-
1
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy, J., and Selkoe, D. J. (2002) The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science 297, 353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
2
-
-
0033844944
-
Characterization of copper interactions with Alzheimer amyloid β peptides: Identification of an attomolar-affinity copper binding site on amyloid β 1-42
-
Atwood, C. S., Scarpa, R. C., Huang, X., Moir, R. D., Jones, W. D., Fairlie, D. P., Tanzi, R. E., and Bush, A. I. (2000) Characterization of copper interactions with Alzheimer amyloid β peptides: Identification of an attomolar-affinity copper binding site on amyloid β 1-42. J. Neurochem. 75, 1219-1233.
-
(2000)
J. Neurochem.
, vol.75
, pp. 1219-1233
-
-
Atwood, C.S.1
Scarpa, R.C.2
Huang, X.3
Moir, R.D.4
Jones, W.D.5
Fairlie, D.P.6
Tanzi, R.E.7
Bush, A.I.8
-
3
-
-
0037160028
-
Overexpression of Alzheimer's disease amyloid-β opposes the age-dependent elevations of brain copper and iron
-
Maynard, C. J., Cappai, R., Volitakis, I., Cherny, R. A., White, A. R., Beyreuther, K., Masters, C. L., Bush, A. L., and Li, Q. X. (2002) Overexpression of Alzheimer's disease amyloid-β opposes the age-dependent elevations of brain copper and iron. J. Biol. Chem. 277, 44670-44676.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 44670-44676
-
-
Maynard, C.J.1
Cappai, R.2
Volitakis, I.3
Cherny, R.A.4
White, A.R.5
Beyreuther, K.6
Masters, C.L.7
Bush, A.L.8
Li, Q.X.9
-
4
-
-
0029935396
-
The amyloid precursor protein of Alzheimer's disease in the reduction of copper (II) to copper (I)
-
Multhaup, G., Schlicksupp, A., Hesse, L., Beher, D., Ruppert, T., Masters, C. L., and Beyreuther, K. (1996) The amyloid precursor protein of Alzheimer's disease in the reduction of copper (II) to copper (I). Science 271, 1406-1409.
-
(1996)
Science
, vol.271
, pp. 1406-1409
-
-
Multhaup, G.1
Schlicksupp, A.2
Hesse, L.3
Beher, D.4
Ruppert, T.5
Masters, C.L.6
Beyreuther, K.7
-
5
-
-
0345035452
-
Cysteine 144 is a key residue in the copper reduction by the β-amyloid precursor protein
-
Ruiz, F. H., Gonzalez, M., Bodini, M., Opazo, C., and Inestrosa, N. C. (1999) Cysteine 144 is a key residue in the copper reduction by the β-amyloid precursor protein. J. Neurochem. 73, 1288-1292.
-
(1999)
J. Neurochem.
, vol.73
, pp. 1288-1292
-
-
Ruiz, F.H.1
Gonzalez, M.2
Bodini, M.3
Opazo, C.4
Inestrosa, N.C.5
-
6
-
-
9444271637
-
2+ neurotoxicity in vivo
-
2+ neurotoxicity in vivo. FASEB J. 18, 1701-1703.
-
(2004)
FASEB J.
, vol.18
, pp. 1701-1703
-
-
Cerpa, W.F.1
Barria, M.I.2
Chacon, M.A.3
Suazo, M.4
Gonzalez, M.5
Opazo, C.6
Bush, A.I.7
Inestrosa, N.C.8
-
7
-
-
0033516677
-
Alterations of 3-nitrotyrosine concentration in the cerebrospinal fluid during aging and in patients with Alzheimer's disease
-
Tohgi, H., Abe, T., Yamazaki, K., Murata, T., Ishizaki, E., and Isobe, C. (1999) Alterations of 3-nitrotyrosine concentration in the cerebrospinal fluid during aging and in patients with Alzheimer's disease. Neurosci. Lett. 269, 52-54.
-
(1999)
Neurosci. Lett.
, vol.269
, pp. 52-54
-
-
Tohgi, H.1
Abe, T.2
Yamazaki, K.3
Murata, T.4
Ishizaki, E.5
Isobe, C.6
-
8
-
-
0026648872
-
Axonal sprouting induced in the sciatic nerve by the amyloid precursor protein (APP) and other antiproteases
-
Alvarez, J., Moreno, R. D., Llanos, O., Inestrosa, N. C., Brandan, E., Colby, T., and Esch, F. S. (1992) Axonal sprouting induced in the sciatic nerve by the amyloid precursor protein (APP) and other antiproteases. Neurosci. Lett. 144, 130-134.
-
(1992)
Neurosci. Lett.
, vol.144
, pp. 130-134
-
-
Alvarez, J.1
Moreno, R.D.2
Llanos, O.3
Inestrosa, N.C.4
Brandan, E.5
Colby, T.6
Esch, F.S.7
-
9
-
-
0027478347
-
Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein
-
Mattson, M. P., Cheng, B., Culwell, A. R., Esch, F. S., Lieberburg, I., and Rydel, R. E. (1993) Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein. Neuron 10, 243-254.
-
(1993)
Neuron
, vol.10
, pp. 243-254
-
-
Mattson, M.P.1
Cheng, B.2
Culwell, A.R.3
Esch, F.S.4
Lieberburg, I.5
Rydel, R.E.6
-
10
-
-
0037355742
-
Copper reduction by copper binding proteins and its relation to neurodegenerative diseases
-
Opazo, C., Barria, M. I., Ruiz, F. H., and Inestrosa, N. C. (2003) Copper reduction by copper binding proteins and its relation to neurodegenerative diseases. Biometals 16, 91-98.
-
(2003)
Biometals
, vol.16
, pp. 91-98
-
-
Opazo, C.1
Barria, M.I.2
Ruiz, F.H.3
Inestrosa, N.C.4
-
11
-
-
0034643831
-
Metal binding modes of Alzheimer's amyloid β-peptide in insoluble aggregates and soluble complexes
-
Miura, T., Suzuki, K., Kohata, N., and Takeuchi, H. (2000) Metal binding modes of Alzheimer's amyloid β-peptide in insoluble aggregates and soluble complexes. Biochemistry 39, 7024-7031.
-
(2000)
Biochemistry
, vol.39
, pp. 7024-7031
-
-
Miura, T.1
Suzuki, K.2
Kohata, N.3
Takeuchi, H.4
-
12
-
-
0032507975
-
Copper, iron and zinc in Alzheimer's disease senile plaques
-
Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L., and Markesbery, W. R. (1998) Copper, iron and zinc in Alzheimer's disease senile plaques. J. Neurol. Sci. 158, 47-52.
-
(1998)
J. Neurol. Sci.
, vol.158
, pp. 47-52
-
-
Lovell, M.A.1
Robertson, J.D.2
Teesdale, W.J.3
Campbell, J.L.4
Markesbery, W.R.5
-
13
-
-
0034964390
-
Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice
-
Cherny, R. A., Atwood, C. S., Xilinas, M. E., Gray, D. N., Jones, W. D., McLean, C. A., Barnham, K. J., Volitakis, I., Fraser, F. W., Kim, Y., Huang, X., Goldstein, L. E., Moir, R. D., Lim, J. T., Beyreuther, K., Zheng, H., Tanzi, R. E., Masters, C. L., and Bush, A. I. (2001) Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 30, 665-676.
-
(2001)
Neuron
, vol.30
, pp. 665-676
-
-
Cherny, R.A.1
Atwood, C.S.2
Xilinas, M.E.3
Gray, D.N.4
Jones, W.D.5
McLean, C.A.6
Barnham, K.J.7
Volitakis, I.8
Fraser, F.W.9
Kim, Y.10
Huang, X.11
Goldstein, L.E.12
Moir, R.D.13
Lim, J.T.14
Beyreuther, K.15
Zheng, H.16
Tanzi, R.E.17
Masters, C.L.18
Bush, A.I.19
-
14
-
-
0037174856
-
2
-
2. J. Biol. Chem. 111, 40302-40308.
-
(2002)
J. Biol. Chem.
, vol.111
, pp. 40302-40308
-
-
Opazo, C.1
Huang, X.2
Cherny, R.A.3
Moir, R.D.4
Roher, A.E.5
White, A.R.6
Cappai, R.7
Masters, C.L.8
Tanzi, R.E.9
Inestrosa, N.C.10
Bush, A.I.11
-
15
-
-
0037096251
-
A novel function of monomeric amyloid β-protein sarving as an antioxidant molecule against metal induced oxidative damage
-
Zou, K., Gong, J. S., Yanagisawa, K., and Michikawa, M. (2002) A novel function of monomeric amyloid β-protein sarving as an antioxidant molecule against metal induced oxidative damage. J. Neurosci. 22, 4833-4841.
-
(2002)
J. Neurosci.
, vol.22
, pp. 4833-4841
-
-
Zou, K.1
Gong, J.S.2
Yanagisawa, K.3
Michikawa, M.4
-
16
-
-
0141702360
-
Trace amounts of copper in water induce β-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease
-
Sparks, D. L., and Schreurs, B. G. (2003) Trace amounts of copper in water induce β-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 100, 11065-11069.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 11065-11069
-
-
Sparks, D.L.1
Schreurs, B.G.2
-
17
-
-
20144371701
-
Excess of serum copper not related to ceruloplasmin in Alzheimer disease
-
Squitti, R., Pasqualetti, P., Dal Forno, G., Moffa, F., Cassetta, E., Lupoi, D., Vernieri, F., Rossi, L., Baldassini, M., and Rossini, P. M. (2005) Excess of serum copper not related to ceruloplasmin in Alzheimer disease. Neurology 64, 1040-1046.
-
(2005)
Neurology
, vol.64
, pp. 1040-1046
-
-
Squitti, R.1
Pasqualetti, P.2
Dal Forno, G.3
Moffa, F.4
Cassetta, E.5
Lupoi, D.6
Vernieri, F.7
Rossi, L.8
Baldassini, M.9
Rossini, P.M.10
-
18
-
-
10744226316
-
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Aβ production in APP23 transgenic mice
-
Bayer, T. A., Schafer, S., Simons, A., Kemmling, A., Kamer, T., Tepest, R., Eckert, A., Schussel, K., Eikenberg, O., Sturchler-Pierrat, C., Abramowski, D., Staufenbiel, M., and Multhaup, G. (2003) Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Aβ production in APP23 transgenic mice. Proc. Natl. Acad. Sci. USA 100, 14187-14192.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 14187-14192
-
-
Bayer, T.A.1
Schafer, S.2
Simons, A.3
Kemmling, A.4
Kamer, T.5
Tepest, R.6
Eckert, A.7
Schussel, K.8
Eikenberg, O.9
Sturchler-Pierrat, C.10
Abramowski, D.11
Staufenbiel, M.12
Multhaup, G.13
-
19
-
-
10744228112
-
In vivo reduction of amyloid-β by a mutant copper transporter
-
Phinney, A. L., Drisaldi, B., Schmidt, S. D., Lugowski, S., Coronado, V., Liang, Y., Horne, P., Yang, J., Sekoulidis, J., Coomaraswamy, J., Chishti, M. A., Cox, D. W., Mathews, P. M., Nixon, R. A., Carlson, G. A., St George-Hyslop, P., and Westaway, D. (2003) In vivo reduction of amyloid-β by a mutant copper transporter. Proc. Natl. Acad. Sci. USA 100, 14193-14198.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 14193-14198
-
-
Phinney, A.L.1
Drisaldi, B.2
Schmidt, S.D.3
Lugowski, S.4
Coronado, V.5
Liang, Y.6
Horne, P.7
Yang, J.8
Sekoulidis, J.9
Coomaraswamy, J.10
Chishti, M.A.11
Cox, D.W.12
Mathews, P.M.13
Nixon, R.A.14
Carlson, G.A.15
St. George-Hyslop, P.16
Westaway, D.17
-
21
-
-
0025991466
-
The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive
-
Caughey, B., and Raymond, G. J. (1991) The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive. J. Biol. Chem. 266, 18217-18223.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 18217-18223
-
-
Caughey, B.1
Raymond, G.J.2
-
22
-
-
0022569404
-
Scrapie prion proteins are synthesized in neurons
-
Kretzschmar, H. A., Prusiner, S. B., Stowring, L. E., and DeArmond, S. J. (1986) Scrapie prion proteins are synthesized in neurons. Am. J. Pathol. 122, 1-5.
-
(1986)
Am. J. Pathol.
, vol.122
, pp. 1-5
-
-
Kretzschmar, H.A.1
Prusiner, S.B.2
Stowring, L.E.3
Dearmond, S.J.4
-
23
-
-
0023663071
-
Scrapie prion protein contains a phosphatidylinositol glycolipid
-
Stahl, N., Borchelt, D. R., Hsiao, K., and Prusiner, S. B. (1987) Scrapie prion protein contains a phosphatidylinositol glycolipid. Cell 51, 229-240.
-
(1987)
Cell
, vol.51
, pp. 229-240
-
-
Stahl, N.1
Borchelt, D.R.2
Hsiao, K.3
Prusiner, S.B.4
-
24
-
-
0037965529
-
Prion protein selectively binds copper(II) ions
-
Stockel, J., Safar, J., Wallace, A. C., Cohen, F. E., and Prusiner, S. B. (1998) Prion protein selectively binds copper(II) ions. Biochemistry 37, 7185-7193.
-
(1998)
Biochemistry
, vol.37
, pp. 7185-7193
-
-
Stockel, J.1
Safar, J.2
Wallace, A.C.3
Cohen, F.E.4
Prusiner, S.B.5
-
25
-
-
0033515029
-
Copper binding to the prion protein: Structural implications of four identical cooperative binding sites
-
Viles, J. H., Cohen, F. E., Prusiner, S. B., Goodin, D. B., Wright, P. E., and Dyson, H. J. (1999) Copper binding to the prion protein: Structural implications of four identical cooperative binding sites. Proc. Natl. Acad. Sci. USA 96, 2042-2047.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 2042-2047
-
-
Viles, J.H.1
Cohen, F.E.2
Prusiner, S.B.3
Goodin, D.B.4
Wright, P.E.5
Dyson, H.J.6
-
26
-
-
0033130083
-
Strain-specific prion-protein conformation determined by metal ions
-
Wadsworth, J. D., Hill, A. F., Joiner, S., Jackson, G. S., Clarke, A. R., and Collinge, J. (1999) Strain-specific prion-protein conformation determined by metal ions. Nat. Cell Biol. 1, 55-59.
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 55-59
-
-
Wadsworth, J.D.1
Hill, A.F.2
Joiner, S.3
Jackson, G.S.4
Clarke, A.R.5
Collinge, J.6
-
27
-
-
0034673578
-
The N-terminal tandem repeat region of human prion protein reduces copper: Role of tryptophan residues
-
Ruiz, F. H., Silva, E., and Inestrosa, N. C. (2000) The N-terminal tandem repeat region of human prion protein reduces copper: Role of tryptophan residues. Biochem. Biophys. Res. Commun. 269, 491-495.
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.269
, pp. 491-495
-
-
Ruiz, F.H.1
Silva, E.2
Inestrosa, N.C.3
-
28
-
-
20544450600
-
Copper reduction by the octapeptide repeat region of prion protein: PH dependence and implications in cellular copper uptake
-
Miura, T., Sasaki, S., Toyama, A., and Takeuchi, H. (2005) Copper reduction by the octapeptide repeat region of prion protein: pH dependence and implications in cellular copper uptake. Biochemistry 44, 8712-8720.
-
(2005)
Biochemistry
, vol.44
, pp. 8712-8720
-
-
Miura, T.1
Sasaki, S.2
Toyama, A.3
Takeuchi, H.4
-
29
-
-
0242288831
-
A human prion protein peptide (PrP(59-91)) protects against copper neurotoxicity
-
Chacon, M. A., Barria, M. I., Lorca, R., Huidobro-Toro, J. P., and Inestrosa, N. C. (2003) A human prion protein peptide (PrP(59-91)) protects against copper neurotoxicity. Mol. Psychiatry 8, 853-862.
-
(2003)
Mol. Psychiatry
, vol.8
, pp. 853-862
-
-
Chacon, M.A.1
Barria, M.I.2
Lorca, R.3
Huidobro-Toro, J.P.4
Inestrosa, N.C.5
-
30
-
-
0032509499
-
Copper stimulates endocytosis of the prion protein
-
Pauly, P. C., and Harris, D. A. (1998) Copper stimulates endocytosis of the prion protein. J. Biol. Chem. 273, 33107-33110.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 33107-33110
-
-
Pauly, P.C.1
Harris, D.A.2
-
31
-
-
0037715143
-
Expression of prion protein increases cellular copper binding and antioxidant enzyme activities but not copper delivery
-
Rachidi, W., Vilette, D., Guiraud, P., Arlotto, M., Riondel, J., Laude, H., Lehmann, S., and Favier, A. (2003) Expression of prion protein increases cellular copper binding and antioxidant enzyme activities but not copper delivery. J. Biol. Chem. 278, 9064-9072.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 9064-9072
-
-
Rachidi, W.1
Vilette, D.2
Guiraud, P.3
Arlotto, M.4
Riondel, J.5
Laude, H.6
Lehmann, S.7
Favier, A.8
-
32
-
-
27444442715
-
The cellular prion protein gene expression is induced by copper in neuronal cells
-
in revision
-
Varela-Nallar, E., Toledo, E., Cabrai, A. E. B., Martins, V. R., and Inestrosa, N. C. (2005) The cellular prion protein gene expression is induced by copper in neuronal cells. Am. J. Physiol. Cell. Physiol. (in revision).
-
(2005)
Am. J. Physiol. Cell. Physiol.
-
-
Varela-Nallar, E.1
Toledo, E.2
Cabrai, A.E.B.3
Martins, V.R.4
Inestrosa, N.C.5
-
33
-
-
3542999252
-
2+ coordination by His96 and His111 induces β-sheet formation in the unstructured amyloidogenic region of the prion protein
-
2+ coordination by His96 and His111 induces β-sheet formation in the unstructured amyloidogenic region of the prion protein. J. Biol. Chem. 279, 32018-32027.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 32018-32027
-
-
Jones, C.E.1
Abdelraheim, S.R.2
Brown, D.R.3
Viles, J.H.4
-
34
-
-
0035815738
-
Copper converts the cellular prion protein into a protease-resistant species that is distinct from the scrapie isoform
-
Quaglio, E., Chiesa, R., and Harris, D. A. (2001) Copper converts the cellular prion protein into a protease-resistant species that is distinct from the scrapie isoform. J. Biol. Chem. 276, 11432-11438.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 11432-11438
-
-
Quaglio, E.1
Chiesa, R.2
Harris, D.A.3
-
35
-
-
2642553049
-
Copper induces increased β-sheet content in the scrapie-susceptible ovine prion protein PrPVRQ compared with the resistant allelic variant PrPARR
-
Wong, E., Thackray, A. M., and Bujdoso, R. (2004) Copper induces increased β-sheet content in the scrapie-susceptible ovine prion protein PrPVRQ compared with the resistant allelic variant PrPARR. Biochem. J. 380, 273-282.
-
(2004)
Biochem. J.
, vol.380
, pp. 273-282
-
-
Wong, E.1
Thackray, A.M.2
Bujdoso, R.3
-
36
-
-
0345306739
-
Copper chelation delays the onset of prion disease
-
Sigurdsson, E. M., Brown, D. R., Alim, M. A., Scholtzova, H., Carp, R., Meeker, H. C., Prelli, F., Frangione, B., and Wisniewski, T. (2003) Copper chelation delays the onset of prion disease. J. Biol. Chem. 278, 46199-46202.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 46199-46202
-
-
Sigurdsson, E.M.1
Brown, D.R.2
Alim, M.A.3
Scholtzova, H.4
Carp, R.5
Meeker, H.C.6
Prelli, F.7
Frangione, B.8
Wisniewski, T.9
-
37
-
-
0032476035
-
Reversibility of scrapie inactivation is enhanced by copper
-
McKenzie, D., Bartz, J., Mirwald, J., Olander, D., Marsh, R., and Aiken, J. (1998) Reversibility of scrapie inactivation is enhanced by copper. J. Biol. Chem. 273, 25545-25547.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 25545-25547
-
-
McKenzie, D.1
Bartz, J.2
Mirwald, J.3
Olander, D.4
Marsh, R.5
Aiken, J.6
-
38
-
-
2942672188
-
Misfolding of the prion protein at the plasma membrane induces endocytosis, intracellular retention and degradation
-
Kiachopoulos, S., Heske, J., Tatzeit, J., and Winklhofer, K. F. (2004) Misfolding of the prion protein at the plasma membrane induces endocytosis, intracellular retention and degradation. Traffic 5, 426-436.
-
(2004)
Traffic
, vol.5
, pp. 426-436
-
-
Kiachopoulos, S.1
Heske, J.2
Tatzeit, J.3
Winklhofer, K.F.4
-
39
-
-
27444438077
-
Role of copper on prion diseases: Misfolding versus trafficking effects on prion protein
-
in press
-
Varela-Nallar, L., Gonzalez, A., and Inestrosa, N. C. (2005) Role of copper on prion diseases: Misfolding versus trafficking effects on prion protein. Curr. Pharm. Design (in press).
-
(2005)
Curr. Pharm. Design
-
-
Varela-Nallar, L.1
Gonzalez, A.2
Inestrosa, N.C.3
-
40
-
-
0037195617
-
Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol
-
Ma, J., and Lindquist, S. (2002) Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol. Science 298, 1785-1788.
-
(2002)
Science
, vol.298
, pp. 1785-1788
-
-
Ma, J.1
Lindquist, S.2
-
41
-
-
0345714734
-
Copper binding to PrPC may inhibit prion disease propagation
-
Hijazi, N., Shaked, Y., Rosenmann, H., Ben-Hur, T., and Gabizon, R. (2003) Copper binding to PrPC may inhibit prion disease propagation. Brain Res. 993, 192-200.
-
(2003)
Brain Res.
, vol.993
, pp. 192-200
-
-
Hijazi, N.1
Shaked, Y.2
Rosenmann, H.3
Ben-Hur, T.4
Gabizon, R.5
|