAN; LEUKOCYTE MIGRATION; LIPID PEROXIDATION; META ANALYSIS; NEUTROPHIL; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PATHOGENESIS; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; RISK FACTOR; SIGNAL TRANSDUCTION;

ANIMALS; ASTHMA; HUMANS; INFLAMMATION; LUNG; LUNG DISEASES, OBSTRUCTIVE; OXIDATIVE STRESS;

EID: 0035840849     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01320-6     Document Type: Review

References (136)

1. Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease
2. Acute effect of smoking on the functional activity of alpha-1-protease inhibitor in bronchoalveolar lavage fluid
3. Nitric oxide modulates beta(2)-adrenergic receptor palmitoylation and signaling
4. Role of redox potential and reactive oxygen species in stress signaling
5. Increased amount of nitric oxide in exhaled air of asthmatics
6. Increased hydrogen peroxide and thiobarbituric acid-reactive products in expired breath condensate of asthmatic patients
7. LPS stimulation of IL-8 release is inhibited by thiol antioxidant at the transcriptional level in THP-1 macrophage cells
8. Nitric oxide and asthma: A review
9. Mechanisms in chronic obstructive pulmonary disease: Differences from asthma
10. Characterization of the inflammatory reaction in the peripheral airways of cigarette smokers using immunocytochemistry
11. Asthma: From bronchoconstriction to airways inflammation and remodeling
12. Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine
13. Effect of N-acetyl cysteine on the concentrations of thiols in plasma, bronchoalveolar lavage fluid, and lung tissue
14. Dietary antioxidant vitamin intake and lung function in the general population
15. Deformability and CD11/CD18 expression of sequestered neutrophils in normal and inflamed lungs
16. Arachidonic acid metabolism in inflammatory cells of patients with bronchial asthma
17. Enhanced superoxide production by alveolar macrophages and air-space cells, airway inflammation, and alveolar macrophage density changes after segmental antigen bronchoprovocation in allergic subjects
18. Leukocyte count, smoking and lung function
19. Peripheral leucocyte count and longitudinal decline in lung function
20. Free-radical chemistry of cigarette smoke and its toxicological implications
21. Rapid loss of superoxide dismutase activity during antigen-induced asthmatic response
22. Increased exhaled nitric oxide in patients with stable chronic obstructive pulmonary disease
23. Contraction of human airways by oxidative stress protection by N-acetylcysteine
24. Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease
25. Increased exhaled nitric oxide in chronic bronchitis: Comparison with asthma and chronic obstructive pulmonary disease
26. Expired breath hydrogen peroxide is a marker of acute airway inflammation in pediatric patients with asthma
27. The effects of experimental exposure to tobacco smoke on the oxidative metabolism of alveolar macrophages
28. Changes in neutrophil deformability following in vitro smoke exposure: Mechanism and protection
29. Decreased leukocyte deformability after acute cigarette smoking in humans
30. Allergen-induced synthesis of F(2)-isoprostanes in atopic asthmatics. Evidence for oxidant stress
31. Oxidant stress in asthma
32. Assessment of oxidant stress in allergic asthma by measurement of the major urinary metabolite of F2-isoprostane, 15-F2t-IsoP (8-iso-PGF2alpha)
33. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
34. Effect of cigarette smoking on pentane excretion in alveolar breath
35. Serum ECP and MPO are increased during exacerbations of chronic bronchitis with airway obstruction
36. Antioxidant gene expression in rat lung after exposure to cigarette smoke
37. Peroxynitrite: Reactive, invasive and enigmatic
38. Lipid peroxidation and antioxidants as biomarkers of tissue damage
39. Free radicals and antioxidants in the year 2000. A historical look to the future
40. Activation of mitogen-activated protein kinase by H2O2: Role in cell survival following oxidant injury
41. Cigarette smoking and ethane exhalation in humans
42. Role of free radicals and catalytic metal ions in human disease: An overview
43. Increased nitrotyrosine in exhaled breath condensate of patients with asthma
44. Xanthine oxidase is involved in exercise-induced oxidative stress in chronic obstructive pulmonary disease
45. Vitamin E suppresses increased lipid peroxidation in cigarette smokers
46. Oxidative epithelial damage produces hyperresponsiveness of human peripheral airways
47. Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways
48. Comparison of the structural and inflammatory features of chronic obstructive pulmonary disease and asthma
49. Activation of NF-kappaB by PM(10) occurs via an iron-mediated mechanism in the absence of IkappaB degradation
50. Nitrotyrosine formation in the airways and lung parenchyma of patients with asthma
51. The role of free radicals in airway obstruction in asthmatic patients
52. Activation of neutrophils within pulmonary microvessels of rabbits exposed to cigarette smoke
53. Effects of 0.2 ppm ozone on biomarkers of inflammation in bronchoalveolar lavage fluid and bronchial mucosa of healthy subjects
54. A molecular redox switch on p21(ras): Structural basis for the nitric oxide-p21(ras) interaction
55. Effect of cigarette smoke and its condensates on alveolar epithelial cell injury in vitro
56. Cigarette smoke, ferritin, and lipid peroxidation
57. Cigarette smoke elicits leukocyte adhesion to endothelium in hamsters: Inhibition by CuZn-SOD
58. An investigation of the role of glutathione in increased epithelial permeability induced by cigarette smoke in vivo and in vitro
59. The role of tumor necrosis factor in increased airspace epithelial permeability in acute lung inflammation
60. Mechanisms of cigarette smoke induced increased airspace permeability
61. Antioxidants
62. Is oxidative stress central to the pathogenesis of chronic obstructive pulmonary disease?
63. New perspectives on basic mechanisms in lung disease. 2. Neutrophil traffic in the lungs: Role of haemodynamics, cell adhesion, and deformability
64. Eosinophils are a major source of nitric oxide-derived oxidants in severe asthma: Characterization of pathways available to eosinophils for generating reactive nitrogen species
65. Iron metabolism in the lower respiratory tract
66. Exhaled nitric oxide in chronic obstructive pulmonary disease
67. Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients
68. Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis
69. Epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers
70. The isoprostanes: Unique bioactive products of lipid peroxidation
71. The cellular stress response induced by aqueous extracts of cigarette smoke is critically dependent on the intracellular glutathione concentration
72. Phagocytosis and oxidative burst of blood phagocytes in chronic obstructive airway disease
73. Receptor-mediated O2-release by alveolar macrophages and peripheral blood monocytes from smokers and nonsmokers: Priming and triggering effects of monomeric IgG, concanavalin A, N-formyl-methionyl-leucyl- phenylalanine, phorbol myristate acetate, and cytochalasin D
74. Quantitative analysis of the hydrogen peroxide formed in aqueous cigarette tar extracts
75. Superoxide mediates cigarette smoke-induced infiltration of neutrophils into the airways through nuclear factor-kappaB activation and IL-8 mRNA expression in guinea pigs in vivo
76. Expression of adhesion molecules and G proteins in circulating neutrophils in chronic obstructive pulmonary disease
77. Increased content of hydrogen peroxide in the expired breath of cigarette smokers
78. Cigarette smoking does not increase hydrogen peroxide levels in expired breath condensate of patients with stable chronic obstructive pulmonary disease
79. Increased content of thiobarbituric acid-reactive substances and hydrogen peroxide in the expired breath condensate of patients with stable chronic obstructive pulmonary disease: No significant effect of cigarette smoking
80. Exhaled pentane levels in acute asthma
81. Evidence of free-radical activity in asthma
82. Elevation of exhaled ethane concentration in asthma
83. 4-Hydroxynonenal as a biological signal: Molecular basis and pathophysiological implications
84. Plasma 3-nitrotyrosine in cigarette smokers
85. Nitrated and oxidized plasma proteins in smokers and lung cancer patients
86. Xanthine oxidase activity in bronchoalveolar lavage fluid from patients with chronic obstructive pulmonary disease
87. Detection of xanthine oxidase activity products by EPR and HPLC in bronchoalveolar lavage fluid from patients with chronic obstructive pulmonary disease
88. Association between nonspecific bronchial hyperreactivity and superoxide anion production by polymorphonuclear leukocytes in chronic air-flow obstruction
89. Chronic obstructive pulmonary disease is associated with an increase in urinary levels of isoprostane F2alpha-III, an index of oxidant stress
90. Oxidants in cigarette smoke: Radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite
91. Role of oxidants/antioxidants in smoking-induced lung diseases
92. Role of transcription factors in inflammatory lung diseases
93. Lung glutathione and oxidative stress: Implications in cigarette smoke-induced airway disease
94. Oxidative stress and regulation of glutathione in lung inflammation
95. Regulation of redox glutathione levels and gene transcription in lung inflammation: Therapeutic approaches
96. Glutathione homeostasis in alveolar epithelial cells in vitro and lung in vivo under oxidative stress
97. Systemic oxidative stress in asthma, chronic obstructive pulmonary disease, and smokers
98. Induction of gamma-glutamylcysteine synthetase by cigarette smoke is associated with AP-1 in human alveolar epithelial cells
99. Transcriptional regulation of gamma-glutamylcysteine synthetase-heavy subunit by oxidants in human alveolar epithelial cells
100. Attenuation of oxidant/antioxidant imbalance during treatment of exacerbations of chronic obstructive pulmonary disease
101. Characterisation of gamma-glutamylcysteine synthetase-heavy subunit promoter: A critical role for AP-1
102. Molecular mechanism of the regulation of glutathione synthesis by tumor necrosis factor-alpha and dexamethasone in human alveolar epithelial cells
103. 4 hydrozy-2-nonenal, a specific lipid peroxidation product is evaluated in lungs of patients with chronic obstructive pulmonary disease (COPD)
104. Inflammation and repair processes in chronic obstructive pulmonary disease
105. Oxidative stress in chronic obstructive pulmonary disease
106. Spirometric abnormalities in young smokers correlate with increased chemiluminescence responses of activated blood phagocytes
107. Smoking cessation is associated with an increase in exhaled nitric oxide
108. Concurrent production of reactive oxygen and nitrogen species by airway epithelial cells in vitro
109. Markers of nitric oxide metabolism in sputum and exhaled air are not increased in chronic obstructive pulmonary disease
110. Peroxynitrite induces airway hyperresponsiveness in guinea pigs in vitro and in vivo
111. Cellular and structural bases of chronic obstructive pulmonary disease
112. Spontaneous oxygen radical production at sites of antigen challenge in allergic subjects
113. Subpopulations of alveolar macrophages in smokers and nonsmokers: Relation to the expression of CD11/CD18 molecules and superoxide anion production
114. Enhanced superoxide generation by eosinophils from asthmatic children
115. Superoxide generation by hypodense eosinophils from patients with asthma
116. In vivo neutrophil sequestration within lungs of humans is determined by in vitro "filterability"
117. O3-induced change in bronchial reactivity to methacholine and airway inflammation in humans
118. Redox signaling and the emerging therapeutic potential of thiol antioxidants
119. Airway nitric oxide diffusion in asthma: Role in pulmonary function and bronchial responsiveness
120. Reduced superoxide dismutase in lung cells of patients with asthma
121. The effect of oral N-acetylcysteine in chronic bronchitis: A quantitative systematic review
122. Increased spontaneous production and generation of superoxide anion by blood neutrophils in patients with asthma
123. Reactive oxygen species in cell signaling
124. Lower respiratory tract iron burden is increased in association with cigarette smoking
125. Evidence of oxidative stress in asthma and chronic obstructive pulmonary disease: Potential inhibitory effect of theophylline
126. Activation of stress signaling pathways by the end product of lipid peroxidation: 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production
127. Increased oxygen species generation in blood monocytes of asthmatic patients
128. Vitamin E, pulmonary functions, and phagocyte-mediated oxidative stress in smokers and nonsmokers
129. Interactions of peroxynitrite with human plasma and its constituents: Oxidative damage and antioxidant depletion
130. Advances in the immunobiology of eosinophils and their role in disease
131. Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma: Relationship to bronchial hyperreactivity
132. Increased release of ferritin and iron by iron-loaded alveolar macrophages in cigarette smokers
133. Lipid peroxidation as determined by plasma isoprostanes is related to disease severity in mild asthma
134. Eosinophils generate brominating oxidants in allergen-induced asthma
135. Detection of free radicals in aqueous extracts of cigarette tar by electron spin resonance
136. Peroxynitrite targets the epidermal growth factor receptor, Raf-1, and MEK independently to activate MAPK